Research Promotion and Support Headquarters

Research Output

2007

Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population: The Hisayama Study

Ninomiya, T., Kubo, M., Doi, Y., Yonemoto, K., Tanizaki, Y., Rahman, M., Arima, H., Tsuryuya, K., Iida, M. & Kiyohara, Y., 01-07-2007, In : Stroke. 38, 7, p. 2063-2069 7 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)

Isolation of multipotent stem cells from mouse adipose tissue

Yamamoto, N., Akamatsu, H., Hasegawa, S., Yamada, T., Nakata, S., Ohkuma, M., Miyachi, E. I., Marunouchi, T. & Matsunaga, K., 01-10-2007, In : Journal of Dermatological Science. 48, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Liver enzymes as a predictor for incident diabetes in a Japanese population: The Hisayama study

Doi, Y., Kubo, M., Yonemoto, K., Ninomiya, T., Iwase, M., Tanizaki, Y., Shikata, K., Iida, M. & Kiyohara, Y., 01-07-2007, In : Obesity. 15, 7, p. 1841-1850 10 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment

Mori, D., Yano, Y., Toyo-Oka, K., Yoshida, N., Yamada, M., Muramatsu, M., Zhang, D., Saya, H., Toyoshima, Y. Y., Kinoshita, K., Wynshaw-Boris, A. & Hirotsune, S., 01-01-2007, In : Molecular and Cellular Biology. 27, 1, p. 352-367 16 p.

Research output: Contribution to journalArticle

Open Access
107 Citations (Scopus)

Prehypertension increases the risk for renal arteriosclerosis in autopsies: The Hisayama study

Ninomiya, T., Kubo, M., Doi, Y., Yonemoto, K., Tanizaki, Y., Tsuruya, K., Sueishi, K., Tsuneyoshi, M., Iida, M. & Kiyohara, Y., 01-07-2007, In : Journal of the American Society of Nephrology. 18, 7, p. 2135-2142 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Relationship between cytokine concentration and activities of daily living in rehabilitation patients with stroke

Ozaki, S., Beppu, H., Sonoda, S., Okazaki, H., Mizutani, K., Itani, Y., Hayashi, N., Okamotos, S. & Matsui, T., 06-2007, In : Rinsho byori. The Japanese journal of clinical pathology. 55, 6, p. 522-527 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Reply from the authors [4]

Kubo, M., Ninomiya, T., Tanizaki, Y. & Kiyohara, Y., 01-01-2007, In : Neurology. 68, 4, p. 311-312 2 p.

Research output: Contribution to journalLetter

Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation

Kuninaka, S., Iida, S. I., Hara, T., Nomura, M., Naoe, H., Morisaki, T., Nitta, M., Arima, Y., Mimori, T., Yonehara, S. & Saya, H., 12-04-2007, In : Oncogene. 26, 17, p. 2395-2406 12 p.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

Study on the mechanism of neuropsychological abnormalities induced by drugs of abuse

Nagai, T., 01-12-2007, In : Folia Pharmacologica Japonica. 129, 5, p. 354-359 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Vasopressin stimulates Na-dependent phosphate transport and calcification in rat aortic smooth muscle cells

Nishiwaki-Yasuda, K., Suzuki, A., Kakita, A., Sekiguchi, S., Asano, S., Nishii, K., Nagao, S., Oiso, Y. & Itoh, M., 30-03-2007, In : endocrine journal. 54, 1, p. 103-112 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2006

Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association: The Hisayama Study

Arima, H., Kiyohara, Y., Tanizaki, Y., Nakabeppu, Y., Kubo, M., Kato, I., Sueishi, K., Tsuneyoshi, M., Fujishima, M. & Iida, M., 01-06-2006, In : European Journal of Cancer Prevention. 15, 3, p. 196-201 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: The Hisayama study

Shikata, K., Kiyohara, Y., Kubo, M., Yonemoto, K., Ninomiya, T., Shirota, T., Tanizaki, Y., Doi, Y., Tanaka, K., Oishi, Y., Matsumoto, T. & Iida, M., 01-07-2006, In : International Journal of Cancer. 119, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

166 Citations (Scopus)

Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells

Nitta, T., Kanai, M., Sugihara, E., Tanaka, M., Sun, B., Nagasawa, T., Sonoda, S., Saya, H. & Miwa, M., 01-09-2006, In : Cancer science. 97, 9, p. 836-841 6 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Clinical course of myocarditis through the acute, fulminant and fatal chronic stages - An autopsy case

Hiramitsu, S., Morimoto, S. I., Kato, S., Uemura, A., Ohtsuki, M., Kato, Y., Miyagishima, K., Mori, N., Yoda, R., Mori, K., Kimura, H., Yamamoto, N. & Hishida, H., 08-08-2006, In : Circulation Journal. 70, 8, p. 1086-1090 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

C-reactive protein and risk of first-ever ischemic and hemorrhagic stroke in a general Japanese population: The Hisayama study

Wakugawa, Y., Kiyohara, Y., Tanizaki, Y., Kubo, M., Ninomiya, T., Hata, J., Doi, Y., Okubo, K., Oishi, Y., Shikata, K., Yonemoto, K., Maebuchi, D., Ibayashi, S. & Iida, M., 01-01-2006, In : Stroke. 37, 1, p. 27-32 6 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Decreasing incidence of lacunar vs other types of cerebral infarction in a Japanese population

Kubo, M., Kiyohara, Y., Ninomiya, T., Tanizaki, Y., Yonemoto, K., Doi, Y., Hata, J., Oishi, Y., Shikata, K. & Iida, M., 01-05-2006, In : Neurology. 66, 10, p. 1539-1544 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Dynamics of mitotic spindle

Kinoshita, K. & Saya, H., 01-05-2006, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.. 51, 6 Suppl, p. 761-766 6 p.

Research output: Contribution to journalReview article

Erratum: Effects of memantine and donepezil on amyloid β-induced memory impairment in a delayed-matching to position task in rats (Behavioural Brain Research (2005) 162 (191-199) DOI: 10.1016/j.bbr.2005.02.036)

Yamada, K., Takayanagi, M., Kamei, H., Nagai, T., Dohniwa, M., Kobayashi, K., Yoshida, S., Ohhara, T., Takuma, K. & Nabeshima, T., 30-01-2006, In : Behavioural Brain Research. 166, 2, 1 p.

Research output: Contribution to journalComment/debate

Increased water intake decreases progression of polycystic kidney disease in the PCK rat

Nagao, S., Nishii, K., Katsuyama, M., Kurahashi, H., Marunouchi, T., Takahashi, H. & Wallace, D. P., 01-08-2006, In : Journal of the American Society of Nephrology. 17, 8, p. 2220-2227 8 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Metabolic Syndrome and CKD in a General Japanese Population: The Hisayama Study

Ninomiya, T., Kiyohara, Y., Kubo, M., Yonemoto, K., Tanizaki, Y., Doi, Y., Hirakata, H. & Iida, M., 01-09-2006, In : American Journal of Kidney Diseases. 48, 3, p. 383-391 9 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)

Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S. I., Tahara, H., Nakayama, K., Nakayama, K. I., Ide, T., Saya, H. & Hara, E., 01-11-2006, In : Nature Cell Biology. 8, 11, p. 1291-1297 7 p.

Research output: Contribution to journalArticle

313 Citations (Scopus)

Molecular mechanisms of anti-cancer therapies

Saya, H., 10-2006, In : Japanese Journal of Neurosurgery. 15, 10, p. 688-693 6 p.

Research output: Contribution to journalReview article

Open Access

Organization and structure of hox gene loci in medaka genome and comparison with those of pufferfish and zebrafish genomes

Kurosawa, G., Takamatsu, N., Takahashi, M., Sumitomo, M., Sanaka, E., Yamada, K., Nishii, K., Matsuda, M., Asakawa, S., Ishiguro, H., Miura, K., Kurosawa, Y., Shimizu, N., Kohara, Y. & Hori, H., 29-03-2006, In : Gene. 370, 1-2, p. 75-82 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Maeno, Y., Nakazawa, S., Yamamoto, N., Shinzato, M., Nagashima, S., Tanaka, K., Sasaki, J., Rittling, S. R., Denhardt, D. T., Uede, T. & Taniguchi, K., 01-04-2006, In : Infection and Immunity. 74, 4, p. 2423-2427 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Repeated methamphetamine treatment impairs recognition memory through a failure of novelty-induced ERK1/2 activation in the prefrontal cortex of mice

Kamei, H., Nagai, T., Nakano, H., Togan, Y., Takayanagi, M., Takahashi, K., Kobayashi, K., Yoshida, S., Maeda, K., Takuma, K., Nabeshima, T. & Yamada, K., 01-01-2006, In : Biological Psychiatry. 59, 1, p. 75-84 10 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)

Studies of the role of steroid hormone in the regulation of oocyte maturation in cattle

Wang, H. F., Isobe, N., Kumamoto, K., Yamashiro, H., Yamashita, Y. & Terada, T., 03-02-2006, In : Reproductive Biology and Endocrinology. 4, 4.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Suppression of centrosome amplification after DNA damage depends on p27 accumulation

Sugihara, E., Kanai, M., Saito, S., Nitta, T., Toyoshima, H., Nakayama, K., Nakayama, K. I., Fukasawa, K., Schwab, M., Saya, H. & Miwa, M., 15-04-2006, In : Cancer Research. 66, 8, p. 4020-4029 10 p.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)

Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice

Inagaki-Ohara, K., Sasaki, A., Matsuzaki, G., Ikeda, T., Hotokezaka, M., Chijiiwa, K., Kubo, M., Yoshida, H., Nawa, Y. & Yoshimura, A., 01-02-2006, In : Gut. 55, 2, p. 212-219 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The effect of fexofenadine on pruritus in a mouse model (HR-ADf) of atopic dermatitis

Akamatsu, H., Makiura, M., Yamamoto, N., Yagami, A., Shimizu, Y. & Matsunaga, K., 01-01-2006, In : Journal of International Medical Research. 34, 5, p. 495-504 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The influence of current and former smoking on gingival bleeding: The hisayama study

Shimazaki, Y., Saito, T., Kiyohara, Y., Kato, I., Kubo, M., Iida, M. & Yamashita, Y., 01-08-2006, In : Journal of Periodontology. 77, 8, p. 1430-1435 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

The serum pepsinogen test as a predictor of gastric cancer: The Hisayama study

Oishi, Y., Kiyohara, Y., Kubo, M., Tanaka, K., Tanizaki, Y., Ninomiya, T., Doi, Y., Shikata, K., Yonemoto, K., Shirota, T., Matsumoto, T. & Iida, M., 01-04-2006, In : American Journal of Epidemiology. 163, 7, p. 629-637 9 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)
2005

Androgen receptor pathway in rats with autosomal dominant polycystic kidney disease

Nagao, S., Kusaka, M., Nishii, K., Marunouchi, T., Kurahashi, H., Takahashi, H. & Grantham, J., 09-12-2005, In : Journal of the American Society of Nephrology. 16, 7, p. 2052-2062 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Aurora-A - A guardian of poles

Marumoto, T., Zhang, D. & Saya, H., 01-01-2005, In : Nature Reviews Cancer. 5, 1, p. 42-50 9 p.

Research output: Contribution to journalReview article

553 Citations (Scopus)

Behavioral approaches for analyzing emotionality in mutant mice

Nagai, T., Yamada, K. & Nabeshima, T., 11-03-2005, In : Folia Pharmacologica Japonica. 125, 2, p. 71-76 6 p.

Research output: Contribution to journalReview article

Cell Death: Its Style and Significance

Saya, H., 01-12-2005, Taking Life and Death Seriously - Bioethics from Japan. Takahashi, T. (ed.). p. 209-223 15 p. (Advances in Bioethics; vol. 8).

Research output: Chapter in Book/Report/Conference proceedingChapter

Chronic kidney disease and cardiovascular disease in a general Japanese population: The Hisayama Study

Ninomiya, T., Kiyohara, Y., Kubo, M., Tanizaki, Y., Doi, Y., Okubo, K., Wakugawa, Y., Hata, J., Oishi, Y., Shikata, K., Yonemoto, K., Hirakata, H. & Iida, M., 01-07-2005, In : Kidney International. 68, 1, p. 228-236 9 p.

Research output: Contribution to journalArticle

296 Citations (Scopus)

Concentration of transforming growth factor β2 in aqueous humor

Yamamoto, N., Itonaga, K., Marunouchi, T. & Majima, K., 25-05-2005, In : Ophthalmic Research. 37, 1, p. 29-33 5 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Contribution of Vα24+Vβ11+ natural killer T cells in Wilsonian hepatitis

Kinebuchi, M., Matsuura, A., Ohya, K., Abo, W. & Kitazawa, J., 01-01-2005, In : Clinical and Experimental Immunology. 139, 1, p. 144-151 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Effects of memantine and donepezil on amyloid β-induced memory impairment in a delayed-matching to position task in rats

Yamada, K., Takayanagi, M., Kamei, H., Nagai, T., Dohniwa, M., Kobayashi, K., Yoshida, S., Ohhara, T., Takauma, K. & Nabeshima, T., 30-07-2005, In : Behavioural Brain Research. 162, 2, p. 191-199 9 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Elevated C-reactive protein is a predictor of the development of diabetes in a general Japanese population: The Hisayama study

Doi, Y., Kiyohara, Y., Kubo, M., Ninomiya, T., Wakugawa, Y., Yonemoto, K., Iwase, M. & Iida, M., 01-10-2005, In : Diabetes care. 28, 10, p. 2497-2500 4 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion

Sato, Y., Araki, H., Kato, J., Nakamura, K., Kawano, Y., Kobune, M., Sato, T., Miyanishi, K., Takayama, T., Takahashi, M., Takimoto, R., Iyama, S., Matsunaga, T., Ohtani, S., Matsuura, A., Hamada, H. & Niitsu, Y., 15-07-2005, In : Blood. 106, 2, p. 756-763 8 p.

Research output: Contribution to journalArticle

521 Citations (Scopus)

Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population: The Hisayama study

Yamagata, H., Kiyohara, Y., Nakamura, S., Kubo, M., Tanizaki, Y., Matsumoto, T., Tanaka, K., Kato, I., Shirota, T. & Iida, M., 01-04-2005, In : Diabetes care. 28, 4, p. 789-794 6 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Molecular mechanism of tumorigenesis by cell cycle regulation and new therapeutical approaches

Saya, H., 06-2005, In : Japanese Journal of Neurosurgery. 14, 6, p. 373-378 6 p.

Research output: Contribution to journalArticle

Open Access

Observation of the intracellular behavior of recombinant Yersinia pseudotuberculosis invasin protein

Koga, H., Izawa, I., Araki, N., Saya, H. & Mimori, T., 01-01-2005, In : MICROBIOLOGY and IMMUNOLOGY. 49, 4, p. 297-302 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1

Sasayama, T., Marumoto, T., Kunitoku, N., Zhang, D., Tamaki, N., Kohmura, E., Saya, H. & Hirota, T., 01-07-2005, In : Genes to Cells. 10, 7, p. 627-638 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Pro- and anti-addictive factors related to drug addiction

Yamada, K., Nagai, T., Nakajima, A. & Nabeshima, T., 29-07-2005, In : Folia Pharmacologica Japonica. 126, 1, p. 49-53 5 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Relationship between C-reactive protein and glucose levels in community-dwelling subjects without diabetes: The Hisayama study

Doi, Y., Kiyohara, Y., Kubo, M., Tanizaki, Y., Okubo, K., Ninomiya, T., Iwase, M. & Iida, M., 01-05-2005, In : Diabetes care. 28, 5, p. 1211-1213 3 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Relationship between drinking and periodontitis: The Hisayama study

Shimazaki, Y., Saito, T., Kiyohara, Y., Kato, I., Kubo, M., Iida, M. & Yamashita, Y., 01-09-2005, In : Journal of Periodontology. 76, 9, p. 1534-1541 8 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Relationship between obesity, glucose tolerance, and periodontal disease in Japanese women: The Hisayama study

Saito, T., Shimazaki, Y., Kiyohara, Y., Kato, I., Kubo, M., Iida, M. & Yamashita, Y., 01-08-2005, In : Journal of Periodontal Research. 40, 4, p. 346-353 8 p.

Research output: Contribution to journalReview article

150 Citations (Scopus)

RNA interference targeting aurora kinase A suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells

Hata, T., Furukawa, T., Sunamura, M., Egawa, S., Motoi, F., Ohmura, N., Marumoto, T., Saya, H. & Horii, A., 01-04-2005, In : Cancer Research. 65, 7, p. 2899-2905 7 p.

Research output: Contribution to journalArticle

Open Access
192 Citations (Scopus)