Liposarcoma is the second most common soft-tissue malignancy following malignant fibrous histocytoma. Only 5. 6% of liposarcomas are found in the head and neck, and most arise in soft neck tissue. Liposarcoma of the larynx is extremely rare, with only 34 cases reported in the English literature. We report case number 35. The World Health Organization (WHO) identifies five histological liposarcoma subtypes-welldifferentiated, myxoid, round cell, pleomorphic, and dedifferentiated. Our subject was a 38-year-old man with well-differentiated a primary arytenoids liposarcoma. We treated him using wide-excision directsuspension laryngoscopy, entirely preserving laryngeal structures and function. Laryngeal liposarcoma is easily mistaken for a benign soft tissue tumor. We diagnosed our subject with well-differentiated liposarcoma based on genetic studies confirming murine double minute 2 (MDM2) and cyclin-dependent kinase 4 (CDK4) amplification having the characteristic giant chromosome derived from the 12q(13-15) region. Laryngeal liposarcoma recurrence is high, but with no reported cervical lymph node metastasis. Wide surgical excision is the mainstay of treatment, although the usefulness of radiation therapy remains to be determined. Because well-differentiated liposarcoma has low malignancy, we retain larynx function and recommend removing a tumor surgically with sufficient margins and comprehensive long-term follow-up.
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