TY - JOUR
T1 - σ Receptor ligands (+)-SKF10,047 and SA4503 improve dizocilpine-induced spatial memory deficits in rats
AU - Zou, Li Bo
AU - Yamada, Kiyofumi
AU - Nabeshima, Toshitaka
N1 - Funding Information:
We are grateful to Santen Pharmaceutical (Osaka, Japan) and Taisho Pharmaceutical (Tokyo, Japan) for the generous donation of SA4503 and NE-100, respectively. This study was supported, in part, by a Grant-in-Aid for Science Research from the Ministry of Education, Science, and Culture of Japan (Nos. 08457027 and 10044260).
PY - 1998/8/14
Y1 - 1998/8/14
N2 - This study examined the effects of the σ receptor ligands (+)-N-allylnormetazocine ((+)-SKF10,047) and 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503) on dizocilpine-induced impairment of working and reference memory in a radial arm maze task in rats. Dizocilpine, a non-competitive NMDA receptor antagonist, significantly impaired both reference and working memory, an effect which was accompanied by ataxia and impairment of food intake. The dizocilpine-induced impairment of reference memory was dose-dependently attenuated by (+)-SKF10,047 and SA4503. SA4503 also attenuated the dizocilpine-induced working memory impairment, although (+)-SKF10,047 had no effect. Neither σ receptor ligand affected the behavioral symptoms such as ataxia and impairment of food intake induced by dizocilpine. The ameliorating effects of both (+)-SKF10,047 and SA4503 on dizocilpine-induced spatial memory impairment were completely antagonized by a σ1 receptor antagonist N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine-monohydrochloride. These results suggest that the interaction of σ1 receptors with NMDA receptors modulates spatial memory in rats. Copyright (C) 1998 Elsevier Science B.V.
AB - This study examined the effects of the σ receptor ligands (+)-N-allylnormetazocine ((+)-SKF10,047) and 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503) on dizocilpine-induced impairment of working and reference memory in a radial arm maze task in rats. Dizocilpine, a non-competitive NMDA receptor antagonist, significantly impaired both reference and working memory, an effect which was accompanied by ataxia and impairment of food intake. The dizocilpine-induced impairment of reference memory was dose-dependently attenuated by (+)-SKF10,047 and SA4503. SA4503 also attenuated the dizocilpine-induced working memory impairment, although (+)-SKF10,047 had no effect. Neither σ receptor ligand affected the behavioral symptoms such as ataxia and impairment of food intake induced by dizocilpine. The ameliorating effects of both (+)-SKF10,047 and SA4503 on dizocilpine-induced spatial memory impairment were completely antagonized by a σ1 receptor antagonist N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine-monohydrochloride. These results suggest that the interaction of σ1 receptors with NMDA receptors modulates spatial memory in rats. Copyright (C) 1998 Elsevier Science B.V.
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U2 - 10.1016/S0014-2999(98)00464-6
DO - 10.1016/S0014-2999(98)00464-6
M3 - Article
C2 - 9754932
AN - SCOPUS:0031709351
SN - 0014-2999
VL - 355
SP - 1
EP - 10
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -