TY - JOUR
T1 - α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion
AU - Yamakado, Hodaka
AU - Moriwaki, Yasuhiro
AU - Yamasaki, Nobuyuki
AU - Miyakawa, Tsuyoshi
AU - Kurisu, Junko
AU - Uemura, Kengo
AU - Inoue, Haruhisa
AU - Takahashi, Makio
AU - Takahashi, Ryosuke
N1 - Funding Information:
We thank Dr. Sigeo Kitayama (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) for the gift of SERT antibody, Ms Ai Tanigaki and Ms Rie Hikawa for the technical support in immunoblotting of DAT and SERT in mice brains, Ms Yoshiko Karatsu for animal care and Dr. Roberto Gavinio in proofreading the manuscript. This study is supported in part by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan (No. 18390255 ) and is also supported by a Grant-in-Aid for Scientific Research on Innovative Areas (Comprehensive Brain Science Network) from the Ministry of Education, Science, Sports and Culture of Japan.
PY - 2012/6
Y1 - 2012/6
N2 - α-Synuclein (α-syn), the main component of Lewy bodies, was identified as a genetic risk factor for idiopathic Parkinson's disease (PD). As a model for PD, we generated human α-syn bacterial artificial chromosome transgenic mice (BAC tg mice) harboring the entire human α-syn gene and its gene expression regulatory regions. The α-syn BAC tg mice manifested decreased anxiety-like behaviors which may reflect non-motor symptoms of early PD, and they exhibited increased SERT expression that may be responsible for decreased anxiety-like behaviors. Our α-syn BAC tg mice could be a valuable tool to evaluate α-syn gene dosage effects in vivo.
AB - α-Synuclein (α-syn), the main component of Lewy bodies, was identified as a genetic risk factor for idiopathic Parkinson's disease (PD). As a model for PD, we generated human α-syn bacterial artificial chromosome transgenic mice (BAC tg mice) harboring the entire human α-syn gene and its gene expression regulatory regions. The α-syn BAC tg mice manifested decreased anxiety-like behaviors which may reflect non-motor symptoms of early PD, and they exhibited increased SERT expression that may be responsible for decreased anxiety-like behaviors. Our α-syn BAC tg mice could be a valuable tool to evaluate α-syn gene dosage effects in vivo.
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U2 - 10.1016/j.neures.2012.03.010
DO - 10.1016/j.neures.2012.03.010
M3 - Article
C2 - 22475625
AN - SCOPUS:84860320623
SN - 0168-0102
VL - 73
SP - 173
EP - 177
JO - Neuroscience Research
JF - Neuroscience Research
IS - 2
ER -
