A case of acquired hepatocerebral degeneration with prominent improvement of parkinsonism and cognitive deficits after living-donor liver transplantation

Tetsuro Ishihara, Mizuki Ito, Hirohisa Watanabe, Masatoshi Ishigami, Tetsuya Kiuchi, Gen Sobue

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A 53-year-old woman visited us for a neurological consultation before her liver transplantation. She had a history of primary biliary cirrhosis that began at 37 years of age. She showed falling episodes and met with a traffic accident at 52 years old. Since then, her symptoms had worsened. The neurological examination showed masked face, rigidity on bilateral arms and legs, and lack of balance. Her Mini-Mental State Examination Score was 28/30, but she suffered from loss of memory and had trouble with executive function in detailed examinations. Her T1 weighted image showed hyperintensity in bilateral globus pallidus, putamen, dentate nucleus and cerebral peduncle. There was a significant improvement in intellectual function and neurological signs 6 months after her orthotopic liver transplantation. In addition, post-liver transplantation images showed a decrease in the area of hyperintensities. This case suggests that even in a patient with severe liver cirrhosis a complete cure of neurological manifestations can be obtained after the liver transplantation.

Original languageEnglish
Pages (from-to)581-584
Number of pages4
JournalClinical Neurology
Volume52
Issue number8
DOIs
Publication statusPublished - 08-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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