TY - JOUR
T1 - ω-Conotoxin GVIA inhibits the methylphenidate-induced but not methamphetamine-induced behavior
AU - Yamada, Kiyofumi
AU - Teraoka, Tomomi
AU - Morita, Seiji
AU - Hasegawa, Takaaki
AU - Nabeshima, Toshitaka
PY - 1994/1/3
Y1 - 1994/1/3
N2 - We investigated the effects of antagonists for ω-conotoxin GVIA (ω-CTX)-sensitive N-type voltage-sensitive calcium channels (N-channels) on methylphenidate- and methamphetamine-induced behavior. I.c.v. injection of ω-CTX or neomycin, both N-channel antagonists, caused a dose-dependent inhibition of methylphenidate-induced hypermotility in mice but failed to inhibit methamphetamine-induced hyperactivity. Further, ω-CTX inhibited the circling behavior induced by methylphenidate in rats that had kainic acid-induced unilateral striatal lesions. These results suggest that calcium influx through ω-CTX-sensitive N-channels plays an important role in methylphenidate-induced behavior.
AB - We investigated the effects of antagonists for ω-conotoxin GVIA (ω-CTX)-sensitive N-type voltage-sensitive calcium channels (N-channels) on methylphenidate- and methamphetamine-induced behavior. I.c.v. injection of ω-CTX or neomycin, both N-channel antagonists, caused a dose-dependent inhibition of methylphenidate-induced hypermotility in mice but failed to inhibit methamphetamine-induced hyperactivity. Further, ω-CTX inhibited the circling behavior induced by methylphenidate in rats that had kainic acid-induced unilateral striatal lesions. These results suggest that calcium influx through ω-CTX-sensitive N-channels plays an important role in methylphenidate-induced behavior.
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U2 - 10.1016/0304-3940(94)90742-0
DO - 10.1016/0304-3940(94)90742-0
M3 - Article
C2 - 8015724
AN - SCOPUS:0028178277
SN - 0304-3940
VL - 165
SP - 191
EP - 194
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -