Research Promotion and Support Headquarters

Research Output

2020

2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche

Koike, N., Kota, R., Naito, Y., Hayakawa, N., Matsuura, T., Hishiki, T., Onishi, N., Fukada, J., Suematsu, M., Shigematsu, N., Saya, H. & Sampetrean, O., 01-12-2020, In : Communications biology. 3, 1, 450.

Research output: Contribution to journalArticle

Open Access

Aggressive periodontitis and NOD2 variants

Mizuno, N., Kume, K., Nagatani, Y., Matsuda, S., Iwata, T., Ouhara, K., Kajiya, M., Takeda, K., Matsuda, Y., Tada, Y., Ohsawa, R., Morino, H., Mihara, K., Fujita, T., Kawaguchi, H., Shiba, H., Kawakami, H. & Kurihara, H., 2020, (Accepted/In press) In : Journal of Human Genetics. 65, 10, p. 841-846 6 p.

Research output: Contribution to journalArticle

A Glimpse of the Peptide Profile Presentation by Xenopus laevis MHC Class I: Crystal structure of PxeLA-UAA reveals a distinct peptide-binding groove

Ma, L., Zhang, N., Qu, Z., Liang, R., Zhang, L., Zhang, B., Meng, G., Dijkstra, J. M., Li, S. & Xia, M. C., 2020, In : Journal of Immunology. 204, 1

Research output: Contribution to journalArticle

Open Access

Analysis of O-glycoforms of the IgA1 hinge region by sequential deglycosylation

Ohyama, Y., Yamaguchi, H., Nakajima, K., Mizuno, T., Fukamachi, Y., Yokoi, Y., Tsuboi, N., Inaguma, D., Hasegawa, M., Renfrow, M. B., Novak, J., Yuzawa, Y. & Takahashi, K., 01-12-2020, In : Scientific reports. 10, 1, 671.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

An analysis of monocytes and dendritic cells differentiated from human peripheral blood monocyte-derived induced pluripotent stem cells

Hiramatsu, N., Yamamoto, N., Isogai, S., Onouchi, T., Hirayama, M., Maeda, S., Ina, T., Kondo, M. & Imaizumi, K., 01-06-2020, In : Medical Molecular Morphology. 53, 2, p. 63-72 10 p.

Research output: Contribution to journalArticle

A potent blood–brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model

Machida, Y., Nakagawa, M., Matsunaga, H., Yamaguchi, M., Ogawara, Y., Shima, Y., Yamagata, K., Katsumoto, T., Hattori, A., Itoh, M., Seki, T., Nishiya, Y., Nakamura, K., Suzuki, K., Imaoka, T., Baba, D., Suzuki, M., Sampetrean, O., Saya, H., Ichimura, K. & 1 others, Kitabayashi, I., 02-2020, In : Molecular Cancer Therapeutics. 19, 2, p. 375-383 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Author Correction: CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake (Scientific Reports, (2018), 8, 1, (2785), 10.1038/s41598-018-20973-2)

Kobayashi, N., Okazaki, S., Sampetrean, O., Irie, J., Itoh, H. & Saya, H., 01-12-2020, In : Scientific reports. 10, 1, 6084.

Research output: Contribution to journalComment/debate

Open Access

AUTS2 Regulation of Synapses for Proper Synaptic Inputs and Social Communication

Hori, K., Yamashiro, K., Nagai, T., Shan, W., Egusa, S. F., Shimaoka, K., Kuniishi, H., Sekiguchi, M., Go, Y., Tatsumoto, S., Yamada, M., Shiraishi, R., Kanno, K., Miyashita, S., Sakamoto, A., Abe, M., Sakimura, K., Sone, M., Sohya, K., Kunugi, H. & 4 others, Wada, K., Yamada, M., Yamada, K. & Hoshino, M., 26-06-2020, In : iScience. 23, 6, 101183.

Research output: Contribution to journalArticle

Open Access

Comparison of physiological and behavioral responses to chronic restraint stress between C57BL/6J and BALB/c mice

Tsuchimine, S., Matsuno, H., O'Hashi, K., Chiba, S., Yoshimura, A., Kunugi, H. & Sohya, K., 23-04-2020, In : Biochemical and Biophysical Research Communications. 525, 1, p. 33-38 6 p.

Research output: Contribution to journalArticle

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

Saito, R., Koebis, M., Nagai, T., Shimizu, K., Liao, J., Wulaer, B., Sugaya, Y., Nagahama, K., Uesaka, N., Kushima, I., Mori, D., Maruyama, K., Nakao, K., Kurihara, H., Yamada, K., Kano, M., Fukada, Y., Ozaki, N. & Aiba, A., 01-12-2020, In : Translational psychiatry. 10, 1, 35.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access

Development and characterisation of NKp44-based chimeric antigen receptors that confer T cells with NK cell-like specificity

Kasahara, Y., Shin, C., Kubo, N., Mihara, K., Iwabuchi, H., Takachi, T., Imamura, M., Saitoh, A. & Imai, C., 2020, In : Clinical and Translational Immunology. 9, 7, e1147.

Research output: Contribution to journalArticle

Open Access

Development and evaluation of a novel loop-mediated isothermal amplification (LAMP) method targeting Theileria parasites infecting Yezo sika deer

Shirozu, T., Badolo, A., Soga, A., Yoshimura, A., Morishita, Y. K., Koketsu, M., Shirafuji, R. U., Inokuma, H., Yokoyama, N. & Fukumoto, S., 08-2020, In : Parasitology International. 77, 102130.

Research output: Contribution to journalArticle

Development of anti-human CADM1 monoclonal antibodies as a potential therapy for adult T-cell leukemia/lymphoma

Chilmi, S., Nakahata, S., Fauzi, Y. R., Ichikawa, T., Tani, C., Suwanruengsri, M., Yamaguchi, R., Matsuura, T., Kurosawa, G. & Morishita, K., 2020, (Accepted/In press) In : International Journal of Hematology.

Research output: Contribution to journalArticle

Differential labeling of glycoproteins with alkynyl fucose analogs

Ma, C., Takeuchi, H., Hao, H., Yonekawa, C., Nakajima, K., Nagae, M., Okajima, T., Haltiwanger, R. S. & Kizuka, Y., 01-09-2020, In : International journal of molecular sciences. 21, 17, p. 1-18 18 p., 6007.

Research output: Contribution to journalArticle

Open Access

Enhanced homologous recombination by the modulation of targeting vector ends

Hirotsune, S., Kiyonari, H., Jin, M., Kumamoto, K., Yoshida, K., Shinohara, M., Watanabe, H., Wynshaw-Boris, A. & Matsuzaki, F., 01-12-2020, In : Scientific reports. 10, 1, 2518.

Research output: Contribution to journalArticle

Open Access

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity

El-Boraie, A., Taghavi, T., Chenoweth, M. J., Fukunaga, K., Mushiroda, T., Kubo, M., Lerman, C., Nollen, N. L., Benowitz, N. L. & Tyndale, R. F., 01-01-2020, In : Addiction Biology. 25, 1, e12741.

Research output: Contribution to journalArticle

2 Citations (Scopus)
Open Access
1 Citation (Scopus)

Eye lens dosimetry for workers at Fukushima Daiichi Nuclear Power Plant—1: Laboratory study on the dosemeter position and the shielding effect of full face mask respirators

Hoshi, K., Yoshitomi, H., Aoki, K., Tanimura, Y., Tsujimura, N. & Yokoyama, S., 06-2020, In : Radiation Measurements. 134, 106304.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Eye lens dosimetry for workers at Fukushima Daiichi Nuclear Power Plant—2: Field study using humanoid phantoms

Tsujimura, N., Hoshi, K., Aoki, K., Yoshitomi, H., Tanimura, Y. & Yokoyama, S., 06-2020, In : Radiation Measurements. 134, 106305.

Research output: Contribution to journalArticle

Full genome characterization of novel DS-1like G9P[8] rotavirus strains that have emerged in Thailand

Fukuda, S., Tacharoenmuang, R., Guntapong, R., Upachai, S., Singchai, P., Ide, T., Hatazawa, R., Sutthiwarakom, K., Kongjorn, S., Onvimala, N., Ruchusatsawast, K., Rungnopakun, P., Mekmallika, J., Kawamura, Y., Motomura, K., Tatsumi, M., Takeda, N., Murata, T., Yoshikawa, T., Uppapong, B. & 2 others, Taniguchi, K. & Komoto, S., 04-2020, In : PloS one. 15, 4, e0231099.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Functional variants in ADH1B and ALDH2 are non-additively associated with all-cause mortality in Japanese population

Sakaue, S., Akiyama, M., Hirata, M., Matsuda, K., Murakami, Y., Kubo, M., Kamatani, Y. & Okada, Y., 01-03-2020, In : European Journal of Human Genetics. 28, 3, p. 378-382 5 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia

Sawahata, M., Mori, D., Arioka, Y., Kubo, H., Kushima, I., Kitagawa, K., Sobue, A., Shishido, E., Sekiguchi, M., Kodama, A., Ikeda, R., Aleksic, B., Kimura, H., Ishizuka, K., Nagai, T., Kaibuchi, K., Nabeshima, T., Yamada, K. & Ozaki, N., 01-05-2020, In : Psychiatry and clinical neurosciences. 74, 5, p. 318-327 10 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect

Tamura, R., Miyoshi, H., Morimoto, Y., Oishi, Y., Sampetrean, O., Iwasawa, C., Mine, Y., Saya, H., Yoshida, K., Okano, H. & Toda, M., 03-2020, In : Human Gene Therapy. 31, 5-6, p. 352-366 15 p.

Research output: Contribution to journalArticle

Open Access

Genome-Wide Natural Selection Signatures Are Linked to Genetic Risk of Modern Phenotypes in the Japanese Population

Yasumizu, Y., Sakaue, S., Konuma, T., Suzuki, K., Matsuda, K., Murakami, Y., Kubo, M., Palamara, P. F., Kamatani, Y. & Okada, Y., 01-05-2020, In : Molecular biology and evolution. 37, 5, p. 1306-1316 11 p.

Research output: Contribution to journalArticle

Open Access

Germline Pathogenic Variants in 7636 Japanese Patients with Prostate Cancer and 12 366 Controls

Momozawa, Y., Iwasaki, Y., Hirata, M., Liu, X., Kamatani, Y., Takahashi, A., Sugano, K., Yoshida, T., Murakami, Y., Matsuda, K., Nakagawa, H., Spurdle, A. B. & Kubo, M., 01-04-2020, In : Journal of the National Cancer Institute. 112, 4, p. 369-376 8 p., djz124.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits

Matoba, N., Akiyama, M., Ishigaki, K., Kanai, M., Takahashi, A., Momozawa, Y., Ikegawa, S., Ikeda, M., Iwata, N., Hirata, M., Matsuda, K., Murakami, Y., Kubo, M., Kamatani, Y. & Okada, Y., 01-03-2020, In : Nature Human Behaviour. 4, 3, p. 308-316 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

GWAS of five gynecologic diseases and cross-trait analysis in Japanese

Masuda, T., Low, S. K., Akiyama, M., Hirata, M., Ueda, Y., Matsuda, K., Kimura, T., Murakami, Y., Kubo, M., Kamatani, Y. & Okada, Y., 01-01-2020, In : European Journal of Human Genetics. 28, 1, p. 95-107 13 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

High prevalence of equine-like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand

Tacharoenmuang, R., Komoto, S., Guntapong, R., Upachai, S., Singchai, P., Ide, T., Fukuda, S., Ruchusatsawast, K., Sriwantana, B., Tatsumi, M., Motomura, K., Takeda, N., Murata, T., Sangkitporn, S., Taniguchi, K. & Yoshikawa, T., 01-02-2020, In : Journal of Medical Virology. 92, 2, p. 174-186 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

High Salt Intake Impairs Erectile Function in Salt-Sensitive Rats Through Mineralocorticoid Receptor Pathway Beyond Its Effect on Blood Pressure

Kishimoto, T., Kataoka, T., Yamamoto, Y., Asano, G., Fukamoto, A., Hotta, Y., Maeda, Y., Takahashi, M., Kanayama, H. O. & Kimura, K., 07-2020, In : Journal of Sexual Medicine. 17, 7, p. 1280-1287 8 p.

Research output: Contribution to journalArticle

Open Access

HLA-B*51:01 and CYP2C9*3 Are Risk Factors for Phenytoin-Induced Eruption in the Japanese Population: Analysis of Data From the Biobank Japan Project

Hikino, K., Ozeki, T., Koido, M., Terao, C., Kamatani, Y., Mizukawa, Y., Shiohara, T., Tohyama, M., Azukizawa, H., Aihara, M., Nihara, H., Morita, E., Murakami, Y., Kubo, M. & Mushiroda, T., 01-05-2020, In : Clinical Pharmacology and Therapeutics. 107, 5, p. 1170-1178 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of kit-ligand a as the gene responsible for the medaka pigment cell mutant few melanophore

Otsuki, Y., Okuda, Y., Naruse, K. & Saya, H., 01-01-2020, In : G3: Genes, Genomes, Genetics. 10, 1, p. 311-319 9 p.

Research output: Contribution to journalArticle

Open Access

Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice

Tashita, C., Hoshi, M., Hirata, A., Nakamoto, K., Ando, T., Hattori, T., Yamamoto, Y., Tezuka, H., Tomita, H., Hara, A. & Saito, K., 07-03-2020, In : World Journal of Gastroenterology. 26, 9, p. 918-932 15 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Mass spectrometry for the identification and analysis of highly complex glycosylation of therapeutic or pathogenic proteins

Ohyama, Y., Nakajima, K., Renfrow, M. B., Novak, J. & Takahashi, K., 02-04-2020, In : Expert Review of Proteomics. 17, 4, p. 275-296 22 p.

Research output: Contribution to journalReview article

Measurements of the doses of eye lens for the workers of Fukushima Daiichi Nuclear Power Plant

Yokoyama, S., Ezaki, I., Tatsuzaki, H., Tachiki, S., Hirao, S., Aoki, K., Tanimura, Y., Hoshi, K., Yoshitomi, H. & Tsujimura, N., 11-2020, In : Radiation Measurements. 138, 106399.

Research output: Contribution to journalArticle

Mechanism of atopic cataract caused by eosinophil granule major basic protein

Yamamoto, N., Hiramatsu, N., Isogai, S., Kondo, M., Imaizumi, K. & Horiguchi, M., 01-06-2020, In : Medical Molecular Morphology. 53, 2, p. 94-103 10 p.

Research output: Contribution to journalArticle

Molecular and cellular mechanisms underlying brain metastasis of breast cancer

Hosonaga, M., Saya, H. & Arima, Y., 01-09-2020, In : Cancer and Metastasis Reviews. 39, 3, p. 711-720 10 p.

Research output: Contribution to journalReview article

Open Access

Molecular characterization of rotaviruses obtained from patients with rotavirus-associated encephalitis/encephalopathy

Ihira, M., Kawamura, Y., Miura, H., Hattori, F., Higashimoto, Y., Sugata, K., Ide, T., Komoto, S., Taniguchi, K. & Yoshikawa, T., 01-08-2020, In : MICROBIOLOGY and IMMUNOLOGY. 64, 8, p. 541-555 15 p.

Research output: Contribution to journalArticle

Morphological and functional abnormalities of hippocampus in APC 1638T/1638T mice

Li, C., Onouchi, T., Hirayama, M., Sakai, K., Matsuda, S., Yamada, N. O. & Senda, T., 2020, (Accepted/In press) In : Medical Molecular Morphology.

Research output: Contribution to journalArticle

Optineurin regulates osteoblastogenesis through STAT1

Mizuno, N., Iwata, T., Ohsawa, R., Ouhara, K., Matsuda, S., Kajiya, M., Matsuda, Y., Kume, K., Tada, Y., Morino, H., Yoshimoto, T., Ueki, Y., Mihara, K., Sotomaru, Y., Takeda, K., Munenaga, S., Fujita, T., Kawaguchi, H., Shiba, H., Kawakami, H. & 1 others, Kurihara, H., 14-05-2020, In : Biochemical and Biophysical Research Communications. 525, 4, p. 889-894 6 p.

Research output: Contribution to journalArticle

Oral intake of α-glucosyl-hesperidin ameliorates selenite-induced cataract formation

Nakazawa, Y., Aoki, M., Ishiwa, S., Morishita, N., Endo, S., Nagai, N., Yamamoto, N., Funakoshi-Tago, M. & Tamura, H., 2020, In : Molecular Medicine Reports. 21, 3, p. 1258-1266 9 p.

Research output: Contribution to journalArticle

Open Access

Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma

Padthaisong, S., Thanee, M., Namwat, N., Phetcharaburanin, J., Klanrit, P., Khuntikeo, N., Titapun, A., Sungkhamanon, S., Saya, H. & Loilome, W., 10-02-2020, In : Journal of Translational Medicine. 18, 1, 64.

Research output: Contribution to journalArticle

Open Access

Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell

Tanno, N., Kuninaka, S., Fujimura, S., Takemoto, K., Okamura, K., Takeda, N., Araki, K., Araki, M., Saya, H. & Ishiguro, K. I., 01-12-2020, In : Scientific reports. 10, 1, 10094.

Research output: Contribution to journalArticle

Open Access

Polygenic risk scores in schizophrenia with clinically significant copy number variants

Taniguchi, S., Ninomiya, K., Kushima, I., Saito, T., Shimasaki, A., Sakusabe, T., Momozawa, Y., Kubo, M., Kamatani, Y., Ozaki, N., Ikeda, M. & Iwata, N., 01-01-2020, In : Psychiatry and clinical neurosciences. 74, 1, p. 35-39 5 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Preliminary investigation of pretreatment methods for liquid scintillation measurements of environmental water samples using ion exchange resins

Nakasone, S., Yokoyama, S., Takahashi, T., Ota, M., Kakiuchi, H., Sugihara, S., Hirao, S., Momoshima, N., Tamari, T., Shima, N., Atarashi-Andoh, M., Fukutani, S., Ishimine, A., Furukawa, M., Tanaka, M. & Akata, N., 2020, In : Plasma and Fusion Research. 15, SpecialIssue1, 2405027.

Research output: Contribution to journalArticle

Open Access

Radiolabeled human monoclonal antibody 067-213 has the potential for noninvasive quantification of cd73 expression

Sudo, H., Tsuji, A. B., Sugyo, A., Kurosawa, G., Kurosawa, Y., Alexander, D., Tsuda, H., Saga, T. & Higashi, T., 01-04-2020, In : International journal of molecular sciences. 21, 7, 2304.

Research output: Contribution to journalArticle

Open Access

Rare primary extramedullary hematopoiesis of the thyroid without intranodular vascularity and mutations in the JAK2, MPL, and calreticulin genes

Matsumura, N., Sasaki, N., Cho, Y., Daimaru, Y., Nojima, T., Mizuno, N., Takei, Y. & Mihara, K., 01-09-2020, In : Annals of Hematology. 99, 9, p. 2211-2213 3 p.

Research output: Contribution to journalLetter

Risk Factors of Infectious Complications After Endobronchial Ultrasound-Guided Transbronchial Biopsy

Souma, T., Minezawa, T., Yatsuya, H., Okamura, T., Yamatsuta, K., Morikawa, S., Horiguchi, T., Maeda, S., Goto, Y., Hayashi, M., Isogai, S., Yamamoto, N., Kondo, M. & Imaizumi, K., 08-2020, In : Chest. 158, 2, p. 797-807 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)