A case of delayed emergence after propofol anesthesia: Genetic analysis

Hiroshi Yonekura; Norie Murayama; Hiroshi Yamazaki; Kazuya Sobue

doi:10.1213/XAA.0000000000000397

A case of delayed emergence after propofol anesthesia: Genetic analysis

Hiroshi Yonekura, Norie Murayama, Hiroshi Yamazaki, Kazuya Sobue

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Citations (Scopus)

Abstract

This case report describes a 71-year-old woman who experienced unusual delayed emergence from propofol, which lasted for 3 hours and resulted in admission to the intensive care unit. Because genetic variations of propofol-metabolizing enzymes are proposed to be causal factors, we explored genetic polymorphisms of cytochrome P450 2B6 (CYP2B6) and uridine 5'-diphospho-glucuronosyltransferase 1A9 (UGT1A9). Suggested high-risk factors (advanced age, CYP2B6 516 G/T, and UGT1A9 1399 C/C) were observed in this case of delayed propofol metabolism. Therefore, genetic variants involved in propofol metabolism should be considered in unexplained delayed emergence.

Original language	English
Title of host publication	100 Selected Case Reports from Anesthesia and Analgesia
Publisher	Wolters Kluwer Health
ISBN (Electronic)	9781975115333
ISBN (Print)	9781975115326
DOIs	https://doi.org/10.1213/XAA.0000000000000397
Publication status	Published - 01-01-2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1213/XAA.0000000000000397

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abstract = "This case report describes a 71-year-old woman who experienced unusual delayed emergence from propofol, which lasted for 3 hours and resulted in admission to the intensive care unit. Because genetic variations of propofol-metabolizing enzymes are proposed to be causal factors, we explored genetic polymorphisms of cytochrome P450 2B6 (CYP2B6) and uridine 5'-diphospho-glucuronosyltransferase 1A9 (UGT1A9). Suggested high-risk factors (advanced age, CYP2B6 516 G/T, and UGT1A9 1399 C/C) were observed in this case of delayed propofol metabolism. Therefore, genetic variants involved in propofol metabolism should be considered in unexplained delayed emergence.",

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AU - Yonekura, Hiroshi

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AU - Yamazaki, Hiroshi

AU - Sobue, Kazuya

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AB - This case report describes a 71-year-old woman who experienced unusual delayed emergence from propofol, which lasted for 3 hours and resulted in admission to the intensive care unit. Because genetic variations of propofol-metabolizing enzymes are proposed to be causal factors, we explored genetic polymorphisms of cytochrome P450 2B6 (CYP2B6) and uridine 5'-diphospho-glucuronosyltransferase 1A9 (UGT1A9). Suggested high-risk factors (advanced age, CYP2B6 516 G/T, and UGT1A9 1399 C/C) were observed in this case of delayed propofol metabolism. Therefore, genetic variants involved in propofol metabolism should be considered in unexplained delayed emergence.

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A case of delayed emergence after propofol anesthesia: Genetic analysis

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