International Center for Cell and Gene Therapy

Research Output

  • 2352 Citations
  • 25 h-Index
  • 101 Article
  • 2 Review article
  • 1 Chapter
2019

CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration

Yamada, T., Hasegawa, S., Hasebe, Y., Kawagishi-Hotta, M., Arima, M., Iwata, Y., Kobayashi, T., Numata, S., Yamamoto, N., Nakata, S., Sugiura, K. & Akamatsu, H., 22-01-2019, In : Archives of Dermatological Research. 311, 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

Cytokine expression profiles in cervical mucus from patients with cervical cancer and its precursor lesions

Otani, S., Fujii, T., Kukimoto, I., Yamamoto, N., Tsukamoto, T., Ichikawa, R., Nishio, E. & Iwata, A., 08-2019, In : Cytokine. 120, p. 210-219 10 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Periodontal Regeneration by Allogeneic Transplantation of Adipose Tissue Derived Multi-Lineage Progenitor Stem Cells in vivo

Venkataiah, V. S., Handa, K., Njuguna, M. M., Hasegawa, T., Maruyama, K., Nemoto, E., Yamada, S., Sugawara, S., Lu, L., Takedachi, M., Murakami, S., Okura, H., Matsuyama, A. & Saito, M., 01-12-2019, In : Scientific reports. 9, 1, 921.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Trends in clinical trials for stroke by cell therapy: data mining ClinicalTrials.gov and the ICTRP portal site

Negoro, T., Okura, H., Maehata, M., Hayashi, S., Yoshida, S., Takada, N. & Matsuyama, A., 01-12-2019, In : npj Regenerative Medicine. 4, 1, 20.

Research output: Contribution to journalArticle

Open Access
2018

A proteomic approach for understanding the mechanisms of delayed corneal wound healing in diabetic keratopathy using diabetic model rat

Yamamoto, T., Otake, H., Hiramatsu, N., Yamamoto, N., Taga, A. & Nagai, N., 18-11-2018, In : International journal of molecular sciences. 19, 11, 3635.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Availability of a Magnetic Method for Hepatocyte Transplantation

Ito, R., Ito, M., Asano, Y., Murakumo, A., Yamamoto, N. & Horiguchi, A., 06-2018, In : Transplantation Proceedings. 50, 5, p. 1525-1531 7 p.

Research output: Contribution to journalArticle

Extracellular proteoglycan decorin maintains human hair follicle stem cells

Miyachi, K., Yamada, T., Kawagishi-Hotta, M., Hasebe, Y., Date, Y., Hasegawa, S., Arima, M., Iwata, Y., Kobayashi, T., Numata, S., Yamamoto, N., Nakata, S., Sugiura, K. & Akamatsu, H., 12-2018, In : Journal of Dermatology. 45, 12, p. 1403-1410 8 p.

Research output: Contribution to journalArticle

Identification of miRNAs in cervical mucus as a novel diagnostic marker for cervical neoplasia

Kawai, S., Fujii, T., Kukimoto, I., Yamada, H., Yamamoto, N., Kuroda, M., Otani, S., Ichikawa, R., Nishio, E., Torii, Y. & Iwata, A., 01-12-2018, In : Scientific reports. 8, 1, 7070.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Isolation of human monoclonal antibodies that bind to two different antigens and are encoded by germline VH and VL genes

Sumitomo-Kondo, M., Ukai, Y., Iba, Y., Ohshima, N., Miura, K., Takasaki, A., Kurosawa, Y. & Kurosawa, G., 05-09-2018, In : Biochemical and Biophysical Research Communications. 503, 2, p. 1141-1147 7 p.

Research output: Contribution to journalArticle

Laminin-332 regulates differentiation of human interfollicular epidermal stem cells

Yamada, T., Hasegawa, S., Miyachi, K., Date, Y., Inoue, Y., Yagami, A., Arima, M., Iwata, Y., Yamamoto, N., Nakata, S., Matsunaga, K., Sugiura, K. & Akamatsu, H., 04-2018, In : Mechanisms of Ageing and Development. 171, p. 37-46 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Three types of broadly reacting antibodies against influenza B viruses induced by vaccination with seasonal influenza viruses

Hirano, D., Ohshima, N., Kubota-Koketsu, R., Yamasaki, A., Kurosawa, G., Okuno, Y., Yoshida, S. & Kurosawa, Y., 01-01-2018, In : Journal of Immunology Research. 2018, 7251793.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Trends in clinical trials for articular cartilage repair by cell therapy

Negoro, T., Takagaki, Y., Okura, H. & Matsuyama, A., 01-12-2018, In : npj Regenerative Medicine. 3, 1, 17.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Trends of clinical trials for drug development in rare diseases

Sakate, R., Fukagawa, A., Takagaki, Y., Okura, H. & Matsuyama, A., 01-01-2018, In : Current Clinical Pharmacology. 13, 3, p. 199-208 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors

Ogawa, K., Suga, H., Ozone, C., Sakakibara, M., Yamada, T., Kano, M., Mitsumoto, K., Kasai, T., Kodani, Y., Nagasaki, H., Yamamoto, N., Hagiwara, D., Goto, M., Banno, R., Sugimura, Y. & Arima, H., 01-12-2018, In : Scientific reports. 8, 1, 3615.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

Characterization of the Capsule Surrounding Smooth and Textured Tissue Expanders and Correlation with Contracture

Kuriyama, E., Ochiai, H., Inoue, Y., Sakamoto, Y., Yamamoto, N., Utsumi, T., Kishi, K., Okumoto, T. & Matsuura, A., 01-07-2017, In : Plastic and Reconstructive Surgery - Global Open. 5, 7, e1403.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Enhancement of individual differences in proliferation and differentiation potentials of aged human adipose-derived stem cells

Kawagishi-Hotta, M., Hasegawa, S., Igarashi, T., Yamada, T., Takahashi, M., Numata, S., Kobayashi, T., Iwata, Y., Arima, M., Yamamoto, N., Yagami, A., Nakata, S., Uzawa, T., Matsunaga, K., Sugiura, K. & Akamatsu, H., 01-06-2017, In : Regenerative Therapy. 6, p. 29-40 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Identification of novel splicing variants of protein tyrosine phosphatase receptor type Z

Fujikawa, A., Chow, J. P. H., Matsumoto, M., Suzuki, R., Kuboyama, K., Yamamoto, N. & Noda, M., 01-01-2017, In : Journal of Biochemistry. 162, 5, p. 381-390 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Induced pluripotent stem cells: Global research trends

Negoro, T., Okura, H. & Matsuyama, A., 05-2017, In : BioResearch Open Access. 6, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Ligation-mediated PCR with a back-to-back adapter reduces amplification bias resulting from variations in GC content

Ishihara, S., Kotomura, N., Yamamoto, N. & Ochiai, H., 15-08-2017, In : Analytical Biochemistry. 531, p. 37-44 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Ophthalmic formulation containing nilvadipine nanoparticles prevents retinal dysfunction in rats injected with streptozotocin

Deguchi, S., Otake, H., Nakazawa, Y., Hiramatsu, N., Yamamoto, N. & Nagai, N., 15-12-2017, In : International journal of molecular sciences. 18, 12, 2720.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Promethazine Hydrochloride Inhibits Ectopic Fat Cell Formation in Skeletal Muscle

Kasai, T., Nakatani, M., Ishiguro, N., Ohno, K., Yamamoto, N., Morita, M., Yamada, H., Tsuchida, K. & Uezumi, A., 12-2017, In : American Journal of Pathology. 187, 12, p. 2627-2634 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Therapeutic effect of cilostazol ophthalmic nanodispersions on retinal dysfunction in streptozotocin-induced diabetic rats

Nagai, N., Deguchi, S., Otake, H., Hiramatsu, N. & Yamamoto, N., 14-09-2017, In : International journal of molecular sciences. 18, 9, 1971.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2016

A lower volume culture method for obtaining a larger yield of neuron-like cells from mesenchymal stem cells

Shimomura, A., Iizuka-Kogo, A., Yamamoto, N. & Nomura, R., 01-06-2016, In : Medical Molecular Morphology. 49, 2, p. 119-126 8 p.

Research output: Contribution to journalArticle

A simple method of bronchial occlusion with silicone spigots (Endobronchial Watanabe Spigot; EWS®) using a curette

Morikawa, S., Okamura, T., Minezawa, T., Goto, Y., Hayashi, M., Yamaguchi, T., Isogai, S., Mieno, Y., Yamamoto, N., Uozu, S., Nakanishi, T., Okazawa, M. & Imaizumi, K., 01-12-2016, In : Therapeutic Advances in Respiratory Disease. 10, 6, p. 518-524 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cell-Surface Protein Profiling Identifies Distinctive Markers of Progenitor Cells in Human Skeletal Muscle

Uezumi, A., Nakatani, M., Ikemoto-Uezumi, M., Yamamoto, N., Morita, M., Yamaguchi, A., Yamada, H., Kasai, T., Masuda, S., Narita, A., Miyagoe-Suzuki, Y., Takeda, S., Fukada, S. I., Nishino, I. & Tsuchida, K., 09-08-2016, In : Stem Cell Reports. 7, 2, p. 263-278 16 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Critical path initiative for regenerative medicine in japan

Okura, H. & Matsuyama, A., 01-01-2016, Gene Therapy and Cell Therapy Through the Liver: Current Aspects and Future Prospects. Springer Japan, p. 139-146 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Establishment of a new immortalized human corneal epithelial cell line (iHCE-NY1) for use in evaluating eye irritancy by in vitro test methods

Yamamoto, N., Kato, Y., Sato, A., Hiramatsu, N., Yamashita, H., Ohkuma, M., Miyachi, E. I., Horiguchi, M., Hirano, K. & Kojima, H., 01-08-2016, In : In Vitro Cellular and Developmental Biology - Animal. 52, 7, p. 742-748 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition

Balachandran, C., Emi, N., Arun, Y., Yamamoto, N., Duraipandiyan, V., Inaguma, Y., Okamoto, A., Ignacimuthu, S., Al-Dhabi, N. A. & Perumal, P. T., 05-04-2016, In : Chemico-Biological Interactions. 249, p. 23-35 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthetic investigation on chirally pure Mannich derivatives of pseudophenylpropanolamine and their anticancer properties against HepG-2 cells with inhibition of JAK2/STAT3

Balachandran, C., Chennakesava Rao, K., Arun, Y., Emi, N., Yamamoto, N., Inaguma, Y., Okamoto, A., Easwaramoorthi, K. & Perumal, P. T., 01-01-2016, In : RSC Advances. 6, 99, p. 96946-96962 17 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The level of IgA antibodies to endothelial cells correlates with histological evidence of disease activity in patients with lupus nephritis

Kondo, A., Takahashi, K., Mizuno, T., Kato, A., Hirano, D., Yamamoto, N., Hayashi, H., Koide, S., Takahashi, H., Hasegawa, M., Hiki, Y., Yoshida, S., Miura, K. & Yuzawa, Y., 10-2016, In : PloS one. 11, 10, e0163085.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

Bronchus sign on thin-section computed tomography is a powerful predictive factor for successful transbronchial biopsy using endobronchial ultrasound with a guide sheath for small peripheral lung lesions: A retrospective observational study

Minezawa, T., Okamura, T., Yatsuya, H., Yamamoto, N., Morikawa, S., Yamaguchi, T., Morishita, M., Niwa, Y., Takeyama, T., Mieno, Y., Hoshino, T., Uozu, S., Goto, Y., Hayashi, M., Isogai, S., Matsuo, M., Nakanishi, T., Hashimoto, N., Okazawa, M. & Imaizumi, K., 21-06-2015, In : BMC Medical Imaging. 15, 1, 21.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Characterization of invivo tumorigenicity tests using severe immunodeficient NOD/Shi-scid IL2Rγnull mice for detection of tumorigenic cellular impurities in human cell-processed therapeutic products

Kusakawa, S., Machida, K., Yasuda, S., Takada, N., Kuroda, T., Sawada, R., Okura, H., Tsutsumi, H., Kawamata, S. & Sato, Y., 01-06-2015, In : Regenerative Therapy. 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Effects of aloe-emodin and emodin on proliferation of the MKN45 human gastric cancer cell line

Chihara, T., Shimpo, K., Beppu, H., Yamamoto, N., Kaneko, T., Wakamatsu, K. & Sonoda, S., 01-01-2015, In : Asian Pacific Journal of Cancer Prevention. 16, 9, p. 3887-3891 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration

Ikemoto-Uezumi, M., Uezumi, A., Tsuchida, K., Fukada, S. I., Yamamoto, H., Yamamoto, N., Shiomi, K. & Hashimoto, N., 01-08-2015, In : Stem Cells. 33, 8, p. 2456-2468 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Therapeutic potential of human adipose tissue-derived multi-lineage progenitor cells in liver fibrosis

Okura, H., Soeda, M., Morita, M., Fujita, M., Naba, K., Ito, C., Ichinose, A. & Matsuyama, A., 24-01-2015, In : Biochemical and Biophysical Research Communications. 456, 4, p. 860-865 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Trophic factors from adipose tissue-derived multi-lineage progenitor cells promote cytodifferentiation of periodontal ligament cells

Sawada, K., Takedachi, M., Yamamoto, S., Morimoto, C., Ozasa, M., Iwayama, T., Lee, C. M., Okura, H., Matsuyama, A., Kitamura, M. & Murakami, S., 20-07-2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 299-305 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014

Accelerated differentiation of melanocyte stem cells contributes to the formation of hyperpigmented maculae

Yamada, T., Hasegawa, S., Inoue, Y., Date, Y., Arima, M., Yagami, A., Iwata, Y., Takahashi, M., Yamamoto, N., Mizutani, H., Nakata, S., Matsunaga, K. & Akamatsu, H., 01-01-2014, In : Experimental Dermatology. 23, 9, p. 652-658 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Comprehensive analysis of melanogenesis and proliferation potential of melanocyte lineage in solar lentigines

Yamada, T., Hasegawa, S., Inoue, Y., Date, Y., Arima, M., Yagami, A., Iwata, Y., Abe, M., Takahashi, M., Yamamoto, N., Mizutani, H., Nakata, S., Matsunaga, K. & Akamatsu, H., 01-03-2014, In : Journal of Dermatological Science. 73, 3, p. 251-257 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Conserved neutralizing epitope at globular head of hemagglutinin in H3N2 influenza viruses

Iba, Y., Fujii, Y., Ohshima, N., Sumida, T., Kubota-Koketsu, R., Ikeda, M., Wakiyama, M., Shirouzu, M., Okada, J., Okuno, Y., Kurosawa, Y. & Yokoyama, S., 2014, In : Journal of Virology. 88, 13, p. 7130-7144 15 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Construction and molecular characterization of a T-cell receptor-like antibody and CAR-T cells specific for minor histocompatibility antigen HA-1H

Inaguma, Y., Akahori, Y., Murayama, Y., Shiraishi, K., Tsuzuki-Iba, S., Endoh, A., Tsujikawa, J., Demachi-Okamura, A., Hiramatsu, K., Saji, H., Yamamoto, Y., Yamamoto, N., Nishimura, Y., Takahashi, T., Kuzushima, K., Emi, N. & Akatsuka, Y., 06-2014, In : Gene therapy. 21, 6, p. 575-584 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Effects of edaravone, a radical scavenger, on hepatocyte transplantation

Hayashi, C., Ito, M., Ito, R., Murakumo, A., Yamamoto, N., Hiramatsu, N., Fox, I. J. & Horiguchi, A., 01-12-2014, In : Journal of Hepato-Biliary-Pancreatic Sciences. 21, 12, p. 919-924 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice

Wada, K., Matsushima, Y., Tada, T., Hasegawa, S., Obara, Y., Yoshizawa, Y., Takahashi, G., Hiai, H., Shimanuki, M., Suzuki, S., Saitou, J., Yamamoto, N., Ichikawa, M., Watanabe, K. & Kikkawa, Y., 27-10-2014, In : PloS one. 9, 10, e111432.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Identification and characterization of PDGFR + mesenchymal progenitors in human skeletal muscle

Uezumi, A., Fukada, S., Yamamoto, N., Ikemoto-Uezumi, M., Nakatani, M., Morita, M., Yamaguchi, A., Yamada, H., Nishino, I., Hamada, Y. & Tsuchida, K., 04-2014, In : Cell Death and Disease. 5, 4, e1186.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus

Lee, P. S., Ohshima, N., Stanfield, R. L., Yu, W., Iba, Y., Okuno, Y., Kurosawa, Y. & Wilson, I. A., 10-04-2014, In : Nature Communications. 5, 3614.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Role of notch signaling in the maintenance of human mesenchymal stem cells under hypoxic conditions

Moriyama, H., Moriyama, M., Isshi, H., Ishihara, S., Okura, H., Ichinose, A., Ozawa, T., Matsuyama, A. & Hayakawa, T., 15-09-2014, In : Stem Cells and Development. 23, 18, p. 2211-2224 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

The effect of sevoflurane on developing A/J strain mouse embryos using a whole-embryo culture system - The incidence of cleft lip in culture embryos

Yamada, M., Yamamoto, N., Ohgami, S., Kanazawa, M., Harada, J., Ohno, N. & Natsume, N., 03-2014, In : In Vitro Cellular and Developmental Biology - Animal. 50, 3, p. 237-242 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Two types of antibodies are induced by vaccination with A/California/2009pdm virus: Binding near the sialic acid-binding pocket and neutralizing both H1N1 and H5N1 viruses

Ohshima, N., Kubota-Koketsu, R., Iba, Y., Okuno, Y. & Kurosawa, Y., 05-02-2014, In : PloS one. 9, 2, e87305.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2013

Circadian expressions of cardiac ion channel genes in mouse might be associated with the central clock in the SCN but not the peripheral clock in the heart

Tong, M., Watanabe, E., Yamamoto, N., Nagahata-Ishiguro, M., Maemura, K., Takeda, N., Nagai, R. & Ozaki, Y., 01-08-2013, In : Biological Rhythm Research. 44, 4, p. 519-530 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)