α-lipoic acid reduces congenital malformations in the offspring of diabetic mice

Y. Sugimura, T. Murase, K. Kobayashi, K. Oyama, S. Hayasaka, Y. Kanou, Y. Oiso, Y. Murata

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Abstract

Background: The mechanism of diabetes-induced congenital malformation remains to be elucidated. It has been reported that α-lipoic acid (LA) prevents neural tube defects (NTDs) in offsprings of rats with streptozotocin-induced diabetes. Here, we evaluate the protective effect of LA against diabetic embryopathy, including NTDs, cardiovascular malformations (CVMs), and skeletal malformations, in mice. Methods: Female mice were rendered hyperglycemic using streptozotocin and then mated with normal male mouse. Pregnant diabetic or non-diabetic mice were treated daily with either LA (100 mg/kg body weight) or saline between gestational days 0 and 18. On day 18, fetuses were examined for congenital malformations. Results: Plasma glucose levels on day 18 were not affected by LA treatment. No congenital malformations were observed either in the saline-treated or LA-treated non-diabetic group. In the saline-treated diabetic group, 39% of fetuses had external malformations and 30% had NTDs. In the LA-treated diabetic group, the corresponding proportions were 11 and 8%, respectively. LA treatment also decreased the incidence of CVMs from 30-3% and of skeletal malformations from 29-6%. Conclusions: We conclude that LA can reduce NTDs, CVMs and skeletal malformations in the offspring of diabetic mice at term delivery.

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalDiabetes/Metabolism Research and Reviews
Volume25
Issue number3
DOIs
Publication statusPublished - 04-06-2009

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Sugimura, Y., Murase, T., Kobayashi, K., Oyama, K., Hayasaka, S., Kanou, Y., Oiso, Y., & Murata, Y. (2009). α-lipoic acid reduces congenital malformations in the offspring of diabetic mice. Diabetes/Metabolism Research and Reviews, 25(3), 287-294. https://doi.org/10.1002/dmrr.947