A 71-year-old male who has had a nontender subcutaneous nodule on his neck for 35 years and another nodule on the right arm for seven years is reported. Urticaria-like eruptions occurred when the nodules were getting larger and the eruptions disappeared while the nodules became smaller. When he was hospitalized, eosinophilia (34%) and hyperimmunoglobulinemia (IgE, 15895 IU/ml) were found in the peripheral blood. Specific antibodies to various exogeneous antigens were detected by IgE-radioallergosorbent test. Immediate skin test to both candida and penicillium allergens were positive, too. Excision of the nodule revealed classical histological findings of Kimura's disease. After the excision the peripheral eosinophil counts and IgE titer were significantly decreased. Four months after the operation, itchy eruptions appeared on the upper arms, but these eruptions regressively disappeared after injestion of indomethacine orally and similar eruptions have not developed ever since. Although, high titers of both anti-thyroglo-bulin antibodies and antithyroid microsomal antibodies were not changed through the clinical course, the possibility of underlying autoimmune thyroiditis could be considered. The pathogenic relation between Kimura's disease and autoimmune thyroiditis is indistinct, however.
All Science Journal Classification (ASJC) codes
- Infectious Diseases