A Case of Mediastinal Large Cell Lymphoma with Sclerosis

Yoshiharu Ohno, Masahiko Kusumoto, Masahiro Endo, Eiichiro Itouji, Michio Kono, Chiho Ohbayashi

Research output: Contribution to journalArticlepeer-review


A 38-year-old female was admitted because of discomfort and right chest pain. An anterior mediastinal mass was determined on chest X-ray and CT. On the MR image, the tumor showed expansive extension and necrosis, showing a high signal intensity on the T2-weighted image. Necrosis was not enhanced by Gd-DTPA. CT guided needle biopsy was performed and the tumor was diagnosed pathologically to be a diffuse large cell lymphoma with sclerosis. On immunohistochemical examination, the cells positively stained with leukocyte common antigen (LCA) and L-26. Chemotherapy combined with radiation therapy obtained a complete response. Almost all cases of this disease are treated surgically because it is difficult to diagnose it preoperatively. It was considered that the percutaneous needle biopsy can be useful for diagnosis of this disease, and that chemo-radiation therapy is effective.

Original languageEnglish
Pages (from-to)485-490
Number of pages6
Issue number4
Publication statusPublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine


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