• 499 Citations
  • 12 h-Index
1990 …2017
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Research Output 1990 2017

  • 499 Citations
  • 12 h-Index
  • 34 Article
  • 1 Review article
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Article
2017
Narcotic Antagonists
Opioid Analgesics
Neoplasms
Respiratory Insufficiency
Morphine

Effects of combined treatment with branched-chain amino acids, citric acid, L-Carnitine, coenzyme Q10, Zinc, and Various Vitamins in tumor-bearing mice

Awa, H., Futamura, A., Higashiguchi, T., Ito, A., Mori, N., Murai, M., Ohara, H., Chihara, T. & Kaneko, T., 01-01-2017, In : Biological and Pharmaceutical Bulletin. 40, 3, p. 266-271 6 p.

Research output: Contribution to journalArticle

coenzyme Q10
Branched Chain Amino Acids
Carnitine
Dietary Supplements
Vitamins
2 Citations (Scopus)

Reliability of stiffness measurement device during passive isokinetic spastic wrist movements of healthy subjects and hemiplegics

Orand, A., Miyasaka, H., Takeda, K., Tanino, G., Chihara, T., Beppu, H. & Sonoda, S., 01-01-2017, In : Biocybernetics and Biomedical Engineering. 37, 1, p. 114-123 10 p.

Research output: Contribution to journalArticle

Angular velocity
Stiffness
Torque measurement
Standardization
Torque
2016
2 Citations (Scopus)

Effects of exercise and bryostatin-1 on serotonin dynamics after cerebral infarction

Mizutani, K., Sonoda, S., Wakita, H., Okazaki, H., Katoh, Y., Chihara, T. & Shimpo, K., 15-06-2016, In : NeuroReport. 27, 9, p. 659-664 6 p.

Research output: Contribution to journalArticle

Cerebral Infarction
Rotarod Performance Test
Serotonin
Cerebral Cortex
bryostatin 1
2015

Dietary Aloe Vera gel powder and extract inhibit azoxymethaneinduced colorectal aberrant crypt foci in mice fed a highfat diet

Chihara, T., Shimpo, K., Kaneko, T., Beppu, H., Higashiguchi, T., Sonoda, S., Tanaka, M., Yamada, M. & Abe, F., 01-01-2015, In : Asian Pacific Journal of Cancer Prevention. 16, 2, p. 683-687 5 p.

Research output: Contribution to journalArticle

Aberrant Crypt Foci
Powders
Diet
High Fat Diet
Aloe
12 Citations (Scopus)

Effects of aloe-emodin and emodin on proliferation of the MKN45 human gastric cancer cell line

Chihara, T., Shimpo, K., Beppu, H., Yamamoto, N., Kaneko, T., Wakamatsu, K. & Sonoda, S., 01-01-2015, In : Asian Pacific Journal of Cancer Prevention. 16, 9, p. 3887-3891 5 p.

Research output: Contribution to journalArticle

Emodin
Stomach Neoplasms
Anthraquinones
Cell Line
Cell Death
1 Citation (Scopus)
Aberrant Crypt Foci
Azoxymethane
Pleurotus
High Fat Diet
Agaricales
2014
2 Citations (Scopus)

Inhibitory effects of low-dose aloe-emodin on the development of colorectal tumors in Min mice

Shimpo, K., Chihara, T., Kaneko, T., Beppu, H., Wakamatsu, K., Shinzato, M., Yukitake, J. & Sonoda, S., 01-01-2014, In : Asian Pacific Journal of Cancer Prevention. 15, 14, p. 5587-5592 6 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Dextran Sulfate
Diet
Mucous Membrane
Cell Proliferation
2013
11 Citations (Scopus)

Effects of exercise after focal cerebral cortex infarction on basal ganglion

Mizutani, K., Sonoda, S., Karasawa, N., Yamada, K., Shimpo, K., Chihara, T., Takeuchi, T., Hasegawa, Y. & Kubo, K. Y., 01-06-2013, In : Neurological Sciences. 34, 6, p. 861-867 7 p.

Research output: Contribution to journalArticle

Cerebral Infarction
Basal Ganglia
Cerebral Cortex
Infarction
Rotarod Performance Test
1 Citation (Scopus)

Experimental research on stimulation of wound healing by n-3 fatty acids

Futamura, A., Higashiguchi, T., Ito, A., Kodama, Y., Chihara, T., Kaneko, T., Tomatsu, A. & Shimpo, K., 01-07-2013, In : Wounds. 25, 7, p. 186-192 7 p.

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
Wound Healing
Diet
Research
Fatty Acids
8 Citations (Scopus)

Reduction of Intestinal Polyp Formation in Min Mice Fed a High-Fat Diet with Aloe Vera Gel Extract

Chihara, T., Shimpo, K., Beppu, H., Tomatsu, A., Kaneko, T., Tanaka, M., Yamada, M., Abe, F. & Sonoda, S., 01-01-2013, In : Asian Pacific Journal of Cancer Prevention. 14, 7, p. 4435-4440 6 p.

Research output: Contribution to journalArticle

Intestinal Polyps
High Fat Diet
Diet
Adiponectin
Aloe vera gel
2012
3 Citations (Scopus)

Inhibition of ENNG-induced pyloric stomach and small intestinal carcinogenesis in mice by high temperature- and pressure-treated garlic

Kaneko, T., Shimpo, K., Chihara, T., Beppu, H., Tomatsu, A., Shinzato, M., Yanagida, T., Ieike, T., Sonoda, S., Futamura, A., Ito, A. & Higashiguchi, T., 01-01-2012, In : Asian Pacific Journal of Cancer Prevention. 13, 5, p. 1983-1988 6 p.

Research output: Contribution to journalArticle

Garlic
Stomach
Carcinogenesis
Pressure
Temperature
2011
1 Citation (Scopus)

Effects of high temperature- and pressure-treated garlic on 1,2-dimethylhydrazine-induced premalignant lesions in the rat colorectum at the post-initiation stage

Chihara, T., Shimpo, K., Kaneko, T., Beppu, H., Tomatsu, A., Higashiguchi, T. & Sonoda, S., 08-09-2011, In : Nippon Shokuhin Kagaku Kogaku Kaishi. 58, 3, p. 131-135 5 p.

Research output: Contribution to journalArticle

1,2-dimethylhydrazine
1,2-Dimethylhydrazine
Garlic
garlic
lesions (animal)
2010
13 Citations (Scopus)
1,2-Dimethylhydrazine
Garlic
DNA Adducts
Mucins
Dimenhydrinate
132 Citations (Scopus)

Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase

Hosono, K., Endo, H., Takahashi, H., Sugiyama, M., Uchiyama, T., Suzuki, K., Nozaki, Y., Yoneda, K., Fujita, K., Yoneda, M., Inamori, M., Tomatsu, A., Chihara, T., Shimpo, K., Nakagama, H. & Nakajima, A., 01-07-2010, In : Molecular Carcinogenesis. 49, 7, p. 662-671 10 p.

Research output: Contribution to journalArticle

Aberrant Crypt Foci
Azoxymethane
AMP-Activated Protein Kinases
Metformin
Sirolimus
2009
9 Citations (Scopus)
1,2-Dimethylhydrazine
Garlic
Dimethylhydrazines
DNA Adducts
Mucins
2007

Erythrocyte spermidine as a biomarker for focal cerebral infarction in rat

Mizutani, K., Shimpo, K., Chihara, T. & Sonoda, S., 01-12-2007, In : Biogenic Amines. 21, 3, p. 169-176 8 p.

Research output: Contribution to journalArticle

Spermidine
Cerebral Infarction
Polyamines
Erythrocytes
Biomarkers
2006
53 Citations (Scopus)

Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice: Investigation on hypoglycemic action and systemic absorption dynamics of aloe components

Beppu, H., Shimpo, K., Chihara, T., Kaneko, T., Tamai, I., Yamaji, S., Ozaki, S., Kuzuya, H. & Sonoda, S., 20-02-2006, In : Journal of Ethnopharmacology. 103, 3, p. 468-477 10 p.

Research output: Contribution to journalArticle

Aloe
Experimental Diabetes Mellitus
Hypoglycemic Agents
Powders
Streptozocin
8 Citations (Scopus)

Effects of Aloe arborescens ingestion on azoxymethane-induced intestinal carcinogenesis and hematological and biochemical parameters of male F344 rats

Shimpo, K., Beppu, H., Chihara, T., Kaneko, T., Shinzato, M. & Sonoda, S., 01-01-2006, In : Asian Pacific Journal of Cancer Prevention. 7, 4, p. 585-590 6 p.

Research output: Contribution to journalArticle

Azoxymethane
Aloe
Inbred F344 Rats
Carcinogenesis
Eating
6 Citations (Scopus)

Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets

Beppu, H., Shimpo, K., Chihara, T., Tamai, I., Nomoto-Yamaji, S., Ozaki, S., Ito, S. & Kuzuya, H., 05-01-2006, In : Phytomedicine. 13, 1-2, p. 49-60 12 p.

Research output: Contribution to journalArticle

Aloe
Carboxypeptidases
Capillary Permeability
Streptozocin
Islets of Langerhans
2004

Modulation of Quinone Reductase, Alcohol Dehydrogenase and Cytochrome P450 2E1 Activities in Rat Liver by Aloe arborescens var. natalensis (Kidachi aloe)

Shimpo, K., Ida, C., Chihara, T., Beppu, H., Kaneko, T. & Kuzuya, H., 01-02-2004, In : Natural Medicines. 58, 1, p. 27-30 4 p.

Research output: Contribution to journalArticle

NAD(P)H Dehydrogenase (Quinone)
Aloe
Cytochrome P-450 CYP2E1
Alcohol Dehydrogenase
Liver
25 Citations (Scopus)

Studies on the components of Aloe arborescens from Japan - Monthly variation and differences due to part and position of the leaf

Beppu, H., Kawai, K., Shimpo, K., Chihara, T., Tamai, I., Ida, C., Ueda, M. & Kuzuya, H., 01-09-2004, In : Biochemical Systematics and Ecology. 32, 9, p. 783-795 13 p.

Research output: Contribution to journalArticle

Aloe arborescens
Aloe
carboxypeptidases
Carboxypeptidases
Japan
2003
13 Citations (Scopus)

Inhibition of azoxymethane-induced DNA adduct formation by: Aloe arborescens var. Natalensis

Shimpo, K., Chihara, T., Beppu, H., Ida, C., Kaneko, T., Hoshino, M. & Kuzuya, H., 01-01-2003, In : Asian Pacific Journal of Cancer Prevention. 4, 3, p. 247-251 5 p.

Research output: Contribution to journalArticle

Azoxymethane
Aloe
DNA Adducts
Cytochrome P-450 CYP2E1
Aberrant Crypt Foci
39 Citations (Scopus)

Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats

Beppu, H., Koike, T., Shimpo, K., Chihara, T., Hoshino, M., Ida, C. & Kuzuya, H., 01-11-2003, In : Journal of Ethnopharmacology. 89, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

Aloe
Insulin-Secreting Cells
Islets of Langerhans
Alloxan
Streptozocin
4 Citations (Scopus)

Reduction of 1,2-dimethylhydrazine-induced colorectal proliferative lesions in mice by Aloe arborescens var. natalensis (Kidachi aloe)

Shimpo, K., Chihara, T., Shinzato, M., Beppu, H., Kaneko, T., Shamoto, M. & Kuzuya, H., 01-12-2003, In : Pharmaceutical Biology. 41, 8, p. 631-636 6 p.

Research output: Contribution to journalArticle

Aloe arborescens
Dimethylhydrazines
1,2-dimethylhydrazine
1,2-Dimethylhydrazine
Aloe
2002
16 Citations (Scopus)

Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin

Shimpo, K., Ida, C., Chihara, T., Beppu, H., Kaneko, T. & Kuzuya, H., 01-08-2002, In : Phytotherapy Research. 16, 5, p. 491-493 3 p.

Research output: Contribution to journalArticle

Aloe
Putrescine
Tetradecanoylphorbol Acetate
Ear
Tumors
29 Citations (Scopus)

Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters

Furukawa, F., Nishikawa, A., Chihara, T., Shimpo, K., Beppu, H., Kuzuya, H., Lee, I. S. & Hirose, M., 25-04-2002, In : Cancer Letters. 178, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

nitrosobis(2-oxopropyl)amine
Aloe
Cricetinae
Carcinogenesis
Adenocarcinoma
7 Citations (Scopus)

Inhibitory effects of heated garlic on N-Ethyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis in the duodenum and jejunum of C57BL/6 mice

Shimpo, K., Chihara, T., Kaneko, T., Shinzato, M., Beppu, H., Hoshino, M., Ida, C., Shamoto, M. & Kuzuya, H., 01-01-2002, In : Asian Pacific Journal of Cancer Prevention. 3, 4, p. 339-344 6 p.

Research output: Contribution to journalArticle

Garlic
Jejunum
Inbred C57BL Mouse
Duodenum
Carcinogenesis
2001
45 Citations (Scopus)

Determination of aloenin, barbaloin and isobarbaloin in Aloe species by micellar electrokinetic chromatography

Kuzuya, H., Tamai, I., Beppu, H., Shimpo, K. & Chihara, T., 05-03-2001, In : Journal of Chromatography B: Biomedical Sciences and Applications. 752, 1, p. 91-97 7 p.

Research output: Contribution to journalArticle

Chromatography
Sodium Dodecyl Sulfate
barbaloin
aloenin
2 Citations (Scopus)

High-performance liquid chromatographic determination of diacetylpolyamines using benzoyl chloride as a derivatizing agent: Application to human urine

Shimpo, K., Chihara, T., Ida, C., Kawai, K., Wakamatsu, K., Ito, S., Matsui, T., Hirano, M., Watanabe, T., Nagatsu, T. & Kuzuya, H., 01-01-2001, In : Biogenic Amines. 16, 3, p. 211-223 13 p.

Research output: Contribution to journalArticle

Urine
Neoplasms
Healthy Volunteers
Pregnant Women
High Pressure Liquid Chromatography
22 Citations (Scopus)

Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by whole leaf Aloe arborescens Miller var. natalensis Berger

Shimpo, K., Chihara, T., Beppu, H., Ida, C., Kaneko, T., Nagatsu, T. & Kuzuya, H., 01-12-2001, In : Phytotherapy Research. 15, 8, p. 705-711 7 p.

Research output: Contribution to journalArticle

Aberrant Crypt Foci
Azoxymethane
Aloe
Diet
Liver
2000
10 Citations (Scopus)

Inhibition of N-ethyl-N'-nitro-N-nitrosoguanidine-induced Duodenal Tumorigenesis in Mice by whole-leaf aloe arborescens miller var. natalensis berger

Chihara, T., Shimpo, K., Shinzato, M., Beppu, H., Kaneko, T., Ida, C., Kawai, K., Hirono, I., Shamoto, M., Nagatsu, T. & Kuzuya, H., 01-01-2000, In : Asian Pacific Journal of Cancer Prevention. 1, 4, p. 283-288 6 p.

Research output: Contribution to journalArticle

Aloe
Carcinogenesis
Diet
Neoplasms
ENNG
1998
17 Citations (Scopus)

In vivo effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on experimental tinea pedis in guinea-pig feet

Kawai, K., Beppu, H., Shimpo, K., Chihara, T., Yamamoto, N., Nagatsu, T., Ueda, H. & Yamada, Y., 01-01-1998, In : Phytotherapy Research. 12, 3, p. 178-182 5 p.

Research output: Contribution to journalArticle

Tinea Pedis
Aloe
Foot
Guinea Pigs
Trichophyton
1990
6 Citations (Scopus)

Polyamine levels of urine and erythrocytes on inhibition of DMBA-induced oral carcinogenesis by topical beta-carotene

Hibino, T., Shimpo, K., Kawai, K., Chihara, T., Maruta, K., Arai, M., Nagatsu, T. & Fujita, K., 17-10-1990, In : Biogenic Amines. 7, 3, p. 209-216 8 p.

Research output: Contribution to journalArticle

9,10-Dimethyl-1,2-benzanthracene
Spermidine
beta Carotene
Polyamines
Carcinogenesis