A case of allergic granulomatous angitis-accompained by colonic changes with many aphthous lesions

Akemi Kamatani, Ichiro Hirata, Yoshio Kamiya, Naoko Maruyama, Toshiaki Kamano, Hiroshi Fujita, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Makoto Kuroda

Research output: Contribution to journalArticle

Abstract

A 56 year old woman had been suffering from recurrent attacks of bronchial asthma for 15 years and she sometimes had pneumonia. She was admitted to our hospital complaining of DOE (dyspnea on exertion), diarrhea and purpura on her legs. Gastrointestinal endoscopy showed a reddish and edematous mucosa at the duodenal bulb. On colonoscopy the mucosa appeared red and edematous with an erosive lesion and many aphthous lesions were extending from the rectum to cecum. Some irregular ulcers were shown in some parts of the sigmoid colon. Each biopsy revealed only eosinophilic infiltration of the mucosa Skin biopsy results showed vasculitis. Based on these findings, a diagnosis of allergic granulomatous angitis (AGA) was made. After PSL40 mg / day and cyclophosphamide 400 mg / day therapy was initiated, the DOE and diarrhea abated. Colonoscopy examination performed after the treatment demonstrated a decreased number of mucosal erosions, aphthae and ulcers. PSL-dose tapering was stopped at 30 mg / day and the patient was discharged, since no aggravation of symptoms was observed. We report herein on a rare case of AGA with colonic changes and the greatest number of aphthous lesions we have encountered.

Original languageEnglish
Pages (from-to)3426-3432
Number of pages7
JournalGastroenterological Endoscopy
Volume54
Issue number10
Publication statusPublished - 01-10-2012

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Mucous Membrane
Colonoscopy
Dyspnea
Ulcer
Diarrhea
Aphthous Stomatitis
Biopsy
Gastrointestinal Endoscopy
Purpura
Cecum
Sigmoid Colon
Vasculitis
Rectum
Cyclophosphamide
Leg
Pneumonia
Asthma
Skin
Therapeutics

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Kamatani, A., Hirata, I., Kamiya, Y., Maruyama, N., Kamano, T., Fujita, H., ... Kuroda, M. (2012). A case of allergic granulomatous angitis-accompained by colonic changes with many aphthous lesions. Gastroenterological Endoscopy, 54(10), 3426-3432.
Kamatani, Akemi ; Hirata, Ichiro ; Kamiya, Yoshio ; Maruyama, Naoko ; Kamano, Toshiaki ; Fujita, Hiroshi ; Nagasaka, Mitsuo ; Nakagawa, Yoshihito ; Shibata, Tomoyuki ; Kuroda, Makoto. / A case of allergic granulomatous angitis-accompained by colonic changes with many aphthous lesions. In: Gastroenterological Endoscopy. 2012 ; Vol. 54, No. 10. pp. 3426-3432.
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Kamatani, A, Hirata, I, Kamiya, Y, Maruyama, N, Kamano, T, Fujita, H, Nagasaka, M, Nakagawa, Y, Shibata, T & Kuroda, M 2012, 'A case of allergic granulomatous angitis-accompained by colonic changes with many aphthous lesions', Gastroenterological Endoscopy, vol. 54, no. 10, pp. 3426-3432.

A case of allergic granulomatous angitis-accompained by colonic changes with many aphthous lesions. / Kamatani, Akemi; Hirata, Ichiro; Kamiya, Yoshio; Maruyama, Naoko; Kamano, Toshiaki; Fujita, Hiroshi; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Shibata, Tomoyuki; Kuroda, Makoto.

In: Gastroenterological Endoscopy, Vol. 54, No. 10, 01.10.2012, p. 3426-3432.

Research output: Contribution to journalArticle

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AU - Kuroda, Makoto

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AB - A 56 year old woman had been suffering from recurrent attacks of bronchial asthma for 15 years and she sometimes had pneumonia. She was admitted to our hospital complaining of DOE (dyspnea on exertion), diarrhea and purpura on her legs. Gastrointestinal endoscopy showed a reddish and edematous mucosa at the duodenal bulb. On colonoscopy the mucosa appeared red and edematous with an erosive lesion and many aphthous lesions were extending from the rectum to cecum. Some irregular ulcers were shown in some parts of the sigmoid colon. Each biopsy revealed only eosinophilic infiltration of the mucosa Skin biopsy results showed vasculitis. Based on these findings, a diagnosis of allergic granulomatous angitis (AGA) was made. After PSL40 mg / day and cyclophosphamide 400 mg / day therapy was initiated, the DOE and diarrhea abated. Colonoscopy examination performed after the treatment demonstrated a decreased number of mucosal erosions, aphthae and ulcers. PSL-dose tapering was stopped at 30 mg / day and the patient was discharged, since no aggravation of symptoms was observed. We report herein on a rare case of AGA with colonic changes and the greatest number of aphthous lesions we have encountered.

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Kamatani A, Hirata I, Kamiya Y, Maruyama N, Kamano T, Fujita H et al. A case of allergic granulomatous angitis-accompained by colonic changes with many aphthous lesions. Gastroenterological Endoscopy. 2012 Oct 1;54(10):3426-3432.