779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects

Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Fangyu Wang, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Masahiko Nakamura, Hiroshi Fujita, Mitsuo Nagasaka, Masami Iwata, Kazuya Takahama, Makoto Watanabe, Hiromi Yamashita, Hiroshi Nakano, Ichiro Hirata

Research output: Contribution to journalArticle

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Abstract

Background/Aims: The role of genetics in the susceptibility to functional dyspepsia (FD) is not well established. Cholecystokinin (CCK) is released from enteroendocrine cells in the duodenal mucosa after food ingestion and signals satiation through peripheral or central actions. A common polymorphisms of CCK and it's receptor gene has been shown to be associated with panic disorder and schizophrenia. It was investigated the prevalence of CCK polymorphism in dyspeptic patients in a Japanese population. Methodology: A total of 124 dyspeptic patients, 119 non-symptomatic healthy controls participated in this study. Dyspeptic patients were also classified by Rome III criteria. T779C of Cholecystokinin (CCK)-1 intron 1, by polymerase chain reaction-restriction fragment length polymorphism. H.pylori infection status was examined by histology or antibody against H.pylori. Results: Although frequency of CCK-1 polymorphisms in overall dyspeptic patients, subgroups by Roma III criteria and non-symptomatic healthy controls did not show any significant differences, 779 T carriers significantly increased the risk of postprandial syndrome (PDS) in male subjects (53.5%vs, 84.2; OR=4.63, 95%CI=1.24-17.31, p=0.018). This significant association was also remained after logistic regression analysis with adjustment for age and H.pylori infection status (OR=4.99, 95%CI=1.31-18.95, p=0.018). In female and different H. pylori infection status, no significant association was observed between CCK-1 polymorphisms and dyspepsia. Conclusion: Our data suggest that the 779 T carriers of CCK-1 intron 1 is associated with an increased risk of PDS in Japanese male subjects.

Original languageEnglish
Pages (from-to)1245-1248
Number of pages4
JournalHepato-gastroenterology
Volume56
Issue number93
Publication statusPublished - 01-07-2009

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Cholecystokinin
Introns
Pylorus
Dyspepsia
Infection
Enteroendocrine Cells
Roma
Satiation
Cholecystokinin Receptors
Panic Disorder
Genetic Predisposition to Disease
Restriction Fragment Length Polymorphisms
Schizophrenia
Histology
Mucous Membrane
Eating
Logistic Models
Regression Analysis
Food
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Tahara, T., Arisawa, T., Shibata, T., Nakamura, M., Wang, F., Yoshioka, D., ... Hirata, I. (2009). 779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects. Hepato-gastroenterology, 56(93), 1245-1248.
Tahara, Tomomitsu ; Arisawa, Tomiyasu ; Shibata, Tomoyuki ; Nakamura, Masakatsu ; Wang, Fangyu ; Yoshioka, Daisuke ; Okubo, Masaaki ; Maruyama, Naoko ; Kamano, Toshiaki ; Kamiya, Yoshio ; Nakamura, Masahiko ; Fujita, Hiroshi ; Nagasaka, Mitsuo ; Iwata, Masami ; Takahama, Kazuya ; Watanabe, Makoto ; Yamashita, Hiromi ; Nakano, Hiroshi ; Hirata, Ichiro. / 779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects. In: Hepato-gastroenterology. 2009 ; Vol. 56, No. 93. pp. 1245-1248.
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title = "779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects",
abstract = "Background/Aims: The role of genetics in the susceptibility to functional dyspepsia (FD) is not well established. Cholecystokinin (CCK) is released from enteroendocrine cells in the duodenal mucosa after food ingestion and signals satiation through peripheral or central actions. A common polymorphisms of CCK and it's receptor gene has been shown to be associated with panic disorder and schizophrenia. It was investigated the prevalence of CCK polymorphism in dyspeptic patients in a Japanese population. Methodology: A total of 124 dyspeptic patients, 119 non-symptomatic healthy controls participated in this study. Dyspeptic patients were also classified by Rome III criteria. T779C of Cholecystokinin (CCK)-1 intron 1, by polymerase chain reaction-restriction fragment length polymorphism. H.pylori infection status was examined by histology or antibody against H.pylori. Results: Although frequency of CCK-1 polymorphisms in overall dyspeptic patients, subgroups by Roma III criteria and non-symptomatic healthy controls did not show any significant differences, 779 T carriers significantly increased the risk of postprandial syndrome (PDS) in male subjects (53.5{\%}vs, 84.2; OR=4.63, 95{\%}CI=1.24-17.31, p=0.018). This significant association was also remained after logistic regression analysis with adjustment for age and H.pylori infection status (OR=4.99, 95{\%}CI=1.31-18.95, p=0.018). In female and different H. pylori infection status, no significant association was observed between CCK-1 polymorphisms and dyspepsia. Conclusion: Our data suggest that the 779 T carriers of CCK-1 intron 1 is associated with an increased risk of PDS in Japanese male subjects.",
author = "Tomomitsu Tahara and Tomiyasu Arisawa and Tomoyuki Shibata and Masakatsu Nakamura and Fangyu Wang and Daisuke Yoshioka and Masaaki Okubo and Naoko Maruyama and Toshiaki Kamano and Yoshio Kamiya and Masahiko Nakamura and Hiroshi Fujita and Mitsuo Nagasaka and Masami Iwata and Kazuya Takahama and Makoto Watanabe and Hiromi Yamashita and Hiroshi Nakano and Ichiro Hirata",
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Tahara, T, Arisawa, T, Shibata, T, Nakamura, M, Wang, F, Yoshioka, D, Okubo, M, Maruyama, N, Kamano, T, Kamiya, Y, Nakamura, M, Fujita, H, Nagasaka, M, Iwata, M, Takahama, K, Watanabe, M, Yamashita, H, Nakano, H & Hirata, I 2009, '779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects', Hepato-gastroenterology, vol. 56, no. 93, pp. 1245-1248.

779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects. / Tahara, Tomomitsu; Arisawa, Tomiyasu; Shibata, Tomoyuki; Nakamura, Masakatsu; Wang, Fangyu; Yoshioka, Daisuke; Okubo, Masaaki; Maruyama, Naoko; Kamano, Toshiaki; Kamiya, Yoshio; Nakamura, Masahiko; Fujita, Hiroshi; Nagasaka, Mitsuo; Iwata, Masami; Takahama, Kazuya; Watanabe, Makoto; Yamashita, Hiromi; Nakano, Hiroshi; Hirata, Ichiro.

In: Hepato-gastroenterology, Vol. 56, No. 93, 01.07.2009, p. 1245-1248.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects

AU - Tahara, Tomomitsu

AU - Arisawa, Tomiyasu

AU - Shibata, Tomoyuki

AU - Nakamura, Masakatsu

AU - Wang, Fangyu

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Maruyama, Naoko

AU - Kamano, Toshiaki

AU - Kamiya, Yoshio

AU - Nakamura, Masahiko

AU - Fujita, Hiroshi

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Takahama, Kazuya

AU - Watanabe, Makoto

AU - Yamashita, Hiromi

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Background/Aims: The role of genetics in the susceptibility to functional dyspepsia (FD) is not well established. Cholecystokinin (CCK) is released from enteroendocrine cells in the duodenal mucosa after food ingestion and signals satiation through peripheral or central actions. A common polymorphisms of CCK and it's receptor gene has been shown to be associated with panic disorder and schizophrenia. It was investigated the prevalence of CCK polymorphism in dyspeptic patients in a Japanese population. Methodology: A total of 124 dyspeptic patients, 119 non-symptomatic healthy controls participated in this study. Dyspeptic patients were also classified by Rome III criteria. T779C of Cholecystokinin (CCK)-1 intron 1, by polymerase chain reaction-restriction fragment length polymorphism. H.pylori infection status was examined by histology or antibody against H.pylori. Results: Although frequency of CCK-1 polymorphisms in overall dyspeptic patients, subgroups by Roma III criteria and non-symptomatic healthy controls did not show any significant differences, 779 T carriers significantly increased the risk of postprandial syndrome (PDS) in male subjects (53.5%vs, 84.2; OR=4.63, 95%CI=1.24-17.31, p=0.018). This significant association was also remained after logistic regression analysis with adjustment for age and H.pylori infection status (OR=4.99, 95%CI=1.31-18.95, p=0.018). In female and different H. pylori infection status, no significant association was observed between CCK-1 polymorphisms and dyspepsia. Conclusion: Our data suggest that the 779 T carriers of CCK-1 intron 1 is associated with an increased risk of PDS in Japanese male subjects.

AB - Background/Aims: The role of genetics in the susceptibility to functional dyspepsia (FD) is not well established. Cholecystokinin (CCK) is released from enteroendocrine cells in the duodenal mucosa after food ingestion and signals satiation through peripheral or central actions. A common polymorphisms of CCK and it's receptor gene has been shown to be associated with panic disorder and schizophrenia. It was investigated the prevalence of CCK polymorphism in dyspeptic patients in a Japanese population. Methodology: A total of 124 dyspeptic patients, 119 non-symptomatic healthy controls participated in this study. Dyspeptic patients were also classified by Rome III criteria. T779C of Cholecystokinin (CCK)-1 intron 1, by polymerase chain reaction-restriction fragment length polymorphism. H.pylori infection status was examined by histology or antibody against H.pylori. Results: Although frequency of CCK-1 polymorphisms in overall dyspeptic patients, subgroups by Roma III criteria and non-symptomatic healthy controls did not show any significant differences, 779 T carriers significantly increased the risk of postprandial syndrome (PDS) in male subjects (53.5%vs, 84.2; OR=4.63, 95%CI=1.24-17.31, p=0.018). This significant association was also remained after logistic regression analysis with adjustment for age and H.pylori infection status (OR=4.99, 95%CI=1.31-18.95, p=0.018). In female and different H. pylori infection status, no significant association was observed between CCK-1 polymorphisms and dyspepsia. Conclusion: Our data suggest that the 779 T carriers of CCK-1 intron 1 is associated with an increased risk of PDS in Japanese male subjects.

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Tahara T, Arisawa T, Shibata T, Nakamura M, Wang F, Yoshioka D et al. 779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects. Hepato-gastroenterology. 2009 Jul 1;56(93):1245-1248.