α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion

Hodaka Yamakado, Yasuhiro Moriwaki, Nobuyuki Yamasaki, Tsuyoshi Miyakawa, Junko Kurisu, Kengo Uemura, Haruhisa Inoue, Makio Takahashi, Ryosuke Takahashi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

α-Synuclein (α-syn), the main component of Lewy bodies, was identified as a genetic risk factor for idiopathic Parkinson's disease (PD). As a model for PD, we generated human α-syn bacterial artificial chromosome transgenic mice (BAC tg mice) harboring the entire human α-syn gene and its gene expression regulatory regions. The α-syn BAC tg mice manifested decreased anxiety-like behaviors which may reflect non-motor symptoms of early PD, and they exhibited increased SERT expression that may be responsible for decreased anxiety-like behaviors. Our α-syn BAC tg mice could be a valuable tool to evaluate α-syn gene dosage effects in vivo.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalNeuroscience Research
Volume73
Issue number2
DOIs
Publication statusPublished - 06-2012

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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