ω-Conotoxin GVIA inhibits the methylphenidate-induced but not methamphetamine-induced behavior

Kiyofumi Yamada, Tomomi Teraoka, Seiji Morita, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated the effects of antagonists for ω-conotoxin GVIA (ω-CTX)-sensitive N-type voltage-sensitive calcium channels (N-channels) on methylphenidate- and methamphetamine-induced behavior. I.c.v. injection of ω-CTX or neomycin, both N-channel antagonists, caused a dose-dependent inhibition of methylphenidate-induced hypermotility in mice but failed to inhibit methamphetamine-induced hyperactivity. Further, ω-CTX inhibited the circling behavior induced by methylphenidate in rats that had kainic acid-induced unilateral striatal lesions. These results suggest that calcium influx through ω-CTX-sensitive N-channels plays an important role in methylphenidate-induced behavior.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalNeuroscience Letters
Volume165
Issue number1-2
DOIs
Publication statusPublished - 03-01-1994
Externally publishedYes

Fingerprint

Conotoxins
Methylphenidate
Methamphetamine
Calcium Channels
Corpus Striatum
Neomycin
Kainic Acid
Calcium Channel Blockers
Calcium
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Yamada, Kiyofumi ; Teraoka, Tomomi ; Morita, Seiji ; Hasegawa, Takaaki ; Nabeshima, Toshitaka. / ω-Conotoxin GVIA inhibits the methylphenidate-induced but not methamphetamine-induced behavior. In: Neuroscience Letters. 1994 ; Vol. 165, No. 1-2. pp. 191-194.
@article{8c93435ed0504b9396a9b9bc58d2db46,
title = "ω-Conotoxin GVIA inhibits the methylphenidate-induced but not methamphetamine-induced behavior",
abstract = "We investigated the effects of antagonists for ω-conotoxin GVIA (ω-CTX)-sensitive N-type voltage-sensitive calcium channels (N-channels) on methylphenidate- and methamphetamine-induced behavior. I.c.v. injection of ω-CTX or neomycin, both N-channel antagonists, caused a dose-dependent inhibition of methylphenidate-induced hypermotility in mice but failed to inhibit methamphetamine-induced hyperactivity. Further, ω-CTX inhibited the circling behavior induced by methylphenidate in rats that had kainic acid-induced unilateral striatal lesions. These results suggest that calcium influx through ω-CTX-sensitive N-channels plays an important role in methylphenidate-induced behavior.",
author = "Kiyofumi Yamada and Tomomi Teraoka and Seiji Morita and Takaaki Hasegawa and Toshitaka Nabeshima",
year = "1994",
month = "1",
day = "3",
doi = "10.1016/0304-3940(94)90742-0",
language = "English",
volume = "165",
pages = "191--194",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

ω-Conotoxin GVIA inhibits the methylphenidate-induced but not methamphetamine-induced behavior. / Yamada, Kiyofumi; Teraoka, Tomomi; Morita, Seiji; Hasegawa, Takaaki; Nabeshima, Toshitaka.

In: Neuroscience Letters, Vol. 165, No. 1-2, 03.01.1994, p. 191-194.

Research output: Contribution to journalArticle

TY - JOUR

T1 - ω-Conotoxin GVIA inhibits the methylphenidate-induced but not methamphetamine-induced behavior

AU - Yamada, Kiyofumi

AU - Teraoka, Tomomi

AU - Morita, Seiji

AU - Hasegawa, Takaaki

AU - Nabeshima, Toshitaka

PY - 1994/1/3

Y1 - 1994/1/3

N2 - We investigated the effects of antagonists for ω-conotoxin GVIA (ω-CTX)-sensitive N-type voltage-sensitive calcium channels (N-channels) on methylphenidate- and methamphetamine-induced behavior. I.c.v. injection of ω-CTX or neomycin, both N-channel antagonists, caused a dose-dependent inhibition of methylphenidate-induced hypermotility in mice but failed to inhibit methamphetamine-induced hyperactivity. Further, ω-CTX inhibited the circling behavior induced by methylphenidate in rats that had kainic acid-induced unilateral striatal lesions. These results suggest that calcium influx through ω-CTX-sensitive N-channels plays an important role in methylphenidate-induced behavior.

AB - We investigated the effects of antagonists for ω-conotoxin GVIA (ω-CTX)-sensitive N-type voltage-sensitive calcium channels (N-channels) on methylphenidate- and methamphetamine-induced behavior. I.c.v. injection of ω-CTX or neomycin, both N-channel antagonists, caused a dose-dependent inhibition of methylphenidate-induced hypermotility in mice but failed to inhibit methamphetamine-induced hyperactivity. Further, ω-CTX inhibited the circling behavior induced by methylphenidate in rats that had kainic acid-induced unilateral striatal lesions. These results suggest that calcium influx through ω-CTX-sensitive N-channels plays an important role in methylphenidate-induced behavior.

UR - http://www.scopus.com/inward/record.url?scp=0028178277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028178277&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(94)90742-0

DO - 10.1016/0304-3940(94)90742-0

M3 - Article

VL - 165

SP - 191

EP - 194

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -