α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion

Hodaka Yamakado, Yasuhiro Moriwaki, Nobuyuki Yamasaki, Tsuyoshi Miyakawa, Junko Kurisu, Kengo Uemura, Haruhisa Inoue, Makio Takahashi, Ryosuke Takahashi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

α-Synuclein (α-syn), the main component of Lewy bodies, was identified as a genetic risk factor for idiopathic Parkinson's disease (PD). As a model for PD, we generated human α-syn bacterial artificial chromosome transgenic mice (BAC tg mice) harboring the entire human α-syn gene and its gene expression regulatory regions. The α-syn BAC tg mice manifested decreased anxiety-like behaviors which may reflect non-motor symptoms of early PD, and they exhibited increased SERT expression that may be responsible for decreased anxiety-like behaviors. Our α-syn BAC tg mice could be a valuable tool to evaluate α-syn gene dosage effects in vivo.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalNeuroscience Research
Volume73
Issue number2
DOIs
Publication statusPublished - 01-06-2012

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Synucleins
Bacterial Artificial Chromosomes
Transgenic Mice
Parkinson Disease
Anxiety
Lewy Bodies
Gene Dosage
Nucleic Acid Regulatory Sequences
Gene Expression
Genes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Yamakado, Hodaka ; Moriwaki, Yasuhiro ; Yamasaki, Nobuyuki ; Miyakawa, Tsuyoshi ; Kurisu, Junko ; Uemura, Kengo ; Inoue, Haruhisa ; Takahashi, Makio ; Takahashi, Ryosuke. / α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. In: Neuroscience Research. 2012 ; Vol. 73, No. 2. pp. 173-177.
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Yamakado, H, Moriwaki, Y, Yamasaki, N, Miyakawa, T, Kurisu, J, Uemura, K, Inoue, H, Takahashi, M & Takahashi, R 2012, 'α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion', Neuroscience Research, vol. 73, no. 2, pp. 173-177. https://doi.org/10.1016/j.neures.2012.03.010

α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. / Yamakado, Hodaka; Moriwaki, Yasuhiro; Yamasaki, Nobuyuki; Miyakawa, Tsuyoshi; Kurisu, Junko; Uemura, Kengo; Inoue, Haruhisa; Takahashi, Makio; Takahashi, Ryosuke.

In: Neuroscience Research, Vol. 73, No. 2, 01.06.2012, p. 173-177.

Research output: Contribution to journalArticle

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AU - Kurisu, Junko

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