• 8875 Citations
  • 48 h-Index
1985 …2020

Research output per year

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Research Output

2020

A method for the automated classification of benign and malignant masses on digital breast tomosynthesis images using machine learning and radiomic features

Sakai, A., Onishi, Y., Matsui, M., Adachi, H., Teramoto, A., Saito, K. & Fujita, H., 01-03-2020, In : Radiological Physics and Technology. 13, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access

Automated detection and segmentation of early gastric cancer from endoscopic images using mask R-CNN

Shibata, T., Teramoto, A., Yamada, H., Omiya, N., Saito, K. & Fujita, H., 01-06-2020, In : Applied Sciences (Switzerland). 10, 11, 3842.

Research output: Contribution to journalArticle

Open Access

Decision Support System for Lung Cancer Using PET/CT and Microscopic Images

Teramoto, A., Yamada, A., Tsukamoto, T., Imaizumi, K., Toyama, H., Saito, K. & Fujita, H., 01-01-2020, Advances in Experimental Medicine and Biology. Springer, p. 73-94 22 p. (Advances in Experimental Medicine and Biology; vol. 1213).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Deep learning approach to classification of lung cytological images: Two-step training using actual and synthesized images by progressive growing of generative adversarial networks

Teramoto, A., Tsukamoto, T., Yamada, A., Kiriyama, Y., Imaizumi, K., Saito, K. & Fujita, H., 01-01-2020, In : PloS one. 15, 3, e0229951.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Indoleamine-2,3-dioxygenase-1 is a molecular target for the protective activity of mood stabilizers against mania-like behavior induced by d-amphetamine

Tran, H. Q., Shin, E. J., Saito, K., Tran, T. V., Phan, D. H., Sharma, N., Kim, D. W., Choi, S. Y., Jeong, J. H., Jang, C. G., Cheong, J. H., Nabeshima, T. & Kim, H. C., 02-2020, In : Food and Chemical Toxicology. 136, 110986.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Investigation of pulmonary nodule classification using multi-scale residual network enhanced with 3DGAN-synthesized volumes

Onishi, Y., Teramoto, A., Tsujimoto, M., Tsukamoto, T., Saito, K., Toyama, H., Imaizumi, K. & Fujita, H., 01-06-2020, In : Radiological Physics and Technology. 13, 2, p. 160-169 10 p.

Research output: Contribution to journalArticle

Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice

Tashita, C., Hoshi, M., Hirata, A., Nakamoto, K., Ando, T., Hattori, T., Yamamoto, Y., Tezuka, H., Tomita, H., Hara, A. & Saito, K., 07-03-2020, In : World Journal of Gastroenterology. 26, 9, p. 918-932 15 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice

Hoshi, M., Osawa, Y., Nakamoto, K., Morita, N., Yamamoto, Y., Ando, T., Tashita, C., Nabeshima, T. & Saito, K., 30-05-2020, In : Toxicology. 438, 152458.

Research output: Contribution to journalArticle

Lithium attenuates d-amphetamine-induced hyperlocomotor activity in mice via inhibition of interaction between cyclooxygenase-2 and indoleamine-2,3-dioxygenase

Phan, D. H., Shin, E. J., Jeong, J. H., Tran, H. Q., Sharma, N., Nguyen, B. T., Jung, T. W., Nah, S. Y., Saito, K., Nabeshima, T. & Kim, H. C., 01-05-2020, In : Clinical and Experimental Pharmacology and Physiology. 47, 5, p. 790-797 8 p.

Research output: Contribution to journalArticle

Multiplanar analysis for pulmonary nodule classification in CT images using deep convolutional neural network and generative adversarial networks

Onishi, Y., Teramoto, A., Tsujimoto, M., Tsukamoto, T., Saito, K., Toyama, H., Imaizumi, K. & Fujita, H., 01-01-2020, In : International Journal of Computer Assisted Radiology and Surgery. 15, 1, p. 173-178 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder

Sakurai, M., Yamamoto, Y., Kanayama, N., Hasegawa, M., Mouri, A., Takemura, M., Matsunami, H., Miyauchi, T., Tokura, T., Kimura, H., Ito, M., Umemura, E., Boku, A. S., Nagashima, W., Tonoike, T., Kurita, K., Ozaki, N., Nabeshima, T. & Saito, K., 01-12-2020, In : Scientific reports. 10, 1, 1961.

Research output: Contribution to journalArticle

Open Access

Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus

Wulaer, B., Kunisawa, K., Hada, K., Jaya Suento, W., Kubota, H., Iida, T., Kosuge, A., Nagai, T., Yamada, K., Nitta, A., Yamamoto, Y., Saito, K., Mori, A. & Nabeshima, T., 01-01-2020, (Accepted/In press) In : Journal of neurochemistry.

Research output: Contribution to journalArticle

2019

5-HT 1A receptor agonist 8-OH-DPAT induces serotonergic behaviors in mice via interaction between PKCδ and p47phox

Tran, H. Q., Shin, E. J., Hoai Nguyen, B. C., Phan, D. H., Kang, M. J., Jang, C. G., Jeong, J. H., Nah, S. Y., Mouri, A., Saito, K., Nabeshima, T. & Kim, H. C., 01-01-2019, In : Food and Chemical Toxicology. 123, p. 125-141 17 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A complementary scheme for automated detection of high-uptake regions on dedicated breast PET and whole-body PET/CT

Minoura, N., Teramoto, A., Ito, A., Yamamuro, O., Nishio, M., Saito, K. & Fujita, H., 01-09-2019, In : Radiological Physics and Technology. 12, 3, p. 260-267 8 p.

Research output: Contribution to journalArticle

Alteration of specific cytokine expression patterns in patients with breast cancer

Kawaguchi, K., Sakurai, M., Yamamoto, Y., Suzuki, E., Tsuda, M., Kataoka, T. R., Hirata, M., Nishie, M., Nojiri, T., Kumazoe, M., Saito, K. & Toi, M., 01-12-2019, In : Scientific reports. 9, 1, 2924.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Altered kynurenine pathway metabolites in a mouse model of human attention-deficit hyperactivity/autism spectrum disorders: A potential new biological diagnostic marker

Murakami, Y., Imamura, Y., Saito, K., Sakai, D. & Motyama, J., 01-12-2019, In : Scientific reports. 9, 1, 13182.

Research output: Contribution to journalArticle

Open Access

Automated classification of benign and malignant cells from lung cytological images using deep convolutional neural network

Teramoto, A., Yamada, A., Kiriyama, Y., Tsukamoto, T., Yan, K., Zhang, L., Imaizumi, K., Saito, K. & Fujita, H., 2019, In : Informatics in Medicine Unlocked. 16, 100205.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks

Onishi, Y., Teramoto, A., Tsujimoto, M., Tsukamoto, T., Saito, K., Toyama, H., Imaizumi, K. & Fujita, H., 01-01-2019, In : BioMed Research International. 2019, 6051939.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Bone suppression for chest X-ray image using a convolutional neural filter

Matsubara, N., Teramoto, A., Saito, K. & Fujita, H., 01-01-2019, (Accepted/In press) In : Australasian Physical and Engineering Sciences in Medicine.

Research output: Contribution to journalArticle

Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms

Teshigawara, T., Mouri, A., Kubo, H., Nakamura, Y., Shiino, T., Okada, T., Morikawa, M., Nabeshima, T., Ozaki, N., Yamamoto, Y. & Saito, K., 01-08-2019, In : Journal of Affective Disorders. 255, p. 168-176 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Changes of liver fibrosis markers in patients with treatment by antiviral therapy

Ishidalr, H., Suetsugu, A., Furuta, N., Nohisa, Y., Takemura, M., Saito, K., Shirakam, Y. & Itou, H., 04-2019, In : Japanese Journal of Clinical Chemistry. 48, 2, p. 137-143 7 p.

Research output: Contribution to journalArticle

Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression

Lu, Q., Mouri, A., Yang, Y., Kunisawa, K., Teshigawara, T., Hirakawa, M., Mori, Y., Yamamoto, Y., Libo, Z., Nabeshima, T. & Saito, K., 17-10-2019, In : Behavioural Brain Research. 372, 112053.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications

Kimura, A., Takemura, M., Yamamoto, Y., Hayashi, Y., Saito, K. & Shimohata, T., 15-09-2019, In : Journal of Neuroimmunology. 334, 576999.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Decline of plasma concentrations of interleukin-18 in severely malnourished patients with anorexia nervosa: Exploratory analysis

Tanaka, S., Oya-Ito, T., Murakami, Y., Saito, K., Furuta, S., Yu, Y., Imaeda, M., Kunimoto, S. & Ozaki, N., 03-2019, In : Nutrients. 11, 3, 540.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

Miyauchi, T., Tokura, T., Kimura, H., Ito, M., Umemura, E., Sato (Boku), A., Nagashima, W., Tonoike, T., Yamamoto, Y., Saito, K., Kurita, K. & Ozaki, N., 07-2019, In : Human Psychopharmacology. 34, 4, e2698.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma

Yamasuge, W., Yamamoto, Y., Fujigaki, H., Hoshi, M., Nakamoto, K., Kunisawa, K., Mouri, A., Nabeshima, T. & Saito, K., 01-10-2019, In : Cancer science. 110, 10, p. 3061-3067 7 p.

Research output: Contribution to journalArticle

Open Access

Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues

Yoshida, Y., Fujigaki, H., Kato, K., Yamazaki, K., Fujigaki, S., Kunisawa, K., Yamamoto, Y., Mouri, A., Oda, A., Nabeshima, T. & Saito, K., 01-12-2019, In : Scientific reports. 9, 1, 10243.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes

Sobue, A., Ito, N., Nagai, T., Shan, W., Hada, K., Nakajima, A., Murakami, Y., Mouri, A., Yamamoto, Y., Nabeshima, T., Saito, K. & Yamada, K., 05-2018, In : GLIA. 66, 5, p. 1034-1052 19 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter

Yamazaki, M., Yamada, H., Munetsuna, E., Ishikawa, H., Mizuno, G., Mukuda, T., Mouri, A., Nabeshima, T., Saito, K., Suzuki, K., Hashimoto, S. & Ohashi, K., 05-2018, In : FASEB Journal. 32, 5, p. 2549-2562 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Higher levels of progranulin in cerebrospinal fluid of patients with lymphoma and carcinoma with CNS metastasis

Kimura, A., Takemura, M., Serrero, G., Yoshikura, N., Hayashi, Y., Saito, K. & Inuzuka, T., 01-05-2018, In : Journal of Neuro-Oncology. 137, 3, p. 455-462 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

IL-6 knockout mice are protected from cocaine-induced kindling behaviors; possible involvement of JAK2/STAT3 and PACAP signalings

Mai, H. N., Chung, Y. H., Shin, E. J., Sharma, N., Jeong, J. H., Jang, C. G., Saito, K., Nabeshima, T., Reglodi, D. & Kim, H. C., 01-06-2018, In : Food and Chemical Toxicology. 116, p. 249-263 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
4 Citations (Scopus)

PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT1A Receptor and Upregulation of Nrf2-Dependent GSH Synthesis

Tran, H. Q., Lee, Y., Shin, E. J., Jang, C. G., Jeong, J. H., Mouri, A., Saito, K., Nabeshima, T. & Kim, H. C., 01-10-2018, In : Molecular Neurobiology. 55, 10, p. 7802-7821 20 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice

Kubo, H., Hoshi, M., Mouri, A., Tashita, C., Yamamoto, Y., Nabeshima, T. & Saito, K., 01-01-2017, In : Immunology Letters. 181, p. 94-100 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Association between increased serum GP88 (progranulin) concentrations and prognosis in patients with malignant lymphomas

Yamamoto, Y., Goto, N., Takemura, M., Yamasuge, W., Yabe, K., Takami, T., Miyazaki, T., Takeuchi, T., Shiraki, M., Shimizu, M., Adachi, S., Saito, K., Shibata, Y., Nakamura, N., Hara, T., Serrero, G., Saito, K. & Tsurumi, H., 10-2017, In : Clinica Chimica Acta. 473, p. 139-146 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Association between naturally occurring anti-amyloid β autoantibodies and medial temporal lobe atrophy in Alzheimer's disease

Kimura, A., Takemura, M., Saito, K., Yoshikura, N., Hayashi, Y. & Inuzuka, T., 01-02-2017, In : Journal of Neurology, Neurosurgery and Psychiatry. 88, 2, p. 126-131 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Comparison of cerebrospinal fluid profiles in Alzheimer’s disease with multiple cerebral microbleeds and cerebral amyloid angiopathy-related inflammation

Kimura, A., Takemura, M., Saito, K., Yoshikura, N., Hayashi, Y., Harada, N., Nishida, H., Nakajima, H. & Inuzuka, T., 01-02-2017, In : Journal of Neurology. 264, 2, p. 373-381 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues

Ohta, Y., Kubo, H., Yashiro, K., Ohashi, K., Tsuzuki, Y., Wada, N., Yamamoto, Y. & Saito, K., 01-05-2017, In : Journal of Physiological Sciences. 67, 3, p. 361-372 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder

Kimura, A., Takemura, M., Saito, K., Serrero, G., Yoshikura, N., Hayashi, Y. & Inuzuka, T., 15-04-2017, In : Journal of Neuroimmunology. 305, p. 175-181 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions

Tashiro, T., Murakami, Y., Mouri, A., Imamura, Y., Nabeshima, T., Yamamoto, Y. & Saito, K., 15-01-2017, In : Behavioural Brain Research. 317, p. 279-285 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

L-tryptophan-kynurenim pathway enzymes are a therapeutic target for various neurological disorders

Saito, K., 01-08-2017, In : Japanese Journal of Neuropsychopharmacology. 37, 4, p. 103-107 5 p.

Research output: Contribution to journalReview article

44 Citations (Scopus)

Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice

Kubo, H., Hoshi, M., Matsumoto, T., Irie, M., Oura, S., Tsutsumi, H., Hata, Y., Yamamoto, Y. & Saito, K., 03-06-2017, In : Lipids in Health and Disease. 16, 1, 106.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified

Shibata, Y., Hara, T., Matsumoto, T., Nakamura, N., Nakamura, H., Ninomiya, S., Kitagawa, J., Goto, N., Nannya, Y., Ito, H., Kito, Y., Miyazaki, T., Takeuchi, T., Saito, K., Seishima, M., Takami, T., Moriwaki, H., Shimizu, M. & Tsurumi, H., 12-2017, In : Hematological Oncology. 35, 4, p. 637-644 8 p.

Research output: Contribution to journalArticle

Bio-Resources and Database for Preemptive Medicine

Saito, K., 01-05-2016, In : Rinsho byori. The Japanese journal of clinical pathology. 64, 4, p. 445-450 6 p.

Research output: Contribution to journalArticle

Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

Murakami, Y., Ishibashi, T., Tomita, E., Imamura, Y., Tashiro, T., Watcharanurak, K., Nishikawa, M., Takahashi, Y., Takakura, Y., Mitani, S., Fujigaki, H., Ohta, Y., Kubo, H., Mamiya, T., Nabeshima, T., Kim, H. C., Yamamoto, Y. & Saito, K., 20-07-2016, In : Scientific reports. 6, 29920.

Research output: Contribution to journalArticle

23 Citations (Scopus)