A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population

Masahiro Banno, Takayoshi Koide, Branko Aleksic, Kazuo Yamada, Tsutomu Kikuchi, Kunihiro Kohmura, Yasunori Adachi, Naoko Kawano, Itaru Kushima, Masashi Ikeda, Toshiya Inada, Takeo Yoshikawa, Nakao Iwata, Norio Ozaki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Using a knock-out mouse model, it was shown that NETO1 is a critical component of the NMDAR complex, and that loss of Neto1 leads to impaired hippocampal long term potentiation and hippocampal-dependent learning and memory. Moreover, hemizygosity of NETO1 was shown to be associated with autistic-like behavior in humans. Purpose of the Research: We examined the association between schizophrenia and the neuropilin and tolloid-like 1 gene (NETO1). First, we selected eight single nucleotide polymorphisms (SNPs) within the NETO1 locus, based on the Japanese schizophrenia genome wide association study (JGWAS) results and previously conducted association studies. These SNPs were genotyped in the replication sample comprised of 963 schizophrenic patients and 919 healthy controls. We also examined the effect of associated SNPs on scores in the Continuous Performance Test and the Wisconsin Card Sorting Test Keio version (schizophrenic patients 107, healthy controls 104). Results: There were no significant allele-wise and haplotype-wise associations in the replication analysis after Bonferroni correction. However, in meta-analysis (JGWAS and replication dataset) three association signals were observed (rs17795324: p = 0.028, rs8098760: p = 0.017, rs17086492: p = 0.003). These SNPs were followed up but we could not detect the allele-specific effect on cognitive performance measured by the Continuous performance test (CPT) and Wisconsin Card Sorting test (WCST). Major Conclusions: We did not detect evidence for the association of NETO1 with schizophrenia in the Japanese population. Common variants within the NETO1 locus may not increase the genetic risk for schizophrenia in the Japanese population. Additionally, common variants investigated in the current study did not affect cognitive performance, as measured by the CPT and WCST.

Original languageEnglish
Article numbere28929
JournalPLoS One
Volume6
Issue number12
DOIs
Publication statusPublished - 20-11-2011

Fingerprint

Neuropilins
cognition
Cognition
Case-Control Studies
Schizophrenia
Genes
single nucleotide polymorphism
Single Nucleotide Polymorphism
Polymorphism
sorting
Population
genes
Nucleotides
Genome-Wide Association Study
Sorting
testing
Alleles
alleles
gene dosage
loci

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Banno, Masahiro ; Koide, Takayoshi ; Aleksic, Branko ; Yamada, Kazuo ; Kikuchi, Tsutomu ; Kohmura, Kunihiro ; Adachi, Yasunori ; Kawano, Naoko ; Kushima, Itaru ; Ikeda, Masashi ; Inada, Toshiya ; Yoshikawa, Takeo ; Iwata, Nakao ; Ozaki, Norio. / A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population. In: PLoS One. 2011 ; Vol. 6, No. 12.
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abstract = "Background: Using a knock-out mouse model, it was shown that NETO1 is a critical component of the NMDAR complex, and that loss of Neto1 leads to impaired hippocampal long term potentiation and hippocampal-dependent learning and memory. Moreover, hemizygosity of NETO1 was shown to be associated with autistic-like behavior in humans. Purpose of the Research: We examined the association between schizophrenia and the neuropilin and tolloid-like 1 gene (NETO1). First, we selected eight single nucleotide polymorphisms (SNPs) within the NETO1 locus, based on the Japanese schizophrenia genome wide association study (JGWAS) results and previously conducted association studies. These SNPs were genotyped in the replication sample comprised of 963 schizophrenic patients and 919 healthy controls. We also examined the effect of associated SNPs on scores in the Continuous Performance Test and the Wisconsin Card Sorting Test Keio version (schizophrenic patients 107, healthy controls 104). Results: There were no significant allele-wise and haplotype-wise associations in the replication analysis after Bonferroni correction. However, in meta-analysis (JGWAS and replication dataset) three association signals were observed (rs17795324: p = 0.028, rs8098760: p = 0.017, rs17086492: p = 0.003). These SNPs were followed up but we could not detect the allele-specific effect on cognitive performance measured by the Continuous performance test (CPT) and Wisconsin Card Sorting test (WCST). Major Conclusions: We did not detect evidence for the association of NETO1 with schizophrenia in the Japanese population. Common variants within the NETO1 locus may not increase the genetic risk for schizophrenia in the Japanese population. Additionally, common variants investigated in the current study did not affect cognitive performance, as measured by the CPT and WCST.",
author = "Masahiro Banno and Takayoshi Koide and Branko Aleksic and Kazuo Yamada and Tsutomu Kikuchi and Kunihiro Kohmura and Yasunori Adachi and Naoko Kawano and Itaru Kushima and Masashi Ikeda and Toshiya Inada and Takeo Yoshikawa and Nakao Iwata and Norio Ozaki",
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Banno, M, Koide, T, Aleksic, B, Yamada, K, Kikuchi, T, Kohmura, K, Adachi, Y, Kawano, N, Kushima, I, Ikeda, M, Inada, T, Yoshikawa, T, Iwata, N & Ozaki, N 2011, 'A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population', PLoS One, vol. 6, no. 12, e28929. https://doi.org/10.1371/journal.pone.0028929

A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population. / Banno, Masahiro; Koide, Takayoshi; Aleksic, Branko; Yamada, Kazuo; Kikuchi, Tsutomu; Kohmura, Kunihiro; Adachi, Yasunori; Kawano, Naoko; Kushima, Itaru; Ikeda, Masashi; Inada, Toshiya; Yoshikawa, Takeo; Iwata, Nakao; Ozaki, Norio.

In: PLoS One, Vol. 6, No. 12, e28929, 20.11.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population

AU - Banno, Masahiro

AU - Koide, Takayoshi

AU - Aleksic, Branko

AU - Yamada, Kazuo

AU - Kikuchi, Tsutomu

AU - Kohmura, Kunihiro

AU - Adachi, Yasunori

AU - Kawano, Naoko

AU - Kushima, Itaru

AU - Ikeda, Masashi

AU - Inada, Toshiya

AU - Yoshikawa, Takeo

AU - Iwata, Nakao

AU - Ozaki, Norio

PY - 2011/11/20

Y1 - 2011/11/20

N2 - Background: Using a knock-out mouse model, it was shown that NETO1 is a critical component of the NMDAR complex, and that loss of Neto1 leads to impaired hippocampal long term potentiation and hippocampal-dependent learning and memory. Moreover, hemizygosity of NETO1 was shown to be associated with autistic-like behavior in humans. Purpose of the Research: We examined the association between schizophrenia and the neuropilin and tolloid-like 1 gene (NETO1). First, we selected eight single nucleotide polymorphisms (SNPs) within the NETO1 locus, based on the Japanese schizophrenia genome wide association study (JGWAS) results and previously conducted association studies. These SNPs were genotyped in the replication sample comprised of 963 schizophrenic patients and 919 healthy controls. We also examined the effect of associated SNPs on scores in the Continuous Performance Test and the Wisconsin Card Sorting Test Keio version (schizophrenic patients 107, healthy controls 104). Results: There were no significant allele-wise and haplotype-wise associations in the replication analysis after Bonferroni correction. However, in meta-analysis (JGWAS and replication dataset) three association signals were observed (rs17795324: p = 0.028, rs8098760: p = 0.017, rs17086492: p = 0.003). These SNPs were followed up but we could not detect the allele-specific effect on cognitive performance measured by the Continuous performance test (CPT) and Wisconsin Card Sorting test (WCST). Major Conclusions: We did not detect evidence for the association of NETO1 with schizophrenia in the Japanese population. Common variants within the NETO1 locus may not increase the genetic risk for schizophrenia in the Japanese population. Additionally, common variants investigated in the current study did not affect cognitive performance, as measured by the CPT and WCST.

AB - Background: Using a knock-out mouse model, it was shown that NETO1 is a critical component of the NMDAR complex, and that loss of Neto1 leads to impaired hippocampal long term potentiation and hippocampal-dependent learning and memory. Moreover, hemizygosity of NETO1 was shown to be associated with autistic-like behavior in humans. Purpose of the Research: We examined the association between schizophrenia and the neuropilin and tolloid-like 1 gene (NETO1). First, we selected eight single nucleotide polymorphisms (SNPs) within the NETO1 locus, based on the Japanese schizophrenia genome wide association study (JGWAS) results and previously conducted association studies. These SNPs were genotyped in the replication sample comprised of 963 schizophrenic patients and 919 healthy controls. We also examined the effect of associated SNPs on scores in the Continuous Performance Test and the Wisconsin Card Sorting Test Keio version (schizophrenic patients 107, healthy controls 104). Results: There were no significant allele-wise and haplotype-wise associations in the replication analysis after Bonferroni correction. However, in meta-analysis (JGWAS and replication dataset) three association signals were observed (rs17795324: p = 0.028, rs8098760: p = 0.017, rs17086492: p = 0.003). These SNPs were followed up but we could not detect the allele-specific effect on cognitive performance measured by the Continuous performance test (CPT) and Wisconsin Card Sorting test (WCST). Major Conclusions: We did not detect evidence for the association of NETO1 with schizophrenia in the Japanese population. Common variants within the NETO1 locus may not increase the genetic risk for schizophrenia in the Japanese population. Additionally, common variants investigated in the current study did not affect cognitive performance, as measured by the CPT and WCST.

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