A case of Budd-Chiari syndrome: Gd-EOB-DTPA-enhanced MR findings

Kazuhiro Kitajima, Takeshi Yoshikawa, Yasushi Seo, Yoshiharu Ohno, Yoshihiko Yano, Akira Miki, Tomonori Kanda, Naoki Kanata, Takeshi Azuma, Kazuro Sugimura

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Budd-Chiari syndrome (BCS) is a rare disorder caused by the obstruction of hepatic venous outflow, leading to sinusoidal congestion, ischemic injury to liver cells and portal hypertension. Long-term survival largely depends on whether hepatocellular carcinoma occurs. A recently available liver-specific contrast medium, gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA), reportedly has high diagnostic capability for detection of malignant liver tumors. However, there has been no report of the sue of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for BCS. We present a case of chronic BCS who underwent both gadopentetate dimeglumine (Gd-DTPA) and Gd-EOB-DTPA-enhanced MRI. Hepatic congestion and edema were seen as slightly hypointense areas on Gd-EOB-DTPA-enhanced hepatobiliary-phase images, although these areas were observed as slightly hyperintense on previously obtained Gd-DTPA-enhanced delayed-phase image. Reduced uptake of Gd-EOB-DTPA by hepatocytes in the region of congestion or edema may account for this difference, which should be recognized in image interpretations.

Original languageEnglish
Pages (from-to)579-583
Number of pages5
JournalMagnetic Resonance Imaging
Issue number4
Publication statusPublished - 05-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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