β-Amyloid protein-induced Alzheimer's disease animal model

Atsumi Nitta, Akio Itoh, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

To investigate the toxicity of β-amyloid protein which consisted of senile plaques of Alzheimer's disease (AD), this was infused into cerebral ventricle for 14 days by using mini-osmotic pump. The performance of the water maze task in β-amyloid protein-treated rats was impaired. Choline acetyltransferase activity significantly decreased in the frontal cortex and hippocampus. These results suggest that the deposition of β-amyloid protein in the brain is related to the impairment of learning and cholinergic neuronal degeneration, and that β-amyloid protein-treated rats could be used as an animal model for AD.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalNeuroscience Letters
Volume170
Issue number1
DOIs
Publication statusPublished - 28-03-1994
Externally publishedYes

Fingerprint

Amyloidogenic Proteins
Alzheimer Disease
Animal Models
Cerebral Ventricles
Choline O-Acetyltransferase
Amyloid Plaques
Frontal Lobe
Cholinergic Agents
Hippocampus
Learning
Water
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nitta, Atsumi ; Itoh, Akio ; Hasegawa, Takaaki ; Nabeshima, Toshitaka. / β-Amyloid protein-induced Alzheimer's disease animal model. In: Neuroscience Letters. 1994 ; Vol. 170, No. 1. pp. 63-66.
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β-Amyloid protein-induced Alzheimer's disease animal model. / Nitta, Atsumi; Itoh, Akio; Hasegawa, Takaaki; Nabeshima, Toshitaka.

In: Neuroscience Letters, Vol. 170, No. 1, 28.03.1994, p. 63-66.

Research output: Contribution to journalArticle

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