TY - JOUR
T1 - A case of early neuroendocrine carcinoma of the gallbladder with extensive intraductal extension
AU - Kumamoto, Tsutomu
AU - Hashimoto, Masaji
AU - Sasaki, Kazunari
AU - Kaida, Sachiko
AU - Matoba, Shuichiro
AU - Matsuda, Masamichi
AU - Kuroyanagi, Hiroya
AU - Udagawa, Harushi
AU - Watanabe, Goro
AU - Inoue, Masafumi
PY - 2013
Y1 - 2013
N2 - We present a case of early neuroendocrine carcinoma of the gallbladder with bile duct extension. A 70-year-old woman with a chief complaint of appetite loss was admitted to our hospital with a diagnosis of obstructive jaundice caused by a gallbladder tumor. Abdominal CT showed the gallbladder wall was irregularly thickened and the extrahepatic bile duct was contiguously filled with the tumor. Tumor biopsy under endoscopic retrograde cholangiography revealed neuroendocrine carcinoma. We performed extrahepatic bile duct resection and cholecystectomy with choledochoduodenostomy. Immunochemical examination revealed synaptophysin (+), chromogranin A (+) and an MIB-I labeling index 70%, which confirmed large cell neuroendocrine carcinoma as defined by the WHO classification, 2010. The final diagnosis was fT1 (fm, pHinf0, pBinf0, pV0, pA0), N0 (0/1), INFα, ly1, v0, pN0, H0, P0, M (-) Stage I. The postoperative course of the patient was uneventful and she was recurrence free 14 months after the operation.
AB - We present a case of early neuroendocrine carcinoma of the gallbladder with bile duct extension. A 70-year-old woman with a chief complaint of appetite loss was admitted to our hospital with a diagnosis of obstructive jaundice caused by a gallbladder tumor. Abdominal CT showed the gallbladder wall was irregularly thickened and the extrahepatic bile duct was contiguously filled with the tumor. Tumor biopsy under endoscopic retrograde cholangiography revealed neuroendocrine carcinoma. We performed extrahepatic bile duct resection and cholecystectomy with choledochoduodenostomy. Immunochemical examination revealed synaptophysin (+), chromogranin A (+) and an MIB-I labeling index 70%, which confirmed large cell neuroendocrine carcinoma as defined by the WHO classification, 2010. The final diagnosis was fT1 (fm, pHinf0, pBinf0, pV0, pA0), N0 (0/1), INFα, ly1, v0, pN0, H0, P0, M (-) Stage I. The postoperative course of the patient was uneventful and she was recurrence free 14 months after the operation.
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U2 - 10.5833/jjgs.2013.0021
DO - 10.5833/jjgs.2013.0021
M3 - Article
AN - SCOPUS:84885718894
SN - 0386-9768
VL - 46
SP - 742
EP - 750
JO - Japanese Journal of Gastroenterological Surgery
JF - Japanese Journal of Gastroenterological Surgery
IS - 10
ER -