A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel

Naoki Nakagawa; Tatsunori Nakano; Ryohei Sak-Aguchi; Toshitaka Fukui; Kunihiro Higuchi; Shigehito Nakashima; Satoshi Takaji; Miho Miyoshi; Shigeo Nagashima; Masaharu Takahashi; Shozo Watanabe; Yoshiyuki Takei; Hiroaki Okamoto

doi:10.2957/kanzo.61.270

A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel

Naoki Nakagawa, Tatsunori Nakano, Ryohei Sak-Aguchi, Toshitaka Fukui, Kunihiro Higuchi, Shigehito Nakashima, Satoshi Takaji, Miho Miyoshi, Shigeo Nagashima, Masaharu Takahashi, Shozo Watanabe, Yoshiyuki Takei, Hiroaki Okamoto

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We experienced a case of autochthonous hepatitis E by hepatitis E virus (HEV) genotype 4. The phyloge-netic tree analysis indicated that the HEV isolate ob-tained from the patient was segregated into the HEV subgenotype 4a (HEV-4a) cluster. The patient had no history of travel abroad, e.g., to China, where HEV-4a strains are endemic. The source and the route of the HEV-4a infection were unknown. Strains of HEV-4a may be indigenous to Japan despite remaining unde-tected to date, either in swine or wild animals. Addi-tional HEV subgenotypes circulating in swine and wild animals in Japan require investigation to reveal the characteristics of HEV-4a infection in autochthonous cases in Japan.

Original language	English
Pages (from-to)	270-272
Number of pages	3
Journal	Kanzo/Acta Hepatologica Japonica
Volume	61
Issue number	5
DOIs	https://doi.org/10.2957/kanzo.61.270
Publication status	Published - 2020

All Science Journal Classification (ASJC) codes

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2957/kanzo.61.270

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Nakagawa, N., Nakano, T., Sak-Aguchi, R., Fukui, T., Higuchi, K., Nakashima, S., Takaji, S., Miyoshi, M., Nagashima, S., Takahashi, M., Watanabe, S., Takei, Y., & Okamoto, H. (2020). A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel. Kanzo/Acta Hepatologica Japonica, 61(5), 270-272. https://doi.org/10.2957/kanzo.61.270

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title = "A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel",

abstract = "We experienced a case of autochthonous hepatitis E by hepatitis E virus (HEV) genotype 4. The phyloge-netic tree analysis indicated that the HEV isolate ob-tained from the patient was segregated into the HEV subgenotype 4a (HEV-4a) cluster. The patient had no history of travel abroad, e.g., to China, where HEV-4a strains are endemic. The source and the route of the HEV-4a infection were unknown. Strains of HEV-4a may be indigenous to Japan despite remaining unde-tected to date, either in swine or wild animals. Addi-tional HEV subgenotypes circulating in swine and wild animals in Japan require investigation to reveal the characteristics of HEV-4a infection in autochthonous cases in Japan.",

author = "Naoki Nakagawa and Tatsunori Nakano and Ryohei Sak-Aguchi and Toshitaka Fukui and Kunihiro Higuchi and Shigehito Nakashima and Satoshi Takaji and Miho Miyoshi and Shigeo Nagashima and Masaharu Takahashi and Shozo Watanabe and Yoshiyuki Takei and Hiroaki Okamoto",

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year = "2020",

doi = "10.2957/kanzo.61.270",

language = "English",

volume = "61",

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Nakagawa, N, Nakano, T, Sak-Aguchi, R, Fukui, T, Higuchi, K, Nakashima, S, Takaji, S, Miyoshi, M, Nagashima, S, Takahashi, M, Watanabe, S, Takei, Y & Okamoto, H 2020, 'A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel', Kanzo/Acta Hepatologica Japonica, vol. 61, no. 5, pp. 270-272. https://doi.org/10.2957/kanzo.61.270

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T1 - A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel

AU - Nakagawa, Naoki

AU - Nakano, Tatsunori

AU - Sak-Aguchi, Ryohei

AU - Fukui, Toshitaka

AU - Higuchi, Kunihiro

AU - Nakashima, Shigehito

AU - Takaji, Satoshi

AU - Miyoshi, Miho

AU - Nagashima, Shigeo

AU - Takahashi, Masaharu

AU - Watanabe, Shozo

AU - Takei, Yoshiyuki

AU - Okamoto, Hiroaki

PY - 2020

Y1 - 2020

N2 - We experienced a case of autochthonous hepatitis E by hepatitis E virus (HEV) genotype 4. The phyloge-netic tree analysis indicated that the HEV isolate ob-tained from the patient was segregated into the HEV subgenotype 4a (HEV-4a) cluster. The patient had no history of travel abroad, e.g., to China, where HEV-4a strains are endemic. The source and the route of the HEV-4a infection were unknown. Strains of HEV-4a may be indigenous to Japan despite remaining unde-tected to date, either in swine or wild animals. Addi-tional HEV subgenotypes circulating in swine and wild animals in Japan require investigation to reveal the characteristics of HEV-4a infection in autochthonous cases in Japan.

AB - We experienced a case of autochthonous hepatitis E by hepatitis E virus (HEV) genotype 4. The phyloge-netic tree analysis indicated that the HEV isolate ob-tained from the patient was segregated into the HEV subgenotype 4a (HEV-4a) cluster. The patient had no history of travel abroad, e.g., to China, where HEV-4a strains are endemic. The source and the route of the HEV-4a infection were unknown. Strains of HEV-4a may be indigenous to Japan despite remaining unde-tected to date, either in swine or wild animals. Addi-tional HEV subgenotypes circulating in swine and wild animals in Japan require investigation to reveal the characteristics of HEV-4a infection in autochthonous cases in Japan.

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A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel

Abstract

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