A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel

Naoki Nakagawa, Tatsunori Nakano, Ryohei Sak-Aguchi, Toshitaka Fukui, Kunihiro Higuchi, Shigehito Nakashima, Satoshi Takaji, Miho Miyoshi, Shigeo Nagashima, Masaharu Takahashi, Shozo Watanabe, Yoshiyuki Takei, Hiroaki Okamoto

Research output: Contribution to journalArticle

Abstract

We experienced a case of autochthonous hepatitis E by hepatitis E virus (HEV) genotype 4. The phyloge-netic tree analysis indicated that the HEV isolate ob-tained from the patient was segregated into the HEV subgenotype 4a (HEV-4a) cluster. The patient had no history of travel abroad, e.g., to China, where HEV-4a strains are endemic. The source and the route of the HEV-4a infection were unknown. Strains of HEV-4a may be indigenous to Japan despite remaining unde-tected to date, either in swine or wild animals. Addi-tional HEV subgenotypes circulating in swine and wild animals in Japan require investigation to reveal the characteristics of HEV-4a infection in autochthonous cases in Japan.

Original languageEnglish
Pages (from-to)270-272
Number of pages3
JournalActa Hepatologica Japonica
Volume61
Issue number5
DOIs
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Hepatology

Fingerprint Dive into the research topics of 'A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel'. Together they form a unique fingerprint.

  • Cite this

    Nakagawa, N., Nakano, T., Sak-Aguchi, R., Fukui, T., Higuchi, K., Nakashima, S., Takaji, S., Miyoshi, M., Nagashima, S., Takahashi, M., Watanabe, S., Takei, Y., & Okamoto, H. (2020). A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel. Acta Hepatologica Japonica, 61(5), 270-272. https://doi.org/10.2957/kanzo.61.270