免疫不全患者におけるCOVID–19 疾病負担

Immuno compromised patients with congenital or acquired immune function-related abnormalities and those with depressed immune function due to the effects of medication(s) for treating another disease(s) are at greater risk of severe COVID-19 or death after contracting COVID-19 than the general population. Therefore, measures for preventing COVID-19 are extremely important in immuno compromised patients. However, the antibody response after vaccination is lower in immuno compromised patients than that in the general population due to the nature of the disease, i.e., immune deficiency. In this paper, we discuss the immune state and the effectiveness of COVID-19 vaccines in patients with hematological malignancies, solid organ transplantation, primary immunodeficiency disease, human immunodeficiency virus, rheumatic disease, and renal disease. We also consider the importance of new infection-preventing measures in addition to vaccines.