TY - JOUR
T1 - A case of a heavily pigmented orbital melanocytoma
AU - Tsugu, Hitoshi
AU - Nabeshima, Kazuki
AU - Matsumoto, Shinji
AU - Omura, Tadahiro
AU - Yahiro, Tatsumi
AU - Oshiro, Shinya
AU - Komatsu, Fuminari
AU - Abe, Hiroshi
AU - Fukushima, Takeo
AU - Inoue, Toru
AU - Takano, Koichi
PY - 2009/4
Y1 - 2009/4
N2 - We present an extremely rare case of an orbital melanocytoma that occurred in a 51-year-old man. The patient suffered from diplopia and mild exophthalmos of the right eye for 2 months. Brain magnetic resonance imaging showed a well-demarcated round mass 3.5 cm in diameter in the right orbit. We performed total resection of this tumor. Histological findings revealed a proliferation of large polygonal cells with fine pigment granules in the cytoplasm and prominent nucleoli. Although these tumor cells revealed immunohistochemical reactivity in HMB-1, there was no S-100 or Melan A antibody reactivity. Also, there were no malignant findings of nuclear polymorphism, mitoses, or necrosis. The brown pigments were confirmed to be melanin by bleaching and the Fontana-Masson silver stain method. The MIB-1 labeling index was less than 1%. This tumor also consisted of 50% melanophages, which revealed immunohistochemical reactivity in CD68, CD163, and in (1-AT antibodies. These histological findings led us to diagnose an orbital melanocytoma with partial tumor regression.
AB - We present an extremely rare case of an orbital melanocytoma that occurred in a 51-year-old man. The patient suffered from diplopia and mild exophthalmos of the right eye for 2 months. Brain magnetic resonance imaging showed a well-demarcated round mass 3.5 cm in diameter in the right orbit. We performed total resection of this tumor. Histological findings revealed a proliferation of large polygonal cells with fine pigment granules in the cytoplasm and prominent nucleoli. Although these tumor cells revealed immunohistochemical reactivity in HMB-1, there was no S-100 or Melan A antibody reactivity. Also, there were no malignant findings of nuclear polymorphism, mitoses, or necrosis. The brown pigments were confirmed to be melanin by bleaching and the Fontana-Masson silver stain method. The MIB-1 labeling index was less than 1%. This tumor also consisted of 50% melanophages, which revealed immunohistochemical reactivity in CD68, CD163, and in (1-AT antibodies. These histological findings led us to diagnose an orbital melanocytoma with partial tumor regression.
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U2 - 10.1007/s10014-008-0242-8
DO - 10.1007/s10014-008-0242-8
M3 - Article
C2 - 19408094
AN - SCOPUS:65149083584
SN - 1433-7398
VL - 26
SP - 25
EP - 29
JO - Brain tumor pathology
JF - Brain tumor pathology
IS - 1
ER -