A case of gastric cancer with peritoneal dissemination who achieved long survival from control of ascites for over 2 years by successive treatments with S-1 in combination with docetaxel as first-line followed by irinotecan in combination with cisplatin as second-line

Tomoyoshi Ohno, Noriyuki Horiguchi, Koki Asukai, Aki Miura, Hiroki Koguchi, Shuya Shimizu, Seijiro Matsunaga, Shozo Togawa, Izumi Hasegawa, Kenji Sakakibara

Research output: Contribution to journalArticle

Abstract

The patient was a 66-year-old male, admitted and diagnosed as having advanced gastric cancer with peritoneal dissemination, leading to ascites and obstructive jaundice. After reducing the degree of obstructive jaundice, combination chemotherapy of S-1 80 mg/m2/day (2 weeks administration and 1 week rest) and docetaxel (TXT) 40 mg/m2 (day 1) was administered from Februar, 2008. After 3 courses of this regimen, CT revealed no evidence of ascites, and this chemotherapy was successively continued on an outpatient basis until June, 2009. After the relapse of ascites from July, 2009, combination chemotherapy of irinotecan (CPT-11) 60 mg/m2 and cisplatin (CDDP) 30 mg/m2 biweekly was performed as second-line chemotherapy, and the ascites disappeared again after around 2 courses of this regimen. This chemotherapy was continued on an outpatient basis until February, 2010. No major adverse reaction to either chemotherapy was observed. This case suggests that these chemotherapies, such as the combination chemotherapy of S-1 plus TXT as a first-line treatment and CPT-11 plus CDDP as the following second-line treatment, can be administered to an outpatient, can keep good patient's QOL and can be one of the effective chemotherapy options for advanced gastric cancer with peritoneal dissemination.

Original languageEnglish
Pages (from-to)1123-1126
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume39
Issue number7
Publication statusPublished - 07-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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