• 719 Citations
  • 18 h-Index
20022020

Research output per year

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Research Output

  • 719 Citations
  • 18 h-Index
  • 31 Article
  • 4 Review article
  • 3 Chapter
  • 2 Comment/debate
2020

Analysis of O-glycoforms of the IgA1 hinge region by sequential deglycosylation

Ohyama, Y., Yamaguchi, H., Nakajima, K., Mizuno, T., Fukamachi, Y., Yokoi, Y., Tsuboi, N., Inaguma, D., Hasegawa, M., Renfrow, M. B., Novak, J., Yuzawa, Y. & Takahashi, K., 01-12-2020, In : Scientific reports. 10, 1, 671.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Differential labeling of glycoproteins with alkynyl fucose analogs

Ma, C., Takeuchi, H., Hao, H., Yonekawa, C., Nakajima, K., Nagae, M., Okajima, T., Haltiwanger, R. S. & Kizuka, Y., 01-09-2020, In : International journal of molecular sciences. 21, 17, p. 1-18 18 p., 6007.

Research output: Contribution to journalArticle

Open Access

Mass spectrometry for the identification and analysis of highly complex glycosylation of therapeutic or pathogenic proteins

Ohyama, Y., Nakajima, K., Renfrow, M. B., Novak, J. & Takahashi, K., 02-04-2020, In : Expert Review of Proteomics. 17, 4, p. 275-296 22 p.

Research output: Contribution to journalReview article

2019

Bisecting GlcNAc is a general suppressor of terminal modification of N-glycan

Nakano, M., Mishra, S. K., Tokoro, Y., Sato, K., Nakajima, K., Yamaguchi, Y., Taniguchi, N. & Kizuka, Y., 2019, In : Molecular and Cellular Proteomics. 18, 10, p. 2044-2057 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Free glycans derived from O-mannosylated glycoproteins suggest the presence of an O-glycoprotein degradation pathway in yeast

Hirayama, H., Matsuda, T., Tsuchiya, Y., Oka, R., Seino, J., Huang, C., Nakajima, K., Noda, Y., Shichino, Y., Iwasaki, S. & Suzuki, T., 01-11-2019, In : Journal of Biological Chemistry. 294, 44, p. 15900-15911 12 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Mannose impairs tumor growth and enhance chemotherapy

Nakajima, K., 01-01-2019, In : Trends in Glycoscience and Glycotechnology. 31, 180, p. J87-J88

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Mannose impairs tumor growth and enhance chemotherapy

Nakajima, K., 01-01-2019, In : Trends in Glycoscience and Glycotechnology. 31, 180, p. E87-E88

Research output: Contribution to journalArticle

Structural analysis of glycans (analytical and detection methods)

Nakajima, K., Takahashi, K., Yamaguchi, Y., Shinohara, Y., Kaji, H., Furukawa, J. I., Suzuki, A., Haga, Y., Ueda, K., Suda, Y., Hirabayashi, Y., Furukawa, K., Yamamoto, K., Kawasaki, T. & Honke, K., 01-01-2019, Glycoscience: Basic Science to Applications: Insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG). Springer Singapore, p. 3-33 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Identification and characterization of UDP-mannose in human cell lines and mouse organs: Differential distribution across brain regions and organs

Nakajima, K., Kizuka, Y., Yamaguchi, Y., Hirabayashi, Y., Takahashi, K., Yuzawa, Y. & Taniguchi, N., 01-01-2018, In : Biochemical and Biophysical Research Communications. 495, 1, p. 401-407 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mass spectrometry-based approach for development of biomarkers in IgA nephropathy: a pilot trial

Kondo, A., Takahashi, K., Yamaguchi, H., Yoshida, Y., Mizuno, T., Nakajima, K., Hayashi, H., Koide, S., Inaguma, D., Hasegawa, M., Hiki, Y. & Yuzawa, Y., 2018, In : Fujita medical journal. 4, 2, p. 36-41 6 p.

Research output: Contribution to journalArticle

Metabolic reprogramming by the hexosamine pathway and N-acetylglucosaminyltransferase

Nakajima, K., 01-01-2018, In : Trends in Glycoscience and Glycotechnology. 30, 173, p. E75-E46, J23-J24

Research output: Contribution to journalComment/debate

2017

An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3

Kizuka, Y., Nakano, M., Yamaguchi, Y., Nakajima, K., Oka, R., Sato, K., Ren, C. T., Hsu, T. L., Wong, C. H. & Taniguchi, N., 21-12-2017, In : Cell Chemical Biology. 24, 12, p. 1467-1478.e5

Research output: Contribution to journalArticle

17 Citations (Scopus)
2016

Aglycon diversity of brain sterylglucosides: Structure determination of cholesteryl- and sitosterylglucoside

Akiyama, H., Nakajima, K., Itoh, Y., Sayano, T., Ohashi, Y., Yamaguchi, Y., Greimel, P. & Hirabayashi, Y., 2016, In : Journal of Lipid Research. 57, 11, p. 2061-2072 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

High-Sensitivity and Low-Toxicity Fucose Probe for Glycan Imaging and Biomarker Discovery

Kizuka, Y., Funayama, S., Shogomori, H., Nakano, M., Nakajima, K., Oka, R., Kitazume, S., Yamaguchi, Y., Sano, M., Korekane, H., Hsu, T. L., Lee, H. Y., Wong, C. H. & Taniguchi, N., 21-07-2016, In : Cell Chemical Biology. 23, 7, p. 782-792 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Hyaluronan production regulates metabolic and cancer stem-like properties of breast cancer cells via hexosamine biosynthetic pathway-coupled HIF-1 signaling

Chanmee, T., Ontong, P., Izumikawa, T., Higashide, M., Mochizuki, N., Chokchaitaweesuk, C., Khansai, M., Nakajima, K., Kakizaki, I., Kongtawelert, P., Taniguchi, N. & Itano, N., 11-11-2016, In : Journal of Biological Chemistry. 291, 46, p. 24105-24120 16 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Separation and analysis of mono-glucosylated lipids in brain and skin by hydrophilic interaction chromatography based on carbohydrate and lipid moiety

Nakajima, K., Akiyama, H., Tanaka, K., Kohyama-Koganeya, A., Greimel, P. & Hirabayashi, Y., 15-09-2016, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1031, p. 146-153 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2015

Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling

Yang, Y. R., Kim, D. H., Seo, Y. K., Park, D., Jang, H. J., Choi, S. Y., Lee, Y. H., Lee, G. H., Nakajima, K., Taniguchi, N., Kim, J. M., Choi, E. J., Moon, H. Y., Kim, I. S., Choi, J. H., Lee, H., Ryu, S. H., Cocco, L. & Suh, P. G., 2015, In : Oncotarget. 6, 14, p. 12529-12542 14 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease

Suzuki, M., Fujikake, N., Takeuchi, T., Kohyama-Koganeya, A., Nakajima, K., Hirabayashi, Y., Wada, K. & Nagai, Y., 01-12-2015, In : Human molecular genetics. 24, 23, p. 6675-6686 12 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Profiling of glucosylceramides by liquid chromatography-tandem mass spectrometry

Nakajima, K., Kohyama-Koganeya, A. & Hirabayashi, Y., 01-01-2015, Glycoscience: Biology and Medicine. Springer Japan, p. 565-571 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Simultaneous quantification of nucleotide sugar metabolism by LC and LC-MS

Nakajima, K. & Taniguchi, N., 01-01-2015, Glycoscience: Biology and Medicine. Springer Japan, p. 103-110 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
2014

Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2

Okahara, K., Kizuka, Y., Kitazume, S., Ota, F., Nakajima, K., Hirabayashi, Y., Maekawa, M., Yoshikawa, T. & Taniguchi, N., 01-10-2014, In : Glycobiology. 24, 10, p. 926-934 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Novel functions of brain lipids modified with glucose

Hirabayashi, Y., Akiyama, H. & Nakajima, K., 01-01-2014, In : Seikagaku. 86, 6, p. 735-743 9 p.

Research output: Contribution to journalReview article

The absence of core fucose up-regulates gnt-iii and wnt target genes: A possible mechanism for an adaptive response in terms of glycan function

Kurimoto, A., Kitazume, S., Kizuka, Y., Nakajima, K., Oka, R., Fujinawa, R., Korekane, H., Yamaguchi, Y., Wada, Y. & Taniguchi, N., 25-04-2014, In : Journal of Biological Chemistry. 289, 17, p. 11704-11714 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2013

Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)

Korekane, H., Park, J. Y., Matsumoto, A., Nakajima, K., Takamatsu, S., Ohtsubo, K., Miyamoto, Y., Hanashima, S., Kanekiyo, K., Kitazume, S., Yamaguchi, Y., Matsuo, I. & Taniguchi, N., 27-09-2013, In : Journal of Biological Chemistry. 288, 39, p. 27912-27926 15 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Mass isotopomer analysis of metabolically labeled nucleotide sugars and N-and O-glycans for tracing nucleotide sugar metabolisms

Nakajima, K., Ito, E., Ohtsubo, K., Shirato, K., Takamiya, R., Kitazume, S., Angata, T. & Taniguchi, N., 09-2013, In : Molecular and Cellular Proteomics. 12, 9, p. 2468-2480 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Metabolically programmed quality control system for dolichol-linked oligosaccharides

Harada, Y., Nakajima, K., Masahara-Negish, Y., Freeze, H. H., Angata, T., Taniguchi, N. & Suzuki, T., 26-11-2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19366-19371 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Structural characterization of pyridylaminated oligosaccharides derived from neutral glycosphingolipids by high-sensitivity capillary electrophoresis-mass spectrometry

Ito, E., Nakajima, K., Waki, H., Miseki, K., Shimada, T., Sato, T. A., Kakehi, K., Suzuki, M., Taniguchi, N. & Suzuki, A., 20-08-2013, In : Analytical Chemistry. 85, 16, p. 7859-7865 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2012

Integrated approach toward the discovery of glyco-biomarkers of inflammation-Related diseases

Angata, T., Fujinawa, R., Kurimoto, A., Nakajima, K., Kato, M., Takamatsu, S., Korekane, H., Gao, C. X., Ohtsubo, K., Kitazume, S. & Taniguchi, N., 04-2012, In : Annals of the New York Academy of Sciences. 1253, 1, p. 159-169 11 p.

Research output: Contribution to journalReview article

31 Citations (Scopus)

Structural characterization of monosialo-, disialo- and trisialo-gangliosides by negative ion AP-MALDI-QIT-TOF mass spectrometry with MS n switching

Ito, E., Tominaga, A., Waki, H., Miseki, K., Tomioka, A., Nakajima, K., Kakehi, K., Suzuki, M., Taniguchi, N. & Suzuki, A., 01-06-2012, In : Neurochemical Research. 37, 6, p. 1315-1324 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2011

Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle

Shirato, K., Nakajima, K., Korekane, H., Takamatsu, S., Gao, C., Angata, T., Ohtsubo, K. & Taniguchi, N., 01-2011, In : Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 20-25 6 p.

Research output: Contribution to journalReview article

38 Citations (Scopus)
2010

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC

Nakajima, K., Kitazume, S., Angata, T., Fujinawa, R., Ohtsubo, K., Miyoshi, E. & Taniguchi, N., 07-2010, In : Glycobiology. 20, 7, p. 865-871 7 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)
2009

Carbohydrate-protein interactions investigated on plastic chips statically coated with hydrophobically modified hydroxyethylcellulose

Dang, F., Maeda, E., Osafune, T., Nakajima, K., Kakehi, K., Ishikawa, M. & Baba, Y., 15-12-2009, In : Analytical Chemistry. 81, 24, p. 10055-10060 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Structural characterization of multibranched oligosaccharides from seal milk by a combination of off-line high-performance liquid chromatography-matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and sequential exoglycosidase digestion

Kinoshita, M., Ohta, H., Higaki, K., Kojima, Y., Urashima, T., Nakajima, K., Suzuki, M., Kovacs, K. M., Lydersen, C., Hayakawa, T. & Kakehi, K., 15-05-2009, In : Analytical Biochemistry. 388, 2, p. 242-253 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2006

Capillary affinity electrophoresis using lectins for the analysis of milk oligosaccharide structure and its application to bovine colostrum oligosaccharides

Nakajima, K., Kinoshita, M., Matsushita, N., Urashima, T., Suzuki, M., Suzuki, A. & Kakehi, K., 01-01-2006, In : Analytical Biochemistry. 348, 1, p. 105-114 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Hybrid dynamic coating with n-dodecyl β-D-maltoside and methyl cellulose for high-performance carbohydrate analysis on poly(methyl methacrylate) chips

Dang, F., Kakehi, K., Cheng, J., Tabata, O., Kurokawa, M., Nakajima, K., Ishikawa, M. & Baba, Y., 01-03-2006, In : Analytical Chemistry. 78, 5, p. 1452-1458 7 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Rapid analysis of oligosaccharides derived from glycoproteins by microchip electrophoresis

Dang, F., Kakehi, K., Nakajima, K., Shinohara, Y., Ishikawa, M., Kaji, N., Tokeshi, M. & Baba, Y., 24-03-2006, In : Journal of Chromatography A. 1109, 2, p. 138-143 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2004

Screening method of carbohydrate-binding proteins in biological sources by capillary affinity electrophoresis and its application to determination of Tulipa gesneriana agglutinin in tulip bulbs

Nakajima, K., Kinoshita, M., Oda, Y., Masuko, T., Kaku, H., Shibuya, N. & Kakehi, K., 01-09-2004, In : Glycobiology. 14, 9, p. 793-804 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2003

A new fungal lectin recognizing α(1-6)-linked fucose in the N-glycan

Oda, Y., Senaha, T., Matsuno, Y., Nakajima, K., Naka, R., Kinoshita, M., Honda, E., Furuta, I. & Kakehi, K., 22-08-2003, In : Journal of Biological Chemistry. 278, 34, p. 32439-32447 9 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Capillary affinity electrophoresis for the screening of post-translational modification of proteins with carbohydrates

Nakajima, K., Oda, Y., Kinoshita, M. & Kakehi, K., 25-02-2003, In : Journal of Proteome Research. 2, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2002

Time-resolved fluorometric analysis of carbohydrates labeled with amino-aromatic compounds by reductive amination

Nakajima, K., Oda, Y., Kinoshita, M., Masuko, T. & Kakehi, K., 01-01-2002, In : Analyst. 127, 7, p. 972-976 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)