We report a 50-year-old female patient of malignant melanoma (MM) on the right sole arising from a lesion of palmoplantar keratoderma. The keratotic lesion appeared on her palm and sole at birth. She was treated with topical ointment, and shave resection of the keratotic lesion was performed many times. The melanotic macule on the right sole had appeared two years before her visiting our hospital. Because of the spreading pigmented macule and developing erosive nodule, she visited our hospital in August, 2008. The clinical findings revealed malignant melanoma with palmoplantar keratoderma. The tumor resection was performed with 2 cm margin. After treatment of etretinate for the keratoderma, the remaining pigmented macule appeared. Additional operation for removal of the remaining tumor was performed. It is suggested that malignant melanoma with palmoplantar keratoderma should be treated carefully before operation for the accurate resection margin.
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