TY - JOUR
T1 - A case of lymphomatoid gastropathy
T2 - An indolent CD56-positive atypical gastric lymphoid proliferation, mimicking aggressive NK/T cell lymphomas
AU - Tanaka, Tsutomu
AU - Megahed, Nirmeen
AU - Takata, Katsuyoshi
AU - Asano, Naoko
AU - Niwa, Yasumasa
AU - Hirooka, Yoshiki
AU - Goto, Hidemi
N1 - Funding Information:
This work was supported in part by a Grant-in-aid for Cancer Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan , and a Grant-in-aid for delineation of molecular biological profile of the refractory lymphoid malignancy and the development of its tumor type-specific management from the Ministry of Health, Labor, and Welfare, Japan .
PY - 2011/12/15
Y1 - 2011/12/15
N2 - Lymphomatoid gastropathy (LyGa) is a new evolving pathological entity that has been introduced recently. It is designated to describe CD56-positive atypical gastric lymphoid proliferation, mimicking NK/T cell lymphomas, that shows an indolent clinical course with spontaneous regression. We here present our experience with one new case diagnosed and treated in our hospital. An annual upper endoscopic check-up of a 50-year-old male with an unremarkable past history revealed a small reddish lesion on the posterior wall of the gastric angle. Endoscopic biopsy showed atypical cells of NK-cell lineage expressing CD56, CD16, CD3, perforin, and TIA-1, but not CD4, CD5, and CD8. Epstein-Barr virus encoded RNA was negative. The lesion regressed spontaneously after one month without treatment, but recurred two years later in a different site of the stomach with spontaneous regression again one month later. The recurrence of lymphomatoid gastropathy is very rare and should be diagnosed carefully to distinguish it from the aggressive lymphoma.
AB - Lymphomatoid gastropathy (LyGa) is a new evolving pathological entity that has been introduced recently. It is designated to describe CD56-positive atypical gastric lymphoid proliferation, mimicking NK/T cell lymphomas, that shows an indolent clinical course with spontaneous regression. We here present our experience with one new case diagnosed and treated in our hospital. An annual upper endoscopic check-up of a 50-year-old male with an unremarkable past history revealed a small reddish lesion on the posterior wall of the gastric angle. Endoscopic biopsy showed atypical cells of NK-cell lineage expressing CD56, CD16, CD3, perforin, and TIA-1, but not CD4, CD5, and CD8. Epstein-Barr virus encoded RNA was negative. The lesion regressed spontaneously after one month without treatment, but recurred two years later in a different site of the stomach with spontaneous regression again one month later. The recurrence of lymphomatoid gastropathy is very rare and should be diagnosed carefully to distinguish it from the aggressive lymphoma.
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U2 - 10.1016/j.prp.2011.09.012
DO - 10.1016/j.prp.2011.09.012
M3 - Article
C2 - 22078056
AN - SCOPUS:82655187145
SN - 0344-0338
VL - 207
SP - 786
EP - 789
JO - Pathology Research and Practice
JF - Pathology Research and Practice
IS - 12
ER -