Research Output

2019

Human tyrosine hydroxylase in Parkinson’s disease and in related disorders

Nagatsu, T., Nakashima, A., Ichinose, H. & Kobayashi, K., 01-04-2019, In : Journal of Neural Transmission. 126, 4, p. 397-409 13 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)

Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells

Nakashima, A., Yamaguchi, H., Kodani, Y., Kaneko, Y. S., Kawata, M., Nagasaki, H., Nagatsu, T. & Ota, A., 03-09-2019, In : Biochemical and Biophysical Research Communications. 516, 4, p. 1060-1065 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Proteasome-mediated degradation of tyrosine hydroxylase triggered by its phosphorylation: a new question as to the intracellular location at which the degradation occurs

Nakashima, A., Kodani, Y., Kaneko, Y. S., Nagasaki, H. & Ota, A., 01-01-2018, In : Journal of Neural Transmission. 125, 1, p. 9-15 7 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)
2016

Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells

Nakashima, A., Ohnuma, S., Kodani, Y., Kaneko, Y. S., Nagasaki, H., Nagatsu, T. & Ota, A., 15-04-2016, In : Biochemical and Biophysical Research Communications. 472, 4, p. 598-602 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2015

Aripiprazole increases NAD(P)H–quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells

Kaneko, Y. S., Takayanagi, T., Nagasaki, H., Kodani, Y., Nakashima, A., Mori, K., Suzuki, A., Itoh, M., Kondo, K., Nagatsu, T., Ota, M. & Ota, A., 01-06-2015, In : Journal of Neural Transmission. 122, 6, p. 757-772 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G1 phase and protects them from UV light-induced apoptosis

Kaneko, Y. S., Ota, A., Nakashima, A., Nagasaki, H., Kodani, Y., Mori, K. & Nagatsu, T., 01-01-2015, In : Journal of Neural Transmission. 122, 2, p. 187-199 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014

Aripiprazole increases NADPH level in PC12 cells: The role of NADPH oxidase

Nagasaki, H., Nakashima, A., Kaneko, Y. S., Kodani, Y., Takayanagi, T., Itoh, M., Kondo, K., Nagatsu, T., Hamada, Y., Ota, M. & Ota, A., 01-01-2014, In : Journal of Neural Transmission. 121, 1, p. 91-103 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2013
17 Citations (Scopus)

Intracellular Stability of Tyrosine Hydroxylase: Phosphorylation and Proteasomal Digestion of the Enzyme

Nakashima, A., Kaneko, Y. S., Mori, K., Nagasaki, H., Nagatsu, T. & Ota, A., 01-12-2013, Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. Elsevier Inc., p. 11-12 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Intracellular stability of tyrosine hydroxylase. Phosphorylation and proteasomal digestion of the enzyme.

Nakashima, A., Kaneko, Y. S., Kodani, Y., Mori, K., Nagasaki, H., Nagatsu, T. & Ota, A., 2013, Advances in Pharmacology. Academic Press Inc., p. 3-11 9 p. (Advances in Pharmacology; vol. 68).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)
2012

Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells

Ota, A., Nakashima, A., Kaneko, Y. S., Mori, K., Nagasaki, H., Takayanagi, T., Itoh, M., Kondo, K., Nagatsu, T. & Ota, M., 01-11-2012, In : Journal of Neural Transmission. 119, 11, p. 1327-1342 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Microglial activation in neuroinflammation: Implications for the etiology of neurodegeneration

Kaneko, Y. S., Nakashima, A., Mori, K., Nagatsu, T., Nagatsu, I. & Ota, A., 01-04-2012, In : Neurodegenerative Diseases. 10, 1-4, p. 100-103 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Proteasomal degradation of tyrosine hydroxylase and neurodegeneration

Nakashima, A., 01-01-2012, In : Journal of Neurochemistry. 120, 2, p. 199-201 3 p.

Research output: Contribution to journalEditorial

8 Citations (Scopus)

Regulation of oxidative stress in long-lived lipopolysaccharide-activated microglia

Kaneko, Y. S., Ota, A., Nakashima, A., Mori, K., Nagatsu, I. & Nagatsu, T., 01-07-2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 7, p. 599-607 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Subventricular zone under the neuroinflammatory stress and Parkinson's disease

Mori, K., Kaneko, Y. S., Nakashima, A., Nagasaki, H., Nagatsu, T., Nagatsu, I. & Ota, A., 01-07-2012, In : Cellular and molecular neurobiology. 32, 5, p. 777-785 9 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2011

Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme

Nakashima, A., Mori, K., Kaneko, Y. S., Hayashi, N., Nagatsu, T. & Ota, A., 08-04-2011, In : Biochemical and Biophysical Research Communications. 407, 2, p. 343-347 5 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Trial of integrated laboratory practice

Matsuo, O., Takahashi, Y., Abe, C., Tanaka, K., Nakashima, A. & Morita, H., 06-2011, In : American Journal of Physiology - Advances in Physiology Education. 35, 2, p. 237-240 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2010

Effects of atypical antipsychotics and haloperidol on PC12 cells: Only aripiprazole phosphorylates AMP-activated protein kinase

Takami, G., Ota, M., Nakashima, A., Kaneko, Y. S., Mori, K., Nagatsu, T. & Ota, A., 01-10-2010, In : Journal of Neural Transmission. 117, 10, p. 1139-1153 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Peripherally injected lipopolysaccharide induces apoptosis in the subventricular zone of young adult mice

Mori, K., Kaneko, Y. S., Nakashima, A., Nagatsu, T., Nagatsu, I. & Ota, A., 01-09-2010, In : Neuroscience Letters. 481, 2, p. 126-130 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2009

Lipopolysaccharide extends the lifespan of mouse primary-cultured microglia

Kaneko, Y. S., Nakashima, A., Mori, K., Nagatsu, T., Nagatsu, I. & Ota, A., 07-07-2009, In : Brain Research. 1279, p. 9-20 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines

Nakashima, A., Hayashi, N., Kaneko, Y. S., Mori, K., Sabban, E. L., Nagatsu, T. & Ota, A., 01-11-2009, In : Journal of Neural Transmission. 116, 11, p. 1355-1362 8 p.

Research output: Contribution to journalReview article

47 Citations (Scopus)
2008

Peripheral lipopolysaccharide administration affects the olfactory dopamine system in mice

Ota, A., Mori, K., Kaneko, Y. S., Nakashima, A., Nagatsu, I. & Nagatsu, T., 12-2008, Stress, Neurotransmitters, and Hormones Neuroendocrine and Genetic Mechanisms. Blackwell Publishing Inc., p. 127-135 9 p. (Annals of the New York Academy of Sciences; vol. 1148).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)
2007

Effect of peripherally administered lipopolysaccharide (LPS) on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice

Ota, A., Kaneko, Y. S., Mori, K., Nakashima, A., Nagatsu, I. & Nagatsu, T., 01-06-2007, In : Stress. 10, 2, p. 131-136 6 p.

Research output: Contribution to journalReview article

19 Citations (Scopus)

Risperidone reduces mRNA expression levels of Sulfonylurea Receptor 1 and TASK1 in PC12 cells

Ota, M., Nakashima, A., Kaneko, Y. S., Mori, K., Takami, G. & Ota, A., 02-02-2007, In : Neuroscience Letters. 412, 3, p. 254-258 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

RNAi of 14-3-3η protein increases intracellular stability of tyrosine hydroxylase

Nakashima, A., Hayashi, N., Kaneko, Y. S., Mori, K., Sabban, E. L., Nagatsu, T. & Ota, A., 23-11-2007, In : Biochemical and Biophysical Research Communications. 363, 3, p. 817-821 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2006

Cytosolic catechols inhibit α-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates

Mazzulli, J. R., Mishizen, A. J., Giasson, B. I., Lynch, D. R., Thomas, S. A., Nakashima, A., Nagatsu, T., Ota, A. & Ischiropoulos, H., 27-09-2006, In : Journal of Neuroscience. 26, 39, p. 10068-10078 11 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)
2005

Corticotropin-releasing factor receptor antagonist attenuates LPS-induced increase of GTP cyclohydrolase I expression at murine locus coeruleus

Kaneko, Y. S., Mori, K., Nakashima, A., Nagatsu, I., Nagatsu, T. & Ota, A., 01-12-2005, In : Biogenic Amines. 19, 4-6, p. 289-297 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells

Nakashima, A., Hayashi, N., Kaneko, Y. S., Mori, K., Egusa, H., Nagatsu, T. & Ota, A., 01-07-2005, In : Journal of Neuroscience Research. 81, 1, p. 110-120 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

mRNA expression levels of leptin-related substances can be modified in risperidone-injected rats

Ota, M., Mori, K., Nakashima, A., Kaneko, Y. S., Takami, G. & Ota, A., 01-12-2005, In : Biogenic Amines. 19, 4-6, p. 299-308 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokines in murine locus coeruleus: Possible role of increased norepinephrine turnover

Kaneko, Y. S., Mori, K., Nakashima, A., Sawada, M., Nagatsu, I. & Ota, A., 01-07-2005, In : Journal of neurochemistry. 94, 2, p. 393-404 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Peripheral lipopolysaccharide induces apoptosis in the murine olfactory bulb

Mori, K., Kaneko, Y. S., Nakashima, A., Nagatsu, I., Takahashi, H. & Ota, A., 28-03-2005, In : Brain Research. 1039, 1-2, p. 116-129 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Resistance to excessive bodyweight gain in risperidone-injected rats

Ota, M., Mori, K., Nakashima, A., Kaneko, Y. S., Takahashi, H. & Ota, A., 01-04-2005, In : Clinical and Experimental Pharmacology and Physiology. 32, 4, p. 279-287 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

The phosphorylation of Ser40 of tyrosine hydroxylase has no effect on the stability of the enzyme in PC12 cells

Nakashima, A., Kaneko, Y. S., Mori, K., Nagatsu, T. & Ota, A., 01-12-2005, In : Biogenic Amines. 19, 4-6, p. 279-288 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2004

Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide

Fujiwara, K., Mori, K., Kaneko, Y. S., Nakashima, A., Nagasaka, A., Itoh, M. & Ota, A., 24-02-2004, In : Biochimica et Biophysica Acta - General Subjects. 1670, 3, p. 181-198 18 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2003

Effect of peripheral lipopolysaccharide injection on dopamine content in murine anterior olfactory nucleus

Mori, K., Kaneko, Y. S., Nakashima, A., Fujiwara, K., Nagatsu, I. & Ota, A., 01-01-2003, In : Journal of Neural Transmission. 110, 1, p. 31-50 20 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Interactions between Egr1 and AP1 factors in regulation of tyrosine hydroxylase transcription

Nakashima, A., Ota, A. & Sabban, E. L., 10-04-2003, In : Molecular Brain Research. 112, 1-2, p. 61-69 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Peripheral administration of lipopolysaccharide enhances the expression of guanosine triphosphate cyclohydrolase I mRNA in murine locus coeruleus

Kaneko, Y. S., Mori, K., Nakashima, A., Nagatsu, I. & Ota, A., 15-01-2003, In : Neuroscience. 116, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Peripheral injection of risperidone, an atypical antipsychotic, alters the body weight gain of rats (multiple letters)

Goudie, A. J., Halford, J. C. G., Cooper, G. D., Dovey, T., Pickavance, L. C., Wilding, J. P. H., Ota, M., Mori, K., Nakashima, A., Kaneko, Y. S., Ota, A., Fujiwara, K., Itoh, M. & Nagasaka, A., 07-2003, In : Clinical and Experimental Pharmacology and Physiology. 30, 7, p. 513-514 2 p.

Research output: Contribution to journalLetter

2002

Estradiol stimulates gene expression of norepinephrine biosynthetic enzymes in rat locus coeruleus

Serova, L., Rivkin, M., Nakashima, A. & Sabban, E. L., 06-04-2002, In : Neuroendocrinology. 75, 3, p. 193-200 8 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gain of rats

Ota, M., Mori, K., Nakashima, A., Kaneko, Y. S., Fujiwara, K., Itoh, M., Nagasaka, A. & Ota, A., 29-10-2002, In : Clinical and Experimental Pharmacology and Physiology. 29, 11, p. 980-989 10 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2001

Determination of tetrahydrobiopterin in murine locus coeruleus by HPLC with fluorescence detection

Kaneko, Y. S., Mori, K., Nakashima, A., Nagatsu, I., Nagatsu, T. & Ota, A., 01-01-2001, In : Brain Research Protocols. 8, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Exon 3 of tyrosine hydroxylase gene: Lack of association with Japanese schizophrenic patients

Ota, M., Nakashima, A., Ikemoto, K., Nojima, S., Tanaka, M., Okuda, M., Koga, H., Mori, K., Kaneko, Y. S., Fujiwara, K., Yamamoto, H., Nagatsu, T. & Ota, A., 18-04-2001, In : Molecular Psychiatry. 6, 3, p. 315-319 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Expression of GTP cyclohydrolase I in murine locus ceruleus is enhanced by peripheral administration of lipopolysaccharide

Kaneko, Y. S., Ikemoto, K., Mori, K., Nakashima, A., Nagatsu, I. & Ota, A., 02-02-2001, In : Brain Research. 890, 2, p. 203-210 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
1999

Dopamine inhibition of human tyrosine hydroxylase type 1 is controlled by the specific portion in the N-terminus of the enzyme

Nakashima, A., Mori, K., Suzuki, T., Kurita, H., Otani, M., Nagatsu, T. & Ota, A., 28-04-1999, In : Journal of neurochemistry. 72, 5, p. 2145-2153 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Expression of human tyrosine hydroxylase type I in Escherichia coli as a protease-cleavable fusion protein

Nakashima, A., Mori, K., Nagatsu, T. & Ota, A., 17-11-1999, In : Journal of Neural Transmission. 106, 9-10, p. 819-824 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Risperidone, an atypical antipsychotic, affects the mRNA expressions of monoamine oxidase type B and vesicular monoamine transporter-2 in rat brain

Ota, M., Nakashima, A., Mori, K., Hamanaka, T. & Ota, A., 01-01-1999, In : Biogenic Amines. 15, 2, p. 197-216 20 p.

Research output: Contribution to journalArticle

1998

Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis. Presence of GTP cyclohydrolase I

Nomura, T., Tazawa, M., Ohtsuki, M., Sumi-Ichinose, C., Hagino, Y., Ota, A., Nakashima, A., Mori, K., Sugimoto, T., Ueno, O., Nozawa, Y., Ichinose, H. & Nagatsu, T., 01-01-1998, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 120, 4, p. 753-760 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1997
3 Citations (Scopus)

Effects of dopamine on N-terminus-deleted human tyrosine hydroxylase type 1 expressed in Escherichia coli

Ota, A., Nakashima, A., Mori, K. & Nagatsu, T., 20-06-1997, In : Neuroscience Letters. 229, 1, p. 57-60 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Lymphocytes bursting induced by heparin, dextran sulfate and other polyanions

Mori, K., Nakashima, A. & Sasaki, S., 29-05-1997, In : Biochemical and Biophysical Research Communications. 234, 3, p. 783-787 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)