A case of complete response to combination therapy of S-1 and CDDP for Stage IV gastric cancer with Virchow's lymph node and para-aorta lymph node metastasis

Kazunori Otsuki, Kenichi Saigo, Takashi Kenmochi, Michihiro Maruyama, Naotake Akutsu, Chikara Iwashita

Research output: Contribution to journalArticle

Abstract

The patient was a 53-year-old male with Stage IV gastric cancer with Virchow's lymph node and para-aorta lymph node metastasis. The chemotherapy regimen was given S-1 orally at 80 mg/m(2) day on day 1 to 21 and CDDP intravenously at 60 mg/m(2) day on day 8, repeated for 35 days. After two courses and a reduced regimen with S-1 64 mg/m(2) day plus CDDP 35 mg/m(2) day, the tumor lesion became CR and the serum CEA 575 ng/mL level before therapy decreased to the normal level. The patient received six courses of oral S-1(64 mg/m(2) day)for 28 days followed by a 14- day rest as maintenance therapy. The serum CEA elevated 13 months after the treatment, and the patient received a reduced course and two-course S-1/CDDP therapy. The serum CEA decreased to normal level and the patient has now survived 1 year 5 months without recurrence.

Original languageEnglish
Pages (from-to)1387-1390
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume35
Issue number8
Publication statusPublished - 01-08-2008
Externally publishedYes

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Stomach Neoplasms
Aorta
Lymph Nodes
Neoplasm Metastasis
Serum
Therapeutics
Recurrence
Drug Therapy
S 1 (combination)
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Pharmacology

Cite this

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abstract = "The patient was a 53-year-old male with Stage IV gastric cancer with Virchow's lymph node and para-aorta lymph node metastasis. The chemotherapy regimen was given S-1 orally at 80 mg/m(2) day on day 1 to 21 and CDDP intravenously at 60 mg/m(2) day on day 8, repeated for 35 days. After two courses and a reduced regimen with S-1 64 mg/m(2) day plus CDDP 35 mg/m(2) day, the tumor lesion became CR and the serum CEA 575 ng/mL level before therapy decreased to the normal level. The patient received six courses of oral S-1(64 mg/m(2) day)for 28 days followed by a 14- day rest as maintenance therapy. The serum CEA elevated 13 months after the treatment, and the patient received a reduced course and two-course S-1/CDDP therapy. The serum CEA decreased to normal level and the patient has now survived 1 year 5 months without recurrence.",
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A case of complete response to combination therapy of S-1 and CDDP for Stage IV gastric cancer with Virchow's lymph node and para-aorta lymph node metastasis. / Otsuki, Kazunori; Saigo, Kenichi; Kenmochi, Takashi; Maruyama, Michihiro; Akutsu, Naotake; Iwashita, Chikara.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 35, No. 8, 01.08.2008, p. 1387-1390.

Research output: Contribution to journalArticle

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AU - Otsuki, Kazunori

AU - Saigo, Kenichi

AU - Kenmochi, Takashi

AU - Maruyama, Michihiro

AU - Akutsu, Naotake

AU - Iwashita, Chikara

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AB - The patient was a 53-year-old male with Stage IV gastric cancer with Virchow's lymph node and para-aorta lymph node metastasis. The chemotherapy regimen was given S-1 orally at 80 mg/m(2) day on day 1 to 21 and CDDP intravenously at 60 mg/m(2) day on day 8, repeated for 35 days. After two courses and a reduced regimen with S-1 64 mg/m(2) day plus CDDP 35 mg/m(2) day, the tumor lesion became CR and the serum CEA 575 ng/mL level before therapy decreased to the normal level. The patient received six courses of oral S-1(64 mg/m(2) day)for 28 days followed by a 14- day rest as maintenance therapy. The serum CEA elevated 13 months after the treatment, and the patient received a reduced course and two-course S-1/CDDP therapy. The serum CEA decreased to normal level and the patient has now survived 1 year 5 months without recurrence.

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