1,25-Dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma

Hibi Masahito; Fujio Hara; Hirokazu Tomishige; Yoshihisa Nishida; Takazumi Kato; Naotake Okumura; Takashi Hashimoto; Ryoichi Kato

doi:10.1080/08880010701774033

1,25-Dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma

Hibi Masahito
, Fujio Hara
, Hirokazu Tomishige
, Yoshihisa Nishida
, Takazumi Kato
, Naotake Okumura
, Takashi Hashimoto
, Ryoichi Kato

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25- dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.

Original language	English
Pages (from-to)	73-78
Number of pages	6
Journal	Pediatric Hematology and Oncology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1080/08880010701774033
Publication status	Published - 01-2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1080/08880010701774033

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abstract = "Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25- dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.",

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AU - Masahito, Hibi

AU - Hara, Fujio

AU - Tomishige, Hirokazu

AU - Nishida, Yoshihisa

AU - Kato, Takazumi

AU - Okumura, Naotake

AU - Hashimoto, Takashi

AU - Kato, Ryoichi

PY - 2008/1

Y1 - 2008/1

N2 - Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25- dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.

AB - Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25- dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.

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JO - Pediatric Hematology and Oncology

JF - Pediatric Hematology and Oncology

IS - 1

ER -

1,25-Dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma

Abstract

All Science Journal Classification (ASJC) codes

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