1,25-Dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma

Hibi Masahito, Fujio Hara, Hirokazu Tomishige, Yoshihisa Nishida, Takazumi Kato, Naotake Okumura, Takashi Hashimoto, Ryoichi Kato

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25- dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalPediatric Hematology and Oncology
Issue number1
Publication statusPublished - 01-2008

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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