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Research Output

2018

Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes

Chang, S. W., McDonough, C. W., Gong, Y., Johnson, T. A., Tsunoda, T., Gamazon, E. R., Perera, M. A., Takahashi, A., Tanaka, T., Kubo, M., Pepine, C. J., Johnson, J. A. & Cooper-Dehoff, R. M., 01-01-2018, In : Pharmacogenomics Journal. 18, 1, p. 106-112 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma

Japan Glaucoma Society Omics Group (JGS-OG) & NEIGHBORHOOD Consortium, 15-04-2018, In : Human molecular genetics. 27, 8, p. 1486-1496 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Genomewide association study of leisure-time exercise behavior in Japanese Adults

Hara, M., Hachiya, T., Sutoh, Y., Matsuo, K., Nishida, Y., Shimanoe, C., Tanaka, K., Shimizu, A., Ohnaka, K., Kawaguchi, T., Oze, I., Matsuda, F., Ito, H., Kawai, S., Hishida, A., Okada, R., Sasakabe, T., Hirata, A., Ibusuki, R., Nindita, Y. & 19 others, Furusyo, N., Ikezaki, H., Kuriyama, N., Ozaki, E., Mikami, H., Nakamura, Y., Suzuki, S., Hosono, A., Katsuura-Kamano, S., Arisawa, K., Kuriki, K., Endoh, K., Takashima, N., Kadota, A., Nakatochi, M., Momozawa, Y., Kubo, M., Naito, M. & Wakai, K., 01-12-2018, In : Medicine and Science in Sports and Exercise. 50, 12, p. 2433-2441 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study

Hishida, A., Nakatochi, M., Akiyama, M., Kamatani, Y., Nishiyama, T., Ito, H., Oze, I., Nishida, Y., Hara, M., Takashima, N., Turin, T. C., Watanabe, M., Suzuki, S., Ibusuki, R., Shimoshikiryo, I., Nakamura, Y., Mikami, H., Ikezaki, H., Furusyo, N., Kuriki, K. & 12 others, Endoh, K., Koyama, T., Matsui, D., Uemura, H., Arisawa, K., Sasakabe, T., Okada, R., Kawai, S., Naito, M., Momozawa, Y., Kubo, M. & Wakai, K., 01-06-2018, In : American Journal of Nephrology. 47, 5, p. 304-316 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients

on behalf of the MATURA, and PAMERA & Consortia, 01-07-2018, In : Pharmacogenomics Journal. 18, 4, p. 528-538 11 p.

Research output: Contribution to journalReview article

19 Citations (Scopus)

Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration

Akiyama, M., Takahashi, A., Momozawa, Y., Arakawa, S., Miya, F., Tsunoda, T., Ashikawa, K., Oshima, Y., Yasuda, M., Yoshida, S., Enaida, H., Tan, X., Yanagi, Y., Yasukawa, T., Ogura, Y., Nagai, Y., Takahashi, K., Fujisawa, K., Inoue, M., Arakawa, A. & 6 others, Tanaka, K., Yuzawa, M., Kadonosono, K., Sonoda, K. H., Ishibashi, T. & Kubo, M., 01-10-2018, In : Journal of Human Genetics. 63, 10, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

Wardell, C. P., Fujita, M., Yamada, T., Simbolo, M., Fassan, M., Karlic, R., Polak, P., Kim, J., Hatanaka, Y., Maejima, K., Lawlor, R. T., Nakanishi, Y., Mitsuhashi, T., Fujimoto, A., Furuta, M., Ruzzenente, A., Conci, S., Oosawa, A., Sasaki-Oku, A., Nakano, K. & 18 others, Tanaka, H., Yamamoto, Y., Michiaki, K., Kawakami, Y., Aikata, H., Ueno, M., Hayami, S., Gotoh, K., Ariizumi, S. I., Yamamoto, M., Yamaue, H., Chayama, K., Miyano, S., Getz, G., Scarpa, A., Hirano, S., Nakamura, T. & Nakagawa, H., 05-2018, In : Journal of Hepatology. 68, 5, p. 959-969 11 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab

Ingle, J. N., Kalari, K. R., Wickerham, D. L., Von Minckwitz, G., Fasching, P. A., Furukawa, Y., Mushiroda, T., Goetz, M. P., Barman, P., Carlson, E. E., Rastogi, P., Costantino, J. P., Cairns, J., Paik, S., Bear, H. D., Kubo, M., Wang, L., Wolmark, N. & Weinshilboum, R. M., 2018, In : Pharmacogenetics and genomics. 28, 6, p. 147-152 6 p.

Research output: Contribution to journalArticle

Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls

Momozawa, Y., Iwasaki, Y., Parsons, M. T., Kamatani, Y., Takahashi, A., Tamura, C., Katagiri, T., Yoshida, T., Nakamura, S., Sugano, K., Miki, Y., Hirata, M., Matsuda, K., Spurdle, A. B. & Kubo, M., 01-12-2018, In : Nature communications. 9, 1, 4083.

Research output: Contribution to journalArticle

22 Citations (Scopus)

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

MEGASTROKE Consortium, 01-12-2018, In : Nature communications. 9, 1, 5141.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12

Tanikawa, C., Kamatani, Y., Takahashi, A., Momozawa, Y., Leveque, K., Nagayama, S., Mimori, K., Mori, M., Ishii, H., Inazawa, J., Yasuda, J., Tsuboi, A., Shimizu, A., Sasaki, M., Yamaji, T., Sawada, N., Iwasaki, M., Tsugane, S., Naito, M., Wakai, K. & 7 others, Koyama, T., Takezaki, T., Yuji, K., Murakami, Y., Nakamura, Y., Kubo, M. & Matsuda, K., 03-05-2018, In : Carcinogenesis. 39, 5, p. 652-660 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

HER2 heterogeneity is associated with poor survival in HER2-positive breast cancer

Hosonaga, M., Arima, Y., Sampetrean, O., Komura, D., Koya, I., Sasaki, T., Sato, E., Okano, H., Kudoh, J., Ishikawa, S., Saya, H. & Ishikawa, T., 08-2018, In : International journal of molecular sciences. 19, 8, 2158.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

The International IBD Genetics Consortium, 01-12-2018, In : Nature communications. 9, 1, 2427.

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)

Identification and characterization of UDP-mannose in human cell lines and mouse organs: Differential distribution across brain regions and organs

Nakajima, K., Kizuka, Y., Yamaguchi, Y., Hirabayashi, Y., Takahashi, K., Yuzawa, Y. & Taniguchi, N., 01-01-2018, In : Biochemical and Biophysical Research Communications. 495, 1, p. 401-407 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Identification of a genomic region between SLC29A1 and HsP90AB1 associated with risk of bevacizumab-induced hypertension: CALGB 80405 (Alliance)

Li, M., Mulkey, F., Jiang, C., O'Neil, B. H., Schneider, B. P., Shen, F., Friedman, P. N., Momozawa, Y., Kubo, M., Niedzwiecki, D., Hochster, H. S., Lenz, H. J., Atkins, J. N., Rugo, H. S., Halabi, S., Kelly, W. K., McLeod, H. L., Innocenti, F., Ratain, M. J., Venook, A. P. & 2 others, Owzar, K. & Kroetz, D. L., 01-10-2018, In : Clinical Cancer Research. 24, 19, p. 4734-4744 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Identification of miRNAs in cervical mucus as a novel diagnostic marker for cervical neoplasia

Kawai, S., Fujii, T., Kukimoto, I., Yamada, H., Yamamoto, N., Kuroda, M., Otani, S., Ichikawa, R., Nishio, E., Torii, Y. & Iwata, A., 01-12-2018, In : Scientific reports. 8, 1, 7070.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Yamada, S., Itoh, N., Nagai, T., Nakai, T., Ibi, D., Nakajima, A., Nabeshima, T. & Yamada, K., 22-10-2018, In : Journal of Neuroinflammation. 15, 1, 295.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer’s disease

Yamaguchi-Kabata, Y., Morihara, T., Ohara, T., Ninomiya, T., Takahashi, A., Akatsu, H., Hashizume, Y., Hayashi, N., Shigemizu, D., Boroevich, K. A., Ikeda, M., Kubo, M., Takeda, M. & Tsunoda, T., 01-07-2018, In : Human Genetics. 137, 6-7, p. 521-533 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

The International Genomics of Blood Pressure (iGEN-BP) Consortium, 01-12-2018, In : Nature communications. 9, 1, 5052.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Isolation of human monoclonal antibodies that bind to two different antigens and are encoded by germline VH and VL genes

Sumitomo-Kondo, M., Ukai, Y., Iba, Y., Ohshima, N., Miura, K., Takasaki, A., Kurosawa, Y. & Kurosawa, G., 05-09-2018, In : Biochemical and Biophysical Research Communications. 503, 2, p. 1141-1147 7 p.

Research output: Contribution to journalArticle

Laminin-332 regulates differentiation of human interfollicular epidermal stem cells

Yamada, T., Hasegawa, S., Miyachi, K., Date, Y., Inoue, Y., Yagami, A., Arima, M., Iwata, Y., Yamamoto, N., Nakata, S., Matsunaga, K., Sugiura, K. & Akamatsu, H., 04-2018, In : Mechanisms of Ageing and Development. 171, p. 37-46 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1 Citation (Scopus)

Mass spectrometry-based approach for development of biomarkers in IgA nephropathy: a pilot trial

Kondo, A., Takahashi, K., Yamaguchi, H., Yoshida, Y., Mizuno, T., Nakajima, K., Hayashi, H., Koide, S., Inaguma, D., Hasegawa, M., Hiki, Y. & Yuzawa, Y., 2018, In : Fujita medical journal. 4, 2, p. 36-41 6 p.

Research output: Contribution to journalArticle

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

Shibao, S., Minami, N., Koike, N., Fukui, N., Yoshida, K., Saya, H. & Sampetrean, O., 19-02-2018, In : Neuro-Oncology. 20, 3, p. 343-354 12 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Metabolic reprogramming by the hexosamine pathway and N-acetylglucosaminyltransferase

Nakajima, K., 01-01-2018, In : Trends in Glycoscience and Glycotechnology. 30, 173, p. E75-E46, J23-J24

Research output: Contribution to journalComment/debate

Modeling phenotypes of malignant gliomas

Sampetrean, O. & Saya, H., 01-2018, In : Cancer science. 109, 1, p. 6-14 9 p.

Research output: Contribution to journalReview article

Open Access
3 Citations (Scopus)

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Fujimori, K., Ishikawa, M., Otomo, A., Atsuta, N., Nakamura, R., Akiyama, T., Hadano, S., Aoki, M., Saya, H., Sobue, G. & Okano, H., 01-10-2018, In : Nature Medicine. 24, 10, p. 1579-1589 11 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglyceriwdes by ALDH2 and ADH1B polymorphisms in Japanese men

Sasakabe, T., Wakai, K., Kawai, S., Hishida, A., Naito, M., Suzuki, S., Nindita, Y., Arisawa, K., Kita, Y., Hara, M., Kuriyama, N., Hirata, A., Mikami, H., Oze, I., Kubo, M., Tanaka, H. & Hamajima, N., 2018, In : Journal of epidemiology. 28, 4, p. 185-193 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Demenais, F., Margaritte-Jeannin, P., Barnes, K. C., Cookson, W. O. C., Altmüller, J., Ang, W., Barr, R. G., Beaty, T. H., Becker, A. B., Beilby, J., Bisgaard, H., Bjornsdottir, U. S., Bleecker, E., Bønnelykke, K., Boomsma, D. I., Bouzigon, E., Brightling, C. E., Brossard, M., Brusselle, G. G., Burchard, E. & 155 others, Burkart, K. M., Bush, A., Chan-Yeung, M., Chung, K. F., Couto Alves, A., Curtin, J. A., Custovic, A., Daley, D., De Jongste, J. C., Del-Rio-Navarro, B. E., Donohue, K. M., Duijts, L., Eng, C., Eriksson, J. G., Farrall, M., Fedorova, Y., Feenstra, B., Ferreira, M. A., Freidin, M. B., Gajdos, Z., Gauderman, J., Gehring, U., Geller, F., Genuneit, J., Gharib, S. A., Gilliland, F., Granell, R., Graves, P. E., Gudbjartsson, D. F., Haahtela, T., Heckbert, S. R., Heederik, D., Heinrich, J., Heliövaara, M., Henderson, J., Himes, B. E., Hirose, H., Hirschhorn, J. N., Hofman, A., Holt, P., Hottenga, J., Hudson, T. J., Hui, J., Imboden, M., Ivanov, V., Jaddoe, V. W. V., James, A., Janson, C., Jarvelin, M. R., Jarvis, D., Jones, G., Jonsdottir, I., Jousilahti, P., Kabesch, M., Kähönen, M., Kantor, D. B., Karunas, A. S., Khusnutdinova, E., Koppelman, G. H., Kozyrskyj, A. L., Kreiner, E., Kubo, M., Kumar, R., Kumar, A., Kuokkanen, M., Lahousse, L., Laitinen, T., Laprise, C., Lathrop, M., Lau, S., Lee, Y. A., Lehtimäki, T., Letort, S., Levin, A. M., Li, G., Liang, L., Loehr, L. R., London, S. J., Loth, D. W., Manichaikul, A., Marenholz, I., Martinez, F. J., Matheson, M. C., Mathias, R. A., Matsumoto, K., Mbarek, H., McArdle, W. L., Melbye, M., Melén, E., Meyers, D., Michel, S., Mohamdi, H., Musk, A. W., Myers, R. A., Nieuwenhuis, M. A. E., Noguchi, E., O'Connor, G. T., Ogorodova, L. M., Palmer, C. D., Palotie, A., Park, J. E., Pennell, C. E., Pershagen, G., Polonikov, A., Postma, D. S., Probst-Hensch, N., Puzyrev, V. P., Raby, B. A., Raitakari, O. T., Ramasamy, A., Rich, S. S., Robertson, C. F., Romieu, I., Salam, M. T., Salomaa, V., Schlünssen, V., Scott, R., Selivanova, P. A., Sigsgaard, T., Simpson, A., Siroux, V., Smith, L. J., Solodilova, M., Standl, M., Stefansson, K., Strachan, D. P., Stricker, B. H., Takahashi, A., Thompson, P. J., Thorleifsson, G., Thorsteinsdottir, U., Tiesler, C. M. T., Torgerson, D. G., Tsunoda, T., Uitterlinden, A. G., Van Der Valk, R. J. P., Vaysse, A., Vedantam, S., Von Berg, A., Von Mutius, E., Vonk, J. M., Waage, J., Wareham, N. J., Weiss, S. T., White, W. B., Wickman, M., Widén, E., Willemsen, G., Williams, L. K., Wouters, I. M., Yang, J. J., Zhao, J. H., Moffatt, M. F., Ober, C. & Nicolae, D. L., 01-01-2018, In : Nature Genetics. 50, 1, p. 42-50 9 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGAST ROKE Consortium, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STA RNET BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC) & METAST ROKE Consortium, 01-04-2018, In : Nature Genetics. 50, 4, p. 524-537 14 p.

Research output: Contribution to journalArticle

183 Citations (Scopus)

Multi-ethnic genome-wide association study for atrial fibrillation

Roselli, C., Chaffin, M. D., Weng, L. C., Aeschbacher, S., Ahlberg, G., Albert, C. M., Almgren, P., Alonso, A., Anderson, C. D., Aragam, K. G., Arking, D. E., Barnard, J., Bartz, T. M., Benjamin, E. J., Bihlmeyer, N. A., Bis, J. C., Bloom, H. L., Boerwinkle, E., Bottinger, E. B., Brody, J. A. & 198 others, Calkins, H., Campbell, A., Cappola, T. P., Carlquist, J., Chasman, D. I., Chen, L. Y., Chen, Y. D. I., Choi, E. K., Choi, S. H., Christophersen, I. E., Chung, M. K., Cole, J. W., Conen, D., Cook, J., Crijns, H. J., Cutler, M. J., Damrauer, S. M., Daniels, B. R., Darbar, D., Delgado, G., Denny, J. C., Dichgans, M., Dörr, M., Dudink, E. A., Dudley, S. C., Esa, N., Esko, T., Eskola, M., Fatkin, D., Felix, S. B., Ford, I., Franco, O. H., Geelhoed, B., Grewal, R. P., Gudnason, V., Guo, X., Gupta, N., Gustafsson, S., Gutmann, R., Hamsten, A., Harris, T. B., Hayward, C., Heckbert, S. R., Hernesniemi, J., Hocking, L. J., Hofman, A., Horimoto, A. R. V. R., Huang, J., Huang, P. L., Huffman, J., Ingelsson, E., Ipek, E. G., Ito, K., Jimenez-Conde, J., Johnson, R., Jukema, J. W., Kääb, S., Kähönen, M., Kamatani, Y., Kane, J. P., Kastrati, A., Kathiresan, S., Katschnig-Winter, P., Kavousi, M., Kessler, T., Kietselaer, B. L., Kirchhof, P., Kleber, M. E., Knight, S., Krieger, J. E., Kubo, M., Launer, L. J., Laurikka, J., Lehtimäki, T., Leineweber, K., Lemaitre, R. N., Li, M., Lim, H. E., Lin, H. J., Lin, H., Lind, L., Lindgren, C. M., Lokki, M. L., London, B., Loos, R. J. F., Low, S. K., Lu, Y., Lyytikäinen, L. P., Macfarlane, P. W., Magnusson, P. K., Mahajan, A., Malik, R., Mansur, A. J., Marcus, G. M., Margolin, L., Margulies, K. B., März, W., McManus, D. D., Melander, O., Mohanty, S., Montgomery, J. A., Morley, M. P., Morris, A. P., Müller-Nurasyid, M., Natale, A., Nazarian, S., Neumann, B., Newton-Cheh, C., Niemeijer, M. N., Nikus, K., Nilsson, P., Noordam, R., Oellers, H., Olesen, M. S., Orho-Melander, M., Padmanabhan, S., Pak, H. N., Paré, G., Pedersen, N. L., Pera, J., Pereira, A., Porteous, D., Psaty, B. M., Pulit, S. L., Pullinger, C. R., Rader, D. J., Refsgaard, L., Ribasés, M., Ridker, P. M., Rienstra, M., Risch, L., Roden, D. M., Rosand, J., Rosenberg, M. A., Rost, N., Rotter, J. I., Saba, S., Sandhu, R. K., Schnabel, R. B., Schramm, K., Schunkert, H., Schurman, C., Scott, S. A., Seppälä, I., Shaffer, C., Shah, S., Shalaby, A. A., Shim, J., Shoemaker, M. B., Siland, J. E., Sinisalo, J., Sinner, M. F., Slowik, A., Smith, A. V., Smith, B. H., Smith, J. G., Smith, J. D., Smith, N. L., Soliman, E. Z., Sotoodehnia, N., Stricker, B. H., Sun, A., Sun, H., Svendsen, J. H., Tanaka, T., Tanriverdi, K., Taylor, K. D., Teder-Laving, M., Teumer, A., Thériault, S., Trompet, S., Tucker, N. R., Tveit, A., Uitterlinden, A. G., Van Der Harst, P., Van Gelder, I. C., Van Wagoner, D. R., Verweij, N., Vlachopoulou, E., Völker, U., Wang, B., Weeke, P. E., Weijs, B., Weiss, R., Weiss, S., Wells, Q. S., Wiggins, K. L., Wong, J. A., Woo, D., Worrall, B. B., Yang, P. S., Yao, J., Yoneda, Z. T., Zeller, T., Zeng, L., Lubitz, S. A., Lunetta, K. L. & Ellinor, P. T., 01-09-2018, In : Nature Genetics. 50, 9, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Feitosa, M. F., Kraja, A. T., Chasman, D. I., Sung, Y. J., Winkler, T. W., Ntalla, I., Guo, X., Franceschini, N., Cheng, C. Y., Sim, X., Vojinovic, D., Marten, J., Musani, S. K., Li, C., Bentley, A. R., Brown, M. R., Schwander, K., Richard, M. A., Noordam, R., Aschard, H. & 252 others, Bartz, T. M., Bielak, L. F., Dorajoo, R., Fisher, V., Hartwig, F. P., Horimoto, A. R. V. R., Lohman, K. K., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Wojczynski, M. K., Alver, M., Boissel, M., Cai, Q., Campbell, A., Chai, J. F., Chen, X., Divers, J., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., He, M., Hsu, F. C., Jackson, A. U., Kähönen, M., Kasturiratne, A., Komulainen, P., Kühnel, B., Laguzzi, F., Luan, JA., Matoba, N., Nolte, I. M., Padmanabhan, S., Riaz, M., Rueedi, R., Robino, A., Said, M. A., Scott, R. A., Sofer, T., Stančáková, A., Takeuchi, F., Tayo, B. O., Van Der Most, P. J., Varga, T. V., Vitart, V., Wang, Y., Ware, E. B., Warren, H. R., Weiss, S., Wen, W., Yanek, L. R., Zhang, W., Zhao, J. H., Afaq, S., Amin, N., Amini, M., Arking, D. E., Aung, T., Boerwinkle, E., Borecki, I., Broeckel, U., Brown, M., Brumat, M., Burke, G. L., Canouil, M., Chakravarti, A., Charumathi, S., Chen, Y. D. I., Connell, J. M., Correa, A., De Las Fuentes, L., De Mutsert, R., De Silva, H. J., Deng, X., Ding, J., Duan, Q., Eaton, C. B., Ehret, G., Eppinga, R. N., Evangelou, E., Faul, J. D., Felix, S. B., Forouhi, N. G., Forrester, T., Franco, O. H., Friedlander, Y., Gandin, I., Gao, H., Ghanbari, M., Gigante, B., Gu, C. C., Gu, D., Hagenaars, S. P., Hallmans, G., Harris, T. B., He, J., Heikkinen, S., Heng, C. K., Hirata, M., Howard, B. V., Ikram, M. A., John, U., Katsuya, T., Khor, C. C., Kilpeläinen, T. O., Koh, W. P., Krieger, J. E., Kritchevsky, S. B., Kubo, M., Kuusisto, J., Lakka, T. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lehne, B., Lewis, C. E., Li, Y., Lin, S., Liu, J., Liu, J., Loh, M., Louie, T., Mägi, R., McKenzie, C. A., Meitinger, T., Metspalu, A., Milaneschi, Y., Milani, L., Mohlke, K. L., Momozawa, Y., Nalls, M. A., Nelson, C. P., Sotoodehnia, N., Norris, J. M., O'Connell, J. R., Palmer, N. D., Perls, T., Pedersen, N. L., Peters, A., Peyser, P. A., Poulter, N., Raffel, L. J., Raitakari, O. T., Roll, K., Rose, L. M., Rosendaal, F. R., Rotter, J. I., Schmidt, C. O., Schreiner, P. J., Schupf, N., Scott, W. R., Sever, P. S., Shi, Y., Sidney, S., Sims, M., Sitlani, C. M., Smith, J. A., Snieder, H., Starr, J. M., Strauch, K., Stringham, H. M., Tan, N. Y. Q., Tang, H., Taylor, K. D., Teo, Y. Y., Tham, Y. C., Turner, S. T., Uitterlinden, A. G., Vollenweider, P., Waldenberger, M., Wang, L., Wang, Y. X., Wei, W. B., Williams, C., Yao, J., Yu, C., Yuan, J. M., Zhao, W., Zonderman, A. B., Becker, D. M., Boehnke, M., Bowden, D. W., Chambers, J. C., Deary, I. J., Esko, T., Farrall, M., Franks, P. W., Freedman, B. I., Froguel, P., Gasparini, P., Gieger, C., Jonas, J. B., Kamatani, Y., Kato, N., Kooner, J. S., Kutalik, Z., Laakso, M., Laurie, C. C., Leander, K., Lehtimäki, T., Magnusson, P. K. E., Oldehinkel, A. J., Penninx, B. W. J. H., Polasek, O., Porteous, D. J., Rauramaa, R., Samani, N. J., Scott, J., Shu, X. O., Van Der Harst, P., Wagenknecht, L. E., Wareham, N. J., Watkins, H., Weir, D. R., Wickremasinghe, A. R., Wu, T., Zheng, W., Bouchard, C., Christensen, K., Evans, M. K., Gudnason, V., Horta, B. L., Kardia, S. L. R., Liu, Y., Pereira, A. C., Psaty, B. M., Ridker, P. M., Van Dam, R. M., Gauderman, W. J., Zhu, X., Mook-Kanamori, D. O., Fornage, M., Rotimi, C. N., Cupples, L. A., Kelly, T. N., Fox, E. R., Hayward, C., Van Duijn, C. M., Tai, E. S., Wong, T. Y., Kooperberg, C., Palmas, W., Rice, K., Morrison, A. C., Elliott, P., Caulfield, M. J., Munroe, P. B., Rao, D. C., Province, M. A. & Levy, D., 06-2018, In : PloS one. 13, 6, e0198166.

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13 Citations (Scopus)

Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma

Semba, T., Sugihara, E., Kamoshita, N., Ueno, S., Fukuda, K., Yoshino, M., Takao, K., Yoshikawa, K., Izuhara, K., Arima, Y., Suzuki, M. & Saya, H., 05-2018, In : Cancer science. 109, 5, p. 1447-1454 8 p.

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4 Citations (Scopus)

Preparation of induced pluripotent stem cells using human peripheral blood monocytes

Isogai, S., Yamamoto, N., Hiramatsu, N., Goto, Y., Hayashi, M., Kondo, M. & Imaizumi, K., 12-2018, In : Cellular Reprogramming. 20, 6, p. 347-355 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Protein-altering variants of PTPN2 in childhood-onset Type 1A diabetes

The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, 03-2018, In : Diabetic Medicine. 35, 3, p. 376-380 5 p.

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1 Citation (Scopus)

Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc1Δ2-3/Δ2-3 mice

Wulaer, B., Nagai, T., Sobue, A., Itoh, N., Kuroda, K., Kaibuchi, K., Nabeshima, T. & Yamada, K., 11-2018, In : Genes, Brain and Behavior. 17, 8, e12478.

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3 Citations (Scopus)

Ritanserin, a serotonin-2 receptor antagonist, inhibits functional recovery after cerebral infarction

Mizutani, K., Sonoda, S. & Wakita, H., 03-01-2018, In : Neuroreport. 29, 1, p. 54-58 5 p.

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1 Citation (Scopus)

Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis

Kochi, Y., Kamatani, Y., Kondo, Y., Suzuki, A., Kawakami, E., Hiwa, R., Momozawa, Y., Fujimoto, M., Jinnin, M., Tanaka, Y., Kanda, T., Cooper, R. G., Chinoy, H., Rothwell, S., Lamb, J. A., Vencovský, J., Mann, H., Ohmura, K., Myouzen, K., Ishigaki, K. & 28 others, Nakashima, R., Hosono, Y., Tsuboi, H., Kawasumi, H., Iwasaki, Y., Kajiyama, H., Horita, T., Ogawa-Momohara, M., Takamura, A., Tsunoda, S., Shimizu, J., Fujio, K., Amano, H., Mimori, A., Kawakami, A., Umehara, H., Takeuchi, T., Sano, H., Muro, Y., Atsumi, T., Mimura, T., Kawaguchi, Y., Mimori, T., Takahashi, A., Kubo, M., Kohsaka, H., Sumida, T. & Yamamoto, K., 04-2018, In : Annals of the Rheumatic Diseases. 77, 4, p. 602-611 10 p.

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11 Citations (Scopus)

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

Okazaki, S., Shintani, S., Hirata, Y., Suina, K., Semba, T., Yamasaki, J., Umene, K., Ishikawa, M., Saya, H. & Nagano, O., 01-09-2018, In : Oncotarget. 9, 73, p. 33832-33843 12 p.

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Open Access
13 Citations (Scopus)

TCL1A, a novel transcription factor and a coregulator of nuclear factor kB p65: Single nucleotide polymorphism and estrogen dependences

Ho, M. F., Lummertz da Rocha, E., Zhang, C., Ingle, J. N., Goss, P. E., Shepherd, L. E., Kubo, M., Wang, L., Li, H. & Weinshilboum, R. M., 06-2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 700-710 11 p.

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2 Citations (Scopus)

The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma

Dahlin, A., Qiu, W., Litonjua, A. A., Lima, J. J., Tamari, M., Kubo, M., Irvin, C. G., Peters, S. P., Wu, A. C., Weiss, S. T. & Tantisira, K. G., 01-09-2018, In : Pharmacogenomics Journal. 18, 5, p. 665-677 13 p.

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2 Citations (Scopus)

Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Saya, H., Kawakami, Y. & Tsubota, K., 10-2018, In : PloS one. 13, 10, e0203742.

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Open Access
2 Citations (Scopus)

The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles

Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., Odaka, H., Numakawa, T., Kunugi, H., Ochiya, T. & Tamai, Y., 01-2018, In : DMM Disease Models and Mechanisms. 11, 1, dmm028779.

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Open Access
7 Citations (Scopus)

The Vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation

Innocenti, F., Owzar, K., Jiang, C., Etheridge, A. S., Gordân, R., Sibley, A. B., Mulkey, F., Niedzwiecki, D., Glubb, D., Neel, N., Talamonti, M. S., Bentrem, D. J., Seiser, E., Yeh, J. J., Van Loon, K., McLeod, H., Ratain, M. J., Kindler, H. L., Venook, A. P., Nakamura, Y. & 4 others, Kubo, M., Petersen, G. M., Bamlet, W. R. & McWilliams, R. R., 08-2018, In : PloS one. 13, 8, e0202272.

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4 Citations (Scopus)

Three types of broadly reacting antibodies against influenza B viruses induced by vaccination with seasonal influenza viruses

Hirano, D., Ohshima, N., Kubota-Koketsu, R., Yamasaki, A., Kurosawa, G., Okuno, Y., Yoshida, S. & Kurosawa, Y., 2018, In : Journal of Immunology Research. 2018, 7251793.

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5 Citations (Scopus)

Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells

Harigai, R., Sakai, S., Nobusue, H., Hirose, C., Sampetrean, O., Minami, N., Hata, Y., Kasama, T., Hirose, T., Takenouchi, T., Kosaki, K., Kishi, K., Saya, H. & Arima, Y., 01-12-2018, In : Scientific reports. 8, 1, 6069.

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5 Citations (Scopus)

Trends in clinical trials for articular cartilage repair by cell therapy

Negoro, T., Takagaki, Y., Okura, H. & Matsuyama, A., 01-12-2018, In : npj Regenerative Medicine. 3, 1, 17.

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Open Access
20 Citations (Scopus)

Trends of clinical trials for drug development in rare diseases

Sakate, R., Fukagawa, A., Takagaki, Y., Okura, H. & Matsuyama, A., 2018, In : Current Clinical Pharmacology. 13, 3, p. 199-208 10 p.

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1 Citation (Scopus)

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

Tabata, Y., Imaizumi, Y., Sugawara, M., Andoh-Noda, T., Banno, S., Chai, M. C., Sone, T., Yamazaki, K., Ito, M., Tsukahara, K., Saya, H., Hattori, N., Kohyama, J. & Okano, H., 13-11-2018, In : Stem Cell Reports. 11, 5, p. 1171-1184 14 p.

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20 Citations (Scopus)

UBL3 modification influences protein sorting to small extracellular vesicles

Ageta, H., Ageta-Ishihara, N., Hitachi, K., Karayel, O., Onouchi, T., Yamaguchi, H., Kahyo, T., Hatanaka, K., Ikegami, K., Yoshioka, Y., Nakamura, K., Kosaka, N., Nakatani, M., Uezumi, A., Ide, T., Tsutsumi, Y., Sugimura, H., Kinoshita, M., Ochiya, T., Mann, M. & 2 others, Setou, M. & Tsuchida, K., 01-12-2018, In : Nature communications. 9, 1, 3936.

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16 Citations (Scopus)