• 14396 Citations
  • 50 h-Index
1992 …2019
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Research Output 1992 2019

2019

A single-nucleotide polymorphism influences brain morphology in drug-näve patients with major depressive disorder

Katsuki, A., Kakeda, S., Watanabe, K., Igata, R., Otsuka, Y., Kishi, T., Nguyen, L. H., Ueda, I., Iwata, N., Korogi, Y. & Yoshimura, R., 01-01-2019, In : Neuropsychiatric Disease and Treatment. 15, p. 2425-2432 8 p.

Research output: Contribution to journalArticle

Open Access
Major Depressive Disorder
Single Nucleotide Polymorphism
Brain
Pharmaceutical Preparations
Genotype
1 Citation (Scopus)
Bipolar Disorder
Randomized Controlled Trials
Placebos
Incidence
Network Meta-Analysis

COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder

Otsuka, Y., Kakeda, S., Sugimoto, K., Katsuki, A., Nguyen, L. H., Igata, R., Watanabe, K., Ueda, I., Kishi, T., Iwata, N., Korogi, Y. & Yoshimura, R., 01-01-2019, In : Neuropsychiatric Disease and Treatment. 15, p. 1537-1545 9 p.

Research output: Contribution to journalArticle

Open Access
Catechol O-Methyltransferase
Major Depressive Disorder
Hippocampus
Genotype
Pharmaceutical Preparations

Daytime light exposure in daily life and depressive symptoms in bipolar disorder: A cross-sectional analysis in the APPLE cohort

Esaki, Y., Kitajima, T., Obayashi, K., Saeki, K., Fujita, K. & Iwata, N., 01-09-2019, In : Journal of Psychiatric Research. 116, p. 151-156 6 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Cross-Sectional Studies
Depression
Light
Odds Ratio
2 Citations (Scopus)

Effect of discontinuation v. maintenance of antipsychotic medication on relapse rates in patients with remitted/stable first-episode psychosis: A meta-analysis

Kishi, T., Ikuta, T., Matsui, Y., Inada, K., Matsuda, Y., Mishima, K. & Iwata, N., 01-04-2019, In : Psychological Medicine. 49, 5, p. 772-779 8 p.

Research output: Contribution to journalArticle

Psychotic Disorders
Antipsychotic Agents
Meta-Analysis
Maintenance
Recurrence
4 Citations (Scopus)

Efficacy, Tolerability, and Safety of Blonanserin in Schizophrenia: An Updated and Extended Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kishi, T., Matsui, Y., Matsuda, Y., Katsuki, A., Hori, H., Yanagimoto, H., Sanada, K., Morita, K., Yoshimura, R., Shoji, Y., Hagi, K. & Iwata, N., 07-03-2019, In : Pharmacopsychiatry. 52, 2, p. 52-62 11 p.

Research output: Contribution to journalArticle

Meta-Analysis
Schizophrenia
Randomized Controlled Trials
Safety
Risperidone

Efficacy and safety of blonanserin transdermal patch in patients with schizophrenia: A 6-week randomized, double-blind, placebo-controlled, multicenter study

Iwata, N., Ishigooka, J., Kim, W. H., Yoon, B. H., Lin, S. K., Sulaiman, A. H., Cosca, R., Wang, L., Suchkov, Y., Agarkov, A., Watabe, K., Matsui, T., Sato, T., Inoue, Y., Higuchi, T., Correll, C. U. & Kane, J. M., 01-01-2019, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Open Access
Transdermal Patch
Multicenter Studies
Schizophrenia
Placebos
Safety

Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials with an enrichment design

Oya, K., Sakuma, K., Esumi, S., Hashimoto, Y., Hatano, M., Matsuda, Y., Matsui, Y., Miyake, N., Nomura, I., Okuya, M., Iwata, N., Kato, M., Hashimoto, R., Mishima, K., Watanabe, N. & Kishi, T., 01-09-2019, In : Neuropsychopharmacology reports. 39, 3, p. 241-246 6 p.

Research output: Contribution to journalArticle

Open Access
Bipolar Disorder
Lithium
Meta-Analysis
Randomized Controlled Trials
Placebos
3 Citations (Scopus)

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

iPSYCH-GEMS Schizophrenia Working Group, CommonMind Consortium & The Schizophrenia Working Group of the PsyUniversity of Copenhagenchiatric Genomics Consortium, 01-04-2019, In : Nature Genetics. 51, 4, p. 659-674 16 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Prefrontal Cortex
Schizophrenia
Tay-Sachs Disease
Gene Expression
1 Citation (Scopus)

Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: A diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms

Kakeda, S., Watanabe, K., Katsuki, A., Sugimoto, K., Ueda, I., Igata, N., Kishi, T., Iwata, N., Abe, O., Yoshimura, R. & Korogi, Y., 01-01-2019, In : Neuropsychiatric Disease and Treatment. 15, p. 375-383 9 p.

Research output: Contribution to journalArticle

Open Access
Diffusion Tensor Imaging
Genetic Loci
Major Depressive Disorder
Depression
Single Nucleotide Polymorphism

Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population

Koshimizu, H., Nogawa, S., Asano, S., Ikeda, M., Iwata, N., Takahashi, S., Saito, K. & Miyakawa, T., 01-12-2019, In : Translational psychiatry. 9, 1, 52.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Major Depressive Disorder
Psychology
Population
Far East
1 Citation (Scopus)

GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture

Matoba, N., Akiyama, M., Ishigaki, K., Kanai, M., Takahashi, A., Momozawa, Y., Ikegawa, S., Ikeda, M., Iwata, N., Hirata, M., Matsuda, K., Kubo, M., Okada, Y. & Kamatani, Y., 01-05-2019, In : Nature Human Behaviour. 3, 5, p. 471-477 7 p.

Research output: Contribution to journalLetter

Genetic Loci
Genome-Wide Association Study
Smoking
Linkage Disequilibrium
Tobacco Products
5 Citations (Scopus)

Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population

Suzuki, K., Akiyama, M., Ishigaki, K., Kanai, M., Hosoe, J., Shojima, N., Hozawa, A., Kadota, A., Kuriki, K., Naito, M., Tanno, K., Ishigaki, Y., Hirata, M., Matsuda, K., Iwata, N., Ikeda, M., Sawada, N., Yamaji, T., Iwasaki, M., Ikegawa, S. & 12 others, Maeda, S., Murakami, Y., Wakai, K., Tsugane, S., Sasaki, M., Yamamoto, M., Okada, Y., Kubo, M., Kamatani, Y., Horikoshi, M., Yamauchi, T. & Kadowaki, T., 01-03-2019, In : Nature Genetics. 51, 3, p. 379-386 8 p.

Research output: Contribution to journalLetter

Genome-Wide Association Study
Gene Frequency
Type 2 Diabetes Mellitus
Population
Acinar Cells

Light exposure at night and sleep quality in bipolar disorder: The APPLE cohort study

Esaki, Y., Kitajima, T., Obayashi, K., Saeki, K., Fujita, K. & Iwata, N., 01-10-2019, In : Journal of Affective Disorders. 257, p. 314-320 7 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Sleep
Cohort Studies
Light
Actigraphy
Open Access
Melatonin Receptors
Bipolar Disorder
Meta-Analysis
Randomized Controlled Trials
Melatonin

Plasma levels of IL-6 in patients with untreated major depressive disorder: Comparison with catecholamine metabolites

Yoshimura, R., Kishi, T. & Iwata, N., 01-01-2019, In : Neuropsychiatric Disease and Treatment. 15, p. 2655-2661 7 p.

Research output: Contribution to journalArticle

Open Access
Major Depressive Disorder
Catecholamines
Interleukin-6
Homovanillic Acid
Diagnostic and Statistical Manual of Mental Disorders

Polygenic risk scores in schizophrenia with clinically significant copy number variants

Taniguchi, S., Ninomiya, K., Kushima, I., Saito, T., Shimasaki, A., Sakusabe, T., Momozawa, Y., Kubo, M., Kamatani, Y., Ozaki, N., Ikeda, M. & Iwata, N., 01-01-2019, (Accepted/In press) In : Psychiatry and clinical neurosciences.

Research output: Contribution to journalArticle

Open Access
Schizophrenia
Comparative Genomic Hybridization
Single Nucleotide Polymorphism
1 Citation (Scopus)

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Wellcome Trust Case Control Consortium 2 & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 01-04-2019, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180, 3, p. 223-231 9 p.

Research output: Contribution to journalArticle

Exome
Haplotypes
Genome-Wide Association Study
Schizophrenia
Population

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4)

iPSYCH-GEMS Schizophrenia Working Group, CommonMind Consortium & The Schizophrenia Working Group of the Psychiatric Genomics Consortium, 01-06-2019, In : Nature Genetics. 51, 6, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Genomics
Psychiatry
Schizophrenia
Gene Expression
Brain

Quetiapine extended-release vs olanzapine for Japanese patients with bipolar depression: A Bayesian analysis

Kishi, T., Ikuta, T., Matsuda, Y. & Iwata, N., 01-09-2019, In : Neuropsychopharmacology reports. 39, 3, p. 256-259 4 p.

Research output: Contribution to journalArticle

Open Access
olanzapine
Bayes Theorem
Bipolar Disorder
Odds Ratio
Depression

Rare compound heterozygous missense SPATA7 variations and risk of schizophrenia; whole-exome sequencing in a consanguineous family with affected siblings, follow-up sequencing and a casecontrol study

Igeta, H., Watanabe, Y., Morikawa, R., Ikeda, M., Otsuka, I., Hoya, S., Koizumi, M., Egawa, J., Hishimoto, A., Iwata, N. & Someya, T., 01-01-2019, In : Neuropsychiatric Disease and Treatment. 15, p. 2353-2363 11 p.

Research output: Contribution to journalArticle

Open Access
Exome
Siblings
Schizophrenia
Case-Control Studies
Parents
3 Citations (Scopus)

Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder

Nguyen, L. H., Kakeda, S., Katsuki, A., Sugimoto, K., Otsuka, Y., Ueda, I., Igata, R., Watanabe, K., Kishi, T., Iwata, N., Korogi, Y. & Yoshimura, R., 01-10-2019, In : European Archives of Psychiatry and Clinical Neuroscience. 269, 7, p. 785-794 10 p.

Research output: Contribution to journalArticle

Major Depressive Disorder
Vascular Endothelial Growth Factor A
Single Nucleotide Polymorphism
Brain
Genotype

Response to the Letter from Dr. Jacob Peedicayil

Sakuma, K., Kishi, T. & Iwata, N., 01-04-2019, In : Psychopharmacology. 236, 4, p. 1403-1404 2 p.

Research output: Contribution to journalLetter

Suvorexant for insomnia in patients with psychiatric disorder: A 1-week, open-label study

Kishi, T., Sakuma, K., Okuya, M., Ninomiya, K., Oya, K., Kubo, M., Matsui, Y., Nomura, I., Okuyama, Y., Matsunaga, S. & Iwata, N., 01-09-2019, In : Neuropsychopharmacology reports. 39, 3, p. 252-255 4 p.

Research output: Contribution to journalArticle

Open Access
Sleep Initiation and Maintenance Disorders
Psychiatry
Sleep
Safety
Major Depressive Disorder

The effects of different periods of co-administration of oral and long-acting injectable aripiprazole: A propensity score analysis

Hatano, M., Kamei, H., Takeuchi, I., Tozawa, K., Makino, S., Hanya, M., Yamada, S. & Iwata, N., 01-01-2019, In : Human Psychopharmacology. 34, 1, e2681.

Research output: Contribution to journalArticle

Propensity Score
Oral Administration
Injections
Aripiprazole
Treatment Failure

The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies

Liu, C., Kanazawa, T., Tian, Y., Mohamed Saini, S., Mancuso, S., Mostaid, M. S., Takahashi, A., Zhang, D., Zhang, F., Yu, H., Doo Shin, H., Sub Cheong, H., Ikeda, M., Kubo, M., Iwata, N., Woo, S. I., Yue, W., Kamatani, Y., Shi, Y., Li, Z. & 3 others, Everall, I., Pantelis, C. & Bousman, C., 01-12-2019, In : Translational psychiatry. 9, 1, 205.

Research output: Contribution to journalArticle

Open Access
Knowledge Bases
Schizophrenia
Meta-Analysis
Genes
Single Nucleotide Polymorphism
2018
1 Citation (Scopus)

A Case of Non-24-Hour Sleep-Wake Rhythm Disorder Treated With a Low Dose of Ramelteon and Behavioral Education

Watanabe, A., Hirose, M., Arakawa, C., Iwata, N. & Kitajima, T., 15-07-2018, In : Journal of Clinical Sleep Medicine. 14, 7, p. 1265-1267 3 p.

Research output: Contribution to journalArticle

Circadian Rhythm Sleep Disorders
Education
Actigraphy
Photoperiod
Sleep

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

Schizophrenia and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, 25-06-2018, In : BMC Genomics. 19, 1, 494.

Research output: Contribution to journalArticle

Genome-Wide Association Study
4 Citations (Scopus)

Age at first birth in women is genetically associated with increased risk of schizophrenia

Ni, G., Gratten, J., Wray, N. R., Lee, S. H., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F. & 281 others, Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Degenhardt, F., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Frank, J., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Haan, L. D., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Herms, S., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Juliá, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M. C., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Keong, J. L. C., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B. S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'callaghan, E., O'dushlaine, C., O'neill, F. A., Oh, S. Y., Olincy, A., Olsen, L., Os, J. V., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Ruderfer, D. M., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schulze, T. G., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Strohmaier, J., Stroup, T. S., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Witt, S. H., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Rietschel, M., Riley, B. P., Rujescu, D., Sham, P. C., Sklar, P., Clair, D. S., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., Sullivan, P. F. & O'donovan, M. C., 01-12-2018, In : Scientific reports. 8, 1, 10168.

Research output: Contribution to journalArticle

Birth Order
Schizophrenia
Parents
Mental Health
Genetic Heterogeneity
31 Citations (Scopus)

A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder

Advanced Collaborative Study of Mood Disorder (COSMO) team, 01-03-2018, In : Molecular Psychiatry. 23, 3, p. 639-647 9 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Bipolar Disorder
Population
Psychiatry
Regulator Genes
2 Citations (Scopus)

Anti-dementia drugs for psychopathology and cognitive impairment in schizophrenia: A systematic review and meta-analysis

Kishi, T., Ikuta, T., Oya, K., Matsunaga, S., Matsuda, Y. & Iwata, N., 01-01-2018, In : International Journal of Neuropsychopharmacology. 21, 8, p. 748-757 10 p.

Research output: Contribution to journalReview article

Psychopathology
Antipsychotic Agents
Dementia
Meta-Analysis
Schizophrenia

A retrospective study of the efficacy of ramelteon for insomnia: relevance of dose and timing of administration

Watanabe, A., Hirose, M., Kitajima, T., Tomita, S., Esaki, Y. & Iwata, N., 01-01-2018, In : Sleep and Biological Rhythms. 16, 1, p. 69-75 7 p.

Research output: Contribution to journalArticle

Sleep Initiation and Maintenance Disorders
Retrospective Studies
Sleep
Psychiatry
ramelteon

Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia

Ishizuka, K., Kimura, H., Kushima, I., Inada, T., Okahisa, Y., Ikeda, M., Iwata, N., Mori, D., Aleksic, B. & Ozaki, N., 01-10-2018, In : Psychiatric Genetics. 28, 5, p. 90-93 4 p.

Research output: Contribution to journalArticle

Lactoylglutathione Lyase
Schizophrenia
Penetrance
Gene Frequency
Exons
1 Citation (Scopus)

Assessment of switching to suvorexant versus the use of add-on suvorexant in combination with benzodiazepine receptor agonists in insomnia patients: A retrospective study

Hatano, M., Kamei, H., Inagaki, R., Matsuzaki, H., Hanya, M., Yamada, S. & Iwata, N., 05-2018, In : Clinical Psychopharmacology and Neuroscience. 16, 2, p. 184-189 6 p.

Research output: Contribution to journalArticle

Sleep Initiation and Maintenance Disorders
GABA-A Receptors
Retrospective Studies
Aminobutyrates
Prescription Drugs
21 Citations (Scopus)

Brain-derived neurotrophic factor and major depressive disorder: Evidence from meta-analyses

Kishi, T., Yoshimura, R., Ikuta, T. & Iwata, N., 17-01-2018, In : Frontiers in Psychiatry. 8, JAN, 308.

Research output: Contribution to journalShort survey

Brain-Derived Neurotrophic Factor
Major Depressive Disorder
Meta-Analysis
Antidepressive Agents
Genes
3 Citations (Scopus)
Memantine
Obsessive-Compulsive Disorder
Serotonin Uptake Inhibitors
Meta-Analysis
Randomized Controlled Trials
19 Citations (Scopus)

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights

Kushima, I., Aleksic, B., Nakatochi, M., Shimamura, T., Okada, T., Uno, Y., Morikawa, M., Ishizuka, K., Shiino, T., Kimura, H., Arioka, Y., Yoshimi, A., Takasaki, Y., Yu, Y., Nakamura, Y., Yamamoto, M., Iidaka, T., Iritani, S., Inada, T., Ogawa, N. & 60 others, Shishido, E., Torii, Y., Kawano, N., Omura, Y., Yoshikawa, T., Uchiyama, T., Yamamoto, T., Ikeda, M., Hashimoto, R., Yamamori, H., Yasuda, Y., Someya, T., Watanabe, Y., Egawa, J., Nunokawa, A., Itokawa, M., Arai, M., Miyashita, M., Kobori, A., Suzuki, M., Takahashi, T., Usami, M., Kodaira, M., Watanabe, K., Sasaki, T., Kuwabara, H., Tochigi, M., Nishimura, F., Yamasue, H., Eriguchi, Y., Benner, S., Kojima, M., Yassin, W., Munesue, T., Yokoyama, S., Kimura, R., Funabiki, Y., Kosaka, H., Ishitobi, M., Ohmori, T., Numata, S., Yoshikawa, T., Toyota, T., Yamakawa, K., Suzuki, T., Inoue, Y., Nakaoka, K., Goto, Y. I., Inagaki, M., Hashimoto, N., Kusumi, I., Son, S., Murai, T., Ikegame, T., Okada, N., Kasai, K., Kunimoto, S., Mori, D., Iwata, N. & Ozaki, N., 11-09-2018, In : Cell Reports. 24, 11, p. 2838-2856 19 p.

Research output: Contribution to journalArticle

Schizophrenia
Genes
Oxidative stress
Bioinformatics
Intellectual Disability

Comparison of the efficacy and safety of 4 and 2 mg/day brexpiprazole for acute schizophrenia: A meta-analysis of double-blind, randomized placebo-controlled trials

Kishi, T., Oya, K., Matsui, Y., Nomura, I., Sakuma, K., Okuya, M., Matsuda, Y., Fujita, K., Funahashi, T., Yoshimura, R. & Iwata, N., 01-01-2018, In : Neuropsychiatric Disease and Treatment. 14, p. 2519-2530 12 p.

Research output: Contribution to journalArticle

Meta-Analysis
Schizophrenia
Randomized Controlled Trials
Placebos
Safety
2 Citations (Scopus)

Decreased serum pyridoxal levels in schizophrenia: Meta-analysis and Mendelian randomization analysis

Tomioka, Y., Numata, S., Kinoshita, M., Umehara, H., Watanabe, S. Y., Nakataki, M., Iwayama, Y., Toyota, T., Ikeda, M., Yamamori, H., Shimodera, S., Tajima, A., Hashimoto, R., Iwata, N., Yoshikawa, T. & Ohmori, T., 05-2018, In : Journal of Psychiatry and Neuroscience. 43, 3, p. 194-200 7 p.

Research output: Contribution to journalArticle

Mendelian Randomization Analysis
Pyridoxal
Meta-Analysis
Schizophrenia
Serum
2 Citations (Scopus)

DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder

Sugawara, H., Murata, Y., Ikegame, T., Sawamura, R., Shimanaga, S., Takeoka, Y., Saito, T., Ikeda, M., Yoshikawa, A., Nishimura, F., Kawamura, Y., Kakiuchi, C., Sasaki, T., Iwata, N., Hashimoto, M., Kasai, K., Kato, T., Bundo, M. & Iwamoto, K., 01-04-2018, In : Psychiatry and clinical neurosciences. 72, 4, p. 245-254 10 p.

Research output: Contribution to journalArticle

Genetic Association Studies
DNA Methylation
Bipolar Disorder
Epigenomics
Schizophrenia
2 Citations (Scopus)

Efficacy, Acceptability, and Safety of Intravenous Immunoglobulin Administration for Mild-To-Moderate Alzheimer's Disease: A Systematic Review and Meta-Analysis

Okuya, M., Matsunaga, S., Ikuta, T., Kishi, T. & Iwata, N., 01-01-2018, In : Journal of Alzheimer's Disease. 66, 4, p. 1379-1387 9 p.

Research output: Contribution to journalArticle

Intravenous Immunoglobulins
Intravenous Administration
Meta-Analysis
Alzheimer Disease
Safety
15 Citations (Scopus)

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

Wellcome Trust Case Control Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & Psychosis Endophenotypes International Consortium, 07-06-2018, In : American Journal of Human Genetics. 102, 6, p. 1185-1194 10 p.

Research output: Contribution to journalArticle

Linkage Disequilibrium
Schizophrenia
Likelihood Functions
Genetic Heterogeneity
Nucleic Acid Regulatory Sequences
5 Citations (Scopus)

Folic acid/methylfolate for the treatment of psychopathology in schizophrenia: a systematic review and meta-analysis

Sakuma, K., Matsunaga, S., Nomura, I., Okuya, M., Kishi, T. & Iwata, N., 01-08-2018, In : Psychopharmacology. 235, 8, p. 2303-2314 12 p.

Research output: Contribution to journalArticle

Psychopathology
Folic Acid
Meta-Analysis
Schizophrenia
Randomized Controlled Trials
55 Citations (Scopus)

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

Kanai, M., Akiyama, M., Takahashi, A., Matoba, N., Momozawa, Y., Ikeda, M., Iwata, N., Ikegawa, S., Hirata, M., Matsuda, K., Kubo, M., Okada, Y. & Kamatani, Y., 01-03-2018, In : Nature Genetics. 50, 3, p. 390-400 11 p.

Research output: Contribution to journalArticle

Population
Genome-Wide Association Study
Genetic Pleiotropy
Phenotype
12 Citations (Scopus)
Genome-Wide Association Study
Bipolar Disorder
Single Nucleotide Polymorphism
Disease Susceptibility
Genes
53 Citations (Scopus)

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu, Psychosis Endophenotypes International Consortium & Wellcome Trust Case Control Consortium, 14-06-2018, In : Cell. 173, 7, p. 1705-1715.e16

Research output: Contribution to journalArticle

Dissection
Bipolar Disorder
Schizophrenia
Genes
Potassium
1 Citation (Scopus)
Memantine
Meta-Analysis
Alzheimer Disease
Randomized Controlled Trials
Placebos
4 Citations (Scopus)

Rare loss of function mutations in N-methyl-d-aspartate glutamate receptors and their contributions to schizophrenia susceptibility

Yu, Y., Lin, Y., Takasaki, Y., Wang, C., Kimura, H., Xing, J., Ishizuka, K., Toyama, M., Kushima, I., Mori, D., Arioka, Y., Uno, Y., Shiino, T., Nakamura, Y., Okada, T., Morikawa, M., Ikeda, M., Iwata, N., Okahisa, Y., Takaki, M. & 10 others, Sakamoto, S., Someya, T., Egawa, J., Usami, M., Kodaira, M., Yoshimi, A., Oya-Ito, T., Aleksic, B., Ohno, K. & Ozaki, N., 01-12-2018, In : Translational psychiatry. 8, 1, 61.

Research output: Contribution to journalArticle

Glutamate Receptors
Schizophrenia
Mutation
Frameshift Mutation
Pedigree
1 Citation (Scopus)

Re-evaluating classical body type theories: Genetic correlation between psychiatric disorders and body mass index

Ikeda, M., Tanaka, S., Saito, T., Ozaki, N., Kamatani, Y. & Iwata, N., 01-07-2018, In : Psychological Medicine. 48, 10, p. 1745-1748 4 p.

Research output: Contribution to journalArticle

Somatotypes
Psychiatry
Body Mass Index

Response to the letter from Dr. Kim and colleagues

Kishi, T., Nomura, I., Ikuta, T. & Iwata, N., 01-05-2018, In : Psychiatry Research. 263, p. 291-292 2 p.

Research output: Contribution to journalLetter