Center for Clinial Trial and Research Support

Research Output 2002 2019

  • 653 Citations
  • 18 h-Index
  • 28 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Chapter
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Article
2019
1 Citation (Scopus)

Bisecting GlcNAc is a general suppressor of terminal modification of N-glycan

Nakano, M., Mishra, S. K., Tokoro, Y., Sato, K., Nakajima, K., Yamaguchi, Y., Taniguchi, N. & Kizuka, Y., 01-01-2019, In : Molecular and Cellular Proteomics. 18, 10, p. 2044-2057 14 p.

Research output: Contribution to journalArticle

Polysaccharides
Epitopes
Biosynthesis
Glycosylation
Glycosyltransferases
1 Citation (Scopus)

Free glycans derived from O-mannosylated glycoproteins suggest the presence of an O-glycoprotein degradation pathway in yeast

Hirayama, H., Matsuda, T., Tsuchiya, Y., Oka, R., Seino, J., Huang, C., Nakajima, K., Noda, Y., Shichino, Y., Iwasaki, S. & Suzuki, T., 01-01-2019, In : Journal of Biological Chemistry. 294, 44, p. 15900-15911 12 p.

Research output: Contribution to journalArticle

Open Access
Yeast
Polysaccharides
Glycoproteins
Yeasts
Degradation

Mannose impairs tumor growth and enhance chemotherapy

Nakajima, K., 01-01-2019, In : Trends in Glycoscience and Glycotechnology. 31, 180, p. E87-E88

Research output: Contribution to journalArticle

Mannose-6-Phosphate Isomerase
Chemotherapy
Glycolysis
Mannose
Tumors
2018
2 Citations (Scopus)

Identification and characterization of UDP-mannose in human cell lines and mouse organs: Differential distribution across brain regions and organs

Nakajima, K., Kizuka, Y., Yamaguchi, Y., Hirabayashi, Y., Takahashi, K., Yuzawa, Y. & Taniguchi, N., 01-01-2018, In : Biochemical and Biophysical Research Communications. 495, 1, p. 401-407 7 p.

Research output: Contribution to journalArticle

Mammals
Brain
Cells
Glycosylation
Cell Line
2017
14 Citations (Scopus)

An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3

Kizuka, Y., Nakano, M., Yamaguchi, Y., Nakajima, K., Oka, R., Sato, K., Ren, C. T., Hsu, T. L., Wong, C. H. & Taniguchi, N., 21-12-2017, In : Cell Chemical Biology. 24, 12, p. 1467-1478.e5

Research output: Contribution to journalArticle

GDPmannose 4,6-dehydratase
Guanosine Diphosphate Fucose
Fucose
Cell Movement
Hepatocellular Carcinoma
2016
6 Citations (Scopus)

Aglycon diversity of brain sterylglucosides: Structure determination of cholesteryl- and sitosterylglucoside

Akiyama, H., Nakajima, K., Itoh, Y., Sayano, T., Ohashi, Y., Yamaguchi, Y., Greimel, P. & Hirabayashi, Y., 01-01-2016, In : Journal of Lipid Research. 57, 11, p. 2061-2072 12 p.

Research output: Contribution to journalArticle

Vertebrates
Brain
Animals
Nuclear magnetic resonance
Glucosylceramidase
11 Citations (Scopus)

High-Sensitivity and Low-Toxicity Fucose Probe for Glycan Imaging and Biomarker Discovery

Kizuka, Y., Funayama, S., Shogomori, H., Nakano, M., Nakajima, K., Oka, R., Kitazume, S., Yamaguchi, Y., Sano, M., Korekane, H., Hsu, T. L., Lee, H. Y., Wong, C. H. & Taniguchi, N., 21-07-2016, In : Cell Chemical Biology. 23, 7, p. 782-792 11 p.

Research output: Contribution to journalArticle

Fucose
Biomarkers
Polysaccharides
Toxicity
Imaging techniques
21 Citations (Scopus)

Hyaluronan production regulates metabolic and cancer stem-like properties of breast cancer cells via hexosamine biosynthetic pathway-coupled HIF-1 signaling

Chanmee, T., Ontong, P., Izumikawa, T., Higashide, M., Mochizuki, N., Chokchaitaweesuk, C., Khansai, M., Nakajima, K., Kakizaki, I., Kongtawelert, P., Taniguchi, N. & Itano, N., 11-11-2016, In : Journal of Biological Chemistry. 291, 46, p. 24105-24120 16 p.

Research output: Contribution to journalArticle

Hexosamines
Biosynthetic Pathways
Hyaluronic Acid
Stem cells
Neoplastic Stem Cells
4 Citations (Scopus)

Separation and analysis of mono-glucosylated lipids in brain and skin by hydrophilic interaction chromatography based on carbohydrate and lipid moiety

Nakajima, K., Akiyama, H., Tanaka, K., Kohyama-Koganeya, A., Greimel, P. & Hirabayashi, Y., 15-09-2016, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1031, p. 146-153 8 p.

Research output: Contribution to journalArticle

Chromatography
Hydrophobic and Hydrophilic Interactions
Galactosylceramides
Brain
Skin
2015
38 Citations (Scopus)

Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling

Yang, Y. R., Kim, D. H., Seo, Y. K., Park, D., Jang, H. J., Choi, S. Y., Lee, Y. H., Lee, G. H., Nakajima, K., Taniguchi, N., Kim, J. M., Choi, E. J., Moon, H. Y., Kim, I. S., Choi, J. H., Lee, H., Ryu, S. H., Cocco, L. & Suh, P. G., 01-01-2015, In : Oncotarget. 6, 14, p. 12529-12542 14 p.

Research output: Contribution to journalArticle

Colitis
Carcinogenesis
Inflammation
Dextran Sulfate
Neoplasms
31 Citations (Scopus)

Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease

Suzuki, M., Fujikake, N., Takeuchi, T., Kohyama-Koganeya, A., Nakajima, K., Hirabayashi, Y., Wada, K. & Nagai, Y., 01-12-2015, In : Human molecular genetics. 24, 23, p. 6675-6686 12 p.

Research output: Contribution to journalArticle

Synucleins
Gaucher Disease
Endopeptidase K
Drosophila
Parkinson Disease
2014
8 Citations (Scopus)

Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2

Okahara, K., Kizuka, Y., Kitazume, S., Ota, F., Nakajima, K., Hirabayashi, Y., Maekawa, M., Yoshikawa, T. & Taniguchi, N., 01-10-2014, In : Glycobiology. 24, 10, p. 926-934 9 p.

Research output: Contribution to journalArticle

N-Acylsphingosine Galactosyltransferase
Galactosylceramides
Oligodendroglia
Myelin Sheath
Transcription Factors
22 Citations (Scopus)

The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function

Kurimoto, A., Kitazume, S., Kizuka, Y., Nakajima, K., Oka, R., Fujinawa, R., Korekane, H., Yamaguchi, Y., Wada, Y. & Taniguchi, N., 25-04-2014, In : Journal of Biological Chemistry. 289, 17, p. 11704-11714 11 p.

Research output: Contribution to journalArticle

Fucose
Polysaccharides
Up-Regulation
Genes
Glycosylation
2013
20 Citations (Scopus)

Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)

Korekane, H., Park, J. Y., Matsumoto, A., Nakajima, K., Takamatsu, S., Ohtsubo, K., Miyamoto, Y., Hanashima, S., Kanekiyo, K., Kitazume, S., Yamaguchi, Y., Matsuo, I. & Taniguchi, N., 27-09-2013, In : Journal of Biological Chemistry. 288, 39, p. 27912-27926 15 p.

Research output: Contribution to journalArticle

Pyrophosphatases
Phosphoric Diester Hydrolases
Glycosyltransferases
Glycosylation
Sugars
18 Citations (Scopus)

Mass isotopomer analysis of metabolically labeled nucleotide sugars and N-and O-glycans for tracing nucleotide sugar metabolisms

Nakajima, K., Ito, E., Ohtsubo, K., Shirato, K., Takamiya, R., Kitazume, S., Angata, T. & Taniguchi, N., 01-09-2013, In : Molecular and Cellular Proteomics. 12, 9, p. 2468-2480 13 p.

Research output: Contribution to journalArticle

Uridine Diphosphate
Insulinoma
Metabolism
Sugars
Polysaccharides
19 Citations (Scopus)

Metabolically programmed quality control system for dolichol-linked oligosaccharides

Harada, Y., Nakajima, K., Masahara-Negish, Y., Freeze, H. H., Angata, T., Taniguchi, N. & Suzuki, T., 26-11-2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19366-19371 6 p.

Research output: Contribution to journalArticle

Dolichol
Oligosaccharides
Quality Control
Guanosine Diphosphate Mannose
Glycosylation
18 Citations (Scopus)

Structural characterization of pyridylaminated oligosaccharides derived from neutral glycosphingolipids by high-sensitivity capillary electrophoresis-mass spectrometry

Ito, E., Nakajima, K., Waki, H., Miseki, K., Shimada, T., Sato, T. A., Kakehi, K., Suzuki, M., Taniguchi, N. & Suzuki, A., 20-08-2013, In : Analytical Chemistry. 85, 16, p. 7859-7865 7 p.

Research output: Contribution to journalArticle

Neutral Glycosphingolipids
Capillary electrophoresis
Oligosaccharides
Mass spectrometry
Ions
2012
18 Citations (Scopus)

Structural characterization of monosialo-, disialo- and trisialo-gangliosides by negative ion AP-MALDI-QIT-TOF mass spectrometry with MS n switching

Ito, E., Tominaga, A., Waki, H., Miseki, K., Tomioka, A., Nakajima, K., Kakehi, K., Suzuki, M., Taniguchi, N. & Suzuki, A., 01-06-2012, In : Neurochemical Research. 37, 6, p. 1315-1324 10 p.

Research output: Contribution to journalArticle

Atmospheric Pressure
Gangliosides
Atmospheric pressure
Ionization
Mass spectrometry
2010
73 Citations (Scopus)

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC

Nakajima, K., Kitazume, S., Angata, T., Fujinawa, R., Ohtsubo, K., Miyoshi, E. & Taniguchi, N., 07-2010, In : Glycobiology. 20, 7, p. 865-871 7 p.

Research output: Contribution to journalArticle

Uridine Diphosphate
Sugars
Nucleotides
High Pressure Liquid Chromatography
Ions
2009
9 Citations (Scopus)

Carbohydrate-protein interactions investigated on plastic chips statically coated with hydrophobically modified hydroxyethylcellulose

Dang, F., Maeda, E., Osafune, T., Nakajima, K., Kakehi, K., Ishikawa, M. & Baba, Y., 15-12-2009, In : Analytical Chemistry. 81, 24, p. 10055-10060 6 p.

Research output: Contribution to journalArticle

Polymethyl Methacrylate
Carbohydrates
Plastics
Self assembled monolayers
Proteins
15 Citations (Scopus)

Structural characterization of multibranched oligosaccharides from seal milk by a combination of off-line high-performance liquid chromatography-matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and sequential exoglycosidase digestion

Kinoshita, M., Ohta, H., Higaki, K., Kojima, Y., Urashima, T., Nakajima, K., Suzuki, M., Kovacs, K. M., Lydersen, C., Hayakawa, T. & Kakehi, K., 15-05-2009, In : Analytical Biochemistry. 388, 2, p. 242-253 12 p.

Research output: Contribution to journalArticle

Glycoside Hydrolases
High performance liquid chromatography
Oligosaccharides
Ionization
Seals
2006
36 Citations (Scopus)

Capillary affinity electrophoresis using lectins for the analysis of milk oligosaccharide structure and its application to bovine colostrum oligosaccharides

Nakajima, K., Kinoshita, M., Matsushita, N., Urashima, T., Suzuki, M., Suzuki, A. & Kakehi, K., 01-01-2006, In : Analytical Biochemistry. 348, 1, p. 105-114 10 p.

Research output: Contribution to journalArticle

Colostrum
Capillary Electrophoresis
Electrophoresis
Oligosaccharides
Lectins
46 Citations (Scopus)

Hybrid dynamic coating with n-dodecyl β-D-maltoside and methyl cellulose for high-performance carbohydrate analysis on poly(methyl methacrylate) chips

Dang, F., Kakehi, K., Cheng, J., Tabata, O., Kurokawa, M., Nakajima, K., Ishikawa, M. & Baba, Y., 01-03-2006, In : Analytical Chemistry. 78, 5, p. 1452-1458 7 p.

Research output: Contribution to journalArticle

Methylcellulose
Polymethyl Methacrylate
Carbohydrates
Coatings
Adsorption
24 Citations (Scopus)

Rapid analysis of oligosaccharides derived from glycoproteins by microchip electrophoresis

Dang, F., Kakehi, K., Nakajima, K., Shinohara, Y., Ishikawa, M., Kaji, N., Tokeshi, M. & Baba, Y., 24-03-2006, In : Journal of Chromatography A. 1109, 2, p. 138-143 6 p.

Research output: Contribution to journalArticle

Microchip Electrophoresis
Electrophoresis
Oligosaccharides
Glycoproteins
Buffers
2004
29 Citations (Scopus)

Screening method of carbohydrate-binding proteins in biological sources by capillary affinity electrophoresis and its application to determination of Tulipa gesneriana agglutinin in tulip bulbs

Nakajima, K., Kinoshita, M., Oda, Y., Masuko, T., Kaku, H., Shibuya, N. & Kakehi, K., 01-09-2004, In : Glycobiology. 14, 9, p. 793-804 12 p.

Research output: Contribution to journalArticle

Tulipa
Capillary Electrophoresis
Electrophoresis
Screening
Oligosaccharides
2003
50 Citations (Scopus)

A new fungal lectin recognizing α(1-6)-linked fucose in the N-glycan

Oda, Y., Senaha, T., Matsuno, Y., Nakajima, K., Naka, R., Kinoshita, M., Honda, E., Furuta, I. & Kakehi, K., 22-08-2003, In : Journal of Biological Chemistry. 278, 34, p. 32439-32447 9 p.

Research output: Contribution to journalArticle

Fucose
Lectins
Polysaccharides
Assays
Glycopeptides
51 Citations (Scopus)

Capillary affinity electrophoresis for the screening of post-translational modification of proteins with carbohydrates

Nakajima, K., Oda, Y., Kinoshita, M. & Kakehi, K., 25-02-2003, In : Journal of Proteome Research. 2, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

Capillary Electrophoresis
Post Translational Protein Processing
Electrophoresis
Screening
Carbohydrates
2002
4 Citations (Scopus)

Time-resolved fluorometric analysis of carbohydrates labeled with amino-aromatic compounds by reductive amination

Nakajima, K., Oda, Y., Kinoshita, M., Masuko, T. & Kakehi, K., 08-08-2002, In : Analyst. 127, 7, p. 972-976 5 p.

Research output: Contribution to journalArticle

Amination
Fluorometry
Aromatic compounds
Carbohydrates
carbohydrate