Department of Physiological Chemistry

Fingerprint Dive into the research topics where Department of Physiological Chemistry is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

Tyrosine 3-Monooxygenase Medicine & Life Sciences
Lipopolysaccharides Medicine & Life Sciences
Locus Coeruleus Medicine & Life Sciences
Dopamine Medicine & Life Sciences
GTP Cyclohydrolase Medicine & Life Sciences
PC12 Cells Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Risperidone Medicine & Life Sciences

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Profiles

Research Output 1996 2019

1 Citation (Scopus)

Human tyrosine hydroxylase in Parkinson’s disease and in related disorders

Nagatsu, T., Nakashima, A., Ichinose, H. & Kobayashi, K., 01-04-2019, In : Journal of Neural Transmission. 126, 4, p. 397-409 13 p.

Research output: Contribution to journalReview article

Tyrosine 3-Monooxygenase
Parkinson Disease
Dopaminergic Neurons
Dopamine
Corpus Striatum

Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells

Nakashima, A., Yamaguchi, H., Kodani, Y., Kaneko, Y. S., Kawata, M., Nagasaki, H., Nagatsu, T. & Ota, A., 03-09-2019, In : Biochemical and Biophysical Research Communications. 516, 4, p. 1060-1065 6 p.

Research output: Contribution to journalArticle

Tyrosine 3-Monooxygenase
Protein Binding
Small Interfering RNA
Catecholamines
Down-Regulation
2 Citations (Scopus)

Proteasome-mediated degradation of tyrosine hydroxylase triggered by its phosphorylation: a new question as to the intracellular location at which the degradation occurs

Nakashima, A., Kodani, Y., Kaneko, Y. S., Nagasaki, H. & Ota, A., 01-01-2018, In : Journal of Neural Transmission. 125, 1, p. 9-15 7 p.

Research output: Contribution to journalReview article

Tyrosine 3-Monooxygenase
Proteasome Endopeptidase Complex
Phosphorylation
Nuclear Localization Signals
Cytoplasm