TY - JOUR
T1 - 1,25-Dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma
AU - Masahito, Hibi
AU - Hara, Fujio
AU - Tomishige, Hirokazu
AU - Nishida, Yoshihisa
AU - Kato, Takazumi
AU - Okumura, Naotake
AU - Hashimoto, Takashi
AU - Kato, Ryoichi
PY - 2008/1
Y1 - 2008/1
N2 - Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25- dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.
AB - Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25- dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.
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U2 - 10.1080/08880010701774033
DO - 10.1080/08880010701774033
M3 - Article
C2 - 18231957
AN - SCOPUS:38649139108
SN - 0888-0018
VL - 25
SP - 73
EP - 78
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
IS - 1
ER -