A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging

Yasuyuki Ohta; Hitoshi Shimada; Ken Ikegami; Keiichiro Tsunoda; Nozomi Hishikawa; Toru Yamashita; Mami Takemoto; Yoshio Omote; Kenji Tagai; Kiwamu Matsuoka; Makoto Higuchi; Koji Abe

doi:10.1111/ncn3.12463

A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging

Yasuyuki Ohta, Hitoshi Shimada, Ken Ikegami, Keiichiro Tsunoda, Nozomi Hishikawa, Toru Yamashita, Mami Takemoto, Yoshio Omote, Kenji Tagai, Kiwamu Matsuoka, Makoto Higuchi, Koji Abe

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Abstract

Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC), frequently observed in the Kii peninsula of Japan, is pathologically characterized by widespread tau pathology in the cerebrum and brainstem. Here, we report a case of Kii ALS/PDC predominantly presenting progressive parkinsonism. Tau positron emission tomography (PET) imaging with ¹⁸F-PM-PBB3 suggested tau deposition in the substantia nigra of the midbrain and subcortical areas, but not in the cerebral cortex, which was similar to progressive supranuclear palsy (PSP), suggesting that parkinsonism-predominant type of Kii ALS/PDC may have a similar area of tau deposition to PSP.

Original language	English
Pages (from-to)	124-126
Number of pages	3
Journal	Neurology and Clinical Neuroscience
Volume	9
Issue number	1
DOIs	https://doi.org/10.1111/ncn3.12463
Publication status	Published - 01-2021
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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Ohta, Y., Shimada, H., Ikegami, K., Tsunoda, K., Hishikawa, N., Yamashita, T., Takemoto, M., Omote, Y., Tagai, K., Matsuoka, K., Higuchi, M., & Abe, K. (2021). A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging. Neurology and Clinical Neuroscience, 9(1), 124-126. https://doi.org/10.1111/ncn3.12463

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title = "A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging",

abstract = "Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC), frequently observed in the Kii peninsula of Japan, is pathologically characterized by widespread tau pathology in the cerebrum and brainstem. Here, we report a case of Kii ALS/PDC predominantly presenting progressive parkinsonism. Tau positron emission tomography (PET) imaging with 18F-PM-PBB3 suggested tau deposition in the substantia nigra of the midbrain and subcortical areas, but not in the cerebral cortex, which was similar to progressive supranuclear palsy (PSP), suggesting that parkinsonism-predominant type of Kii ALS/PDC may have a similar area of tau deposition to PSP.",

author = "Yasuyuki Ohta and Hitoshi Shimada and Ken Ikegami and Keiichiro Tsunoda and Nozomi Hishikawa and Toru Yamashita and Mami Takemoto and Yoshio Omote and Kenji Tagai and Kiwamu Matsuoka and Makoto Higuchi and Koji Abe",

note = "Publisher Copyright: {\textcopyright} 2020 Societas Neurologica Japonica (Japanese Society of Neurology) and John Wiley & Sons Australia, Ltd",

year = "2021",

month = jan,

doi = "10.1111/ncn3.12463",

language = "English",

volume = "9",

pages = "124--126",

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Ohta, Y, Shimada, H, Ikegami, K, Tsunoda, K, Hishikawa, N, Yamashita, T, Takemoto, M, Omote, Y, Tagai, K, Matsuoka, K, Higuchi, M & Abe, K 2021, 'A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging', Neurology and Clinical Neuroscience, vol. 9, no. 1, pp. 124-126. https://doi.org/10.1111/ncn3.12463

TY - JOUR

T1 - A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging

AU - Ohta, Yasuyuki

AU - Shimada, Hitoshi

AU - Ikegami, Ken

AU - Tsunoda, Keiichiro

AU - Hishikawa, Nozomi

AU - Yamashita, Toru

AU - Takemoto, Mami

AU - Omote, Yoshio

AU - Tagai, Kenji

AU - Matsuoka, Kiwamu

AU - Higuchi, Makoto

AU - Abe, Koji

PY - 2021/1

Y1 - 2021/1

N2 - Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC), frequently observed in the Kii peninsula of Japan, is pathologically characterized by widespread tau pathology in the cerebrum and brainstem. Here, we report a case of Kii ALS/PDC predominantly presenting progressive parkinsonism. Tau positron emission tomography (PET) imaging with 18F-PM-PBB3 suggested tau deposition in the substantia nigra of the midbrain and subcortical areas, but not in the cerebral cortex, which was similar to progressive supranuclear palsy (PSP), suggesting that parkinsonism-predominant type of Kii ALS/PDC may have a similar area of tau deposition to PSP.

AB - Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC), frequently observed in the Kii peninsula of Japan, is pathologically characterized by widespread tau pathology in the cerebrum and brainstem. Here, we report a case of Kii ALS/PDC predominantly presenting progressive parkinsonism. Tau positron emission tomography (PET) imaging with 18F-PM-PBB3 suggested tau deposition in the substantia nigra of the midbrain and subcortical areas, but not in the cerebral cortex, which was similar to progressive supranuclear palsy (PSP), suggesting that parkinsonism-predominant type of Kii ALS/PDC may have a similar area of tau deposition to PSP.

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A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging

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