Abstract
This case report describes a 71-year-old woman who experienced unusual delayed emergence from propofol, which lasted for 3 hours and resulted in admission to the intensive care unit. Because genetic variations of propofol-metabolizing enzymes are proposed to be causal factors, we explored genetic polymorphisms of cytochrome P450 2B6 (CYP2B6) and uridine 5'-diphospho-glucuronosyltransferase 1A9 (UGT1A9). Suggested high-risk factors (advanced age, CYP2B6 516 G/T, and UGT1A9 1399 C/C) were observed in this case of delayed propofol metabolism. Therefore, genetic variants involved in propofol metabolism should be considered in unexplained delayed emergence.
Original language | English |
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Title of host publication | 100 Selected Case Reports from Anesthesia and Analgesia |
Publisher | Wolters Kluwer Health |
ISBN (Electronic) | 9781975115333 |
ISBN (Print) | 9781975115326 |
DOIs | |
Publication status | Published - 01-01-2018 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Medicine(all)