A Case of Duodenal Gastrointestinal Stromal Tumor Resection with Preservation of the Pancreatic Head Following Chemotherapy with Imatinib

Seiji Inoue, Masaya Nakauchi, Kazuhiro Matsuo, Sayaka Amano, Ai Goto, Makoto Tomatsu, Kenichi Nakamura, Susumu Shibasaki, Kenji Kikuchi, Shinichi Kadoya, Kazuki Inaba, Yutaro Kato, Tsunekazu Hanai, Atsushi Sugioka, Ichiro Uyama

Research output: Contribution to journalArticlepeer-review

Abstract

A 60-year-old male was admitted to our hospital on account of a duodenal submucosal tumor on the opposite side of Vater's papilla identified on a screening gastroduodenoscopy. The tumor was diagnosed as a duodenal gastrointestinal stromal tumor(GIST)due to positive c-kit and DOG1tests. Gastroduodenography and enhanced computed tomography showed a 50mm tumor widely invadingthe descendingportion of the duodenum close to the papilla of Vater and indicated the need for extended resection includingpancreaticoduodenectomy to achieve curation. Preoperative chemotherapy was initiated with imatinib mesylate(imatinib)to preserve the pancreas. A 16 month course of imatinib shrunk the tumor up to 21mm and laparoscopic partial duodenectomy was performed as a curative resection. So far, no local tumor recurrence has been seen for 26 months after the surgery. Herein, we report this case with a review of the literature.

Original languageEnglish
Pages (from-to)2238-2240
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume45
Issue number13
Publication statusPublished - 01-12-2018

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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