• 1153 Citations
  • 16 h-Index
20032020

Research output per year

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Research Output

  • 1153 Citations
  • 16 h-Index
  • 36 Article
  • 5 Review article
2020

Comparison of effectiveness and safety between uninterrupted direct oral anticoagulants with and without switching to dabigatran in atrial fibrillation ablation

Harada, M., Motoike, Y., Nomura, Y., Nishimura, A., Koshikawa, M., Murayama, K., Ohno, Y., Watanabe, E., Izawa, H. & Ozaki, Y., 01-01-2020, (Accepted/In press) In : journal of arrhythmia.

Research output: Contribution to journalArticle

Open Access
2019

Clinical experience of idarucizumab use in cases of cardiac tamponade under uninterrupted anticoagulation of dabigatran during catheter ablation of atrial fibrillation

Okishige, K., Yamauchi, Y., Hanaki, Y., Inoue, K., Tanaka, N., Yamaji, H., Murakami, T., Manita, M., Tabata, K., Ooie, T., Tatsukawa, Y., Sakai, H., Yamaki, M., Murakami, M., Takada, T., Osaka, Y., Ono, Y., Handa, K., Sugiyama, K., Yoshizawa, T. & 8 others, Fukaya, H., Tashiro, H., Takase, S., Harada, M., Watanabe, E., Yamane, T., Yamashita, S. & Aonuma, K., 15-05-2019, In : Journal of Thrombosis and Thrombolysis. 47, 4, p. 487-494 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Current status and clinical outcomes of oral anticoagulant discontinuation after ablation for atrial fibrillation in Japan ― findings from the AF Frontier Ablation Registry ―

Okumura, Y., Nagashima, K., Arai, M., Watanabe, R., Yokoyama, K., Matsumoto, N., Otsuka, T., Suzuki, S., Hirata, A., Murakami, M., Takami, M., Kimura, M., Fukaya, H., Nakahara, S., Kato, T., Shimizu, W., Iwasaki, Y. K., Hayashi, H., Harada, T., Nakajima, I. & 18 others, Okumura, K., Koyama, J., Tokuda, M., Yamane, T., Momiyama, Y., Tanimoto, K., Soejima, K., Nonoguchi, N., Ejima, K., Hagiwara, N., Harada, M., Sonoda, K., Inoue, M., Kumagai, K., Hayashi, H., Satomi, K., Yazaki, Y. & Watari, Y., 01-01-2019, In : Circulation Journal. 83, 12, p. 2418-2427 10 p.

Research output: Contribution to journalArticle

Open Access

Impact of serum albumin levels on supratherapeutic PT-INR control and bleeding risk in atrial fibrillation patients on warfarin: A prospective cohort study

Kawai, M., Harada, M., Motoike, Y., Koshikawa, M., Ichikawa, T., Watanabe, E. & Ozaki, Y., 03-2019, In : IJC Heart and Vasculature. 22, p. 111-116 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

Left atrial appendage thrombus prior to atrial fibrillation ablation in the era of direct oral anticoagulants

Harada, M., Koshikawa, M., Motoike, Y., Ichikawa, T., Sugimoto, K., Watanabe, E. & Ozaki, Y., 01-01-2018, In : Circulation Journal. 82, 11, p. 2715-2721 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Midkine promotes atherosclerotic plaque formation through its pro-inflammatory, angiogenic and anti-apoptotic functions in apolipoprotein E-knockout mice

Takemoto, Y., Horiba, M., Harada, M., Sakamoto, K., Takeshita, K., Murohara, T., Kadomatsu, K. & Kamiya, K., 01-01-2018, In : Circulation Journal. 82, 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Predicting acute kidney injury using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic peptide levels in patients treated at medical cardiac intensive care units

Naruse, H., Ishii, J., Takahashi, H., Kitagawa, F., Nishimura, H., Kawai, H., Muramatsu, T., Harada, M., Yamada, A., Motoyama, S., Matsui, S., Hayashi, M., Sarai, M., Watanabe, E., Izawa, H. & Ozaki, Y., 18-08-2018, In : Critical Care. 22, 1, 197.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Serum microRNA-126 and -223 as new-generation biomarkers for sarcoidosis in patients with heart failure

Fujiwara, W., Kato, Y., Hayashi, M., Sugishita, Y., Okumura, S., Yoshinaga, M., Ishiguro, T., Yamada, R., Ueda, S., Harada, M., Naruse, H., Ishii, J., Ozaki, Y. & Izawa, H., 12-2018, In : Journal of cardiology. 72, 6, p. 452-457 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Thromboembolisms in atrial fibrillation and heart failure patients with a preserved ejection fraction (HFpEF) compared to those with a reduced ejection fraction (HFrEF)

Sobue, Y., Watanabe, E., Lip, G. Y. H., Koshikawa, M., Ichikawa, T., Kawai, M., Harada, M., Inamasu, J. & Ozaki, Y., 01-04-2018, In : Heart and Vessels. 33, 4, p. 403-412 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

Assessment of trough rivaroxaban concentrations on markers of coagulation activation in nonvalvular atrial fibrillation population

Kitagawa, F., Ishii, J., Hiramitsu, S., Takahashi, H., Okuyama, R., Kawai, H., Muramatsu, T., Harada, M., Motoyama, S., Naruse, H., Matsui, S., Sarai, M., Hayashi, M., Watanabe, E., Izawa, H. & Ozaki, Y., 01-05-2017, In : Heart and Vessels. 32, 5, p. 609-617 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Combination of high-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide predicts future hospital admission for heart failure in high-risk hypertensive patients with preserved left ventricular ejection fraction

Okuyama, R., Ishii, J., Takahashi, H., Kawai, H., Muramatsu, T., Harada, M., Yamada, A., Motoyama, S., Matsui, S., Naruse, H., Sarai, M., Hasegawa, M., Watanabe, E., Suzuki, A., Hayashi, M., Izawa, H., Yuzawa, Y. & Ozaki, Y., 01-07-2017, In : Heart and Vessels. 32, 7, p. 880-892 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion

Tadevosyan, A., Xiao, J., Surinkaew, S., Naud, P., Merlen, C., Harada, M., Qi, X., Chatenet, D., Fournier, A., Allen, B. G. & Nattel, S., 05-04-2017, In : Journal of the American Heart Association. 6, 4

Research output: Contribution to journalArticle

16 Citations (Scopus)

Metabolic considerations in atrial fibrillation ― Mechanistic insights and therapeutic opportunities

Harada, M., Melka, J., Sobue, Y. & Nattel, S., 01-01-2017, In : Circulation Journal. 81, 12, p. 1749-1757 9 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Physically triggered Takotsubo cardiomyopathy has a higher in-hospital mortality rate

Sobue, Y., Watanabe, E., Ichikawa, T., Koshikawa, M., Yamamoto, M., Harada, M. & Ozaki, Y., 15-05-2017, In : International Journal of Cardiology. 235, p. 87-93 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Prognostic Importance of Novel Oxygen Desaturation Metrics in Patients With Heart Failure and Central Sleep Apnea

Watanabe, E., Kiyono, K., Matsui, S., Somers, V. K., Sano, K., Hayano, J., Ichikawa, T., Kawai, M., Harada, M. & Ozaki, Y., 01-02-2017, In : Journal of Cardiac Failure. 23, 2, p. 131-137 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Prognostic value of combination of plasma D-dimer concentration and estimated glomerular filtration rate in predicting long-term mortality of patients with stable coronary artery disease

Naruse, H., Ishii, J., Takahashi, H., Kitagawa, F., Okuyama, R., Kawai, H., Muramatsu, T., Harada, M., Yamada, A., Motoyama, S., Matsui, S., Hayashi, M., Sarai, M., Watanabe, E., Izawa, H. & Ozaki, Y., 01-01-2017, In : Circulation Journal. 81, 10, p. 1506-1513 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Exogenous midkine administration prevents cardiac remodeling in pacing-induced congestive heart failure of rabbits

Harada, M., Hojo, M., Kamiya, K., Kadomatsu, K., Murohara, T., Kodama, I. & Horiba, M., 01-01-2016, In : Heart and Vessels. 31, 1, p. 96-104 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling: Potential Role in Metabolic Adaptation and Prevention of Progression

Harada, M., Tadevosyan, A., Qi, X., Xiao, J., Liu, T., Voigt, N., Karck, M., Kamler, M., Kodama, I., Murohara, T., Dobrev, D. & Nattel, S., 07-07-2015, In : Journal of the American College of Cardiology. 66, 1, p. 47-58 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial Remodeling

Qi, X. Y., Huang, H., Ordog, B., Luo, X., Naud, P., Sun, Y., Wu, C. T., Dawson, K., Tadevosyan, A., Chen, Y., Harada, M., Dobrev, D. & Nattel, S., 27-02-2015, In : Circulation research. 116, 5, p. 836-845 10 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Multiscale entropy of the heart rate variability for the prediction of an ischemic stroke in patients with permanent atrial fibrillation

Watanabe, E., Kiyono, K., Hayano, J., Yamamoto, Y., Inamasu, J., Yamamoto, M., Ichikawa, T., Sobue, Y., Harada, M. & Ozaki, Y., 01-09-2015, In : PloS one. 10, 9, e0137144.

Research output: Contribution to journalArticle

19 Citations (Scopus)

QRS-based assessment of myocardial damage and adverse events associated with cardiac sarcoidosis

Sobue, Y., Harada, M., Koshikawa, M., Ichikawa, T., Yamamoto, M., Okuda, K., Kato, Y., Sarai, M., Watanabe, E. & Ozaki, Y., 01-12-2015, In : Heart Rhythm. 12, 12, p. 2499-2507 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Role of inflammation in Atrial fibrillation pathophysiology and management

Harada, M., Van Wagoner, D. R. & Nattel, S., 01-01-2015, In : Circulation Journal. 79, 3, p. 495-502 8 p.

Research output: Contribution to journalReview article

129 Citations (Scopus)
2014

Atrial remodeling and atrial fibrillation: Recent advances and translational perspectives

Nattel, S. & Harada, M., 10-06-2014, In : Journal of the American College of Cardiology. 63, 22, p. 2335-2345 11 p.

Research output: Contribution to journalReview article

229 Citations (Scopus)

Disease and region-related cardiac fibroblast potassium current variations and potential functional significance

Wu, C. T., Qi, X. Y., Huang, H., Naud, P., Dawson, K., Yeh, Y. H., Harada, M., Kuo, C. T. & Nattel, S., 01-06-2014, In : Cardiovascular Research. 102, 3, p. 487-496 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

MicroRNA regulation and cardiac calcium signaling: Role in cardiac disease and therapeutic potential

Harada, M., Luo, X., Murohara, T., Yang, B., Dobrev, D. & Nattel, S., 14-02-2014, In : Circulation research. 114, 4, p. 689-705 17 p.

Research output: Contribution to journalReview article

80 Citations (Scopus)

Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog

Qi, X. Y., Diness, J. G., Brundel, B. J. J. M., Zhou, X. B., Naud, P., Wu, C. T., Huang, H., Harada, M., Aflaki, M., Dobrev, D., Grunnet, M. & Nattel, S., 28-01-2014, In : Circulation. 129, 4, p. 430-440 11 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)
2012

AMP-Activated protein kinase potential role in cardiac electrophysiology and arrhythmias

Harada, M., Nattel, S. N. & Nattel, S., 11-10-2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 4, p. 860-867 8 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)

Inhibition of intercellular coupling stabilizes spiral-wave reentry, whereas enhancement of the coupling destabilizes the reentry in favor of early termination

Takemoto, Y., Takanari, H., Honjo, H., Ueda, N., Harada, M., Kato, S., Yamazaki, M., Sakuma, I., Opthof, T., Kodama, I. & Kamiya, K., 01-09-2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 5, p. H578-H586

Research output: Contribution to journalArticle

10 Citations (Scopus)

Regional cooling facilitates termination of spiral-wave reentry through unpinning of rotors in rabbit hearts

Yamazaki, M., Honjo, H., Ashihara, T., Harada, M., Sakuma, I., Nakazawa, K., Trayanova, N., Horie, M., Kalifa, J., Jalife, J., Kamiya, K. & Kodama, I., 01-01-2012, In : Heart Rhythm. 9, 1, p. 107-114 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation

Harada, M., Luo, X., Qi, X. Y., Tadevosyan, A., Maguy, A., Ordog, B., Ledoux, J., Kato, T., Naud, P., Voigt, N., Shi, Y., Kamiya, K., Murohara, T., Kodama, I., Tardif, J. C., Schotten, U., Van Wagoner, D. R., Dobrev, D. & Nattel, S., 23-10-2012, In : Circulation. 126, 17, p. 2051-2064 14 p.

Research output: Contribution to journalArticle

137 Citations (Scopus)
2011

Bepridil facilitates early termination of spiral-wave reentry in two-dimensional cardiac muscle through an increase of intercellular electrical coupling

Takanari, H., Honjo, H., Takemoto, Y., Suzuki, T., Kato, S., Harada, M., Okuno, Y., Ashihara, T., Opthof, T., Sakuma, I., Kamiya, K. & Kodama, I., 14-03-2011, In : Journal of Pharmacological Sciences. 115, 1, p. 15-26 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Differential protein kinase c isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling

Makary, S., Voigt, N., Maguy, A., Wakili, R., Nishida, K., Harada, M., Dobrev, D. & Nattel, S., 14-10-2011, In : Circulation research. 109, 9, p. 1031-1043 13 p.

Research output: Contribution to journalArticle

Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model

Nishida, K., Qi, X. Y., Wakili, R., Comtois, P., Chartier, D., Harada, M., Iwasaki, Y. K., Romeo, P., Maguy, A., Dobrev, D., Michael, G., Talajic, M. & Nattel, S., 18-01-2011, In : Circulation. 123, 2, p. 137-146 10 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Rate-dependent shortening of action potential duration increases ventricular vulnerability in failing rabbit heart

Harada, M., Tsuji, Y., Ishiguro, Y. S., Takanari, H., Okuno, Y., Inden, Y., Honjo, H., Lee, J. K., Murohara, T., Sakuma, I., Kamiya, K. & Kodama, I., 01-02-2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 2, p. H565-H573

Research output: Contribution to journalArticle

20 Citations (Scopus)
2010

Acute amiodarone promotes drift and early termination of spiral wave re-entry

Nakagawa, H., Honjo, H., Ishiguro, Y. S., Yamazaki, M., Okuno, Y., Harada, M., Takanari, H., Sakuma, I., Kamiya, K. & Kodama, I., 01-07-2010, In : Heart and Vessels. 25, 4, p. 338-347 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2009

Action potential characteristics in the sinus venosa of patients with and without atrial flutter

Harada, M., Osaka, T., Yokoyama, E., Takemoto, Y., Ito, A. & Kodama, I., 01-04-2009, In : Circulation Journal. 73, 4, p. 647-653 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Early termination of spiral wave reentry by combined blockade of Na+ and L-type Ca2+ currents in a perfused two-dimensional epicardial layer of rabbit ventricular myocardium

Ishiguro, Y. S., Honjo, H., Opthof, T., Okuno, Y., Nakagawa, H., Yamazaki, M., Harada, M., Takanari, H., Suzuki, T., Morishima, M., Sakuma, I., Kamiya, K. & Kodama, I., 01-05-2009, In : Heart Rhythm. 6, 5, p. 684-692 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2008

Moderate hypothermia increases the chance of spiral wave collision in favor of self-termination of ventricular tachycardia/fibrillation

Harada, M., Honjo, H., Yamazaki, M., Nakagawa, H., Ishiguro, Y. S., Okuno, Y., Ashihara, T., Sakuma, I., Kamiya, K. & Kodama, I., 01-04-2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 294, 4

Research output: Contribution to journalArticle

37 Citations (Scopus)
2006

Biventricular pacing has an advantage over left ventricular epicardial pacing alone to minimize proarrhythmic perturbation of repolarization

Harada, M., Osaka, T., Yokoyama, E., Takemoto, Y., Ito, A. & Kodama, I., 01-02-2006, In : Journal of Cardiovascular Electrophysiology. 17, 2, p. 151-156 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2005

Subacute pulmonary hypertension due to pulmonary tumor thrombotic microangiopathy from gastric cancer: A case report

Harada, M., Nishi, Y., Hayashida, N. & Koyanagi, H., 01-08-2005, In : Respiration and Circulation. 53, 8, p. 879-885 7 p.

Research output: Contribution to journalArticle

2003

Infective endocarditis with a huge mitral vegetation related to atopic dermatitis and high serum level of infection-related antiphospholipid antibody: A case report

Harada, M., Nishi, Y., Tamura, S., Iba, Y., Abe, K., Yanbe, Y., Akimoto, T., Takao, N., Watanabe, S., Hayashida, N. & Koyanagi, H., 01-09-2003, In : Journal of cardiology. 42, 3, p. 135-140 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)