• 2814 Citations
  • 30 h-Index
1992 …2020

Research output per year

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Research Output

  • 2814 Citations
  • 30 h-Index
  • 62 Article
  • 2 Comment/debate
  • 2 Letter
  • 1 Review article
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Article
2020

Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome

Matsuyama, H., Shindo, A., Shimada, T., Yata, K., Wakita, H., Takahashi, R. & Tomimoto, H., 01-06-2020, In : Brain Research. 1736, 146779.

Research output: Contribution to journalArticle

Selective accumulation of adiponectin in the cerebral cortex under chronic cerebral hypoperfusion in the rat

Takahashi, Y., Wakita, H., Mizutani, K., Watanabe, A., Sonoda, S. & Tomimoto, H., 27-01-2020, In : Neuroreport. 31, 2, p. 148-155 8 p.

Research output: Contribution to journalArticle

2019

Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice

Shimada, T., Shindo, A., Matsuyama, H., Yata, K., Niwa, A., Sasaki, R., Ayaki, T., Maki, T., Wakita, H. & Tomimoto, H., 21-06-2019, In : Neuroscience Letters. 704, p. 133-140 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Ritanserin, a serotonin-2 receptor antagonist, inhibits functional recovery after cerebral infarction

Mizutani, K., Sonoda, S. & Wakita, H., 03-01-2018, In : Neuroreport. 29, 1, p. 54-58 5 p.

Research output: Contribution to journalArticle

2016

Effects of exercise and bryostatin-1 on serotonin dynamics after cerebral infarction

Mizutani, K., Sonoda, S., Wakita, H., Okazaki, H., Katoh, Y., Chihara, T. & Shimpo, K., 15-06-2016, In : NeuroReport. 27, 9, p. 659-664 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning

Miyake, S. I., Wakita, H., Bernstock, J. D., Castri, P., Ruetzler, C., Miyake, J., Lee, Y. J. & Hallenbeck, J. M., 01-12-2015, In : Journal of neurochemistry. 135, 5, p. 943-957 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
9 Citations (Scopus)
2014

Functional recovery and alterations in the expression and localization of protein kinase C following voluntary exercise in rat with cerebral infarction

Mizutani, K., Sonoda, S., Wakita, H., Katoh, Y. & Shimpo, K., 01-01-2014, In : Neurological Sciences. 35, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Stem cells from human exfoliated deciduous teeth enhance recovery from focal cerebral ischemia in rats

Sugiyama, M., Hattori, H., Inoue, T., Wakita, H., Hibi, H. & Ueda, M., 01-10-2014, In : Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 26, 4, p. 443-449 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2013

Stem cells from human exfoliated deciduous tooth-derived conditioned medium enhance recovery of focal cerebral ischemia in rats

Inoue, T., Sugiyama, M., Hattori, H., Wakita, H., Wakabayashi, T. & Ueda, M., 01-01-2013, In : Tissue Engineering - Part A. 19, 1-2, p. 24-29 6 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)
2011

Dental pulp-derived CD31-/CD146- side population stem/progenitor cells enhance recovery of focal cerebral ischemia in rats

Sugiyama, M., Iohara, K., Wakita, H., Hattori, H., Ueda, M., Matsushita, K. & Nakashima, M., 01-05-2011, In : Tissue Engineering - Part A. 17, 9-10, p. 1303-1311 9 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Watershed infarcts in a multiple microembolic model of monkey

Maki, T., Wakita, H., Mase, M., Itagaki, I., Saito, N., Ono, F., Adachi, K., Ito, H., Takahashi, R., Ihara, M. & Tomimoto, H., 20-07-2011, In : Neuroscience Letters. 499, 2, p. 80-83 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2010

E-selectin targeting to visualize tumors in vivo

Hirai, M., Hiramatsu, Y., Iwashita, S., Otani, T., Chen, L., Li, Y. G., Okada, M., Oie, K., Igarashi, K., Wakita, H. & Seno, M., 01-03-2010, In : Contrast Media and Molecular Imaging. 5, 2, p. 70-77 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function

Minagawa, H., Watanabe, A., Akatsu, H., Adachi, K., Ohtsuka, C., Terayama, Y., Hosono, T., Takahashi, S., Wakita, H., Jung, C. G., Komano, H. & Michikawa, M., 03-12-2010, In : Journal of Biological Chemistry. 285, 49, p. 38382-38388 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3

Takahashi, K., Adachi, K., Kunimoto, S., Wakita, H., Takeda, K. & Watanabe, A., 05-11-2010, In : Biochemical and Biophysical Research Communications. 402, 1, p. 54-58 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2008

A novel stem cell source for vasculogenesis in ischemia: Subfraction of side population cells from dental pulp

Iohara, K., Zheng, L., Wake, H., Ito, M., Nabekura, J., Wakita, H., Nakamura, H., Into, T., Matsushita, K. & Nakashima, M., 01-09-2008, In : Stem Cells. 26, 9, p. 2408-2418 11 p.

Research output: Contribution to journalArticle

168 Citations (Scopus)

Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice

Yoshizaki, K., Adachi, K., Kataoka, S., Watanabe, A., Tabira, T., Takahashi, K. & Wakita, H., 01-04-2008, In : Experimental Neurology. 210, 2, p. 585-591 7 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Conditional expression of microRNA against E-selectin inhibits leukocyte-endothelial adhesive interaction under inflammatory condition

Yoshizaki, K., Wakita, H., Takeda, K. & Takahashi, K., 11-07-2008, In : Biochemical and Biophysical Research Communications. 371, 4, p. 747-751 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model

Wakita, H., Ruetzler, C., Illoh, K. O., Chen, Y., Takanohashi, A., Spatz, M. & Hallenbeck, J. M., 01-02-2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 2, p. 341-353 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2007

Expression of S100 protein and protective effect of arundic acid on the rat brain in chronic cerebral hypoperfusion

Ohtani, R., Tomimoto, H., Wakita, H., Kitaguchi, H., Nakaji, K. & Takahashi, R., 02-03-2007, In : Brain Research. 1135, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells

Lee, Y. J., Miyake, S. I., Wakita, H., McMullen, D. C., Azuma, Y., Auh, S. & Hallenbeck, J. M., 16-05-2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 5, p. 950-962 13 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)
2006

Small artery dementia in Japan: Radiological differences between CADASIL, leukoaraiosis and Binswanger's disease

Tomimoto, H., Ohtani, R., Wakita, H., Lin, J. X., Ihara, M., Miki, Y., Oshima, F., Murata, T., Ishibashi, K., Suenaga, T. & Mizuno, T., 01-02-2006, In : Dementia and Geriatric Cognitive Disorders. 21, 3, p. 162-169 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2005

Distribution of ischemic leukoaraiosis in MRI: A difference from white matter lesions in CADASIL

Tomimoto, H., Ohtani, R., Wakita, H., Lin, J. X., Miki, Y. & Mizuno, T., 01-02-2005, In : Brain and Nerve. 57, 2, p. 125-130 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2004

Effects of perindopril-based blood pressure lowering and of patient characteristics on the progression of silent brain infarct: The perindopril protection against recurrent stroke study (PROGRESS) CT substudy in Japan

Hasegawa, Y., Yamaguchi, T., Omae, T., Woodward, M., Chalmers, J., Takasaki, M., Iwamoto, T., Tohgi, H., Takahashi, H., Konno, S., Uchiyama, S., Kimura, Y., Hayakawa, I., Miyamori, T., Ishitsuka, T., Shiokawa, O., Nakano, M., Takenoyama, T., Fukiyama, K., Muratani, H. & 47 others, Hirose, G., Kataoka, S., Sakai, F., Kanda, T., Kitagawa, Y., Yoshitoshi, M., Shinohara, Y., Takizawa, S., Kazabari, S., Mihara, B., Kawagishi, Y., Makishita, H., Isomura, K., Tabata, K., Nakagawa, S., Okada, H., Takeda, A., Nakajima, K., Makino, M., Hirata, Y., Watahiki, Y., Kawamura, J., Yoshikawa, N., Takastuka, K., Akiguchi, I., Wakita, H., Tomimoto, H., Nakamura, S., Kohriyama, T., Hiwada, K., Shigematsu, Y., Yanagihara, T., Matsumoto, M., Ueda, H., Nishimaru, K., Setsu, K., Kobayashi, S., Yamaguchi, S., Hashimoto, S., Nakamura, M., Mitake, S., Uchida, M., Ishihara, N., Imai, N., Imaizumi, M., Hokezu, Y. & Satake, M., 01-03-2004, In : Hypertension Research. 27, 3, p. 147-156 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Ketamine attenuates hypocapnia-induced neuronal damage in the caudoputamen in a rat model of chronic cerebral hypoperfusion

Miyamoto, E., Nakao, S., Tomimoto, H., Wakita, H., Yamada, M., Masuzawa, M., Takahira, K., Sakamoto, S. & Shingu, K., 02-01-2004, In : Neuroscience Letters. 354, 1, p. 26-29 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Topographical and cytopathological lesion analysis of the white matter in Binswamger's disease brains

Akiguchi, I., Tomimoto, H., Wakita, H., Kawamoto, Y., Matsuo, A., Ohnishi, K., Watanabe, T. & Budka, H., 01-06-2004, In : Acta Neuropathologica. 107, 6, p. 563-570 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Upregulation of ceramide and its regulating mechanism in a rat model of chronic cerebral ischemia

Ohtani, R., Tomimoto, H., Kondo, T., Wakita, H., Akiguchi, I., Shibasaki, H. & Okazaki, T., 08-10-2004, In : Brain Research. 1023, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
2003

Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentation in the rat

Tomimoto, H., Ihara, M., Wakita, H., Ohtani, R., Lin, J. X., Akiguchi, I., Kinoshita, M. & Shibasaki, H., 01-12-2003, In : Acta Neuropathologica. 106, 6, p. 527-534 8 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Ibudilast, a phosphodiesterase inhibitor, protects against white matter damage under chronic cerebral hypoperfusion in the rat

Wakita, H., Tomimoto, H., Akiguchi, I., Lin, J. X., Ihara, M., Ohtani, R. & Shibata, M., 28-11-2003, In : Brain Research. 992, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2002

Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat

Wakita, H., Tomimoto, H., Akiguchi, I., Matsuo, A., Lin, J. X., Ihara, M. & McGeer, P. L., 04-01-2002, In : Brain Research. 924, 1, p. 63-70 8 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion

Ueno, M., Tomimoto, H., Akiguchi, I., Wakita, H. & Sakamoto, H., 01-01-2002, In : Journal of Cerebral Blood Flow and Metabolism. 22, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)
2001

Caudoputamen is damaged by hypocapnia during mechanical ventilation in a rat model of chronic cerebral hypoperfusion

Miyamoto, E., Tomimoto, H., Nakao, S. I., Wakita, H., Akiguchi, I., Miyamoto, K. & Shingu, K., 01-01-2001, In : Stroke. 32, 12, p. 2920-2925 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter

Ihara, M., Tomimoto, H., Kinoshita, M., Oh, J., Noda, M., Wakita, H., Akiguchi, I. & Shibasaki, H., 01-01-2001, In : Journal of Cerebral Blood Flow and Metabolism. 21, 7, p. 828-834 7 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

White matter lesions and alteration of vascular cell composition in the brain of spontaneously hypertensive rats

Lin, J. X., Tomimoto, H., Akiguchi, I., Wakita, H., Shibasaki, H. & Horie, R., 03-07-2001, In : Neuroreport. 12, 9, p. 1835-1839 5 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2000

Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans

Tomimoto, H., Akiguchi, I., Wakita, H., Lin, J. X. & Budka, H., 01-2000, In : Acta Neuropathologica. 99, 1, p. 26-30 5 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Effects of an antithrombin drug in patients with subacute exacerbations of Binswanger disease

Tomimoto, H., Akiguchi, I., Ohtani, R., Yagi, H., Ogura, S. & Wakita, H., 11-2000, In : Internal Medicine. 39, 11, p. 966-969 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Vascular cell components of the medullary arteries in Binswanger's disease brains: A morphometric and immunoelectron microscopic study

Lin, J. X., Tomimoto, H., Akiguchi, I., Matsuo, A., Wakita, H., Shibasaki, H. & Budka, H., 01-01-2000, In : Stroke. 31, 8, p. 1838-1842 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
1999

A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia

Wakita, H., Tomimoto, H., Akiguchi, I., Lin, J. X., Miyamoto, K. & Oka, N., 14-05-1999, In : Neuroreport. 10, 7, p. 1461-1465 5 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Coagulation activation in patients with Binswanger disease

Tomimoto, H., Akiguchi, I., Wakita, H., Osaki, A., Hayashi, M. & Yamamoto, Y., 01-09-1999, In : Archives of Neurology. 56, 9, p. 1104-1108 5 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Cytopathological alterations and therapeutic approaches in Binswanger's disease

Akiguchi, I., Tomimoto, H., Wakita, H., Yamamoto, Y., Suenaga, T., Ueno, M. & Budka, H., 08-03-1999, In : Neuropathology. 19, 1, p. 119-128 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Effects of antithrombin on Binswanger's disease with antiphospholipid antibody syndrome

Akiguchi, I., Tomimoto, H., Kinoshita, M., Wakita, H., Osaki, A., Nishimura, M. & Kimura, J., 15-01-1999, In : Neurology. 52, 2, p. 398-401 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Vascular changes in white matter lesions of Alzheimer's disease

Tomimoto, H., Akiguchi, I., Akiyama, H., Ikeda, K., Wakita, H., Lin, J. X. & Budka, H., 01-06-1999, In : Acta Neuropathologica. 97, 6, p. 629-634 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
1998

Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia

Wakita, H., Tomimoto, H., Akiguchi, I. & Kimura, J., 04-05-1998, In : Brain Research. 792, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)
1997

Alterations in glia and axons in the brains of Binswanger's disease patients

Akiguchi, I., Tomimoto, H., Suenaga, T., Wakita, H. & Budka, H., 07-1997, In : Stroke. 28, 7, p. 1423-1429 7 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Blood-brain barrier dysfunction in Binswanger's disease; An immunohistochemical study

Akiguchi, I., Tomimoto, H., Suenaga, T., Wakita, H. & Budka, H., 12-1997, In : Acta Neuropathologica. 95, 1, p. 78-84 7 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions

Tomimoto, H., Akiguchi, I., Matsuo, A., Terai, K., Wakita, H., Kimura, J., McGeer, P. L. & Budka, H., 01-01-1997, In : Neuroreport. 8, 17, p. 3727-3730 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Regressive changes of astroglia in white matter lesions in cerebrovascular disease and Alzheimer's disease patients

Tomimoto, H., Akiguchi, I., Wakita, H., Suenaga, T., Nakamura, S. & Kimura, J., 01-08-1997, In : Acta Neuropathologica. 94, 2, p. 146-152 7 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

White matter lesions after occlusion of the bilateral carotid arteries in the rat -temporal profile of cerebral blood flow (CBF), oligodendroglia and myelin

Tomimoto, H., Akiguchi, I., Wakita, H. & Kimura, J., 01-12-1997, In : Brain and Nerve. 49, 7, p. 639-644 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
1996

Alterations of the blood-brain barrier and glial cells in white-matter lesions in cerebrovascular and Alzheimer's disease patients

Tomimoto, H., Akiguchi, I., Suenaga, T., Nishimura, M., Wakita, H., Nakamura, S. & Kimura, J., 11-1996, In : Stroke. 27, 11, p. 2069-2074 6 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)

Glial expression of cytokines in the brains of cerebrovascular disease patients

Tomimoto, H., Akiguchi, I., Wakita, H., Kinoshita, A., Ikemoto, A., Nakamura, S. & Kimura, J., 01-09-1996, In : Acta Neuropathologica. 92, 3, p. 281-287 7 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)