A case of high-frequency microsatellite instability in colorectal cancer with MSH2 mutation detected using gene panel testing with a next-generation sequencer

Yoshifumi Shimada, Hitoshi Kameyama, Mae Nakano, Chie Toshikawa, Kazuki Moro, Junko Tsuchida, Michiru Arabiki, Akio Matsumoto, Kana Tanaka, Kaoru Abe, Hidehito Oyanagi, Yosuke Tajima, Masato Nakano, Yuki Hirose, Yosuke Kano, Hiroshi Ichikawa, Takaaki Hanyu, Kazuyasu Takizawa, Masayuki Nagahashi, Jun SakataToshifumi Wakai

Research output: Contribution to journalArticlepeer-review

Abstract

Here, we report about a woman in her 30s who had peritoneal dissemination and multiple colon cancer with high-frequency microsatellite instability (MSI-H). Her father, paternal grandfather, and maternal grandmother had a history of colorectal cancer treatment. Thus, Lynch syndrome was suspected. We performed R0 resection for peritoneal dissemination and subsequent peritoneal dissemination. A 435-gene panel testing using a next-generation sequencer identified MSH2 and other mutations in the tumor. Hence, we speculated that she could have a germline mutation of MSH2, which causes Lynch syndrome. In the future, if she wishes to receive genetic counseling and undergo germline testing for variants to confirm the diagnosis of Lynch syndrome, we will perform them after receiving informed consent.

Original languageEnglish
Pages (from-to)1113-1115
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume47
Issue number7
Publication statusPublished - 07-2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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