Find Research Outputs

2019

Glucagon-Like Peptide-1 Receptor Agonist Protects Dorsal Root Ganglion Neurons against Oxidative Insult

Mohiuddin, M. S., Himeno, T., Inoue, R., Miura-Yura, E., Yamada, Y., Nakai-Shimoda, H., Asano, S., Kato, M., Motegi, M., Kondo, M., Seino, Y., Tsunekawa, S., Kato, Y., Suzuki, A., Naruse, K., Kato, K., Nakamura, J. & Kamiya, H., 01-01-2019, In : Journal of Diabetes Research. 2019, 9426014.

Research output: Contribution to journalArticle

Open Access
Diabetic Neuropathies
Spinal Ganglia
Neurons
Neurites
Cyclic AMP

Greater Nutrient Intake Is Associated With Lower Mortality in Western and Eastern Critically Ill Patients With Low BMI: A Multicenter, Multinational Observational Study

Compher, C., Chittams, J., Sammarco, T., Higashibeppu, N., Higashiguchi, T. & Heyland, D. K., 01-01-2019, In : Journal of Parenteral and Enteral Nutrition. 43, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

Critical Illness
Observational Studies
Body Mass Index
Food
Mortality

GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture

Matoba, N., Akiyama, M., Ishigaki, K., Kanai, M., Takahashi, A., Momozawa, Y., Ikegawa, S., Ikeda, M., Iwata, N., Hirata, M., Matsuda, K., Kubo, M., Okada, Y. & Kamatani, Y., 01-05-2019, In : Nature Human Behaviour. 3, 5, p. 471-477 7 p.

Research output: Contribution to journalLetter

Genetic Loci
Genome-Wide Association Study
Smoking
Linkage Disequilibrium
Tobacco Products

Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study

For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan, 15-03-2019, In : Clinical and Experimental Nephrology. 23, 3, p. 387-394 8 p.

Research output: Contribution to journalArticle

Antineutrophil Cytoplasmic Antibodies
Glomerulonephritis
Cohort Studies
Kidney
Glomerular Filtration Rate

HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease

Shimizu, C., Kim, J., Eleftherohorinou, H., Wright, V. J., Hoang, L. T., Tremoulet, A. H., Franco, A., Hibberd, M. L., Takahashi, A., Kubo, M., Ito, K., Tanaka, T., Onouchi, Y., Coin, L. J. M., Levin, M., Burns, J. C. & Shike, H., 01-01-2019, In : Human Immunology.

Research output: Contribution to journalArticle

HLA-C Antigens
Mucocutaneous Lymph Node Syndrome
Amino Acid Substitution
Peptides
Alleles

Human serum albumin redox state is associated with decreased renal function in a community-dwelling population

Fujii, R., Ueyama, J., Kanno, T., Suzuki, K., Hamajima, N., Wakai, K., Hasegawa, Y. & Kondo, T., 01-01-2019, In : American journal of physiology. Renal physiology. 316, 1, p. F214-F218

Research output: Contribution to journalArticle

Independent Living
Serum Albumin
Oxidation-Reduction
Kidney
Population
1 Citation (Scopus)

Human tyrosine hydroxylase in Parkinson’s disease and in related disorders

Nagatsu, T., Nakashima, A., Ichinose, H. & Kobayashi, K., 01-04-2019, In : Journal of Neural Transmission. 126, 4, p. 397-409 13 p.

Research output: Contribution to journalReview article

Tyrosine 3-Monooxygenase
Parkinson Disease
Dopaminergic Neurons
Dopamine
Corpus Striatum
1 Citation (Scopus)

Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population

Suzuki, K., Akiyama, M., Ishigaki, K., Kanai, M., Hosoe, J., Shojima, N., Hozawa, A., Kadota, A., Kuriki, K., Naito, M., Tanno, K., Ishigaki, Y., Hirata, M., Matsuda, K., Iwata, N., Ikeda, M., Sawada, N., Yamaji, T., Iwasaki, M., Ikegawa, S. & 12 othersMaeda, S., Murakami, Y., Wakai, K., Tsugane, S., Sasaki, M., Yamamoto, M., Okada, Y., Kubo, M., Kamatani, Y., Horikoshi, M., Yamauchi, T. & Kadowaki, T., 01-03-2019, In : Nature Genetics. 51, 3, p. 379-386 8 p.

Research output: Contribution to journalLetter

Genome-Wide Association Study
Gene Frequency
Type 2 Diabetes Mellitus
Population
Acinar Cells

Identification of rare coding variants in TYK2 protective for rheumatoid arthritis in the Japanese population and their effects on cytokine signalling

Motegi, T., Kochi, Y., Matsuda, K., Kubo, M., Yamamoto, K. & Momozawa, Y., 01-01-2019, In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Genes
Association reactions
Cytokines
Interferons
1 Citation (Scopus)

Imaging scoring systems for preoperative molecular diagnoses of lower-grade gliomas

Kanazawa, T., Fujiwara, H., Takahashi, H., Nishiyama, Y., Hirose, Y., Tanaka, S., Yoshida, K. & Sasaki, H., 01-06-2019, In : Neurosurgical Review. 42, 2, p. 433-441 9 p.

Research output: Contribution to journalArticle

Glioma
Methylation
Neoplasms
Mutation
Therapeutics

Impact of lumbar hypolordosis on the incidence of symptomatic postoperative spinal epidural hematoma after decompression surgery for lumbar spinal canal stenosis

Fujita, N., Michikawa, T., Yagi, M., Suzuki, S., Tsuji, O., Nagoshi, N., Okada, E., Tsuji, T., Nakamura, M., Matsumoto, M. & Watanabe, K., 25-01-2019, In : European Spine Journal. 28, 1, p. 87-93 7 p.

Research output: Contribution to journalArticle

Spinal Epidural Hematoma
Spinal Stenosis
Spinal Canal
Decompression
Incidence
2 Citations (Scopus)

Impact of serum albumin levels on supratherapeutic PT-INR control and bleeding risk in atrial fibrillation patients on warfarin: A prospective cohort study

Kawai, M., Harada, M., Motoike, Y., Koshikawa, M., Ichikawa, T., Watanabe, E. & Ozaki, Y., 01-03-2019, In : IJC Heart and Vasculature. 22, p. 111-116 6 p.

Research output: Contribution to journalArticle

International Normalized Ratio
Warfarin
Serum Albumin
Atrial Fibrillation
Albumins
1 Citation (Scopus)

Improving TCR affinity on 293T cells

Ohta, R., Demachi-Okamura, A., Akatsuka, Y., Fujiwara, H. & Kuzushima, K., 01-03-2019, In : Journal of Immunological Methods. 466, p. 1-8 8 p.

Research output: Contribution to journalArticle

HEK293 Cells
Peptides
Mutation
HLA-A24 Antigen
Artificial Cells

Incidence and circumstances of falls among community-dwelling ambulatory stroke survivors: A prospective study

Goto, Y., Otaka, Y., Suzuki, K., Inoue, S., Kondo, K. & Shimizu, E., 01-03-2019, In : Geriatrics and Gerontology International. 19, 3, p. 240-244 5 p.

Research output: Contribution to journalArticle

Independent Living
stroke
Survivors
incidence
Accidental Falls

Incidence rate of atrial fibrillation after dialysis initiation and its relationship with cardiovascular events

Tanaka, A., Inaguma, D., Shinjo, H. & Takeda, A., 01-01-2019, In : Acta Cardiologica.

Research output: Contribution to journalArticle

Atrial Fibrillation
Dialysis
Incidence
Cardiovascular Diseases
Albumins

Increased salt intake does not worsen the progression of renal cystic disease in high water-loaded PCK rats

Nagao, S., Kugita, M., Kumamoto, K., Yoshimura, A., Nishii, K. & Yamaguchi, T., 01-03-2019, In : PloS one. 14, 3, e0207461.

Research output: Contribution to journalArticle

Open Access
Cystic Kidney Diseases
Drinking
Rats
Salts
kidneys

Induced pluripotent stem cell-derived melanocyte precursor cells undergoing differentiation into melanocytes

Hosaka, C., Kunisada, M., Koyanagi-Aoi, M., Masaki, T., Takemori, C., Ikeda, M., Aoi, T. & Nishigori, C., 01-01-2019, In : Pigment Cell and Melanoma Research.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Melanocytes
Stem cells
Cell Differentiation
Fibroblasts

Initial characterization of the Epstein–Barr virus BSRF1 gene product

Yanagi, Y., Abdullah Al Masud, H. M., Watanabe, T., Sato, Y., Goshima, F., Kimura, H. & Murata, T., 01-03-2019, In : Viruses. 11, 3, 285.

Research output: Contribution to journalArticle

Open Access
Reading Frames
Viruses
Genes
Cytoplasm
Bacterial Artificial Chromosomes

Initial clinical experience of a prototype ultra-high-resolution CT for assessment of small intracranial arteries

Nagata, H., Murayama, K., Suzuki, S., Watanabe, A., Hayakawa, M., Saito, Y., Katada, K. & Toyama, H., 01-01-2019, In : Japanese Journal of Radiology.

Research output: Contribution to journalArticle

Arteries
Tomography
Ophthalmic Artery
Neurosurgical Procedures
Intracranial Aneurysm

In utero exposure to di(2-ethylhexyl)phthalate suppresses blood glucose and leptin levels in the offspring of wild-type mice

Hayashi, Y., Ito, Y., Naito, H., Tamada, H., Yamagishi, N., Kondo, T., Ishikawa, T., Gonzalez, F. J. & Nakajima, T., 01-03-2019, In : Toxicology. 415, p. 49-55 7 p.

Research output: Contribution to journalArticle

Leptin
Blood Glucose
Peroxisome Proliferator-Activated Receptors
Weaning
Malnutrition

Involvement of interleukin-31 receptor A in morphine-induced itching and antinociception in mice

Tsuji, M., Arai, I., Miyagawa, K., Miyagishi, H., Saito, A., Takeda, K., Takeda, H., Akiyama, N. & Saito, S., 01-02-2019, In : European Journal of Pain (United Kingdom). 23, 2, p. 378-388 11 p.

Research output: Contribution to journalArticle

Interleukin Receptors
Pruritus
Morphine
Pain
Sensory Receptor Cells

Is metatarsus primus elevatus truly observed in hallux rigidus? Radiographic study using mapping methods

Ohara, K., Tanaka, Y., Taniguchi, A., Kurokawa, H., Kumai, T. & Yamada, H., 01-03-2019, In : Journal of Orthopaedic Science. 24, 2, p. 312-319 8 p.

Research output: Contribution to journalArticle

Hallux Rigidus
Metatarsus
Foot
Metatarsal Bones
X-Rays
Dementia
Long-Term Memory
Vision Disorders
Ambulatory Care Facilities
Early Diagnosis

Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns

Harada, S., Aoki, K., Okamoto, K., Kinoshita, O., Nawata, K., Ishii, Y., Tateda, K., Sasaki, M., Saga, T., Doi, Y., Yotsuyanagi, H., Moriya, K. & Ono, M., 01-07-2019, In : International Journal of Infectious Diseases. 84, p. 44-47 4 p.

Research output: Contribution to journalArticle

Open Access
Heart-Assist Devices
Endocarditis
Staphylococcus aureus
Linezolid
Clone Cells
Kynurenine
Phencyclidine
Tryptophan
Schizophrenia
N-Methyl-D-Aspartate Receptors

Localisation of basic fibroblast growth factor in cholesteatoma matrix: An immunochemical study

Hamed, M. A., Sayed, R. H., Shiogama, K., Eltaher, M. A., Suzuki, K. & Nakata, S., 01-03-2019, In : Journal of Laryngology and Otology. 133, 3, p. 183-186 4 p.

Research output: Contribution to journalArticle

Cholesteatoma
Fibroblast Growth Factor 2
Skin
Mast Cells
Cell Membrane
2 Citations (Scopus)

Lumbar spinal canal stenosis leads to locomotive syndrome in elderly patients

Fujita, N., Sakurai, A., Miyamoto, A., Michikawa, T., Tsuji, O., Nagoshi, N., Okada, E., Yagi, M., Otaka, Y., Tsuji, T., Kono, H., Ishii, K., Nakamura, M., Matsumoto, M. & Watanabe, K., 01-01-2019, In : Journal of Orthopaedic Science. 24, 1, p. 19-23 5 p.

Research output: Contribution to journalArticle

Spinal Stenosis
Spinal Canal
Exercise Test
Musculoskeletal System
Logistic Models

Lumbar spinal surgery improves locomotive syndrome in elderly patients with lumbar spinal canal stenosis: A multicenter prospective study

Fujita, N., Michikawa, T., Miyamoto, A., Sakurai, A., Otaka, Y., Suzuki, S., Tsuji, O., Nagoshi, N., Okada, E., Yagi, M., Tsuji, T., Kono, H., Ishii, K., Nakamura, M., Matsumoto, M. & Watanabe, K., 01-01-2019, In : Journal of Orthopaedic Science.

Research output: Contribution to journalArticle

Spinal Stenosis
Spinal Canal
Multicenter Studies
Prospective Studies
Exercise Test
Glioma
Lymphoma
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Glutamic Acid

Malnutrition among elderly patients with severe aortic stenosis

Fukui, S., Kawakami, M., Otaka, Y., Ishikawa, A., Muraoka, K., Yashima, F., Hayashida, K. & Liu, M., 01-01-2019, In : Aging Clinical and Experimental Research.

Research output: Contribution to journalArticle

Aortic Valve Stenosis
Malnutrition
Nutrition Assessment
Activities of Daily Living
Logistic Models

Maternal high-fructose intake increases circulating corticosterone levels via decreased adrenal corticosterone clearance in adult offspring

Munetsuna, E., Yamada, H., Yamazaki, M., Ando, Y., Mizuno, G., Hattori, Y., Sadamoto, N., Ishikawa, H., Ohta, Y., Fujii, R., Suzuki, K., Hashimoto, S. & Ohashi, K., 01-05-2019, In : Journal of Nutritional Biochemistry. 67, p. 44-50 7 p.

Research output: Contribution to journalArticle

Corticosterone
Fructose
Mothers
Dams
Rats

Modic changes in the cervical spine: Prospective 20-year follow-up study in asymptomatic subjects

Tsuji, T., Fujiwara, H., Nishiwaki, Y., Daimon, K., Okada, E., Nojiri, K., Watanabe, M., Katoh, H., Shimizu, K., Ishihama, H., Fujita, N., Nakamura, M., Matsumoto, M. & Watanabe, K., 01-01-2019, (Accepted/In press) In : Journal of Orthopaedic Science. 24, 4, p. 612-617 6 p.

Research output: Contribution to journalArticle

Spine
Intervertebral Disc Degeneration
Neck Pain
Intervertebral Disc
Odds Ratio

Molecular mechanisms for nicotine intoxication

Alkam, T. & Nabeshima, T., 01-05-2019, In : Neurochemistry International. 125, p. 117-126 10 p.

Research output: Contribution to journalReview article

Nicotine
Tobacco
Agriculture
Sudden Infant Death
Peripheral Nervous System

Molecular responses of maize shoot to a plant derived smoke solution

Aslam, M. M., Rehman, S., Khatoon, A., Jamil, M., Yamaguchi, H., Hitachi, K., Tsuchida, K., Li, X., Sunohara, Y., Matsumoto, H. & Komatsu, S., 02-03-2019, In : International journal of molecular sciences. 20, 6, 1319.

Research output: Contribution to journalArticle

Open Access
smoke
Smoke
Zea mays
proteins
Proteins

Molecular subtyping of gastric cancer combining genetic and epigenetic anomalies provides distinct clinicopathological features and prognostic impacts

Tahara, T., Tahara, S., Horiguchi, N., Okubo, M., Terada, T., Yamada, H., Yoshida, D., Omori, T., Osaki, H., Maeda, K., Kamano, T., Funasaka, K., Nagasaka, M., Nakagawa, Y., Shibata, T. & Ohmiya, N., 01-03-2019, In : Human Mutation. 40, 3, p. 347-354 8 p.

Research output: Contribution to journalArticle

CpG Islands
Epigenomics
Stomach Neoplasms
Phenotype
Mutation

Morphologic and kinematic analysis of swallowing using multislice CT

Inamoto, Y. & Saitoh, E., 01-01-2019, Medical Radiology. Springer Verlag, p. 333-349 17 p. (Medical Radiology; vol. 0).

Research output: Chapter in Book/Report/Conference proceedingChapter

Multidetector Computed Tomography
Deglutition
Biomechanical Phenomena
Three-Dimensional Imaging
Deglutition Disorders

Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis

Okazaki, S., Morimoto, T., Kamatani, Y., Kamimura, T., Kobayashi, H., Harada, K., Tomita, T., Higashiyama, A., Takahashi, J. C., Nakagawara, J., Koga, M., Toyoda, K., Washida, K., Saito, S., Takahashi, A., Hirata, M., Matsuda, K., Mochizuki, H., Chong, M., Paré, G. & 9 othersO'Donnell, M., Ago, T., Hata, J., Ninomiya, T., Dichgans, M., Debette, S., Kubo, M., Koizumi, A. & Ihara, M., 08-01-2019, In : Circulation. 139, 2, p. 295-298 4 p.

Research output: Contribution to journalLetter

RING Finger Domains
Moyamoya Disease
Disease Susceptibility
Genetic Predisposition to Disease
Atherosclerosis

Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy

Omiya, N., Hotta, N., Mitsufuji, S., Nakamura, M., Omori, T., Maeda, K., Okuda, K., Yatsuya, H. & Tajiri, H., 01-03-2019, In : Digestive Endoscopy. 31, 2, p. 164-172 9 p.

Research output: Contribution to journalArticle

Castor Oil
Capsule Endoscopy
Feasibility Studies
Multicenter Studies
Colon

Multiethnic genome-wide association study of diabetic retinopathy using liability threshold modeling of duration of diabetes and glycemic control

Family Investigation of Nephropathy and Diabetes-Eye Research Group & DCCT/EDIC Research Group, 01-02-2019, In : Diabetes. 68, 2, p. 441-456 16 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Diabetic Retinopathy
Gene Regulatory Networks
Hispanic Americans
African Americans
1 Citation (Scopus)

Multiplex PCR in noninvasive prenatal diagnosis for FGFR3-related disorders

Terasawa, S., Kato, A., Nishizawa, H., Kato, T., Yoshizawa, H., Noda, Y., Miyazaki, J., Ito, M., Sekiya, T., Fujii, T. & Kurahashi, H., 01-01-2019, In : Congenital Anomalies. 59, 1, p. 4-10 7 p.

Research output: Contribution to journalArticle

Thanatophoric Dysplasia
Achondroplasia
Multiplex Polymerase Chain Reaction
Prenatal Diagnosis
Mutation

Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation

Hitachi, K., Nakatani, M., Takasaki, A., Ouchi, Y., Uezumi, A., Ageta, H., Inagaki, H., Kurahashi, H. & Tsuchida, K., 01-03-2019, In : EMBO Reports. 20, 3, e47468.

Research output: Contribution to journalArticle

Long Noncoding RNA
Myogenin
Muscle
Myoblasts
Skeletal Muscle
2 Citations (Scopus)

Neural symptoms in a gene knockout mouse model of Sjogren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide

Kanetake, T., Sassa, T., Nojiri, K., Sawai, M., Takai, S., Miyakawa, T., Kitamura, T. & Kihara, A., 01-01-2019, In : FASEB Journal. 33, 1, p. 928-941 14 p.

Research output: Contribution to journalArticle

Sjogren-Larsson Syndrome
Gene Knockout Techniques
long-chain-aldehyde dehydrogenase
Knockout Mice
Brain

New findings, pathophysiology, and antigen analysis in pollen-food allergy syndrome

Yagami, A. & Ebisawa, M., 01-06-2019, In : Current opinion in allergy and clinical immunology. 19, 3, p. 218-223 6 p.

Research output: Contribution to journalArticle

Seasonal Allergic Rhinitis
Food Hypersensitivity
Antigens
Allergens
Fruit

New subtyping of insomnia disorder

Kitajima, T., 01-02-2019, In : The Lancet Psychiatry. 6, 2, p. 86-88 3 p.

Research output: Contribution to journalComment/debate

Sleep Initiation and Maintenance Disorders
3 Citations (Scopus)

New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections

Isler, B., Doi, Y., Bonomo, R. A. & Paterson, D. L., 01-01-2019, In : Antimicrobial Agents and Chemotherapy. 63, 1

Research output: Contribution to journalArticle

Acinetobacter Infections
Acinetobacter baumannii
Carbapenems
Pharmaceutical Preparations
Drug Approval

Nonlinear Evolution Equations and Their Application to Chemotaxis Models

Kubo, A. & Hoshino, H., 01-01-2019, Trends in Mathematics. Springer International Publishing, p. 337-347 11 p. (Trends in Mathematics).

Research output: Chapter in Book/Report/Conference proceedingChapter

Chemotaxis
Nonlinear Evolution Equations
Global Existence
Mathematical Biology
Asymptotic Profile

Novel risk loci identified in a genome-wide association study of urolithiasis in a Japanese population

Tanikawa, C., Kamatani, Y., Terao, C., Usami, M., Takahashi, A., Momozawa, Y., Suzuki, K., Ogishima, S., Shimizu, A., Satoh, M., Matsuo, K., Mikami, H., Naito, M., Wakai, K., Yamaji, T., Sawada, N., Iwasaki, M., Tsugane, S., Kohri, K., Yu, A. S. L. & 4 othersYasui, T., Murakami, Y., Kubo, M. & Matsuda, K., 01-05-2019, In : Journal of the American Society of Nephrology. 30, 5, p. 855-864 10 p.

Research output: Contribution to journalArticle

Urolithiasis
Genome-Wide Association Study
Population
Electrolytes
Crystallization

Obstetric complication-associated ANXA5 promoter polymorphisms may affect gene expression via DNA secondary structures

Inagaki, H., Ota, S., Nishizawa, H., Miyamura, H., Nakahira, K., Suzuki, M., Nishiyama, S., Kato, T., Yanagihara, I. & Kurahashi, H., 01-05-2019, In : Journal of Human Genetics. 64, 5, p. 459-466 8 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Annexin A5
Obstetrics
Gene Expression
DNA

Open source code for behavior analysis in rodents

Takai, S., Okumura, Y., Takao, K., Yamaguchi, Y. & Miyakawa, T., 01-03-2019, In : Neuropsychopharmacology Reports. 39, 1, p. 67-69 3 p.

Research output: Contribution to journalArticle

Open Access
Rodentia
Phenotype
Fear
Software
Databases
Open Access
Induced Pluripotent Stem Cells
Stem cells
Technology
Nervous System Diseases
Preclinical Drug Evaluations