Research Output

  • 1177 Citations
  • 17 h-Index
  • 45 Article
  • 2 Chapter
  • 1 Review article
2018

Effects of plasma glycosyltransferase on the ABO(H) blood group antigens of human von Willebrand factor

Kano, T., Kondo, K., Hamako, J., Matsushita, F., Sakai, K. & Matsui, T., 01-08-2018, In : International Journal of Hematology. 108, 2, p. 139-144 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Platelet Aggregation Inhibitory Effects and Pharmacokinetics of Prasugrel Used in Combination With Aspirin in Healthy Japanese Subjects

Umemura, K., Ikeda, Y., Matsushima, N. & Kondo, K., 01-07-2017, In : Clinical Pharmacology in Drug Development. 6, 4, p. 398-407 10 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia

Sumi-Ichinose, C., Suganuma, Y., Kano, T., Ihira, N., Nomura, H., Ikemoto, K., Hata, T., Katoh, S., Ichinose, H. & Kondo, K., 01-03-2017, In : Physiological Reports. 5, 6, e13196.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Pharmacokinetics and pharmacodynamics of prasugrel in healthy Japanese subjects

Umemura, K., Ikeda, Y. & Kondo, K., 01-08-2016, In : Drug Metabolism and Pharmacokinetics. 31, 4, p. 285-291 7 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2015

Aripiprazole increases NAD(P)H–quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells

Kaneko, Y. S., Takayanagi, T., Nagasaki, H., Kodani, Y., Nakashima, A., Mori, K., Suzuki, A., Itoh, M., Kondo, K., Nagatsu, T., Ota, M. & Ota, A., 01-06-2015, In : Journal of Neural Transmission. 122, 6, p. 757-772 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014

Aripiprazole increases NADPH level in PC12 cells: The role of NADPH oxidase

Nagasaki, H., Nakashima, A., Kaneko, Y. S., Kodani, Y., Takayanagi, T., Itoh, M., Kondo, K., Nagatsu, T., Hamada, Y., Ota, M. & Ota, A., 01-01-2014, In : Journal of Neural Transmission. 121, 1, p. 91-103 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse

Xu, F., Sudo, Y., Sanechika, S., Yamashita, J., Shimaguchi, S., Honda, S. I., Sumi-Ichinose, C., Mori-Kojima, M., Nakata, R., Furuta, T., Sakurai, M., Sugimoto, M., Soga, T., Kondo, K. & Ichinose, H., 03-11-2014, In : FEBS Letters. 588, 21, p. 3924-3931 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia

Onouchi, T., Kobayashi, K., Sakai, K., Shimomura, A., Smits, R., Sumi-Ichinose, C., Kurosumi, M., Takao, K., Nomura, R., Iizuka-Kogo, A., Suzuki, H., Kondo, K., Akiyama, T., Miyakawa, T., Fodde, R. & Senda, T., 29-03-2014, In : Molecular brain. 7, 1, 21.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2013

GTP cyclohydrolase regulation. Implications for brain development and function.

Ichinose, H., Homma, D., Sumi-Ichinose, C., Nomura, T. & Kondo, K., 2013, Advances in Pharmacology. Academic Press Inc., p. 23-35 13 p. (Advances in Pharmacology; vol. 68).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)
2012

Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells

Ota, A., Nakashima, A., Kaneko, Y. S., Mori, K., Nagasaki, H., Takayanagi, T., Itoh, M., Kondo, K., Nagatsu, T. & Ota, M., 01-11-2012, In : Journal of Neural Transmission. 119, 11, p. 1327-1342 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy

Yagi, H., Sanechika, S., Ichinose, H., Sumi-Ichinose, C., Mizukami, H., Urabe, M., Ozawa, K. & Kume, A., 04-01-2012, In : NeuroReport. 23, 1, p. 30-34 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2011

Cilostazol inhibits cytokine-induced tetrahydrobiopterin biosynthesis in human umbilical vein endothelial cells.

Shiraishi, H., Ikemoto, K., Tada, S., Udagawa, Y., Ohtsuki, M., Sumi-Ichinose, C., Kondo, K. & Nomura, T., 27-04-2011, In : Journal of atherosclerosis and thrombosis. 18, 4, p. 312-317 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection

Tokuoka, H., Muramatsu, S. I., Sumi-Ichinose, C., Sakane, H., Kojima, M., Aso, Y., Nomura, T., Metzger, D. & Ichinose, H., 16-12-2011, In : Journal of Biological Chemistry. 286, 50, p. 43549-43558 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain

Homma, D., Sumi-Ichinose, C., Tokuoka, H., Ikemoto, K., Nomura, T., Kondo, K., Katoh, S. & Ichinose, H., 14-01-2011, In : Journal of Biological Chemistry. 286, 2, p. 1445-1452 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2010
9 Citations (Scopus)
2009

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons

Kadkhodaei, B., Ito, T., Joodmardi, E., Mattsson, B., Rouillard, C., Carta, M., Muramatsu, S. I., Sumi-Ichinose, C., Nomura, T., Metzger, D., Chambon, P., Lindqvist, E., Larsson, N. G., Olson, L., Björklund, A., Ichinose, H. & Perlmann, T., 16-12-2009, In : Journal of Neuroscience. 29, 50, p. 15923-15932 10 p.

Research output: Contribution to journalArticle

219 Citations (Scopus)
2008

2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH4-independent manner

Ikemoto, K., Matsumoto, T., Ohtsuki, M., Itoh, M., Tada, S., Udagawa, Y., Sumi-Ichinose, C., Kondo, K. & Nomura, T., 01-07-2008, In : Biochimica et Biophysica Acta - General Subjects. 1780, 7-8, p. 960-965 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice-as a mouse model for Parkinson's disease

Takazawa, C., Fujimoto, K., Homma, D., Sumi-Ichinose, C., Nomura, T., Ichinose, H. & Katoh, S., 21-03-2008, In : Biochemical and Biophysical Research Communications. 367, 4, p. 787-792 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus

Sasaki, N., Yamashita, T., Takaya, T., Shinohara, M., Shiraki, R., Takeda, M., Emoto, N., Fukatsu, A., Hayashi, T., Ikemoto, K., Nomura, T., Yokoyariia, M., Hirata, K. I. & Kawashima, S., 01-06-2008, In : Arteriosclerosis, thrombosis, and vascular biology. 28, 6, p. 1068-1076 9 p.

Research output: Contribution to journalArticle

Open Access
42 Citations (Scopus)

Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia

Sato, K., Sumi-Ichinose, C., Kaji, R., Ikemoto, K., Nomura, T., Nagatsu, I., Ichinose, H., Ito, M., Sako, W., Nagahiro, S., Graybiel, A. M. & Goto, S., 26-08-2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 34, p. 12551-12556 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Increased expression of tyrosine hydroxylase and anomalous neurites in catecholaminergic neurons of ATF-2 null mice

Kojima, M., Suzuki, T., Maekawa, T., Ishii, S., Sumi-Ichinose, C., Nomura, T. & Ichinose, H., 15-02-2008, In : Journal of Neuroscience Research. 86, 3, p. 544-552 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Metabolism of tetrahydrobiopterin: Its relevance in monoaminergic neurons and neurological disorders

Ichinose, H., Nomura, T. & Ichinose, C., 01-12-2008, In : Chemical Record. 8, 6, p. 378-385 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2005

Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities

Sumi-Ichinose, C., Urano, F., Shimomura, A., Sato, T., Ikemoto, K., Shiraishi, H., Senda, T., Ichinose, H. & Nomura, T., 14-11-2005, In : Journal of Neurochemistry. 95, 3, p. 703-714 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Stereochemistry of fully acetylated tetrahydropterins and tetrahydroquinoxalines

Chen, N., Ikemoto, K., Komatsu, S. & Murata, S., 01-12-2005, In : Heterocycles. 65, 12, p. 2917-2924 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2004

Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice

Zhao, B. Q., Ikeda, Y., Ihara, H., Urano, T., Fan, W. Y., Mikawa, S., Suzuki, Y., Kondo, K., Sato, K., Nagai, N. & Umemura, K., 01-04-2004, In : Blood. 103, 7, p. 2610-2616 7 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
2003

cGMP inhibits GTP cyclohydrolase I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells

Shiraishi, H., Kato, T., Atsuta, K., Sumi-Ichinose, C., Ohtsuki, M., Itoh, M., Hishida, H., Tada, S., Udagawa, Y., Nagatsu, T., Hagino, Y., Ichinose, H. & Nomura, T., 01-11-2003, In : Journal of Pharmacological Sciences. 93, 3, p. 265-271 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Dietary supplementation with fermented soybeans suppresses intimal thickening

Suzuki, Y., Kondo, K., Ichise, H., Tsukamoto, Y., Urano, T. & Umemura, K., 01-03-2003, In : Nutrition. 19, 3, p. 261-264 4 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Dopa-Responsive Dystonia

Ichinose, H., Nagatsu, T., Ichinose, C. & Nomura, T., 01-01-2003, Genetics of Movement Disorders. Elsevier Inc., p. 419-428 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation

Cheng, J., Kondo, K., Suzuki, Y., Ikeda, Y., Meng, X. & Umemura, K., 04-04-2003, In : Life Sciences. 72, 20, p. 2263-2271 9 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)
2002

cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells

Ohtsuki, M., Shiraishi, H., Kato, T., Kuroda, R., Tazawa, M., Sumi-Ichinose, C., Tada, S., Udagawa, Y., Itoh, M., Hishida, H., Ichinose, H., Nagatsu, T., Hagino, Y. & Nomura, T., 22-03-2002, In : Life Sciences. 70, 18, p. 2187-2198 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Regulations and pathophysiological significance of the biosynthesis of tetrahydrobiopterin in human endothelial cells

Shiraishi, H., Ohtsuki, M., Sumi-Ichinose, C. & Nomura, T., 17-12-2002, In : Folia Pharmacologica Japonica. 120, SUPPL. 1, p. 73P-75P

Research output: Contribution to journalArticle

2001

Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice

Sumi-Ichinose, C., Urano, F., Kuroda, R., Ohye, T., Kojima, M., Tazawa, M., Shiraishi, H., Hagino, Y., Nagatsu, T., Nomura, T. & Ichinose, H., 02-11-2001, In : Journal of Biological Chemistry. 276, 44, p. 41150-41160 11 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)

Perspectives on tetrahydrobiopterin research

Sumi-Ichinose, C., Ohtsuki, M., Shiraishi, H. & Nomura, T., 29-12-2001, In : Folia Pharmacologica Japonica. 118, 6, p. 371-377 7 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2000

Effects of sulfhydryl reagents on nitric oxide release from a nitric oxide donor NOR 3 in the presence of rat hepatocytes

Nomura, H., Tazawa, M., Kuroda, R., Shiraishi, H., Sumi-Ichinose, C., Matsui, S., Ohtsuki, M., Hagino, Y. & Nomura, T., 11-2000, In : Pharmacology and Toxicology. 87, 5, p. 246-248 3 p.

Research output: Contribution to journalArticle

GTP cyclohydrolase I from Tetrahymena pyriformis: Cloning of cDNA and expression

Tazawa, M., Ohtsuki, M., Sumi-Ichinose, C., Shiraishi, H., Kuroda, R., Hagino, Y., Nakashima, S., Nozawa, Y., Ichinose, H., Nagatsu, T. & Nomura, T., 01-09-2000, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 127, 1, p. 65-73 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1999

Molecular cloning of the human Nurr1 gene: Characterization of the human gene and cDNAs

Ichinose, H., Ohye, T., Suzuki, T., Sumi-Ichinose, C., Nomura, T., Hagino, Y. & Nagatsu, T., 16-04-1999, In : Gene. 230, 2, p. 233-239 7 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
1998

Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis. Presence of GTP cyclohydrolase I

Nomura, T., Tazawa, M., Ohtsuki, M., Sumi-Ichinose, C., Hagino, Y., Ota, A., Nakashima, A., Mori, K., Sugimoto, T., Ueno, O., Nozawa, Y., Ichinose, H. & Nagatsu, T., 01-01-1998, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 120, 4, p. 753-760 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Nitric oxide donor NOR 3 inhibits ketogenesis from oleate in isolated rat hepatocytes by a cyclic GMP-independent mechanism

Nomura, T., Ohtsuki, M., Matsui, S., Sumi-Ichinose, C., Nomura, H. & Hagino, Y., 01-01-1998, In : Pharmacology and Toxicology. 82, 1, p. 40-46 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Suppression of intimal hyperplasia by a 5-lipoxygenase inhibitor, MK-886: Studies with a photochemical model of endothelial injury

Kondo, K., Umemura, K., Ohmura, T., Hashimoto, H. & Nakashima, M., 03-1998, In : Thrombosis and Haemostasis. 79, 3, p. 635-639 5 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
1997

Enhancement by ticlopidine of the inhibitory effect on in vitro platelet aggregation of the glycoprotein IIb/IIIa inhibitor tirofiban

Umemura, K., Kondo, K., Ikeda, Y. & Nakashima, M., 11-1997, In : Thrombosis and Haemostasis. 78, 5, p. 1381-1384 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

SNF2β-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells

Sumi-Ichinose, C., Ichinose, H., Metzger, D. & Chambon, P., 01-10-1997, In : Molecular and Cellular Biology. 17, 10, p. 5976-5986 11 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)
1996

Analysis of an alternative promoter that regulates tissue-specific expression of the human aromatic L-amino acid decarboxylase gene in cultured cell lines

Sumi-Ichinose, C., Hasegawa, S., Ohtsuki, M., Nomura, H., Nomura, T., Hagino, Y., Fujita, K. & Nagatsu, T., 01-01-1996, In : Journal of Neural Transmission. 103, 1-2, p. 1-15 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
1995

Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

Nomura, T., Ohtsuki, M., Matsui, S., Sumi-Ichinose, C., Nomura, H., Hagino, Y., Iwase, K., Ichinose, H., Fujita, K. & Nagatsu, T., 01-02-1995, In : Journal of Neural Transmission. 101, 1-3, p. 237-242 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Metabolic Effects of Glibenclamide in Isolated Rat Hepatocytes in the Absence of Extracellular Ca2+

Nomura, T., Ohtsuki, M., Watanabe, T., Hasegawa, S., Matsui, S., Tomita, A., Sumi-Ichinose, C., Nomura, H. & Hagino, Y., 01-01-1995, In : The Japanese Journal of Pharmacology. 69, 2, p. 173-176 4 p.

Research output: Contribution to journalArticle

1993

Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase 1

Nomura, T., Ichinose, H., Sumi-Ichinose, C., Nomura, H., Hagino, Y., Fujita, K. & Nagatsu, T., 15-03-1993, In : Biochemical and Biophysical Research Communications. 191, 2, p. 523-527 5 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

α1B-Adrenoceptor-mediated stimulation of Ca2+ mobilization and cAMP accumulation in isolated rat hepatocytes

Nomura, T., Kondo, H., Hasegawa, S., Watanabe, T., Yokoyama, R., Ukai, K., Tachibana, M., Sumi-Ichinose, C., Nomura, H. & Hagino, Y., 15-07-1993, In : European Journal of Pharmacology: Molecular Pharmacology. 246, 2, p. 113-120 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1992

Tissue-Specific Alternative Splicing of the First Exon Generates Two Types of mRNAs in Human Aromatic L-Amino Acid Decarboxylase

Ichinose, H., Ohye, T., Fujita, K., Nagatsu, T., Sumi-Ichinose, C. & Hagino, Y., 01-02-1992, In : Biochemistry. 31, 46, p. 11546-11550 5 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
1986

The presence of catechol-o-methyltransferase activity in separately cultured cerebromicrovascular endothelial and smooth muscle cells

Spatz, M., Kaneda, N., Sumi, C., Nagatsu, I., Creveling, C. R. & Nagatsu, T., 03-09-1986, In : Brain Research. 381, 2, p. 363-367 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)