フィンゴリモドの長期内服中に tumefactive demyelinating lesion を生じ，開頭減圧術を要した多発性硬化症の 1 例

Wataru Shiraishi; Takeshi Miyata; Ayano Matsuyoshi; Yui Yamada; Taketo Hatano; Tetsuya Hashimoto

doi:10.5692/clinicalneurol.cn-001806

フィンゴリモドの長期内服中に tumefactive demyelinating lesion を生じ，開頭減圧術を要した多発性硬化症の 1 例

Translated title of the contribution: A case of multiple sclerosis with a tumefactive lesion during long-term treatment with fingolimod, leading to decompressive craniotomy

Wataru Shiraishi, Takeshi Miyata, Ayano Matsuyoshi, Yui Yamada, Taketo Hatano, Tetsuya Hashimoto

Research output: Contribution to journal › Article › peer-review

Abstract

We report a 57-year-old man with multiple sclerosis since his 30s who was treated with fingolimod for 9 years. He developed left hemiparesis and consciousness disturbance. Brain MRI revealed a mass lesion in the right frontal lobe with gadolinium enhancement. Cerebrospinal fluid examination showed no pleocytosis. The lesion continued to expand after admission, and on the 9th day after admission, decompressive craniectomy and brain biopsy were performed. Brain pathology revealed demyelination in the lesion, leading to the diagnosis of a tumefactive demyelinating lesion. Corticosteroid therapy ameliorated the brain lesion, and we inducted natalizumab. Tumefactive demyelinating lesions requiring decompressive craniotomy are rare, and we report this case for the further accumulation of similar cases.

Translated title of the contribution	A case of multiple sclerosis with a tumefactive lesion during long-term treatment with fingolimod, leading to decompressive craniotomy
Original language	Japanese
Pages (from-to)	37-44
Number of pages	8
Journal	Clinical Neurology
Volume	63
Issue number	1
DOIs	https://doi.org/10.5692/clinicalneurol.cn-001806
Publication status	Published - 2023
Externally published	Yes

All Science Journal Classification (ASJC) codes

Clinical Neurology

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title = "フィンゴリモドの長期内服中に tumefactive demyelinating lesion を生じ，開頭減圧術を要した多発性硬化症の 1 例",

abstract = "We report a 57-year-old man with multiple sclerosis since his 30s who was treated with fingolimod for 9 years. He developed left hemiparesis and consciousness disturbance. Brain MRI revealed a mass lesion in the right frontal lobe with gadolinium enhancement. Cerebrospinal fluid examination showed no pleocytosis. The lesion continued to expand after admission, and on the 9th day after admission, decompressive craniectomy and brain biopsy were performed. Brain pathology revealed demyelination in the lesion, leading to the diagnosis of a tumefactive demyelinating lesion. Corticosteroid therapy ameliorated the brain lesion, and we inducted natalizumab. Tumefactive demyelinating lesions requiring decompressive craniotomy are rare, and we report this case for the further accumulation of similar cases.",

author = "Wataru Shiraishi and Takeshi Miyata and Ayano Matsuyoshi and Yui Yamada and Taketo Hatano and Tetsuya Hashimoto",

note = "Publisher Copyright: {\textcopyright}2023 Japanese Society of Neurology.",

year = "2023",

doi = "10.5692/clinicalneurol.cn-001806",

language = "日本語",

volume = "63",

pages = "37--44",

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T1 - フィンゴリモドの長期内服中に tumefactive demyelinating lesion を生じ，開頭減圧術を要した多発性硬化症の 1 例

AU - Shiraishi, Wataru

AU - Miyata, Takeshi

AU - Matsuyoshi, Ayano

AU - Yamada, Yui

AU - Hatano, Taketo

AU - Hashimoto, Tetsuya

PY - 2023

Y1 - 2023

N2 - We report a 57-year-old man with multiple sclerosis since his 30s who was treated with fingolimod for 9 years. He developed left hemiparesis and consciousness disturbance. Brain MRI revealed a mass lesion in the right frontal lobe with gadolinium enhancement. Cerebrospinal fluid examination showed no pleocytosis. The lesion continued to expand after admission, and on the 9th day after admission, decompressive craniectomy and brain biopsy were performed. Brain pathology revealed demyelination in the lesion, leading to the diagnosis of a tumefactive demyelinating lesion. Corticosteroid therapy ameliorated the brain lesion, and we inducted natalizumab. Tumefactive demyelinating lesions requiring decompressive craniotomy are rare, and we report this case for the further accumulation of similar cases.

AB - We report a 57-year-old man with multiple sclerosis since his 30s who was treated with fingolimod for 9 years. He developed left hemiparesis and consciousness disturbance. Brain MRI revealed a mass lesion in the right frontal lobe with gadolinium enhancement. Cerebrospinal fluid examination showed no pleocytosis. The lesion continued to expand after admission, and on the 9th day after admission, decompressive craniectomy and brain biopsy were performed. Brain pathology revealed demyelination in the lesion, leading to the diagnosis of a tumefactive demyelinating lesion. Corticosteroid therapy ameliorated the brain lesion, and we inducted natalizumab. Tumefactive demyelinating lesions requiring decompressive craniotomy are rare, and we report this case for the further accumulation of similar cases.

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フィンゴリモドの長期内服中に tumefactive demyelinating lesion を生じ，開頭減圧術を要した多発性硬化症の 1 例

Abstract

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