123I-metaiodobenzylguanidine myocardial scintigraphy with early images alone is useful for the differential diagnosis of dementia with Lewy bodies

Yuta Manabe, Yoshitaka Inui, Hiroshi Toyama, Kenji Kosaka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

123I-metaiodobenzylguanidine cardiac scintigraphy (MIBG) is a useful imaging technique for the diagnosis of dementia with Lewy bodies (DLB). However, MIBG has a serious disadvantage in that it demands a long examination time. The objective of this study was to evaluate statistically the usefulness of the heart/mediastinum ratio (H/M) from the early phase of MIBG for the differential diagnosis of DLB. In total, 113 patients were examined, including 32 non-DLB (19 with Alzheimer's dementia) and 79 DLB patients. The mean early-H/M ratio was 2.83 in the non-DLB group and 1.95 in the DLB group. The mean delayed-H/M ratio was 3.0 in the non-DLB group and 1.76 in the DLB group. With a cutoff point of 2.27 on early images, the sensitivity, specificity, and diagnostic accuracy were 65%, 94%, and 73%, respectively, and the area under the curve was 0.82, indicating moderate accuracy. This analysis indicates that images from the early phase of MIBG alone are sufficient for the differential diagnosis of Alzheimer's disease and DLB.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume261
DOIs
Publication statusPublished - 30-03-2017

Fingerprint

Lewy Body Disease
Myocardial Perfusion Imaging
3-Iodobenzylguanidine
Lewy Bodies
Differential Diagnosis
Mediastinum
Alzheimer Disease
Radionuclide Imaging
Area Under Curve
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

@article{442b1ffaf3d2462daed912ca3853d9ad,
title = "123I-metaiodobenzylguanidine myocardial scintigraphy with early images alone is useful for the differential diagnosis of dementia with Lewy bodies",
abstract = "123I-metaiodobenzylguanidine cardiac scintigraphy (MIBG) is a useful imaging technique for the diagnosis of dementia with Lewy bodies (DLB). However, MIBG has a serious disadvantage in that it demands a long examination time. The objective of this study was to evaluate statistically the usefulness of the heart/mediastinum ratio (H/M) from the early phase of MIBG for the differential diagnosis of DLB. In total, 113 patients were examined, including 32 non-DLB (19 with Alzheimer's dementia) and 79 DLB patients. The mean early-H/M ratio was 2.83 in the non-DLB group and 1.95 in the DLB group. The mean delayed-H/M ratio was 3.0 in the non-DLB group and 1.76 in the DLB group. With a cutoff point of 2.27 on early images, the sensitivity, specificity, and diagnostic accuracy were 65{\%}, 94{\%}, and 73{\%}, respectively, and the area under the curve was 0.82, indicating moderate accuracy. This analysis indicates that images from the early phase of MIBG alone are sufficient for the differential diagnosis of Alzheimer's disease and DLB.",
author = "Yuta Manabe and Yoshitaka Inui and Hiroshi Toyama and Kenji Kosaka",
year = "2017",
month = "3",
day = "30",
doi = "10.1016/j.pscychresns.2016.12.011",
language = "English",
volume = "261",
pages = "75--79",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",

}

123I-metaiodobenzylguanidine myocardial scintigraphy with early images alone is useful for the differential diagnosis of dementia with Lewy bodies. / Manabe, Yuta; Inui, Yoshitaka; Toyama, Hiroshi; Kosaka, Kenji.

In: Psychiatry Research - Neuroimaging, Vol. 261, 30.03.2017, p. 75-79.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 123I-metaiodobenzylguanidine myocardial scintigraphy with early images alone is useful for the differential diagnosis of dementia with Lewy bodies

AU - Manabe, Yuta

AU - Inui, Yoshitaka

AU - Toyama, Hiroshi

AU - Kosaka, Kenji

PY - 2017/3/30

Y1 - 2017/3/30

N2 - 123I-metaiodobenzylguanidine cardiac scintigraphy (MIBG) is a useful imaging technique for the diagnosis of dementia with Lewy bodies (DLB). However, MIBG has a serious disadvantage in that it demands a long examination time. The objective of this study was to evaluate statistically the usefulness of the heart/mediastinum ratio (H/M) from the early phase of MIBG for the differential diagnosis of DLB. In total, 113 patients were examined, including 32 non-DLB (19 with Alzheimer's dementia) and 79 DLB patients. The mean early-H/M ratio was 2.83 in the non-DLB group and 1.95 in the DLB group. The mean delayed-H/M ratio was 3.0 in the non-DLB group and 1.76 in the DLB group. With a cutoff point of 2.27 on early images, the sensitivity, specificity, and diagnostic accuracy were 65%, 94%, and 73%, respectively, and the area under the curve was 0.82, indicating moderate accuracy. This analysis indicates that images from the early phase of MIBG alone are sufficient for the differential diagnosis of Alzheimer's disease and DLB.

AB - 123I-metaiodobenzylguanidine cardiac scintigraphy (MIBG) is a useful imaging technique for the diagnosis of dementia with Lewy bodies (DLB). However, MIBG has a serious disadvantage in that it demands a long examination time. The objective of this study was to evaluate statistically the usefulness of the heart/mediastinum ratio (H/M) from the early phase of MIBG for the differential diagnosis of DLB. In total, 113 patients were examined, including 32 non-DLB (19 with Alzheimer's dementia) and 79 DLB patients. The mean early-H/M ratio was 2.83 in the non-DLB group and 1.95 in the DLB group. The mean delayed-H/M ratio was 3.0 in the non-DLB group and 1.76 in the DLB group. With a cutoff point of 2.27 on early images, the sensitivity, specificity, and diagnostic accuracy were 65%, 94%, and 73%, respectively, and the area under the curve was 0.82, indicating moderate accuracy. This analysis indicates that images from the early phase of MIBG alone are sufficient for the differential diagnosis of Alzheimer's disease and DLB.

UR - http://www.scopus.com/inward/record.url?scp=85010868253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010868253&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2016.12.011

DO - 10.1016/j.pscychresns.2016.12.011

M3 - Article

C2 - 28152401

AN - SCOPUS:85010868253

VL - 261

SP - 75

EP - 79

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

ER -