Research Output

2020

Advances in defining signaling networks for the establishment of neuronal polarity

Funahashi, Y., Watanabe, T. & Kaibuchi, K., 04-2020, In : Current Opinion in Cell Biology. 63, p. 76-87 12 p.

Research output: Contribution to journalReview article

Maternal fructose consumption down-regulates Lxra expression via miR-206-mediated regulation

Yamazaki, M., Munetsuna, E., Yamada, H., Ando, Y., Mizuno, G., Fujii, R., Nouchi, Y., Kageyama, I., Teshigawara, A., Ishikawa, H., Suzuki, K., Shimono, Y., Hashimoto, S. & Ohashi, K., 08-2020, In : Journal of Nutritional Biochemistry. 82, 108386.

Research output: Contribution to journalArticle

MicroRNA-93 targets WASF3 and functions as a metastasis suppressor in breast cancer

Shibuya, N., Kakeji, Y. & Shimono, Y., 01-06-2020, In : Cancer science. 111, 6, p. 2093-2103 11 p.

Research output: Contribution to journalArticle

Open Access

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

Ikezu, S., Ingraham Dixie, K. L., Koro, L., Watanabe, T., Kaibuchi, K. & Ikezu, T., 04-02-2020, In : Acta Neuropathologica Communications. 8, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019

Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell-like properties through adipsin

Goto, H., Shimono, Y., Funakoshi, Y., Imamura, Y., Toyoda, M., Kiyota, N., Kono, S., Takao, S., Mukohara, T. & Minami, H., 07-02-2019, In : Oncogene. 38, 6, p. 767-779 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Association of circulating miR-20a, miR-27a, and miR-126 with non-alcoholic fatty liver disease in general population

Ando, Y., Yamazaki, M., Yamada, H., Munetsuna, E., Fujii, R., Mizuno, G., Ichino, N., Osakabe, K., Sugimoto, K., Ishikawa, H., Ohashi, K., Teradaira, R., Ohta, Y., Hamajima, N., Hashimoto, S. & Suzuki, K., 01-12-2019, In : Scientific reports. 9, 1, 18856.

Research output: Contribution to journalArticle

Open Access

Associations between dietary vitamin intake, ABCA1 gene promoter DNA methylation, and lipid profiles in a Japanese population

Fujii, R., Yamada, H., Munetsuna, E., Yamazaki, M., Ando, Y., Mizuno, G., Tsuboi, Y., Ohashi, K., Ishikawa, H., Hagiwara, C., Maeda, K., Hashimoto, S. & Suzuki, K., 01-11-2019, In : American Journal of Clinical Nutrition. 110, 5, p. 1213-1219 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population: The Yakumo study

Kondo, M., Yamada, H., Munetsuna, E., Yamazaki, M., Hatta, T., Iwahara, A., Ohashi, K., Ishikawa, H., Tsuboi, Y., Inoue, T., Fujii, R. & Suzuki, K., 01-05-2019, In : Archives of Gerontology and Geriatrics. 82, p. 155-160 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake

Fujii, R., Yamada, H., Yamazaki, M., Munetsuna, E., Ando, Y., Ohashi, K., Ishikawa, H., Shimoda, H., Sakata, K., Ogawa, A., Kobayashi, S. & Suzuki, K., 21-12-2019, In : BMC Nephrology. 20, 1, 474.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Dietary vegetable intake is inversely associated with ATP-binding cassette protein A1 (ABCA1) DNA methylation levels among Japanese women

Fujii, R., Yamada, H., Munetsuna, E., Yamazaki, M., Mizuno, G., Tsuboi, Y., Ohashi, K., Ishikawa, H., Ando, Y., Hagiwara, C., Maeda, K., Hashimoto, S., Hamajima, N. & Suzuki, K., 09-2019, In : Nutrition. 65, p. 1-5 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Establishment of a simpler method for measuring HDL-microRNAs

Ishikawa, H., Yamada, H., Kondo, K., Ota, T., Yamazaki, M., Ando, Y., Mizuno, G., Munetsuna, E., Suzuki, K., Teradaira, R. & Ohashi, K., 01-01-2019, In : Annals of Clinical Biochemistry. 56, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

F-Box/WD repeat domain-containing 7 induces chemotherapy resistance in colorectal cancer stem cells

Honma, S., Hisamori, S., Nishiuchi, A., Itatani, Y., Obama, K., Shimono, Y. & Sakai, Y., 05-2019, In : Cancers. 11, 5, 635.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

High-fructose consumption and the epigenetics of DNA methylation

Yamada, H., Munetsuna, E. & Ohashi, K., 05-01-2019, Handbook of Nutrition, Diet, and Epigenetics. Springer International Publishing, Vol. 3. p. 2161-2177 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities

Nishio, E., Hayashi, T., Nakatani, M., Aida, N., Suda, R., Fujii, T., Wakatsuki, T., Honda, S., Harada, N. & Shimono, Y., 12-2019, In : Biochemistry and Biophysics Reports. 20, 100671.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Maternal fructose–induced oxidative stress occurs via Tfam and Ucp5 epigenetic regulation in offspring hippocampi

Yamada, H., Munetsuna, E., Yamazaki, M., Mizuno, G., Sadamoto, N., Ando, Y., Fujii, R., Shiogama, K., Ishikawa, H., Suzuki, K., Shimono, Y., Ohashi, K. & Hashimoto, S., 01-10-2019, In : FASEB Journal. 33, 10, p. 11431-11442 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Maternal high-fructose intake increases circulating corticosterone levels via decreased adrenal corticosterone clearance in adult offspring

Munetsuna, E., Yamada, H., Yamazaki, M., Ando, Y., Mizuno, G., Hattori, Y., Sadamoto, N., Ishikawa, H., Ohta, Y., Fujii, R., Suzuki, K., Hashimoto, S. & Ohashi, K., 05-2019, In : Journal of Nutritional Biochemistry. 67, p. 44-50 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Microrna-9-5p-CDX2 axis: A useful prognostic biomarker for patients with stage II/III colorectal cancer

Nishiuchi, A., Hisamori, S., Sakaguchi, M., Fukuyama, K., Hoshino, N., Itatani, Y., Honma, S., Maekawa, H., Nishigori, T., Tsunoda, S., Obama, K., Miyoshi, H., Shimono, Y., Mark Taketo, M. & Sakai, Y., 12-2019, In : Cancers. 11, 12, 1891.

Research output: Contribution to journalArticle

Open Access

MiR-221 targets QKI to enhance the tumorigenic capacity of human colorectal cancer stem cells

Mukohyama, J., Isobe, T., Hu, Q., Hayashi, T., Watanabe, T., Maeda, M., Yanagi, H., Qian, X., Yamashita, K., Minami, H., Mimori, K., Sahoo, D., Kakeji, Y., Suzuki, A., Dalerba, P. & Shimono, Y., 15-10-2019, In : Cancer Research. 79, 20, p. 5151-5158 8 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

A hypoglycemia-inducing giant borderline phyllodes tumor secreting high-molecular-weight insulin-like growth factor II: Immunohistochemistry and a western blot analysis

Hikichi, M., Kiriyama, Y., Hayashi, T., Ushimado, K., Kobayashi, N., Urano, M., Kuroda, M. & Utsumi, T., 01-01-2018, In : Internal Medicine. 57, 2, p. 237-241 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Association of subcutaneous and visceral fat with circulating microRNAs in a middle-aged Japanese population

Munetsuna, E., Yamada, H., Ando, Y., Yamazaki, M., Tsuboi, Y., Kondo, M., Mizuno, G., Ishikawa, H., Sugimoto, K., Osakabe, K., Ichino, N., Ohashi, K., Hamajima, N. & Suzuki, K., 01-07-2018, In : Annals of Clinical Biochemistry. 55, 4, p. 437-445 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter

Yamazaki, M., Yamada, H., Munetsuna, E., Ishikawa, H., Mizuno, G., Mukuda, T., Mouri, A., Nabeshima, T., Saito, K., Suzuki, K., Hashimoto, S. & Ohashi, K., 05-2018, In : FASEB Journal. 32, 5, p. 2549-2562 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Forskolin increases the effect of everolimus on aromatase inhibitor-resistant breast cancer cells

Hayashi, T., Hikichi, M., Yukitake, J., Wakatsuki, T., Nishio, E., Utsumi, T. & Harada, N., 01-05-2018, In : Oncotarget. 9, 34, p. 23451-23461 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Maternal fructose intake disturbs ovarian estradiol synthesis in rats

Munetsuna, E., Yamada, H., Yamazaki, M., Ando, Y., Mizuno, G., Ota, T., Hattori, Y., Sadamoto, N., Suzuki, K., Ishikawa, H., Hashimoto, S. & Ohashi, K., 01-06-2018, In : Life Sciences. 202, p. 117-123 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Relationship between long interspersed nuclear element-1 DNA methylation in leukocytes and dyslipidemia in the Japanese general population

Tsuboi, Y., Yamada, H., Munetsuna, E., Yamazaki, M., Mizuno, G., Murase, Y., Ohashi, K., Ishikawa, H., Kondo, M., Inoue, T., Hashimoto, S., Hamajima, N. & Suzuki, K., 01-01-2018, In : Journal of atherosclerosis and thrombosis. 25, 12, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Discovery of long-range inhibitory signaling to ensure single axon formation

Takano, T., Wu, M., Nakamuta, S., Naoki, H., Ishizawa, N., Namba, T., Watanabe, T., Xu, C., Hamaguchi, T., Yura, Y., Amano, M., Hahn, K. M. & Kaibuchi, K., 01-12-2017, In : Nature communications. 8, 1, 33.

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)

Estradiol suppresses phosphorylation of ERα serine 167 through upregulation of PP2A in breast cancer cells

Hayashi, T., Hikichi, M., Yukitake, J., Harada, N. & Utsumi, T., 12-2017, In : Oncology Letters. 14, 6, p. 8060-8065 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Fructose intake during gestation and lactation differentially affects the expression of hippocampal neurosteroidogenic enzymes in rat offspring

Mizuno, G., Munetsuna, E., Yamada, H., Ando, Y., Yamazaki, M., Murase, Y., Kondo, K., Ishikawa, H., Teradaira, R., Suzuki, K. & Ohashi, K., 02-01-2017, In : Endocrine Research. 42, 1, p. 71-77 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Ligation-mediated PCR with a back-to-back adapter reduces amplification bias resulting from variations in GC content

Ishihara, S., Kotomura, N., Yamamoto, N. & Ochiai, H., 15-08-2017, In : Analytical Biochemistry. 531, p. 37-44 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Stability of serum high-density lipoprotein-microRNAs for preanalytical conditions

Ishikawa, H., Yamada, H., Taromaru, N., Kondo, K., Nagura, A., Yamazaki, M., Ando, Y., Munetsuna, E., Suzuki, K., Ohashi, K. & Teradaira, R., 01-01-2017, In : Annals of Clinical Biochemistry. 54, 1, p. 134-142 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein

Itoh, N., Nagai, T., Watanabe, T., Taki, K., Nabeshima, T., Kaibuchi, K. & Yamada, K., 02-12-2017, In : Biochemical and Biophysical Research Communications. 493, 4, p. 1384-1389 6 p.

Research output: Contribution to journalArticle

2016

A new approach for the direct visualization of the membrane cytoskeleton in cryo-electron microscopy: A comparative study with freeze-etching electron microscopy

Makihara, M., Watanabe, T., Usukura, E., Kaibuchi, K., Narita, A., Tanaka, N. & Usukura, J., 01-12-2016, In : Microscopy. 65, 6, p. 488-498 11 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Circulating MicroRNAs in Graves' Disease in Relation to Clinical Activity

Hiratsuka, I., Yamada, H., Munetsuna, E., Hashimoto, S. & Itoh, M., 01-10-2016, In : Thyroid. 26, 10, p. 1431-1440 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Fructose consumption induces hypomethylation of hepatic mitochondrial DNA in rats

Yamazaki, M., Munetsuna, E., Yamada, H., Ando, Y., Mizuno, G., Murase, Y., Kondo, K., Ishikawa, H., Teradaira, R., Suzuki, K. & Ohashi, K., 15-03-2016, In : Life Sciences. 149, p. 146-152 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Metabolism and Action of 25-Hydroxy-19-nor-Vitamin D3 in Human Prostate Cells

Munetsuna, E., Kittaka, A., Chen, T. C. & Sakaki, T., 01-01-2016, Vitamin D Hormone, 2016. Litwack, G. (ed.). Academic Press Inc., p. 357-377 21 p. (Vitamins and Hormones; vol. 100).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Tomosyn negatively regulates arginine vasopressin secretion in embryonic stem cell-derived neurons

Takeuchi, S., Iwama, S., Takagi, H., Kiyota, A., Nakashima, K., Izumida, H., Fujisawa, H., Iwata, N., Suga, H., Watanabe, T., Kaibuchi, K., Oiso, Y., Arima, H. & Sugimura, Y., 10-2016, In : PloS one. 11, 10, e0164544.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Breast cancer stem cell research utilizing clinical specimens

Mukohyama, J. & Shimono, Y., 01-05-2015, In : Nihon rinsho. Japanese journal of clinical medicine. 73, 5, p. 831-835 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Correction to LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends [J. Cell Sci, 128 (2015), 385-396]

Kedashiro, S., Pastuhov, S. I., Nishioka, T., Watanabe, T., Kaibuchi, K., Matsumoto, K. & Hanafusa, H., 01-01-2015, In : Journal of Cell Science. 128, 4, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2 Citations (Scopus)

High fructose consumption induces DNA methylation at PPARα and CPT1A promoter regions in the rat liver

Ohashi, K., Munetsuna, E., Yamada, H., Ando, Y., Yamazaki, M., Taromaru, N., Nagura, A., Ishikawa, H., Suzuki, K., Teradaira, R. & Hashimoto, S., 04-12-2015, In : Biochemical and Biophysical Research Communications. 468, 1-2, p. 185-189 5 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

IQGAPS as key regulators of actin-cytoskeleton dynamics

Watanabe, T., Wang, S. & Kaibuchi, K., 06-06-2015, In : Cell structure and function. 40, 2, p. 69-77 9 p.

Research output: Contribution to journalArticle

Open Access
43 Citations (Scopus)

Longitudinal study of circulating miR-122 in a rat model of non-alcoholic fatty liver disease

Yamada, H., Ohashi, K., Suzuki, K., Munetsuna, E., Ando, Y., Yamazaki, M., Ishikawa, H., Ichino, N., Teradaira, R. & Hashimoto, S., 01-01-2015, In : Clinica Chimica Acta. 446, p. 267-271 5 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends

Kedashiro, S., Pastuhov, S. I., Nishioka, T., Watanabe, T., Kaibuchi, K., Matsumoto, K. & Hanafusa, H., 01-01-2015, In : Journal of cell science. 128, 2, p. 385-396 12 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Maternal fructose consumption alters messenger RNA expression of hippocampal StAR, PBR, P450(11β), 11β-HSD, and 17β-HSD in rat offspring

Ohashi, K., Ando, Y., Munetsuna, E., Yamada, H., Yamazaki, M., Nagura, A., Taromaru, N., Ishikawa, H., Suzuki, K. & Teradaira, R., 01-03-2015, In : Nutrition Research. 35, 3, p. 259-264 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The proportion of chromatin graded between closed and open states determines the level of transcripts derived from distinct promoters in the CYP19 gene

Kotomura, N., Harada, N. & Ishihara, S., 28-05-2015, In : PloS one. 10, 5, e0128282.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2014

Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells

Munetsuna, E., Kawanami, R., Nishikawa, M., Ikeda, S., Nakabayashi, S., Yasuda, K., Ohta, M., Kamakura, M., Ikushiro, S. & Sakaki, T., 15-02-2014, In : Molecular and Cellular Endocrinology. 382, 2, p. 960-970 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis

Ubuka, T., Haraguchi, S., Tobari, Y., Narihiro, M., Ishikawa, K., Hayashi, T., Harada, N. & Tsutsui, K., 16-01-2014, In : Nature Communications. 5, 3061.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Post-translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation

Hayashi, T. & Harada, N., 11-2014, In : FEBS Journal. 281, 21, p. 4830-4840 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin

Weng, L., Enomoto, A., Miyoshi, H., Takahashi, K., Asai, N., Morone, N., Jiang, P., An, J., Kato, T., Kuroda, K., Watanabe, T., Asai, M., Ishida-Takagishi, M., Murakumo, Y., Nakashima, H., Kaibuchi, K. & Takahashi, M., 17-09-2014, In : EMBO Journal. 33, 18, p. 2098-2112 15 p.

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

Stimulation of estradiol biosynthesis by tributyltin in rat hippocampal slices

Munetsuna, E., Hattori, M. & Yamazaki, T., 11-01-2014, In : Endocrine Research. 39, 4, p. 168-172 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

TRIM27/MRTF-B-dependent integrin β1 expression defines leading cells in cancer cell collectives

Kato, T., Enomoto, A., Watanabe, T., Haga, H., Ishida, S., Kondo, Y., Furukawa, K., Urano, T., Mii, S., Weng, L., Ishida-Takagishi, M., Asai, M., Asai, N., Kaibuchi, K., Murakumo, Y. & Takahashi, M., 22-05-2014, In : Cell Reports. 7, 4, p. 1156-1167 12 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)
2013

Activated Cdc42-bound IQGAP1 determines the cellular endocytic site

Kimura, T., Yamaoka, M., Taniguchi, S., Okamoto, M., Takei, M., Ando, T., Iwamatsu, A., Watanabe, T., Kaibuchi, K., Ishizaki, T. & Niki, I., 12-2013, In : Molecular and Cellular Biology. 33, 24, p. 4834-4843 10 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)