• 1577 Citations
  • 13 h-Index
1988 …2019
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Research Output 1988 2019

  • 1577 Citations
  • 13 h-Index
  • 29 Article
  • 1 Chapter
  • 1 Letter
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Article
2019

Influx of Tau and Amyloid-β Proteins into the Blood during Hemodialysis as a Therapeutic Extracorporeal Blood Amyloid-β Removal System for Alzheimer's Disease

Kitaguchi, N., Tatebe, H., Sakai, K., Kawaguchi, K., Matsunaga, S., Kitajima, T., Tomizawa, H., Kato, M., Sugiyama, S., Suzuki, N., Mizuno, M., Takechi, H., Nakai, S., Hiki, Y., Kushimoto, H., Hasegawa, M., Yuzawa, Y. & Tokuda, T., 01-01-2019, In : Journal of Alzheimer's Disease. 69, 3, p. 687-707 21 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
tau Proteins
Amyloid
Renal Dialysis
Alzheimer Disease
2018
2 Citations (Scopus)

Adsorptive filtration systems for effective removal of blood amyloid β: a potential therapy for Alzheimer’s disease

Kitaguchi, N., Kawaguchi, K., Yamazaki, K., Kawachi, H., Sakata, M., Kaneko, M., Kato, M., Sakai, K., Ohashi, N., Hasegawa, M., Hiki, Y. & Yuzawa, Y., 01-06-2018, In : Journal of Artificial Organs. 21, 2, p. 220-229 10 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Blood
Brain
Adsorption
2 Citations (Scopus)

Removal of blood amyloid-β with hemodialysis reduced brain amyloid-β, confirmed by brain imaging: A case report

Kitaguchi, N., Kato, T., Matsunaga, S., Hirano, K., Iwata, K., Kawaguchi, K., Fujita, K., Takechi, H., Hasegawa, M., Yuzawa, Y. & Ito, K., 01-01-2018, In : Neuropsychiatric Disease and Treatment. 14, p. 2931-2937 7 p.

Research output: Contribution to journalArticle

Amyloid
Neuroimaging
Renal Dialysis
Brain
Alzheimer Disease
2016
10 Citations (Scopus)

Patients that have undergone hemodialysis exhibit lower amyloid deposition in the brain: Evidence supporting a therapeutic strategy for Alzheimer's disease by removal of blood amyloid

Sakai, K., Senda, T., Hata, R., Kuroda, M., Hasegawa, M., Kato, M., Abe, M., Kawaguchi, K., Nakai, S., Hiki, Y., Yuzawa, Y. & Kitaguchi, N., 12-04-2016, In : Journal of Alzheimer's Disease. 51, 4, p. 997-1002 6 p.

Research output: Contribution to journalArticle

Amyloid
Renal Dialysis
Alzheimer Disease
Brain
Silver Staining
5 Citations (Scopus)
Amyloidogenic Proteins
Polysulfones
Polymethyl Methacrylate
Polymethyl methacrylates
Adsorption
2015
2 Citations (Scopus)

A novel cell-containing device for regenerative medicine: biodegradable nonwoven filters with peripheral blood cells promote wound healing

Iwamoto, U., Hori, H., Takami, Y., Tokushima, Y., Shinzato, M., Yasutake, M. & Kitaguchi, N., 01-12-2015, In : Journal of Artificial Organs. 18, 4, p. 315-321 7 p.

Research output: Contribution to journalArticle

Regenerative Medicine
Wound Healing
Blood Cells
Blood
Cells
5 Citations (Scopus)

Appropriate nonwoven filters effectively capture human peripheral blood cells and mesenchymal stem cells, which show enhanced production of growth factors

Hori, H., Iwamoto, U., Niimi, G., Shinzato, M., Hiki, Y., Tokushima, Y., Kawaguchi, K., Ohashi, A., Nakai, S., Yasutake, M. & Kitaguchi, N., 01-01-2015, In : Journal of Artificial Organs. 18, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Polyethylene Terephthalates
Blood Cells
Intercellular Signaling Peptides and Proteins
16 Citations (Scopus)

A prospective study on blood Aβ levels and the cognitive function of patients with hemodialysis: a potential therapeutic strategy for Alzheimer’s disease

Kitaguchi, N., Hasegawa, M., Ito, S., Kawaguchi, K., Hiki, Y., Nakai, S., Suzuki, N., Shimano, Y., Ishida, O., Kushimoto, H., Kato, M., Koide, S., Kanayama, K., Kato, T., Ito, K., Takahashi, H., Mutoh, T., Sugiyama, S. & Yuzawa, Y., 01-11-2015, In : Journal of Neural Transmission. 122, 11, p. 1593-1607 15 p.

Research output: Contribution to journalArticle

Cognition
Renal Dialysis
Alzheimer Disease
Prospective Studies
Brain
1 Citation (Scopus)

Specificity of two monoclonal antibodies against a synthetic glycopeptide, an analogue to the hypo-galactosylated IgA1 hinge region

Hiki, Y., Hori, H., Yamamoto, K., Yamamoto, Y., Yuzawa, Y., Kitaguchi, N. & Takahashi, K., 01-04-2015, In : Journal of Nephrology. 28, 2, p. 181-186 6 p.

Research output: Contribution to journalArticle

Glycopeptides
Immunoglobulin A
Monoclonal Antibodies
Enzyme-Linked Immunosorbent Assay
Agglutinins
2013
6 Citations (Scopus)

A potential therapeutic system for Alzheimer's disease using adsorbents with alkyl ligands for removal of blood amyloid β

Kawaguchi, K., Takeuchi, M., Yamagawa, H., Murakami, K., Nakai, S., Hori, H., Ohashi, A., Hiki, Y., Suzuki, N., Sugiyama, S., Yuzawa, Y. & Kitaguchi, N., 01-06-2013, In : Journal of Artificial Organs. 16, 2, p. 211-217 7 p.

Research output: Contribution to journalArticle

Amyloid
Cellulose
Adsorbents
Alzheimer Disease
Blood
2012
18 Citations (Scopus)

Potential therapeutic system for Alzheimer's disease: Removal of blood Aβs by hemodialzyers and its effect on the cognitive functions of renal-failure patients

Kato, M., Kawaguchi, K., Nakai, S., Murakami, K., Hori, H., Ohashi, A., Hiki, Y., Ito, S., Shimano, Y., Suzuki, N., Sugiyama, S., Ogawa, H., Kusimoto, H., Mutoh, T., Yuzawa, Y. & Kitaguchi, N., 01-12-2012, In : Journal of Neural Transmission. 119, 12, p. 1533-1544 12 p.

Research output: Contribution to journalArticle

Cognition
Renal Insufficiency
Renal Dialysis
Alzheimer Disease
Therapeutics
2011
18 Citations (Scopus)

Reduction of Alzheimer's disease amyloid-β in plasma by hemodialysis and its relation to cognitive functions

Kitaguchi, N., Kawaguchi, K., Nakai, S., Murakami, K., Ito, S., Hoshino, H., Hori, H., Ohashi, A., Shimano, Y., Suzuki, N., Yuzawa, Y., Mutoh, T. & Sugiyama, S., 01-07-2011, In : Blood Purification. 32, 1, p. 57-62 6 p.

Research output: Contribution to journalArticle

Amyloid
Cognition
Renal Dialysis
Alzheimer Disease
Dialysis
2010
18 Citations (Scopus)

Novel therapeutic approach for Alzheimer's disease by removing amyloid β protein from the brain with an extracorporeal removal system

Kawaguchi, K., Kitaguchi, N., Nakai, S., Murakami, K., Asakura, K., Mutoh, T., Fujita, Y. & Sugiyama, S., 01-04-2010, In : Journal of Artificial Organs. 13, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Brain
Alzheimer Disease
Cellulose
G(M1) Ganglioside
1997
18 Citations (Scopus)

Cell display library for gene cloning of variable regions of human antibodies to hepatitis B surface antigen

Higuchi, K., Araki, T., Matsuzaki, O., Sato, A., Kanno, K., Kitaguchi, N. & Ito, H., 28-03-1997, In : Journal of Immunological Methods. 202, 2, p. 193-204 12 p.

Research output: Contribution to journalArticle

Hepatitis B Surface Antigens
Gene Library
Organism Cloning
Antibodies
Antigens
1995
2 Citations (Scopus)

A New Compound (Az36041) Promotes the Survival of the Neurons and Reduces Neurotoxicity of Alzheimer's Beta-Amyloid Protein

Hasegawa, Y., Sugimoto, E., Endo, T., Ogawa, K., Morikawa, A., Aratake, H., Kitaguchi, N., Hasegawa, Y. & Endo, T., 01-01-1995, In : Biological and Pharmaceutical Bulletin. 18, 12, p. 1750-1754 5 p.

Research output: Contribution to journalArticle

Amyloid beta-Peptides
Neurons
Serum Amyloid A Protein
Poisons
Amyloid Plaques
1994
5 Citations (Scopus)

Amyloid Beta Protein Precursor with Kunitz-Type Protease Inhibitor Domains (APPI) in Cerebrospinal Fluid and APPI mRNAs in Cultured Skin Fibroblasts of Patients with Alzheimer's Disease

Urakami, K., Okada, A., Takahashi, K., Ohno, K., Kitaguchi, N., Tanaka, S. & Nakamura, S., 01-01-1994, In : Tohoku Journal of Experimental Medicine. 174, 3, p. 199-207 9 p.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Amyloid beta-Protein Precursor
Fibroblasts
Protease Inhibitors
Cerebrospinal Fluid
1992
43 Citations (Scopus)

Age-related changes in the proportion of amyloid precursor protein mRNAs in Alzheimer's disease and other neurological disorders

Tanaka, S., Liu, L., Kimura, J., Shiojiri, S., Takahashi, Y., Kitaguchi, N., Nakamura, S. & Ueda, K., 01-01-1992, In : Molecular Brain Research. 15, 3-4, p. 303-310 8 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Nervous System Diseases
Alzheimer Disease
Messenger RNA
Serine Proteinase Inhibitors
12 Citations (Scopus)

Amyloid βprotein precursors with kunitz‐type inhibitor domains and acetyl‐cholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type

Urakami, K., Takahashi, K., Saito, H., Okada, A., Nakamura, S., Tanaka, S., Kitaguchi, N., Tokushima, Y. & Yamamoto, S., 01-01-1992, In : Acta Neurologica Scandinavica. 85, 5, p. 343-346 4 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Cholinesterase Inhibitors
Cerebrospinal Fluid
Alzheimer Disease
Acetylcholinesterase
3 Citations (Scopus)

Immunohistochemical localization of the proteinase inhibitor region of amyloid precursor proteins in the neocortex of Alzheimer's disease and aged controls

Nakamura, S., Suenaga, T., Akiguchi, I., Kimura, J., Nakamura, S., Tokushima, Y., Kitaguchi, N., Takahashi, Y. & Shiojiri, S., 01-08-1992, In : Acta Neuropathologica. 84, 3, p. 244-249 6 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Neocortex
Alzheimer Disease
Peptide Hydrolases
Astrocytes
16 Citations (Scopus)

Occurrence of acetylcholinesterase activity closely associated with amyloid β/A4 protein is not correlated with acetylcholinesterase-positive fiber density in amygdala of Alzheimer's disease

Nakamura, S., Takemura, M., Suenaga, T., Akiguchi, I., Kimura, J., Yasuhara, O., Kimura, T. & Kitaguchi, N., 01-09-1992, In : Acta Neuropathologica. 84, 4, p. 425-432 8 p.

Research output: Contribution to journalArticle

Amyloid beta-Peptides
Acetylcholinesterase
Amygdala
Alzheimer Disease
Amyloid Plaques
1991
177 Citations (Scopus)

Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture

Araki, W., Kitaguchi, N., Tokushima, Y., Ishii, K., Aratake, H., Shimohama, S., Nakamura, S. & Kimura, J., 27-11-1991, In : Biochemical and Biophysical Research Communications. 181, 1, p. 265-271 7 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Neurons
COS Cells
Serum-Free Culture Media
Neurites
1990
39 Citations (Scopus)

Determination of amyloid β protein precursors harboring active form of proteinase inhibitor domains in cerebrospinal fluid of Alzheimer's disease patients by trypsin-antibody sandwich ELISA

Kitaguchi, N., Tokushima, Y., Oishi, K., Takahashi, Y., Shiojiri, S., Nakamura, S., Tanaka, S., Kodaira, R. & Ito, H., 14-02-1990, In : Biochemical and Biophysical Research Communications. 166, 3, p. 1453-1459 7 p.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Amyloid beta-Protein Precursor
Trypsin
Cerebrospinal Fluid
Alzheimer Disease
47 Citations (Scopus)

Enzyme specificity of proteinase inhibitor region in amyloid precursor protein of Alzheimer's disease: different properties compared with protease nexin I

Kitaguchi, N., Takahashi, Y., Oishi, K., Shiojiri, S., Tokushima, Y., Utsunomiya, T. & Ito, H., 29-03-1990, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1038, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

Serpin E2
Serine Proteinase Inhibitors
Amyloid beta-Protein Precursor
Amyloid Plaques
Neurites
6 Citations (Scopus)

Structure prediction of protease inhibitor region in amyloid precursor protein of Alzheimer's disease

Toma, K., Kitaguchi, N. & Ito, H., 01-01-1989, In : Journal of Molecular Graphics. 7, 4, p. 202-205 4 p.

Research output: Contribution to journalArticle

protease
Amyloid beta-Protein Precursor
Protease Inhibitors
inhibitors
trypsin
130 Citations (Scopus)

Tissue-specific expression of three types of β-protein precursor mRNA: Enhancement of protease inhibitor-harboring types in Alzheimer's disease brain

Tanaka, S., Shiojiri, S., Takahashi, Y., Kitaguchi, N., Ito, H., Kameyama, M., Kimura, J., Nakamura, S. & Ueda, K., 30-12-1989, In : Biochemical and Biophysical Research Communications. 165, 3, p. 1406-1414 9 p.

Research output: Contribution to journalArticle

Protein Precursors
Protease Inhibitors
Brain
Alzheimer Disease
Tissue
1988
Amyloid beta-Peptides
Molecular Cloning
Protease Inhibitors
Amyloid
Chromosome Aberrations
854 Citations (Scopus)

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S. & Ito, H., 01-01-1988, In : Nature. 331, 6156, p. 530-532 3 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Protein Precursors
Alzheimer Disease
Peptide Hydrolases
Complementary DNA
114 Citations (Scopus)

Three types of amyloid protein precursor mRNA in human brain: Their differential expression in Alzheimer's disease

Tanaka, S., Nakamura, S., Ueda, K., Kameyama, M., Shiojiri, S., Takahashi, Y., Kitaguchi, N. & Ito, H., 15-12-1988, In : Biochemical and Biophysical Research Communications. 157, 2, p. 472-479 8 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Brain
Alzheimer Disease
Messenger RNA
Amino Acids