• 1022 Citations
  • 15 h-Index
1986 …2017

Research output per year

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Research Output

  • 1022 Citations
  • 15 h-Index
  • 35 Article
  • 2 Chapter
  • 1 Review article
2017

Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia

Sumi-Ichinose, C., Suganuma, Y., Kano, T., Ihira, N., Nomura, H., Ikemoto, K., Hata, T., Katoh, S., Ichinose, H. & Kondo, K., 01-03-2017, In : Physiological Reports. 5, 6, e13196.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014

Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse

Xu, F., Sudo, Y., Sanechika, S., Yamashita, J., Shimaguchi, S., Honda, S. I., Sumi-Ichinose, C., Mori-Kojima, M., Nakata, R., Furuta, T., Sakurai, M., Sugimoto, M., Soga, T., Kondo, K. & Ichinose, H., 03-11-2014, In : FEBS Letters. 588, 21, p. 3924-3931 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia

Onouchi, T., Kobayashi, K., Sakai, K., Shimomura, A., Smits, R., Sumi-Ichinose, C., Kurosumi, M., Takao, K., Nomura, R., Iizuka-Kogo, A., Suzuki, H., Kondo, K., Akiyama, T., Miyakawa, T., Fodde, R. & Senda, T., 29-03-2014, In : Molecular brain. 7, 1, 21.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2013

GTP cyclohydrolase regulation. Implications for brain development and function.

Ichinose, H., Homma, D., Sumi-Ichinose, C., Nomura, T. & Kondo, K., 2013, Advances in Pharmacology. Academic Press Inc., p. 23-35 13 p. (Advances in Pharmacology; vol. 68).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)
2012

Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy

Yagi, H., Sanechika, S., Ichinose, H., Sumi-Ichinose, C., Mizukami, H., Urabe, M., Ozawa, K. & Kume, A., 04-01-2012, In : NeuroReport. 23, 1, p. 30-34 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2011

Cilostazol inhibits cytokine-induced tetrahydrobiopterin biosynthesis in human umbilical vein endothelial cells.

Shiraishi, H., Ikemoto, K., Tada, S., Udagawa, Y., Ohtsuki, M., Sumi-Ichinose, C., Kondo, K. & Nomura, T., 27-04-2011, In : Journal of atherosclerosis and thrombosis. 18, 4, p. 312-317 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection

Tokuoka, H., Muramatsu, S. I., Sumi-Ichinose, C., Sakane, H., Kojima, M., Aso, Y., Nomura, T., Metzger, D. & Ichinose, H., 16-12-2011, In : Journal of Biological Chemistry. 286, 50, p. 43549-43558 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain

Homma, D., Sumi-Ichinose, C., Tokuoka, H., Ikemoto, K., Nomura, T., Kondo, K., Katoh, S. & Ichinose, H., 14-01-2011, In : Journal of Biological Chemistry. 286, 2, p. 1445-1452 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2010
9 Citations (Scopus)
2009

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons

Kadkhodaei, B., Ito, T., Joodmardi, E., Mattsson, B., Rouillard, C., Carta, M., Muramatsu, S. I., Sumi-Ichinose, C., Nomura, T., Metzger, D., Chambon, P., Lindqvist, E., Larsson, N. G., Olson, L., Björklund, A., Ichinose, H. & Perlmann, T., 16-12-2009, In : Journal of Neuroscience. 29, 50, p. 15923-15932 10 p.

Research output: Contribution to journalArticle

215 Citations (Scopus)
2008

2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH4-independent manner

Ikemoto, K., Matsumoto, T., Ohtsuki, M., Itoh, M., Tada, S., Udagawa, Y., Sumi-Ichinose, C., Kondo, K. & Nomura, T., 01-07-2008, In : Biochimica et Biophysica Acta - General Subjects. 1780, 7-8, p. 960-965 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice-as a mouse model for Parkinson's disease

Takazawa, C., Fujimoto, K., Homma, D., Sumi-Ichinose, C., Nomura, T., Ichinose, H. & Katoh, S., 21-03-2008, In : Biochemical and Biophysical Research Communications. 367, 4, p. 787-792 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia

Sato, K., Sumi-Ichinose, C., Kaji, R., Ikemoto, K., Nomura, T., Nagatsu, I., Ichinose, H., Ito, M., Sako, W., Nagahiro, S., Graybiel, A. M. & Goto, S., 26-08-2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 34, p. 12551-12556 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Increased expression of tyrosine hydroxylase and anomalous neurites in catecholaminergic neurons of ATF-2 null mice

Kojima, M., Suzuki, T., Maekawa, T., Ishii, S., Sumi-Ichinose, C., Nomura, T. & Ichinose, H., 15-02-2008, In : Journal of Neuroscience Research. 86, 3, p. 544-552 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Metabolism of tetrahydrobiopterin: Its relevance in monoaminergic neurons and neurological disorders

Ichinose, H., Nomura, T. & Ichinose, C., 01-12-2008, In : Chemical Record. 8, 6, p. 378-385 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2005

Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities

Ichinose, C., Urano, F., Shimomura, A., Sato, T., Ikemoto, K., Shiraishi, H., Senda, T., Ichinose, H. & Nomura, T., 14-11-2005, In : Journal of Neurochemistry. 95, 3, p. 703-714 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2003

cGMP inhibits GTP cyclohydrolase I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells

Shiraishi, H., Kato, T., Atsuta, K., Sumi-Ichinose, C., Ohtsuki, M., Itoh, M., Hishida, H., Tada, S., Udagawa, Y., Nagatsu, T., Hagino, Y., Ichinose, H. & Nomura, T., 01-11-2003, In : Journal of Pharmacological Sciences. 93, 3, p. 265-271 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Dopa-Responsive Dystonia

Ichinose, H., Nagatsu, T., Ichinose, C. & Nomura, T., 01-01-2003, Genetics of Movement Disorders. Elsevier Inc., p. 419-428 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
2002

cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells

Ohtsuki, M., Shiraishi, H., Kato, T., Kuroda, R., Tazawa, M., Sumi-Ichinose, C., Tada, S., Udagawa, Y., Itoh, M., Hishida, H., Ichinose, H., Nagatsu, T., Hagino, Y. & Nomura, T., 22-03-2002, In : Life Sciences. 70, 18, p. 2187-2198 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Regulations and pathophysiological significance of the biosynthesis of tetrahydrobiopterin in human endothelial cells

Shiraishi, H., Ohtsuki, M., Sumi-Ichinose, C. & Nomura, T., 17-12-2002, In : Folia Pharmacologica Japonica. 120, SUPPL. 1, p. 73P-75P

Research output: Contribution to journalArticle

2001

Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice

Sumi-Ichinose, C., Urano, F., Kuroda, R., Ohye, T., Kojima, M., Tazawa, M., Shiraishi, H., Hagino, Y., Nagatsu, T., Nomura, T. & Ichinose, H., 02-11-2001, In : Journal of Biological Chemistry. 276, 44, p. 41150-41160 11 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)

Perspectives on tetrahydrobiopterin research

Ichinose, C., Ohtsuki, M., Shiraishi, H. & Nomura, T., 29-12-2001, In : Folia Pharmacologica Japonica. 118, 6, p. 371-377 7 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2000

Effects of sulfhydryl reagents on nitric oxide release from a nitric oxide donor NOR 3 in the presence of rat hepatocytes

Nomura, H., Tazawa, M., Kuroda, R., Shiraishi, H., Sumi-Ichinose, C., Matsui, S., Ohtsuki, M., Hagino, Y. & Nomura, T., 01-11-2000, In : Pharmacology and Toxicology. 87, 5, p. 246-248 3 p.

Research output: Contribution to journalArticle

GTP cyclohydrolase I from Tetrahymena pyriformis: Cloning of cDNA and expression

Tazawa, M., Ohtsuki, M., Sumi-Ichinose, C., Shiraishi, H., Kuroda, R., Hagino, Y., Nakashima, S., Nozawa, Y., Ichinose, H., Nagatsu, T. & Nomura, T., 01-09-2000, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 127, 1, p. 65-73 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1999

Molecular cloning of the human Nurr1 gene: Characterization of the human gene and cDNAs

Ichinose, H., Ohye, T., Suzuki, T., Sumi-Ichinose, C., Nomura, T., Hagino, Y. & Nagatsu, T., 16-04-1999, In : Gene. 230, 2, p. 233-239 7 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
1998

Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis. Presence of GTP cyclohydrolase I

Nomura, T., Tazawa, M., Ohtsuki, M., Sumi-Ichinose, C., Hagino, Y., Ota, A., Nakashima, A., Mori, K., Sugimoto, T., Ueno, O., Nozawa, Y., Ichinose, H. & Nagatsu, T., 01-01-1998, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 120, 4, p. 753-760 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Nitric oxide donor NOR 3 inhibits ketogenesis from oleate in isolated rat hepatocytes by a cyclic GMP-independent mechanism

Nomura, T., Ohtsuki, M., Matsui, S., Sumi-Ichinose, C., Nomura, H. & Hagino, Y., 01-01-1998, In : Pharmacology and Toxicology. 82, 1, p. 40-46 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
1997

SNF2β-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells

Sumi-Ichinose, C., Ichinose, H., Metzger, D. & Chambon, P., 01-10-1997, In : Molecular and Cellular Biology. 17, 10, p. 5976-5986 11 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)
1996

Analysis of an alternative promoter that regulates tissue-specific expression of the human aromatic L-amino acid decarboxylase gene in cultured cell lines

Sumi-Ichinose, C., Hasegawa, S., Ohtsuki, M., Nomura, H., Nomura, T., Hagino, Y., Fujita, K. & Nagatsu, T., 01-01-1996, In : Journal of Neural Transmission. 103, 1-2, p. 1-15 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
1995

Analysis of the Alternative Promoters that Regulate Tissue‐Specific Expression of Human Aromatic l‐Amino Acid Decarboxylase

Ichinose, C., Hasegawa, S., Ichinose, H., Sawada, H., Kobayashi, K., Sakai, M., Fujii, T., Nomura, H., Nomura, T., Nagatsu, I., Hagino, Y., Fujita, K. & Nagatsu, T., 01-01-1995, In : Journal of Neurochemistry. 64, 2, p. 514-524 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

Nomura, T., Ohtsuki, M., Matsui, S., Ichinose, C., Nomura, H., Hagino, Y., Iwase, K., Ichinose, H., Fujita, K. & Nagatsu, T., 01-02-1995, In : Journal of Neural Transmission. 101, 1-3, p. 237-242 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Metabolic Effects of Glibenclamide in Isolated Rat Hepatocytes in the Absence of Extracellular Ca2+

Nomura, T., Ohtsuki, M., Watanabe, T., Hasegawa, S., Matsui, S., Tomita, A., Sumi-Ichinose, C., Nomura, H. & Hagino, Y., 01-01-1995, In : The Japanese Journal of Pharmacology. 69, 2, p. 173-176 4 p.

Research output: Contribution to journalArticle

1993

Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase 1

Nomura, T., Ichinose, H., Sumi-Ichinose, C., Nomura, H., Hagino, Y., Fujita, K. & Nagatsu, T., 15-03-1993, In : Biochemical and Biophysical Research Communications. 191, 2, p. 523-527 5 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

α1B-Adrenoceptor-mediated stimulation of Ca2+ mobilization and cAMP accumulation in isolated rat hepatocytes

Nomura, T., Kondo, H., Hasegawa, S., Watanabe, T., Yokoyama, R., Ukai, K., Tachibana, M., Sumi-Ichinose, C., Nomura, H. & Hagino, Y., 15-07-1993, In : European Journal of Pharmacology: Molecular Pharmacology. 246, 2, p. 113-120 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1992

Molecular Cloning of Genomic DNA and Chromosomal Assignment of the Gene for Human Aromatic L-Amino Acid Decarboxylase, the Enzyme for Catecholamine and Serotonin Biosynthesis

Sumi-Ichinose, C., Ichinose, H., Nagatsu, T., Takahashi, E. I. & Hon, T. A., 01-02-1992, In : Biochemistry. 31, 8, p. 2229-2238 10 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Tissue-Specific Alternative Splicing of the First Exon Generates Two Types of mRNAs in Human Aromatic L-Amino Acid Decarboxylase

Ichinose, H., Ohye, T., Fujita, K., Nagatsu, T., Sumi-Ichinose, C. & Hagino, Y., 01-02-1992, In : Biochemistry. 31, 46, p. 11546-11550 5 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
1990

Characterization of Recombinant Human Aromatic l‐Amino Acid Decarboxylase Expressed in COS Cells

Sumi, C., Ichinose, H. & Nagatsu, T., 09-1990, In : Journal of neurochemistry. 55, 3, p. 1075-1078 4 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
1986

The presence of catechol-o-methyltransferase activity in separately cultured cerebromicrovascular endothelial and smooth muscle cells

Spatz, M., Kaneda, N., Sumi, C., Nagatsu, I., Creveling, C. R. & Nagatsu, T., 03-09-1986, In : Brain Research. 381, 2, p. 363-367 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)