A case and literature review of ovarian carcinosarcoma with long-Term survival after repeated recurrences

Maki Asano, Kiyoshi Hasegawa, Kazuhiko Tsukada, Shin Tada, Yoshikazu Mizoguchi, Yoshihiro Imaeda, Mina Ikeda, Kyoko Kawamura, Takuma Fujii

Research output: Contribution to journalArticle

Abstract

Ovarian carcinosarcoma is a rare and aggressive tumor with a poor prognosis. We report a case of ovarian carcinosarcoma and also review the literature. In 2000, a 63-year-old woman underwent optimal cytoreductive surgery for ovarian carcinosarcoma (International Federation of Gynaecology and Obstetrics [FIGO] stage 1c [pT3cN0M0]). She received adjuvant chemotherapy with paclitaxel and carboplatin (TC). In 2005, a recurrent tumor was noted anterior to the sacrum. The patient had a complete response after 6 cycles of TC chemotherapy; however, a year later, the tumor recurred and was resected. In 2013, the tumor recurred adjacent to the right kidney and was surgically removed after a partial response to 3 cycles of TC chemotherapy. The pathologic findings included epithelial and non-epithelial components with histologic variation and differentiation; specifically, a leiomyosarcoma, cartilaginous tissues with cellular atypia, and a rhabdomyosarcoma were identified in specimens obtained during the first, second, and third surgical procedures, respectively. In keeping with the combination theory of histogenesis, the ovarian carcinosarcoma described herein may have originated from a monoclonal stem cell. The long survival of this patient is attributed to optimal cytoreduction during the primary operation, solitary recurrent tumors that were completely resected, and sensitivity to chemotherapy.

Original languageEnglish
Pages (from-to)1031-1036
Number of pages6
JournalJapanese Journal of Cancer and Chemotherapy
Volume41
Issue number8
Publication statusPublished - 01-08-2014

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Carcinosarcoma
Recurrence
Survival
Neoplasms
Drug Therapy
Sacrum
Leiomyosarcoma
Rhabdomyosarcoma
Carboplatin
Adjuvant Chemotherapy
Paclitaxel
Gynecology
Obstetrics
Stem Cells
Kidney

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Asano, Maki ; Hasegawa, Kiyoshi ; Tsukada, Kazuhiko ; Tada, Shin ; Mizoguchi, Yoshikazu ; Imaeda, Yoshihiro ; Ikeda, Mina ; Kawamura, Kyoko ; Fujii, Takuma. / A case and literature review of ovarian carcinosarcoma with long-Term survival after repeated recurrences. In: Japanese Journal of Cancer and Chemotherapy. 2014 ; Vol. 41, No. 8. pp. 1031-1036.
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Asano, M, Hasegawa, K, Tsukada, K, Tada, S, Mizoguchi, Y, Imaeda, Y, Ikeda, M, Kawamura, K & Fujii, T 2014, 'A case and literature review of ovarian carcinosarcoma with long-Term survival after repeated recurrences', Japanese Journal of Cancer and Chemotherapy, vol. 41, no. 8, pp. 1031-1036.

A case and literature review of ovarian carcinosarcoma with long-Term survival after repeated recurrences. / Asano, Maki; Hasegawa, Kiyoshi; Tsukada, Kazuhiko; Tada, Shin; Mizoguchi, Yoshikazu; Imaeda, Yoshihiro; Ikeda, Mina; Kawamura, Kyoko; Fujii, Takuma.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 41, No. 8, 01.08.2014, p. 1031-1036.

Research output: Contribution to journalArticle

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Asano M, Hasegawa K, Tsukada K, Tada S, Mizoguchi Y, Imaeda Y et al. A case and literature review of ovarian carcinosarcoma with long-Term survival after repeated recurrences. Japanese Journal of Cancer and Chemotherapy. 2014 Aug 1;41(8):1031-1036.