3D ECG- and respiratory-gated non-contrast-enhanced (CE) perfusion MRI for postoperative lung function prediction in non-small-cell lung cancer patients: A comparison with thin-section quantitative computed tomography, dynamic CE-perfusion MRI, and perfusion scan

Yoshiharu Ohno, Shinichiro Seki, Hisanobu Koyama, Takeshi Yoshikawa, Sumiaki Matsumoto, Daisuke Takenaka, Yoshimori Kassai, Masao Yui, Kazuro Sugimura

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12 Citations (Scopus)

Abstract

Purpose To compare predictive capabilities of non-contrast-enhanced (CE)- and dynamic CE-perfusion MRIs, thin-section multidetector computed tomography (CT) (MDCT), and perfusion scan for postoperative lung function in non-small cell lung cancer (NSCLC) patients. Materials and Methods Sixty consecutive pathologically diagnosed NSCLC patients were included and prospectively underwent thin-section MDCT, non-CE-, and dynamic CE-perfusion MRIs and perfusion scan, and had their pre- and postoperative forced expiratory volume in one second (FEV1) measured. Postoperative percent FEV1 (po%FEV1) was then predicted from the fractional lung volume determined on semiquantitatively assessed non-CE- and dynamic CE-perfusion MRIs, from the functional lung volumes determined on quantitative CT, from the number of segments observed on qualitative CT, and from uptakes detected on perfusion scans within total and resected lungs. Predicted po%FEV1s were then correlated with actual po%FEV1s, which were %FEV1s measured postoperatively. The limits of agreement were also determined. Results All predicted po%FEV1s showed significant correlation (0.73-≤-r-≤-0.93, P-<-0.0001) and limits of agreement with actual po%FEV1 (non-CE-perfusion MRI: 0.3-±-10.0%, dynamic CE-perfusion MRI: 1.0-±-10.8%, perfusion scan: 2.2-±-14.1%, quantitative CT: 1.2-±-9.0%, qualitative CT: 1.5-±-10.2%). Conclusion Non-CE-perfusion MRI may be able to predict postoperative lung function more accurately than qualitatively assessed MDCT and perfusion scan.

Original languageEnglish
Pages (from-to)340-353
Number of pages14
JournalJournal of Magnetic Resonance Imaging
Volume42
Issue number2
DOIs
Publication statusPublished - 01-08-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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