Find Research outputs

Takotsubo cardiomyopathy with involvement of delayed-onset rhabdomyolysis and acute kidney injury after rosuvastatin treatment

Kamada, T., Hayashi, M., Yokoi, H., Fujiwara, W., Yoshikawa, D., Mukaide, D., Sugishita, Y., Yoshinaga, M., Ito, T., Ozaki, Y. & Izawa, H., 2015, In: Internal Medicine. 54, 1, p. 31-35 5 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation

Yahata, N., Matsumoto, Y., Omi, M., Yamamoto, N. & Hata, R., 01-12-2017, In: Scientific reports. 7, 1, 15557.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Tall cell variant of papillary thyroid carcinoma: Its characteristic features demonstrated by fine-needle aspiration cytology and immunohistochemical study

Urano, M., Kiriyama, Y., Takakuwa, Y. & Kuroda, M., 10-2009, In: Diagnostic Cytopathology. 37, 10, p. 732-737 6 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Tandem balloon test occlusion for a large unruptured aneurysm associated with persistent primitive trigeminal artery: Technical note

Tanaka, T., Sadato, A., Hayakawa, M., Oomura, M., Maeda, S., Adachi, K., Watabe, T., Hiramatsu, H., Imizu, S., Negoro, M. & Hirose, Y., 2012, In: Journal of Neuroendovascular Therapy. 5, 3, p. 202-207 6 p.

Research output: Contribution to journal › Article › peer-review

Tangier disease with continuous massive and longitudinal diffuse calcification in the coronary arteries: Demonstration by the sagittal images of intravascular ultrasonography

Komuro, R., Yamashita, S., Sumitsuji, S., Hirano, K. I., Maruyama, T., Nishida, M., Matsuura, F., Matsuyama, A., Sugimoto, T., Ouchi, N., Sakai, N., Nakamura, T., Funahashi, T. & Matsuzawa, Y., 23-05-2000, In: Circulation. 101, 20, p. 2446-2448 3 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Target antigen density governs the efficacy of anti-CD20-CD28-CD3 ζ chimeric antigen receptor-modified effector CD8⁺ T cells

Watanabe, K., Terakura, S., Martens, A. C., Van Meerten, T., Uchiyama, S., Imai, M., Sakemura, R., Goto, T., Hanajiri, R., Imahashi, N., Shimada, K., Tomita, A., Kiyoi, H., Nishida, T., Naoe, T. & Murata, M., 01-02-2015, In: Journal of Immunology. 194, 3, p. 911-920 10 p.

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

Target cattle age of post-slaughter testing for bovine spongiform encephalopathy and infectivity entering the human food chain in Japan

Kiyohara, K., Hashimoto, S., Kawamura, T., Hamasaki, T., Yamamoto, S., Kakehashi, M. & Yoshikawa, Y., 01-2010, In: Food Control. 21, 1, p. 29-35 7 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest

Akatsuka, Y., Kondo, E., Taji, H., Morishima, Y., Yazaki, M., Obata, Y., Kodera, Y., Riddell, S. R. & Takahashi, T., 27-12-2002, In: Transplantation. 74, 12, p. 1773-1780 8 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia

Onouchi, T., Kobayashi, K., Sakai, K., Shimomura, A., Smits, R., Sumi-Ichinose, C., Kurosumi, M., Takao, K., Nomura, R., Iizuka-Kogo, A., Suzuki, H., Kondo, K., Akiyama, T., Miyakawa, T., Fodde, R. & Senda, T., 29-03-2014, In: Molecular brain. 7, 1, 21.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: Hematological, nephrological, and otological studies of heterozygous KO mice

Matsushita, T., Hayashi, H., Kunishima, S., Hayashi, M., Ikejiri, M., Takeshita, K., Yuzawa, Y., Adachi, T., Hirashima, K., Sone, M., Yamamoto, K., Takagi, A., Katsumi, A., Kawai, K., Nezu, T., Takahashi, M., Nakashima, T., Naoe, T., Kojima, T. & Saito, H., 24-12-2004, In: Biochemical and Biophysical Research Communications. 325, 4, p. 1163-1171 9 p.

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells

Zhu, P., Hata, R., Ogasawara, M., Cao, F., Kameda, K., Yamauchi, K., Schinkel, A. H., Maeyama, K. & Sakanaka, M., 10-2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 10, p. 1897-1908 12 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury

Hata, R., Gillardon, F., Michaelidis, T. M. & Hossmann, K. A., 14-09-1999, In: Metabolic Brain Disease. 14, 2, p. 117-124 8 p.

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN

Katschinski, D. M., Marti, H. H., Wagner, K. F., Shibata, J., Eckhardt, K., Martin, F., Depping, R., Paasch, U., Gassmann, M., Ledermann, B., Desbaillets, I. & Wenger, R. H., 10-2003, In: Molecular and Cellular Biology. 23, 19, p. 6780-6789 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Citations (Scopus)

Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice

Kobayashi, K., Morita, S., Sawada, H., Mizuguchi, T., Yamada, K., Nagatsu, I., Hata, T., Watanabe, Y., Fujita, K. & Nagatsu, T., 1995, In: Journal of Biological Chemistry. 270, 45, p. 27235-27243 9 p.

Research output: Contribution to journal › Article › peer-review

178 Citations (Scopus)

Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide

Hatakeyama, S., Sugihara, K., Shibata, T. K., Nakayama, J., Akama, T. O., Tamura, N., Wong, S. M., Bobkov, A. A., Takano, Y., Ohyama, C., Fukuda, M. & Fukuda, M. N., 06-12-2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 49, p. 19587-19592 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Citations (Scopus)

Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells

Asai, N., Fukuda, T., Wu, Z., Enomoto, A., Pachnis, V., Takahashi, M. & Costantini, F., 11-2006, In: Development. 133, 22, p. 4507-4516 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Citations (Scopus)

Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis

and for the Research Committee of Intractable Vasculitis Syndrome and the Research Committee of Intractable Renal Disease of the Ministry of Health, Labour and Welfare of Japan, 29-09-2017, In: Arthritis Research and Therapy. 19, 1, 218.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Targeting Aurora B to the Equatorial Cortex by MKlp2 Is Required for Cytokinesis

Kitagawa, M., Fung, S. Y. S., Onishi, N., Saya, H. & Lee, S. H., 04-06-2013, In: PloS one. 8, 6, e64826.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Citations (Scopus)

Targeting Cancer Stem Cells-Modulating Embryonic Stem Cell Signaling, Epigenetics, and Tumor Metabolism

Takebe, N., Harris, P. J., Kondo, Y., Nair, A., Percy Ivy, S. & Saya, H., 14-04-2014, Cancer Stem Cells. Wiley-Blackwell, Vol. 9781118356166. p. 295-317 23 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Targeting ceramide synthase 6-dependent metastasisprone phenotype in lung cancer cells

Suzuki, M., Cao, K., Kato, S., Komizu, Y., Mizutani, N., Tanaka, K., Arima, C., Chee Tai, M., Yanagisawa, K., Togawa, N., Shiraishi, T., Usami, N., Taniguchi, T., Fukui, T., Yokoi, K., Wakahara, K., Hasegawa, Y., Mizutani, Y., Igarashi, Y., Inokuchi, J. I. & 10 others, Iwaki, S., Fujii, S., Satou, A., Matsumoto, Y., Ueoka, R., Tamiya-Koizumi, K., Murate, T., Nakamura, M., Kyogashima, M. & Takahashi, T., 04-01-2016, In: Journal of Clinical Investigation. 126, 1, p. 254-265 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates

Thiede, J. M., Kordus, S. L., Turman, B. J., Buonomo, J. A., Aldrich, C. C., Minato, Y. & Baughn, A. D., 01-12-2016, In: Scientific reports. 6, 38083.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Targeting lactate dehydrogenase-A promotes docetaxel-induced cytotoxicity predominantly in castration-resistant prostate cancer cells

Muramatsu, H., Sumitomo, M., Morinaga, S., Kajikawa, K., Kobayashi, I., Nishikawa, G., Kato, Y., Watanabe, M., Zennami, K., Kanao, K., Nakamura, K., Suzuki, S. & Yoshikawa, K., 07-2019, In: Oncology reports. 42, 1, p. 224-230 7 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Targeting myostatin for therapies against muscle-wasting disorders

Tsuchida, K., 01-07-2008, In: Current Opinion in Drug Discovery and Development. 11, 4, p. 487-494 8 p.

Research output: Contribution to journal › Review article › peer-review

80 Citations (Scopus)

Targeting of aquaporin 4 into lipid rafts and its biological significance

Asakura, K., Ueda, A., Shima, S., Ishikawa, T., Hikichi, C., Hirota, S., Fukui, T., Ito, S. & Mutoh, T., 2014, In: Brain Research. 1583, 1, p. 237-244 8 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Targeting of cancer stem cells by differentiation therapy

Arima, Y., Nobusue, H. & Saya, H., 01-08-2020, In: Cancer science. 111, 8, p. 2689-2695 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Targeting the Hippo signalling pathway for cancer treatment

Nakatani, K., Maehama, T., Nishio, M., Goto, H., Kato, W., Omori, H., Miyachi, Y., Togashi, H., Shimono, Y. & Suzuki, A., 2017, In: Journal of Biochemistry. 161, 3, p. 237-244 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

20 Citations (Scopus)

Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology

Fujita, K., Chen, X., Homma, H., Tagawa, K., Amano, M., Saito, A., Imoto, S., Akatsu, H., Hashizume, Y., Kaibuchi, K., Miyano, S. & Okazawa, H., 01-12-2018, In: Nature communications. 9, 1, 433.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Target international normalized ratio values for preventing thromboembolic and hemorrhagic events in Japanese patients with non-valvular atrial fibrillation: Results of the J-RHYTHM registry

Inoue, H., Okumura, K., Atarashi, H., Yamashita, T., Origasa, H., Kumagai, N., Sakurai, M., Kawamura, Y., Kubota, I., Matsumoto, K., Kaneko, Y., Ogawa, S., Aizawa, Y., Chinushi, M., Kodama, I., Watanabe, E., Koretsune, Y., Okuyama, Y., Shimizu, A., Igawa, O. & 4 others, Bando, S., Fukatani, M., Saikawa, T. & Chishaki, A., 2013, In: Circulation Journal. 77, 9, p. 2264-2270 7 p.

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior

Yamashita, T. & Petersen, C. C. H., 21-06-2016, In: eLife. 5, JUN2016, e15798.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Citations (Scopus)

Task dependency of the long-latency facilitatory effect on the soleus H-reflex by cerebellar transcranial magnetic stimulation

Matsugi, A., Mori, N., Uehara, S., Kamata, N., Oku, K., Mukai, K. & Nagano, K., 03-12-2014, In: Neuroreport. 25, 17, p. 1375-1380 6 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Tau Accumulation and Network Breakdown in Alzheimer’s Disease

Watanabe, H., Bagarinao, E., Yokoi, T., Yamaguchi, H., Ishigaki, S., Mausuda, M., Katsuno, M. & Sobue, G., 2019, Advances in Experimental Medicine and Biology. Springer, p. 231-240 10 p. (Advances in Experimental Medicine and Biology; vol. 1184).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Taurine-containing uridine modifications in tRNA anticodons are required to decipher non-universal genetic codes in ascidian mitochondria

Suzuki, T., Miyauchi, K., Suzuki, T., Yokobori, S. I., Shigi, N., Kondow, A., Takeuchi, N., Yamagishi, A. & Watanabe, K., 14-10-2011, In: Journal of Biological Chemistry. 286, 41, p. 35494-35498 5 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Taurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous type 2 diabetes

Nakaya, Y., Minami, A., Harada, N., Sakamoto, S., Niwa, Y. & Ohnaka, M., 01-2000, In: American Journal of Clinical Nutrition. 71, 1, p. 54-58 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

150 Citations (Scopus)

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

Ikezu, S., Ingraham Dixie, K. L., Koro, L., Watanabe, T., Kaibuchi, K. & Ikezu, T., 04-02-2020, In: Acta Neuropathologica Communications. 8, 1, 12.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Taxol resistance among the different histological subtypes of ovarian cancer may be associated with the expression of class III β-tubulin

Umezu, T., Shibata, K., Kajiyama, H., Terauchi, M., Ino, K., Nawa, A. & Kikkawa, F., 04-2008, In: International Journal of Gynecological Pathology. 27, 2, p. 207-212 6 p.

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Tbx6, Thylacine1, and E47 synergistically activate bowline expression in Xenopus somitogenesis

Hitachi, K., Kondow, A., Danno, H., Inui, M., Uchiyama, H. & Asashima, M., 15-01-2008, In: Developmental Biology. 313, 2, p. 816-828 13 p.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

T-Cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner

Uchida, Y., Ke, B., Freitas, M. C. S., Yagita, H., Akiba, H., Busuttil, R. W., Najafian, N. & Kupiecweglinski, J. W., 12-2010, In: Gastroenterology. 139, 6, p. 2195-2206 12 p.

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

T-cell immunotherapy with a chimeric receptor against CD38 is effective in eliminating myeloma cells

Mihara, K., Bhattacharyya, J., Kitanaka, A., Yanagihara, K., Kubo, T., Takei, Y., Asaoku, H., Takihara, Y. & Kimura, A., 02-2012, In: Leukemia. 26, 2, p. 365-367 3 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

49 Citations (Scopus)

T-cell immunotherapy with a chimeric receptor against CD38 is effective in eradicating chemotherapy-resistant B-cell lymphoma cells overexpressing survivin induced by BMI-1

Bhattacharyya, J., Mihara, K., Kitanaka, A., Yanagihara, K., Kubo, T., Takei, Y., Kimura, A. & Takihara, Y., 29-06-2012, In: Blood cancer journal. 2, 6, e75.

Research output: Contribution to journal › Letter › peer-review

Open Access

5 Citations (Scopus)

T cell lineage determination precedes the initiation of TCRβ gene rearrangement

Masuda, K., Kakugawa, K., Nakayama, T., Minato, N., Katsura, Y. & Kawamoto, H., 15-09-2007, In: Journal of Immunology. 179, 6, p. 3699-3706 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Citations (Scopus)

T-cell lymphomas diffusely involving the intestine: Report of two rare cases

Tsutsumi, Y., Inada, K. I., Morita, K. & Suzuki, T., 08-1996, In: Japanese journal of clinical oncology. 26, 4, p. 264-272 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

T Cell maturation stage-linked heterogeneity of the glycosylphosphatidylinositol membrane anchor of Thy-1

Nakashima, I., Yoshida, T., Zhang, Y. H., Pu, M. Y., Taguchi, R., Ikezawa, H., Isobe, K. I., Iwamoto, T., Kato, M., Lwin, T. & Parvin, M., 1992, In: Immunobiology. 185, 5, p. 466-474 9 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

T-cell membrane-associated serine protease, tryptase TL₂, binds human immunodeficiency virus type 1 gp120 and cleaves the third-variable-domain loop of gp120 Neutralizing antibodies of human immunodeficiency virus type 1 inhibit cleavage of gp120

Niwa, Y., Yano, M., Futaki, S., Okumura, Y. & Kido, H., 1996, In: European Journal of Biochemistry. 237, 1, p. 64-70 7 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver

Kawamoto, H., Ikawa, T., Ohmura, K., Fujimoto, S. & Katsura, Y., 2000, In: Immunity. 12, 4, p. 441-450 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

132 Citations (Scopus)

T cell receptor clonal diversity following allogeneic marrow grafting

Akatsuka, Y., Cerveny, C. & Hansen, J. A., 1996, In: Human Immunology. 48, 1-2, p. 125-134 10 p.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

T‐Cell Receptor Gene Structures of HLA‐A26‐restricted Cytotoxic T Lymphocyte Lines against Human Autologous Pancreatic Adenocarcinoma

Ueda, D., Sato, N., Matsuura, A., Sasaki, A., Takahashi, S., Ikeda, H., Wada, Y. & Kikuchi, K., 07-1995, In: Japanese Journal of Cancer Research. 86, 7, p. 691-697 7 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

T cells bearing anti-CD19 and/or anti-CD38 chimeric antigen receptors effectively abrogate primary double-hit lymphoma cells

Mihara, K., Yoshida, T., Takei, Y., Sasaki, N., Takihara, Y., Kuroda, J. & Ichinohe, T., 08-06-2017, In: Journal of Hematology and Oncology. 10, 1, 116.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4 + T cell fate and interact with Runx3 to silence Cd4 in CD8 + T cells

Steinke, F. C., Yu, S., Zhou, X., He, B., Yang, W., Zhou, B., Kawamoto, H., Zhu, J., Tan, K. & Xue, H. H., 07-2014, In: Nature Immunology. 15, 7, p. 646-656 11 p.

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

TCL1A, a novel transcription factor and a coregulator of nuclear factor kB p65: Single nucleotide polymorphism and estrogen dependence^s

Ho, M. F., Lummertz da Rocha, E., Zhang, C., Ingle, J. N., Goss, P. E., Shepherd, L. E., Kubo, M., Wang, L., Li, H. & Weinshilboum, R. M., 06-2018, In: Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 700-710 11 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

TCL1A Single-Nucleotide Polymorphisms and Estrogen-Mediated Toll-Like Receptor-MyD88–Dependent Nuclear Factor-kB Activation: Single-Nucleotide Polymorphism– and Selective Estrogen Receptor Modulator–Dependent Modification of Inflammation and Immune Response

Ho, M. F., Ingle, J. N., Bongartz, T., Kalari, K. R., Goss, P. E., Shepherd, L. E., Mushiroda, T., Kubo, M., Wang, L. & Weinshilboum, R. M., 08-2017, In: Molecular Pharmacology. 92, 2, p. 175-184 10 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

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