β-Amyloid protein-induced Alzheimer's disease animal model

Atsumi Nitta, Akio Itoh, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

248 Citations (Scopus)

Abstract

To investigate the toxicity of β-amyloid protein which consisted of senile plaques of Alzheimer's disease (AD), this was infused into cerebral ventricle for 14 days by using mini-osmotic pump. The performance of the water maze task in β-amyloid protein-treated rats was impaired. Choline acetyltransferase activity significantly decreased in the frontal cortex and hippocampus. These results suggest that the deposition of β-amyloid protein in the brain is related to the impairment of learning and cholinergic neuronal degeneration, and that β-amyloid protein-treated rats could be used as an animal model for AD.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalNeuroscience Letters
Volume170
Issue number1
DOIs
Publication statusPublished - 28-03-1994

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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